Determinants of Vaccination Dropout among Children in the Gambia: A Mixed-Method Comparison of Urban and Rural Health Regions
Abstract:
The dropout rate is the proportion of vaccine
recipients who have not completed their vaccination schedules. In
The Gambia, vaccination dropout persists despite rising immunization coverage
from 76% in 2013 to 85% in 2020. The 2020 DHS reports high initial uptake of
multi-dose vaccines (98–99%), but final-dose completion drops to 92–95%. These
disparities highlight systemic barriers and the need to identify determinants
of dropout to guide targeted interventions. This study employed a mixed-methods approach,
combining a quantitative unmatched case–control design with a qualitative
component. In the quantitative phase, mothers of children who completed the
routine immunization schedule (controls) compared with mothers of children who
experienced vaccination dropout (cases). The
qualitative component included in-depth interviews with mothers from both
groups to explore contextual factors, perceptions, and lived experiences
related to vaccination completion. The
findings indicated that maternal education was consistently associated with
vaccination dropout. Children from households in the poorest wealth quintile
were more likely to drop out of routine immunization compared with those in the
highest wealth quintile. Maternal age was also significantly associated with vaccination
dropout. Geographic access played an important role: shorter distance to health
facilities was associated with lower dropout rates, while limited access to
nearby health services contributed to higher vaccination dropout. Identifying
the factors associated with dropout is essential for designing targeted
interventions. Strengthening community-based outreach, improving service
accessibility, and promoting maternal health service use may help reduce
dropout and enhance immunization outcomes.
References:
[1]. World Health Organization (WHO), 2021, Vaccines
and Immunization. WHO Geneva Switz 2021. https://www.who.int/health-topics/vaccines-and-immunization#tab=tab_1.
[2]. Young, B., Sarwar, G., Hossain, I.,
Mackenzie, G., 2021, Risk-factors Associated with Non-Vaccination in Gambian
Children: A Population-Based Cohort Study. MedRxiv.
2021;2021(03):19.21253855. https://doi.org/10.1101/2021.03.19.21253855.
[3]. Animaw, W., Taye, W., Merdekios, B.,
Tilahun, M., Ayele, G., 2013, Expanded program of immunization coverage and
associated factors among children age 12 – 23 months in Arba Minch town and
Zuria District, Southern Ethiopia. BMC Public Health. https://doi.org/10.1186/1471-2458-14-464.
[4]. Ali, H. A., Hartner, A. M.,
Echeverria-Londono, S., Roth, J., Li, X., Abbas, K., Portnoy, A., Vynnycky, E.,
Woodruff, K., Ferguson, N. M., et al, 2022, Vaccine equity in low- and
middle-income countries: A systematic review and meta-analysis. Int. J.
Equity Health..
[5]. Wallace, A. S., Ryman, T. K., Privor-Dumm,
L., Morgan, C., Fields, R., Garcia, C., Sodha, S., Lindstrand, A., Lochlainn,
L. N., 2022, Leaving no one behind: Defining and implementing an integrated
life course approach to vaccination across the next decade as part of the
immunization Agenda 2030. in press.
[6]. Santé, WHO= O mondiale de
la., EXPANDED PROGRAMME ON IMMUNIZATION. Vol. 35, 2000, Weekly Epidemiological Record = Relevé épidémiologique hebdomadaire. World Health Organization
= Organization mondiale de la Santé.
[7].
The Gambia
Health Service Statistics, 2023, The Ministry of Health.
[8]. Chanie, M. G., Ewunetie, G. E., Molla, A.,
Muche, A., 2019, Determinants of vaccination dropout among children 12–23
months age in north Gondar zone, northwest Ethiopia. PLoS ONE 2021, 16,
e0246018.
[9]. Ntenda, P. A., Sixpence,
A., Mwenyenkulu, T. E., Mwanga, K., Chirambo, A. C., Bauleni, A., Nkoka, O.,
2022, Determinants of pentavalent and measles vaccination dropouts among
children aged 12–23 months in The Gambia. BMC Public Health.
[10]. Awasthi, A., Pandey, C. M.,
Singh, U., Kumar, S., Singh, T. B., 2015, Maternal determinants of immunization status of
children aged 12–23 months in urban slums of Varanasi, India. Clin.
Epidemiol. Glob. Health, 3, 110–116.
[11]. Datta, A., Mog, C., Das, S.,
Datta, S., 2017, A
cross-sectional study to assess the immunization coverage and vaccine dropout
rates among 12 to 23 months old children in a rural area of Tripura. Int.
J., 6, 394.
[12]. Haji, A., Lowther, S., Ngan’Ga, Z., Gura,
Z., Tabu, C., Sandhu, H., Arvelo, W., 2014, Reducing routine vaccination
dropout rates: Evaluating two interventions in three Kenyan districts. BMC
Public Health 2016, 16, 152.
[13]. Chanie, M. G.,
Ewunetie, G. E., Molla, A., Muche, A., 2021, Determinants of vaccination
dropout among children 12–23 months age in north Gondar zone, northwest Ethiopia. PLoS
ONE 2021, 16, e0246018.
[14]. Mane, A. B., 2015, Letter to Editor: Immunization Dropout Rates:
Some Issues. Ann. Med. Health Sci. Res.
[15]. Baguune, B., Ndago, J. A., Adokiya, M. N.,
2017, Immunization dropout rate and data quality among children 12–23 months of
age in Ghana. Arch. Public Health 75, 18.
[16]. Thapa, K., Adhikary, P., Faruquee, M. H.,
Suwal, B. R., 2021, Associated Factors for Dropout of First Vs Third Doses of
Diphtheria Tetanus Pertussis (DPT) Vaccination in Nepal. Adv Prev Med.
[17]. Haji, A., Lowther, S., Ngan’Ga,
Z., Gura, Z., Tabu, C., Sandhu, H., et al., 2016, Reducing routine vaccination dropout rates: evaluating
two interventions in three Kenyan districts, 2014. BMC Public Health.
[18]. Baguune, B., Ndago, J. A., Adokiya, M. N.,
2023, Immunization dropout rate and data quality among children 12-23 months of
age in Ghana. Arch Public Heal. 2017. https://doi.org/10.1186/s13690-017-0186-8.
[19]. World Health Organization (WHO), 202. Guidance for
immunization programme managers. Geneva.
[20]. Health Education and Training (HEAT), 2019,
Immunization Module: Monitoring your Immunization Programme n.d. http://www.open.edu/openlearncreate/mod/oucontent/view.php?id=53371§ion=1.4.2.
[21]. Sowe, A., Namatovu, F., Cham, B.,
Gustafsson, P. E., 2023, Starting then stopping: a nationwide register-based
study on the magnitude, predictors, and urban-rural patterns of
under-vaccination variation across health centers in The Gambia. Cite this
article https://doi.org/10.1080/16549716.2024.2348788.
[22]. Sowe, A., Namatovu, F., Cham, B., Gustafsson, P. E., 2023, Missed opportunities for vaccination at point of care and their and urban–rural coverage impact on coverage inequity in the Gambia.
