Bias might occur due to the clinical research study structures,
endogenous bias, and to the investigators’ intention, external bias, on
selecting only the positive outcomes and published them. So the publication
bias still widespread in TCM clinical, but TCM are not unique cases, therefore
study conclusions ought to be interpreted with caution.
to review the article ‘’Prospective registration, bias risk and
outcome-reporting bias in randomized clinical trials of traditional Chinese
medicine: an empirical methodological’’ regarding the contents, strengths,
structures and limitations of Traditional Chinese Medicine (TCM) Clinical
trials. In addition to outcome-reporting bias in randomized clinical trials.
The number of Chinese randomized trials registration increases from
1999 to 2012, as well as the countries where these Chinese trials registered.
As well as the frequency of the type of TCM intervention included in each
registry. Classification of disease based on the International Classification
of Diseases (ICD-10) has been used to classify medical conditions. Only
(46.1%)= 505 out of 1096 registered randomized trials were completed studies.
Only has found 29% of registered TCM trials presented selective
outcome-reporting bias in between the outcomes registered and the outcomes
quality of TCM clinical trials have developed through prospective international
trial registration compared with previous methodological studies. Although
there are some inconsistencies between the registered trial protocols and
subsequent publications and inadequate reporting .Nevertheless it is indistinct
how the study designs have got better-quality.
[1.] Song, F., Parekh, S., Hooper, L., Loke, Y.K.,, Ryder,
J., Sutton, A.J., Hing, C., Kwok, C.S., Pang, C., &Harvey, I., (2010).
Dissemination and publication of research findings: an updated review of
related biases.. Health Technology Assessment; Vol. 14: No. 8.(14(8):iii,
ix-xi, 1-193. doi: 10.3310/hta14080.): 1-193.
[2.] Cao, H., Pan, X., Liu, J.,(2009). Acupuncture for
Treatment of Insomnia, 15 (11:)-171-186- doi: 10.1089/acm.2009.0041 ed.
of Alternative and Complementary Medicine.
[3.] Jiang, M., Lu C., Zhang, C., Yang, J., Tan, Y., Lu,
A., & Chan, K., (2012). Syndrome differentiation in modern research of
traditional Chinese medicine, volume 140, Issue 3, 10, Pages 634–642. ed.: Journal
[4.] Liu., Jian-Ping., Han., Mei; Li., Xin-Xue; Mu, Yu_Jie;
Lewith, George; Wang, Yu-Yi; Witt, Claudia; Yang, Guo-Yan; Manheimer, Eric;
Snellingen, Torkel; Berman, Brian.,&Christian,G., Prospective registration,
bias risk and outcome-reporting bias in randomised clinical trials of
traditional Chinese medicine : an empirical methodological study. B M J Open
2013; , vol 3, no. 7, (2044-6055): pp. e002968.
[5.] Maggie, B., &Covington, M.,(2001) Traditional
Chinese Medicine in the Treatment of Diabetes, vol. 14 no. 3 pages 154-159. ed.
Diabetes Spectrum: doi: 10.2337/diaspect.14.3.154.
[6.] Merck..( 1999)Epidemiology and Basic Pathology of IBS.
http://www.allwayswell.com/irritable-bowel-syndrome.html: All Ways Well LLC.
[7.] Robert, J., & MacCoun, (1998).Biases in the
interpretation and use of research results, . Annual Review of Psychology;Vol.
49: (DOI: 10.1146/annurev.psych.49.1.259): 259-287.
[8.] Suo, T., Gu, X., Andersson, R., Ma, H., Zhang, W.,
Deng, W., Zhang, B., Cai, D., & Qin, X.,(2012). Taking traditional Chinese
medication (TCM) orally for adhesive small bowel obstruction (SBO, Art. No.:
CD008836. pub2Issue 5 ed. DOI: 10.1002/14651858.CD008836.: Cochrane Database of
[9.] Suo, T., Gu, X., Andersson, R., Ma, H., Zhang, W.,
Deng, W., Zhang, B., Cai, D., & Qin., Taking traditional Chinese
medicationn (TCM) orally for adhesive small bowel obstruction (SBO),.
(accessed September 2013).
[10.] Minghang,W., Jiansheng,Li., Suyun,Li., Haifeng,W.,
Xueqing,Y., & Hailong,Z.,(2012).Effect of traditional Chinese medicine on
outcomes in patients with mild/moderate chronic obstructive pulmonary disease:
study protocol for a randomized placebo-controlled trial. Version: 2