Prevalence of Non -Adherence to Tuberculosis Therapy and Associated Factors among Patients with Pulmonary Tuberculosis at Mwananyamala Regional Referral Hospital, Dar- es- salaam

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DOI: 10.21522/TIJAR.2014.13.02.Art027

Authors : Mbeya B., Ambrose T.

Abstract:

This study aimed to assess the prevalence of non- adherence to Tuberculosis therapy and associated factors among patients with pulmonary Tuberculosis at Mwananyamala Regional Referral Hospital, Dar es Salaam. It was a cross-sectional study involving Tuberculosis (TB) patients who attended the outpatient clinic at Mwananyamala Regional Referral Hospital. The sample size of this study consisted of 422 participants who were selected through systematic random sampling. Data collection was done by using structured questionnaires incorporated in Open Data Kit (ODK); in addition, the TB treatment card and the Morisky Medical Adherence scale (MMS) were also used. Data analysis was done by Statistical Package for the Social Sciences (SPSS) version 16.0 to find the proportion of respondents choosing different responses. The study findings indicated that most patients adhere to TB treatment by 98%, and only 2% did not adhere to TB treatment. Factors associated with adherence, such as TB drugs’ side effects and non-compliance, did not influence non-adherence. The study recommends the same modality of treatment to continue to maintain the adherence level of TB patients. This study has implications for all stakeholders involved in TB patients’ management. The practical and theoretical implications provide the benefits of the study to the government, non-governmental organizations, and research organizations.

References:

[1]. Kaufmann, S. H. E., Hussey, G., Lambert, P. H., Town, C., 2010, Tuberculosis 6 New vaccines for tuberculosis. The Lancet, 375(9731):2110–9. Doi:10.1016/S0140-6736(10)60393-5.

[2]. Gunda, D. W., Nkandala, I., Kavishe, G. A., Kilonzo, S. B., Kabangila, R., Mpondo, B. C., 2017, Prevalence and Risk Factors of Delayed Sputum Conversion among Patients Treated for Smear Positive PTB in Northwestern Rural Tanzania: A Retrospective Cohort Study. Vol. 2017.

[3]. Tola, H. H., Tol, A., Shojaeizadeh, D., 2015, Tuberculosis Treatment Non-Adherence and Lost to Follow Up among TB Patients with or without HIV in Developing Countries: A Systematic Review. Vol. 44; 44(1):1–11.

[4]. Aziz, K., Hisam, A., Azam, N., Pervaiz, F., & Mehmood, H., 2019, Knowledge of disease and adherence to anti-tuberculosis treatment-a cross sectional study in Rawalpindi District. Pakistan Armed Forces Medical Journal, (2), S267.

[5]. Seebregts, C. J., 2016, An ontology for factors affecting tuberculosis treatment adherence behavior in sub-Saharan Africa;669–81.

[6]. Ford, S., 2018, Nurses of tomorrow’ Nursing theories 4: adherence and concordance.

[7]. Noor, H., Muhamad, H., 2017, Systematic review of factors associated with medication adherence among pulmonary tuberculosis patients. Vol. 4;4(6).

[8]. Chani, K., 2010, Factors Affecting Compliance to Tuberculosis Treatment in Andara Kavango Region Namibia.

[9]. WHO, 2002, Pharmacovigilance.

[10].Sumari-de Boer, M., Pima, F. M., Ngowi, K. M., Chelangwa, G. M., Mtesha, B. A., Minja, L. M., et al., 2019, Implementation and effectiveness of evriMED with short messages service (SMS) reminders and tailored feedback compared to standard care on adherence to treatment among tuberculosis patients in Kilimanjaro, Tanzania: Proposal for a Cluster Randomized;1–10.

[11].Sani, Z., 2019, University of Ghana https://ugspace.ug.edu.gh Determinants of Medication Adherence Among Patients with Tuberculosis: A Study at Sokoto Metropolis, by This Dissertation is Summited to the University of Ghana, Legon in Partial Fulfilment of the Requiremen;(10702768).

[12].Wang, Y., Chen, H., Mcneil, E. B., Lu, X., 2019, Drug Non-Adherence and Reasons Among Multidrug-Resistant Tuberculosis Patients in Guizhou, China: A Cross-Sectional Study.

[13].WHO., 2018, global TUBERCULOSIS.

[14].Xu, W., Lu, W., Zhou, Y., Zhu, L., Shen, H., Wang, J., 2016, Adherence to anti-tuberculosis treatment among pulmonary tuberculosis patients: a qualitative and quantitative study. Vol. 8; 8:1–8. Doi:10.1186/1472-6963-9-169.

[15].Zegeye, A., Dessie, G., Fasil, W. K., 2019, Prevalence and determinants of anti-tuberculosis treatment non-adherence in Ethiopia. PLoS One.

[16].NTLP, 2020, TB Prevalence in Tanzania. National Tuberculosis and Leplosy program. p. 1–6.

[17].Herrero, M. B., Ramos, S., & Arrossi, S., 2015, Determinants of non adherence to tuberculosis treatment in Argentina: barriers related to access to treatment. Revista Brasileira de Epidemiologia18, 287-298.

[18].Tanzania, M of H., 2017, The National Guidelines for Tuberculosis Infection Control.

