2 diabetes mellitus (T2DM) is a global metabolic disease characterized by impaired
insulin secretion from pancreatic cells and insulin resistance (IR) in liver, muscle
and adipose tissue, in the presence of appropriate environmental factors. Insulin
is a key regulator of glucose homeostasis. IR leads to impaired glucose tolerance,
and has an important role in the development of metabolic syndrome. Recently, a
new protein called omentin has been identified as a novel specific adipokine in
human adipose tissue, which could have a possible role in modulating insulin action.
The physiological role of omentin in glucose metabolism, omentin’s target
tissues, receptors or relevant signal transduction pathways still not clear. The
purpose of the present study is to evaluate serum omentin-1 levels in normoglycemic
First Degree Relatives (FDR) of Type 2 diabetic patients compared with the controls.
Methodology: A total
of 96 study participants were enrolled in the present study. Among them, 48 were
FDRs of T2DM patients and remaining were age and sex matched healthy controls. Body
mass index (BMI), waist circumference and biochemical parameters like, FBS, serum
cholesterol, triglycerides and serum omentin-1 levels were measured in subjects
and age matched controls. The subjects with endocrine disorders, cardiovascular
diseases, hepatic or renal dysfunction were excluded.
Study design: Cross
sectional comparative study.
Statistical Analysis: All
values were expressed as mean ± SD. The results obtained were analyzed statistically
using the unpaired student t-test to evaluate the signiﬁcance of differences between
the mean values. In all the cases probability value of p<0.05 will be considered
Results and Discussion: The
present study observations were in accordance with other studies which suggest that
omentin may be a positional candidate gene for type 2 diabetes susceptibility in
humans. It also demonstrated that plasma omentin-1 levels were significantly decreased
in obesity and diabetes and the circulating omentin-1 levels were lower in FDRs
than the controls. To conclude, the current study demonstrated the significant difference
in mean serum omentin-1 levels in normoglycemic first degree relatives of type 2
diabetes patients when compared with the controls.
Keywords: Diabetes, Insulin, Omentin-1.