Socio-Demographic Predictors of non-communicable Diseases among People Living with HIV on ART in Enugu, Southeast Nigeria

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DOI: 10.21522/TIJAR.2014.12.04.Art017

Authors : Douglas Akpu-Agbata

Abstract:

Human Immunodeficiency Virus remains a major global health burden, with millions affected worldwide. Although Antiretroviral Therapy (ART) has reduced HIV-related deaths, its long-term use has been associated with the development of non-communicable diseases (NCDs). This study investigated socio-demographic predictors of NCDs among People Living with HIV (PLHIV) on ART in Enugu, Southeast Nigeria. A hospital-based cross-sectional design was employed to abstract data on socio-demographic characteristics, prevalence, and risk factors among PLHIV aged ≥18 years. Data were analyzed using IBM SPSS Statistics 25, with results presented as frequencies, percentages, and mean ± standard deviation. Logistic regression was applied to generate adjusted odds ratios (AOR) with p-values ≤0.05 at 95% confidence interval. Findings showed that age, marital status, education, and occupation significantly predicted NCD onset. Participants aged 41–60 years were four times more likely to develop hypertension (AOR: 4.47; CI: 3.32–6.18). Being married increased the likelihood of developing any NCD, while secondary education was strongly associated with hypertension (AOR: 4.52; CI: 3.34–5.94) and diabetes (AOR: 2.55; CI: 1.97–3.02). Unemployment also predicted hypertension (AOR: 3.72; CI: 1.32–3.08). Female participants had higher likelihood of hypertension, obesity, and cervical cancer than males. These results highlight the critical role of socio-demographic factors in NCD development among PLHIV on ART. The study underscores the importance of incorporating targeted, context-specific interventions that address socio-economic determinants in HIV care to reduce NCD comorbidities and improve quality of life of affected individuals.

References:

[1].   WHO, 2021, in HIV, Estimated number of people (all ages) living with HIV 2023 [Available from: .

[2].   National Agency for the control of AIDS 2011, Update on the HIV/AIDS epidemic response in Nigeria.

[3].   Coetzee, L., Bogler, L., De Neve, J-W., Barnighausen, T., Geldsetzer, P., and Vollmer, S., 2019, HIV, antiretroviral therapy and non-communicable diseases in sub-Saharan Africa: empirical evidence from 44 countries over the period 2000 to 2016. J. Int. AIDS Soc. 22(7), e25364.

[4].   WHO, Noncommunicable diseases 2017, World Health Organization.

[5].   Jadeja, S., Pai, G., Bhat, K., and Sathyanarayana, M. B., 2018, President’s emergency plan for AIDS relief. Syst Rev Pharm., 9(1):6–9.

[6].   Bor, J., Herbst, A. J., Newell, M-L., and Barnighausen, T., 2013, Increases in adult life expectancy in rural South Africa: valuing the scale-up of HIV treatment. Science, 3396122:961–965.

[7].   Achwoka, D., Oyugi, J. O., Mutave, R., Munywoki, P., Achia, T., Akolo, M., Muriuki, F., Muthui, M., and Kimani, J., 2020, High prevalence of non-communicable diseases among key populations enrolled at a large HIV prevention & treatment program in Kenya. PLoS One, 15(7), e0235606.

[8].   Feinstein, M. J., Hsue, P. Y., Benjamin, L. A., Bloomfield, G. S., Currier, J. S., Freiberg, M. S., Grinspoon, S. K., Levin, J., Longenecker, C. T., Post, W. S., and American Heart Association Prevention Science Committee of the Council on Epidemiology and Prevention and Council on Cardiovascular and Stroke Nursing; Council on Clinical Cardiology; and Stroke Council. 2019. Characteristics, prevention, and management of cardiovascular disease in people living with HIV: a scientific statement from the American Heart Association. Circulation, 140(2), e98-e124.

[9].   Seang, K., Javanbakht, M., Lee, S-J., Brookmeyer, R., Pheng, P., Chea, P., Saphonn, V., and Gorbach, P. M., 2022, Differences in prevalence and risk factors of non-communicable diseases between young people living with HIV (YLWH) and young general population in Cambodia. PLoS ONE 17(6), e0269989

[10].  Kansiime, S., Mwesigire, D., & Mugerwa, H., Prevalence of non-communicable diseases among HIV positive patients on antiretroviral therapy at joint clinical research centre, Lubowa, Uganda. PLoS ONE 14(8), e0221022 2019.

