This present study was designed to assess the level
of some hematological parameters among pretreatment pulmonary tuberculosis
infected patients, treatment in 2 months, 4 months, 6 months pulmonary
tuberculosis infection and control, non-infected subjects in Anambra State
University Teaching Hospital, Awka. Anambra State, Nigeria. A total of 220
pulmonary tuberculosis (PTB) infected subjects aged 18 – 60 were recruited for
the study. Hundred (100) subjects were in their pretreatment stage (group B),
and 40 each in their 2 months (group C), 4 months (group D) and 6 months (group
E) treatment stages. Eighty (80) non PTB subjects served as control. Blood
samples collected from the subjects were used for the determination of
Haemoglobin concentration (g/dl), packed cell volume (l/l), Mean cell
haemoglobin concentration (g/dl), Erythrocyte sedimentation rate (mm/hr),
platelet count (x109/l), total white blood count (x109/l),
absolute neutrophil count (x109/l), absolute lymphocyte count (x109/l)
and absolute monocyte count (x109/l) using standard laboratory
methods for analysis as described by Dacie and Lewis.
Tuberculosis diagnosis was carried out using Ziehl Neelsen technique. The
result showed that the mean ±SD Haemoglobin concentration and packed cell volume
were significantly lower in pretreatment PTB subjects than the Post treatment
subjects (P<0.05 in each case). The mean ±SD mean cell haemoglobin
concentration showed no significant difference among the groups. The mean ±SD
ESR in pretreatment subjects was significantly higher than the control and post
treatment subjects. The mean (±SD) platelet count (x109/l), TWBC
(x109/l) and ANC (x109/l) were significantly higher while
the ALC (x109/l) was significantly lower respectively in
pretreatment PTB patients compared with the control subjects and post treatment PTB subjects (P <0 .05 in each case). The mean
(±SD) AMC (x109/l) showed no significant difference when compared
among the groups (P<0.05).
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