Abstract:

Introduction: Prostate cancer is currently the sixth most common cancer site in the world, third of importance in men and is a major concern.

Methods: The Current Investigation has a general objective to determine the role of some genetic, hormonal, lifestyle and environmental factors in the risk of developing clinically manifested prostate cancer using information from Demerara Paradise Incorporated, a local health institution in Guyana. The study cases were determined from records of the Institution (n = 33) diagnosed during 2016-2017, with histological verification or cytological cancer of prostate, persons under 90 years. The controls (n = 108) were selected by age and records were obtained from the same hospital. The risk estimation was obtained through a conditional logistic regression.

Results: There was a statistically significant association between skin color and risk of prostate cancer (OR = 1.30, 95% CI: 0.92-1.84) or smoking habit (OR = 0.82, 95% CI: 0.58-1.16). A positive association of the risk of prostate cancer with venereal diseases was observed (p = 0.01), as well as with the age of onset of these diseases (p = 0.06). No differences were found regarding the age of onset of sexual intercourse (p = 0.111) or in the number of sexual partners (p = 0.48).

Conclusion: There was a significant association between the risk of prostate cancer and having suffered from a venereal disease, limited physical exercise between 45 and 50 years and the frequency of sexual intercourse more than 10 times a week.

Keywords: Prostate cancer, Risk factors, Relative risk, Cases and Controls, Multicentre study.

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