Introduction: Diabetes mellitus has been major problem in developed and developing countries.
The progression of disorder cause prolonged exposure of vascular tissues to hyperglycaemia
resulting in long-term microvascular/ macrovascular complications in the health;
and nephropathy is one of them.
Methods: The present study was designed to evaluate the role of N-acetylcysteine on
microalbuminuria and HbA1c level in patients with diabetic nephropathy. A
randomized, open controlled clinical trial which includes 58 diabetic nephropathy
patients (50 men and 8 women) aged between 35–60 years who had diabetes for at least
more than 5 years.
The patients divided in to two groups such
as positive control and N-acetylcysteine group. Each group contains 29 patients
for evaluation of the parameters for four months follow-up for both control as well
as N-acetylcysteine group.
Results: After 4 months of supplementation of N-acetylcysteine, it was found that,
there is a significant decrease in values of microalbuminuria and HbA1c (Glycosylated
haemoglobin) when compare to the positive control group.
Conclusion: The result of study concludes that, the N-acetylcysteine significantly lowers
microalbuminuria and HbA1c in patients with diabetic nephropathy. Therefore, supplementation
of N-acetylcysteine may prevent the diabetic nephropathy.
Keywords: Microalbuminuria, HbA1c, N-acetylcysteine.