There has been an upsurge in the consumption of
herbal remedies due to its availability, increased popularity, poor medical
services and inequalities in health service distribution in developing
countries. However, regulatory and safety issues remain a concern. This study
is aimed at assessing the concentration levels of some microelements and
macroelements in NAFDAC approved herbal remedies, and also to assess the
compliance of those products with national stipulated requirements for outer
pack labelling. A total of ten (10) herbal products that are marketed in
Nigeria were randomly purchased and analysed to determine the concentration
levels of selected elements (Zn, Fe, Ni, Mn, Pb, Cd, Na and K) using AAS. The
results indicated that Zn, Fe, Ni, Mn, Pb, Cd, Na and K have their own trends
of concentrations in all the samples studied. Although all the samples
contained Pb and Cd, the concentrations were below WHO permissible limits.
Also, the assessment of the outer pack labelling of the products revealed that
none of the samples complied totally with the national stipulated requirements.
Conclusively, the study has shown that the quality and safety of herbal
products needs to be regulated effectively before launching into the market.
Herbal remedies, macroelements, microelements,
labelling, NAFDAC, AAS
1. Agency for Toxic
substances and Disease Registry (2007).
Toxicological profile for lead. Atlanta GA: U.S. Department of Health and Human
Services, Public Health Service.
2. Aweng E.R, Noor
Syuviadah S, Norashikin M.F, Nur Izzati S, Ahmad Fadli A.S
(2014). Evaluation of Nutrition and Toxicity level of the Concoction of
Tropical Herbs used for Herbal Rice. Journal
of Applied Phytotechnolgy in Environmental Sanitation, 3(3): 109-115.
accessed on 1 October 2014
(Accessed September, 2014)
5. Isangadeghi B.A
(2012). Herbal medicines in Healthcare. In: NAFDAC Consumer Safety Publication
Issue 01 volume 02 p.17
6. Kabata-Pendias A,
Pendias H (1992). Trace elements in Soil and
Plants. CRC Press Inc., Boca Raton, Florida.
7. Kay I, Incekara N.
(2000). J. Turkish Weed Sci 3:56-64
8. Khan Z.I, Ahmad K,
Rasheed M.J.Z, Nawaz R, Ayub M, Zahoor F.A., Parveen B
(2013). Toxic and some essential metals in medicinal plants used in herbal
medicines: A case study in Pakistan. Afr.
J. Pharm. Pharmacol vol.7(21); pp 1389-1395.
9. National policy on
traditional medicine and regulation of Herbal medicines
(2005)- Report of a WHO Global Survey
10. Ogunrin Y
(2012). Evolution of Herbal medicine. In: NAFDAC Consumer Safety Publication
Issue 01 volume 01 p.6
11. Osakwe A.I
(2012). Safety monitoring of Herbal medicines. In: NAFDAC Consumer Safety
Publication Issue 01 volume 01 p.11
12. Oshikoya K. A.,
Senbanjo I. O., Njokanma O. F., Soipe A.
(2008). “Use of complementary and alternative medicines for children with
chronic health conditions in Lagos, Nigeria” BMC complementary and alternative
medicines vol. 8 p. 66
13. Samali A, Kirim R.A,
Mustapha K.B (2012). Qualitative and
quantitative evaluation of some herbal teas commonly consumed in Nigeria. Afr. J. Pharm. Pharmacol vol.6(6); pp
14. Sayyed M.R. Sayadi M.H
(2011). Variations in the heavy metal accumulations within the surface soils
from the Chigtar Industrial are of Tehran. Proceedings
of the International Academy of Ecology and environmental sciences I(I):
15. Stedman’s Medical
Dictionary (2000). Pugh M.B, editor. 27th
edition Lippincott Williams and Wilkins, USA. p.578, 1051
16. WHO (2005).
Quality Control Methods for Medicinal Plant Materials, Revised, Geneva.
(2008). WHO media centre Traditional Medicine Fact Sheet No 134 2008 (http://www.who.int/mediacentre/factsheets/fs134/en/)
Accessed January 9, 2015.
18. WHO Media Centre:
Traditional Medicine. Fact sheet No
134 2008 [http://www.who.int/mediacentre/factsheets/fs134/en/], (accessed
19. Zaidi M.I, Asrar A,
Mansoor A, Farooqui M.A (2005). The heavy metal
concentrations along roadside trees of Quetta and its effect on public health. Journal of Applied Science, vol.5, pp.