[19].van den Boogaard, J., Msoka, E., Homfray, M., Kibiki, G. S., Heldens, J. J., Felling, A. J., & Aarnoutse, R. E., 2012, An Exploration of Patient Perceptions of Adherence to Tuberculosis Treatment in Tanzania. Doi:10.1177/1049732312438968.

[20].Suliman, Q., Said, S., Ying, L. P., 2019, SCIENCE & TECHNOLOGY Timing and Prognostic Factors of Tuberculosis Treatment Interruption. Vol. 27;27(4):1509–25.

[21].Krasniqi, S., Jakupi, A., Daci, A., Tigani, B., Jupolli-krasniqi, N., Pira, M., et al., 2017, Tuberculosis Treatment Adherence of Patients in Kosovo. Vol. 2017.

[22].Hoza, A. S., Mfinanga, S. G. M., König, B., 2015, Anti-TB drug resistance in Tanga, Tanzania: A cross sectional facility-base prevalence among pulmonary TB patients. Asian Pac J Trop Med;8(11):907–13. Doi:10.1016/j.apjtm.2015.10.014.

[23].Mnyambwa, N. P., Lekule, I., Ngadaya, E. S., Kimaro, G., Petrucka, P., Kim, D. J., ... & Mfinanga, S. G., 2018, Assessment of GeneXpert GxAlert platform for multi drug resistant tuberculosis diagnosis and patients’ linkage to care in Tanzania. BMC.

[24].Mpagama, S. G., Heysell, S. K., Ndusilo, N. D., Kumburu, H. H., Lekule, I. A., Kisonga, R. M., et al., 2013, Diagnosis and Interim Treatment Outcomes from the First Cohort of Multidrug-Resistant Tuberculosis Patients in Tanzania. PLoS One;8(5). Doi: 10.1371/journal.pone.0062034 PubMed PMID: 23675411.

[25].WHO, 2019, Global tuberculosis report 2019.

[26].Chonde, T. M., Doulla, B., van Leth, F., Mfinanga, S. G., Range, N., Lwilla, F., ... & Egwaga, S. M., 2008, Implementation of a national anti-tuberculosis drug resistance survey in Tanzania. Vol. 6. 2008;6:1–6. Doi:10.1186/1471-2458-8-427.

[27].Abraham, C., & Sheeran, P. 2005, The health belief model. Cambridge University Press.

[28].Kuiper, M. E., de Bruijn, A. L., Reinders Folmer, C., Olthuis, E., Brownlee, M., Kooistra, E. B., ... & Van Rooij, B., 2020, The Intelligent Lockdown: Compliance with COVID-19 Mitigation Measures in the Netherlands. SSRN Electronic Journal;1–38. Doi:10.2139/ssrn.3598215.

[29].Mkopi, A., Range, N., Lwilla, F., Egwaga, S., Schulze, A., Geubbels, E., et al., 2012, Adherence to Tuberculosis Therapy among Patients Receiving Home-Based Directly Observed Treatment: Evidence from the United Republic of Tanzania. PLoS One;7(12):1–7. Doi:10.1371/journal.pone.0051828 PubMed PMID: 23284782.

[30].Oshi, D. C., Oshi, S. N., Alobu, I., Ukwaja, K. N., 2014, Profile and treatment outcomes of tuberculosis in the elderly in southeastern Nigeria, 2011-2012. PLoS One;9(11). Doi:10.1371/journal.pone.0111910 PubMed PMID: 25369001.

[31].Neves, L. A. D. S., Castrighini, C. D. C., Reis, R. K., Canini, S. R. M. D. S., & Gir, E., 2018, Social support and quality of life of people with tuberculosis/HIV. Enfermeria Global;17(2):21–9. Doi:10.6018/eglobal.17.2.276351.

[32].Noor Haslinda, I., & Juni, M. H., 2017, Systematic review of factors associated with medication adherence among pulmonary tuberculosis patients. Vol. 4; 4(6).

[33].Popkin, B. M., Anci, K. E., Rosenberg, I. H., 2010, Water, hydration, and health. Nutrition Reviews. Blackwell Publishing Inc; p. 439–58. Doi:10.1111/j.1753-4887.2010.00304.x PubMed PMID: 20646222.

[34].Kidenya, B. R., Mshana, S. E., Gerwing-adima, L., Kidola, J., Kasang, C., 2017, International Journal of Infectious Diseases Drug adherence and ef fi cacy of smear microscopy in the diagnosis of pulmonary tuberculosis after 2 months of medication in. International Journal of Infectious Diseases; 63:43–7. Doi:10.1016/j.ijid.2017.07.025.

[35].Ndwiga, J. M., Kikuvi, G., Omolo, J. O., 2016, Factors influencing knowledge on completion of treatment among tb patients under directly observed treatment strategy, in selected health facilities in embu county, Kenya. Pan African Medical Journal; 25. Doi:10.11604/pamj.2016.25.234.8761 PubMed PMID: 28293350.

[36].Urnila, A., Mohammad Arifin, N., Suyanto, S., 2026, The Relationship Between Family Support and Treatment Adherence Among Patients with Tuberculosis. International Journal of Health Science;6(1):218–43. Doi:10.55606/ijhs.v6i1.6845.