Pesticide Residue and Health Risk Analysis of Six Commonly Used Herbal Medicinal Products in Kumasi, Ghana

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DOI: 10.21522/TIJPH.2013.06.03.Art018

Authors : Frank Adusei Mensah, Isaac Tabiri Henneh, Martins Ekor

Abstract:

Background: Ghana does not have reliable surveillance programme for ensuring safety of food and herbal products on the market. Data from previous studies have shown the presence of pesticide residues in food products and its associated health risk. In this present study we assessed the residual pesticide content of six most patronized herbal preparations in Kumasi, Ghana and the attendant risk of such contamination to public health.

Methodology: The herbal preparations were cleaned up using Quick, Easy, Cheap, Effective, Rugged, and Safe (QuEChERS) method for insecticide analysis. Analysis was carried out on GC-MS using 33 external standards.

Results: The total pesticide content in most of the herbal preparations was below the maximum residue limit (MRL). However, the concentration of pirimiphos-methyl in herbal product ‘E’ (HPE) (0.082 mg/kg) was higher than the MRL (0.05 mg/kg). In addition, the hazard indices’ (HI) for five herbal products were less than ‘1’ and safe for consumption without any possible future health risk. However, the HI for HPE was determined to be greater than ‘1’. Aldrin, dieldrin and chlordane which are banned in Ghana were also identified in 50% of the studied herbal preparations.

Conclusion: Data from this study reveals that HPE is contaminated with pirimiphos-methyl pesticide and unsafe for consumption. Also, the presence of banned pesticides in 50% of the studied herbal preparations calls for concern and urgent intervention by relevant regulatory authorities.

Keywords: Herbal medicinal preparation, hazard index, pesticides, contamination, health risk, safety.

References:

[1].     Abdel-Ghany, R., Mohammed, E., Anis, S., Barakat, W., (2016). Impact of Exposure to Fenitrothion on Vital Organs in Rats [WWW Document]. J. Toxicol. https://doi.org/10.1155/2016/5609734.

[2].     Akoto, O., Gavor, S., Appah, M.K., Apau, J., (2015a). Estimation of human health risk associated with the consumption of pesticide-contaminated vegetables from Kumasi, Ghana. Environ. Monit. Assess. 187, 244. https://doi.org/10.1007/s10661-015-4471-0.

[3].     Akoto, O., Oppong-Otoo, J., Osei-Fosu, P., (2015b). Carcinogenic and non-carcinogenic risk of organochlorine pesticide residues in processed cereal-based complementary foods for infants and young children in Ghana. Chemosphere 132, 193–199. https://doi.org/10.1016/j.chemosphere.2015.02.056

[4].     Amoah, P., Drechsel, P., Abaidoo, R.C., Ntow, W.J., (2006). Pesticide and pathogen contamination of vegetables in Ghana’s urban markets. Arch. Environ. Contam. Toxicol. 50, 1–6. https://doi.org/10.1007/s00244-004-0054-8.

[5].     Chouaïbou, M.S., Fodjo, B.K., Fokou, G., Allassane, O.F., Koudou, B.G., David, J.-P., Antonio-Nkondjio, C., Ranson, H., Bonfoh, B., (2016). Influence of the agrochemicals used for rice and vegetable cultivation on insecticide resistance in malaria vectors in southern Côte d’Ivoire. Malar. J. 15, 426. https://doi.org/10.1186/s12936-016-1481-5.

[6].     Darko, G., Acquaah, S.O., (2008). Levels of organochlorine pesticides residues in dairy products in Kumasi, Ghana. Chemosphere 71, 294–298. https://doi.org/10.1016/j.chemosphere.2007.09.005

[7].     Darko, G., Addai Tabi, J., Adjaloo, M.K., Borquaye, L.S., (2017). Pesticide Residues in Honey from the Major Honey Producing Forest Belts in Ghana. J. Environ. Public Health 2017, 7957431. https://doi.org/10.1155/2017/7957431.

[8].     Darko, G., Akoto, O., (2008). Dietary intake of organophosphorus pesticide residues through vegetables from Kumasi, Ghana. Food Chem. Toxicol. Int. J. Publ. Br. Ind. Biol. Res. Assoc. 46, 3703–3706. https://doi.org/10.1016/j.fct.2008.09.049.

[9].     Di Bella, G., Haddaoui, I., Lo Turco, V., Potortì, A.G., Fede, M.R., Dugo, G., (2017). POP levels in beans from Mediterranean and tropical areas. J. Sci. Food Agric. 97, 2610–2616. https://doi.org/10.1002/jsfa.8083

[10]. Ekhator, O.C., Udowelle, N.A., Igbiri, S., Asomugha, R.N., Igweze, Z.N., Orisakwe, O.E., (2017). Safety Evaluation of Potential Toxic Metals Exposure from Street Foods Consumed in Mid-West Nigeria. J. Environ. Public Health 2017. https://doi.org/10.1155/2017/8458057.

[11]. EPA Bans 25 Dangerous Agro-Chemicals, (2008). Mod. Ghana. URL https://www.modernghana.com/news/180428/epa-bans-25-dangerous-agro-chemicals.html (accessed 2.27.18).

[12]. Essumang, D.K., Asare, E.A., Dodoo, D.K., (2013). Pesticides residues in okra (non-target crop) grown close to a watermelon farm in Ghana. Environ. Monit. Assess. 185, 7617–7625. https://doi.org/10.1007/s10661-013-3123-5.

