Introduction: Chronic Disease Research
Centre and head of the Port of Spain non-communicable diseases (NDCs) Evaluation
team, Dr Alafia Samuels indicated that Guyana and Trinidad and Tobago have the highest
mortality for premature cardiovascular disease and diabetes in the Americas. (Guyana
Methods: The Current Investigation has a general
objective to describe clinical and biochemical features of children,
adolescents and young adults with recent onset type 2 diabetes mellitus.
Retrospective study that included adolescents and adults between
the ages of 13 and 28 with fasting glucose above 126 mg/dl, absence of antiGAD and
C peptide above 1.5 ng/dl. Patients with previous diagnosis of type 1 diabetes,
diabetes type MODY or drug associated diabetes were excluded.
Results: Mean age was 16 years;
59% were females, and 43% had at least one parent with type 2 diabetes. At the time
of diagnosis, the body mass index was 42.8 kg/m2; 85% had acanthosis nigricans and
68% had Tanner stage IV or V. Initial treatment included oral hypoglycemic drugs
in 75%, metformin was the most common drug used (64.3%). Only 41% of cases received
Conclusion: Children and adolescents with type 2 diabetes
in this setting have a high frequency of obesity, acanthosis nigricans and family
history of type 2 diabetes. In general, these patients have poorly metabolic control
and receive metformin as initial treatment.
mellitus type 2, Obesity, Insulin resistance, Child, Adolescent, Young adult.