[11].  Thet, D., and Siritientong, T., 2020, Antiretroviral therapy-associated metabolic complications: Review of the recent studies. HIV/AIDS – Res. Palliative Care 12, 507–524. .

[12].  Gausi, B., Otiku, P., Jacob, N., & Oni, T., Patient outcomes in integrated HIV and non-communicable disease models of care: A scoping review. J. Global Health Rep. 5, e2021084 2021.

[13].  Okeke, F. O., Sam-Amobi, C. G., & Okeke, F. I., 2020, Role of local town planning authorities in building collapse in Nigeria: evidence from Enugu metropolis. Heliyon, 6(7), e04361.

[14].  Ezeala-Adikaibe, B., Aneke, E., Orjioke, C., Ezeala-Adikaibe, N., Mbadiwe, N., Chime, P., & Okafor, U., 2014, Pattern of medical admissions at Enugu state University of Science and Technology Teaching Hospital: a 5-year review. Annals of medical and health sciences research, 4(3), 426–431.

[15].  Abugu, J. O., Chukwu, A. M., Onyeso, O. K., et al., 2023, Determinants of the managerial staff’s disposition towards e-payment platforms in public tertiary hospitals in Enugu, Nigeria: a cross-sectional study. BMC Health Serv Res 23, 1240.

[16].  Magodoro, I. M., Esterhuizen, T. M., Chivese, T., 2016, A cross-sectional, facility-based study of comorbid non-communicable diseases among adults living with HIV infection in Zimbabwe. BMC Res Notes, 9(1):379.

[17].  Achwoka, D., Waruru, A., Chen, T. H., Masamaro, K., Ngugi, E., Kimani, M., Mukui, I., Oyugi, J.O., Mutave, R., Achia, T., Katana, A., Ng'ang'a, L., and De Cock, K. M., 2019, Noncommunicable disease burden among HIV patients in care: a national retrospective longitudinal analysis of HIV-treatment outcomes in Kenya, 2003-2013. BMC Public Health, 3;19(1):372.

[18].  Mathebula, R. L., Maimela, E., & Ntuli, N. S., 2020, The prevalence of selected non-communicable disease risk factors among HIV patients on anti-retroviral therapy in Bushbuckridge sub-district, Mpumalanga province. BMC Public Health 20, 247, https://doi.org/10.1186/s12889-019-8134-x.

[19].  Anish, T. S., Shahulhameed, S., Vijayakumar, K., Joy, T. M., Sreelakshmi, P. R., Kuriakose, A., 2013, Gender Difference in Blood pressure, Blood Sugar, and Cholesterol in Young Adults with Comparable Routine Physical Exertion. J Family Med Prim Care, 2(2):200-203. doi: 10.4103/2249-4863.117424.

[20].  Bogorodskaya, M., Chow, F. C., Triant, V. A., 2013, Stroke in HIV. Canadian Journal of Cardiology, 35(3), 280-287.

[21].  Tate, T., Willig, A. L., Willig, J. H., Raper, J. L., Moneyham, L., Kempf, M. C., Saag, M. S., Mugavero, M. J., 2012, HIV infection and obesity: where did all the wasting go? Antivir Ther. 17(7):1281.

[22].  Kagaruki, G. B., Mayige, M. T., Ngadaya, E. S., Kimaro, G. D., Kalinga, A. K., Kilale, A. M., Kahwa, A. M., Materu, G. S., and Mfinanga, S. G., 2014, Magnitude and risk factors of non-communicable diseases among people living with HIV in Tanzania: a cross-sectional study from Mbeya and Dar es Salaam regions. BMC Public Health, 14(1):904.

[23].  Braithwaite, R. S., Conigliaro, J., McGinnis, K. A., Maisto, S. A., Bryant, K., and Justice, A. C., 2008, Adjusting alcohol quantity for mean consumption and intoxication threshold improves prediction of nonadherence in HIV patients and HIV-negative controls. Alcohol Clin Exp Res., 32(9):1645–51.

[24].  Justice, A., Sullivan, L., and Fiellin, D., 2010, Veterans Aging Cohort Study Project Team. HIV/AIDS, comorbidity, and alcohol: can we make a difference? Alcohol Res Health, 33(3):258.

[25].  da Silva, C. M., Mendoza-Sassi, R. A., da Mota, L. D., Nader, M. M. and de Martinez, A. M., 2017, Alcohol use disorders among people living with HIV/AIDS in Southern Brazil: prevalence, risk factors and biological markers outcomes. BMC Infect Dis., 17(1):263.