[13]. Fosu, P.O., Donkor, A., Ziwu, C., Dubey, B., Kingsford-Adaboh, R., Asante, I., Nyarko, S., Tawiah, R., Nazzah, N., (2017). Surveillance of pesticide residues in fruits and vegetables from Accra Metropolis markets, Ghana, 2010-2012: a case study in Sub-Saharan Africa. Environ. Sci. Pollut. Res. Int. 24, 17187–17205. https://doi.org/10.1007/s11356-017-9287-8.

[14]. Harrison, R.M., Chirgawi, M.B., (1989). The assessment of air and soil as contributors of some trace metals to vegetable plants. I. Use of a filtered air growth cabinet. Sci. Total Environ. 83, 13–34.

[15]. Johnson, L.A., Welch, B., Whitfield, S.M., (2013). Interactive effects of pesticide mixtures, predators, and environmental regimes on the toxicity of two pesticides to red-eyed tree frog larvae. Environ. Toxicol. Chem. 32, 2379–2386. https://doi.org/10.1002/etc.2319.

[16]. Kimaru, H.P.N.I.W., (2014). GC–MS Analysis of an Herbal Medicinal Remedy to Identify Potential Toxic Compounds

http://www.chromatographyonline.com/gc-ms-analysis-herbal-medicinal-remedy-identify-potential-toxic-compounds-0 (accessed 3.12.18).

[17]. Kuranchie-Mensah, H., Yeboah, P.O., Nyarko, E., Golow, A.A., (2013). Studies on organochlorine pesticide residue in fishes from the Densu river basin, Ghana. Bull. Environ. Contam. Toxicol. 90, 421–426. https://doi.org/10.1007/s00128-012-0931-1.

[18]. Mosaddegh, M.H., Emami, F., Asghari, G., (2014). Evaluation of Residual Diazinon and Chlorpiryfos in Children Herbal Medicines by Headspace-SPME and GC-FID. Iran. J. Pharm. Res. IJPR 13, 541–549.

[19]. Naithani, V., Kakkar, P., (2004). An evaluation of residual organochlorine pesticides in popular Indian herbal teas. Arch. Environ. Health 59, 426–430. https://doi.org/10.3200/AEOH.59.8.426-430.

[20]. Ngoula, F., Watcho, P., Dongmo, M.-C., Kenfack, A., Kamtchouing, P., Tchoumboué, J., (2007). Effects of pirimiphos-methyl (an organophosphate insecticide) on the fertility of adult male rats. Afr. Health Sci. 7, 3–9. https://doi.org/10.5555/afhs.2007.7.1.3.

[21]. Obiri-Danso, K., Adonadaga, M.G., Hogarh, J.N., (2011). Effect of agrochemical use on the drinking water quality of Agogo, a tomato growing community in Ashanti Akim, Ghana. Bull. Environ. Contam. Toxicol. 86, 71–77. https://doi.org/10.1007/s00128-010-0183-x.

[22]. Oh, C.-H., (2009). Monitoring of residual pesticides in herbal drug materials of Korea and China. Bull. Environ. Contam. Toxicol. 82, 639–643. https://doi.org/10.1007/s00128-009-9649-0.

[23]. Osei-Fosu, P., Donkor, A.K., Nyarko, S., Nazzah, N.K., Asante, I.K., Kingsford-Adabo, R., Arkorful, N.A., (2014). Monitoring of pesticide residues of five notable vegetables at Agbogbloshie market in Accra, Ghana. Environ. Monit. Assess. 186, 7157–7163. https://doi.org/10.1007/s10661-014-3917-0.

[24]. Ou, X., Wang, L., Guo, L., Cui, X., Liu, D., Yang, Y., (2016). Soil-Plant Metal Relations in Panax notoginseng: An Ecosystem Health Risk Assessment. Int. J. Environ. Res. Public. Health 13. https://doi.org/10.3390/ijerph13111089.

[25]. Pubchem, n.d. Chlorpyrifos-methyl [WWW Document]. URL https://pubchem.ncbi.nlm.nih.gov/compound/21803 (accessed 7.20.18).

[26]. Pubchem, n.d. Pirimiphos-methyl [WWW Document]. URL https://pubchem.ncbi.nlm.nih.gov/compound/34526 (accessed 7.20.18).

[27]. Pubchem, n.d. Fenitrothion [WWW Document]. URL https://pubchem.ncbi.nlm.nih.gov/compound/31200 (accessed 7.20.18).

[28]. Skovgaard, M., Renjel Encinas, S., Jensen, O.C., Andersen, J.H., Condarco, G., Jørs, E., (2017). Pesticide Residues in Commercial Lettuce, Onion, and Potato Samples From Bolivia—A Threat to Public Health? Environ. Health Insights 11. https://doi.org/10.1177/1178630217704194.

[29]. Wang, X., Sato, T., Xing, B., Tao, S., (2005). Health risks of heavy metals to the general public in Tianjin, China via consumption of vegetables and fish. Sci. Total Environ. 350, 28–37. https://doi.org/10.1016/j.scitotenv.2004.09.044.

[30]. Yang, W.-Z., Kang, C.-Z., Ji, R.-F., Zhou, L.I., Wang, S., Li, Z.-H., Ma, Z.-H., Guo, L.-P., (2017). [Situation analysis and standard formulation of pesticide residues in traditional Chinese medicines]. Zhongguo Zhong Yao Za Zhi Zhongguo Zhongyao Zazhi China J. Chin. Mater. Medica 42, 2284–2290.