Evaluating the Impact of Common Technical Document Adoption on Medicines Regulatory Performance in Nigeria: An Interrupted Time-Series Analysis
Abstract:
The Common
Technical Document (CTD) has been widely adopted to harmonise medicines
regulatory submissions and strengthen regulatory systems, yet empirical
evidence on its performance impact in low- and middle-income countries remains
limited. This study evaluated the effect of CTD adoption on medicines
regulatory performance in Nigeria using a quasi-experimental interrupted
time-series design. Monthly regulatory data from January 2018 to December 2024
were analysed, with June 2020 marking the introduction of mandatory CTD
submissions. Outcomes examined included medicines approval volumes, regulatory
safety signals (alerts and recalls per 100 approvals), and post-market quality
outcomes measured through risk-based post-market surveillance (RB-PMS) failure
rates. Segmented regression analysis showed no statistically significant
pre-intervention trend in approvals (p = 0.788), no immediate level change
following CTD adoption (p = 0.658), and no significant post-intervention trend
change (p = 0.723). Similarly, no significant changes were observed in
regulatory safety signal rates at the point of CTD implementation (p = 0.971)
or in post-intervention trends (p = 0.894). In contrast, RB-PMS outcomes showed
a statistically significant immediate reduction in failure rates following CTD
adoption (p < 0.001), followed by a significant positive post-intervention
trend (p < 0.001), indicating that initial quality gains were not sustained
over time. Overall, the findings suggest that CTD adoption functions as a foundational
harmonisation reform but does not independently produce sustained improvements
in regulatory throughput or safety outcomes without complementary institutional
and operational strengthening.
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