Introduction: Prostate cancer is currently
the sixth most common cancer site in the world, third of importance in men and is
a major concern.
Methods: The Current Investigation has a general
objective to determine the role of some genetic, hormonal, lifestyle and environmental
factors in the risk of developing clinically manifested prostate cancer using information
from Demerara Paradise Incorporated, a local health institution in Guyana. The study
cases were determined from records of the Institution (n = 33) diagnosed during
2016-2017, with histological verification or cytological cancer of prostate, persons
under 90 years. The controls (n = 108) were selected by age and records were obtained
from the same hospital. The risk estimation was obtained through a conditional logistic
Results: There was a statistically significant
association between skin color and risk of prostate cancer (OR = 1.30, 95% CI: 0.92-1.84)
or smoking habit (OR = 0.82, 95% CI: 0.58-1.16). A positive association of the risk
of prostate cancer with venereal diseases was observed (p = 0.01), as well as with
the age of onset of these diseases (p = 0.06). No differences were found regarding
the age of onset of sexual intercourse (p = 0.111) or in the number of sexual partners
(p = 0.48).
Conclusion: There was a significant association
between the risk of prostate cancer and having suffered from a venereal disease,
limited physical exercise between 45 and 50 years and the frequency of sexual intercourse
more than 10 times a week.
Keywords: Prostate cancer, Risk factors,
Relative risk, Cases and Controls, Multicentre study.