Abstract:Fast dissolving tablets disintegrate and dissolve rapidly in the saliva without the need for water. This tablet format is designed to allow administration of an oral solid dose form in the absence of water or fluid intake. Flurbiprofen is an anti-inflammatory and analgesic drug used in the treatment of chronic rheumatoid diseases which is a painful condition and therefore requires drugs that has rapid onset of action. Hence the intent of the authors to formulate fast dissolving tablets of Flurbiprofen using different superdisintegrants to improve the dissolution rate and bioavailability of the drug. Flurbiprofen fast dissolving tablets were prepared using various superdisintegrants and the resultant formulations were characterized for different physical parameters. The results of the statistical analysis carried out by the authors on the various data obtained showed that the use of superdisintegrants to formulate fast dissolving tablets of Flurbiprofen was a good way to enhance bioavailability, dissolution rate and absorption rate of the drug.
[1.] Grri, M., Rangoni, C., Maestraelli,
F., Corti, G., Mura, P. (2005). Development of fast developing tablets of
flurbiprofen-cyclodextrin complexes. Drug dev Ind Pharm, Aug, 31(7),
Accessed July 7, 2013.
[3.] Kuchekar, B., S., Badhan, A., C.,
Mahajan, A., S. (2003). Mouth dissolving tablets; A novel drug delivery
systems. Pharma. Times, 35,7-9.
[4.] Shid, S., L., Hiremath, S., P.,
Borkar, S., N., Sawant, V., A., Shende, V., S., Tote, M., V., Birari, R., B.,
and Changrani, S., R. Effect of superdisintegrants in rapidly disintegrating
flurbiprofen sodium orodispersible tablets via direct compression and camphor
[5.] Watanabe, Y., Koizumi, K., Zama, Y.,
and Matsumoto, Y. (1995). New compressed tablet rapidly disintegrating in
saliva in the mouth using crystalline cellulose and a disintegrant. Bio.
Pharm. Bull, 18(9), 1308-13
[6.] Wenat, A., K., Patel, S., M., Patel,
S., R., Patel, N., M. (2012). Fast dissolving tablets: A novel approach to drug
delivery. Asian journal of pharmaceutical sciences and research, 2(8).