Assessment of some haematological parameters among pre-treatment, 2 months, 4 months and 6 months treatment in pulmonary tuberculosis infected individuals in anambra state university teaching hospital, awka. anambra state, nigeria

Download Article

Authors : Michael Olugbamila Dada, Umeh O.E, Ifeanyichukwu O.M, Uche Okudo, Ngozi Ezema


This present study was designed to assess the level of some hematological parameters among pretreatment pulmonary tuberculosis infected patients, treatment in 2 months, 4 months, 6 months pulmonary tuberculosis infection and control, non-infected subjects in Anambra State University Teaching Hospital, Awka. Anambra State, Nigeria. A total of 220 pulmonary tuberculosis (PTB) infected subjects aged 18 – 60 were recruited for the study. Hundred (100) subjects were in their pretreatment stage (group B), and 40 each in their 2 months (group C), 4 months (group D) and 6 months (group E) treatment stages. Eighty (80) non PTB subjects served as control. Blood samples collected from the subjects were used for the determination of Haemoglobin concentration (g/dl), packed cell volume (l/l), Mean cell haemoglobin concentration (g/dl), Erythrocyte sedimentation rate (mm/hr), platelet count (x109/l), total white blood count (x109/l), absolute neutrophil count (x109/l), absolute lymphocyte count (x109/l) and absolute monocyte count (x109/l) using standard laboratory methods for analysis as described by Dacie and Lewis[1]. Tuberculosis diagnosis was carried out using Ziehl Neelsen technique. The result showed that the mean ±SD Haemoglobin concentration and packed cell volume were significantly lower in pretreatment PTB subjects than the Post treatment subjects (P<0.05 in each case). The mean ±SD mean cell haemoglobin concentration showed no significant difference among the groups. The mean ±SD ESR in pretreatment subjects was significantly higher than the control and post treatment subjects. The mean (±SD) platelet count (x109/l), TWBC (x109/l) and ANC (x109/l) were significantly higher while the ALC (x109/l) was significantly lower respectively in pretreatment PTB patients compared with the control subjects and post treatment PTB subjects (P <0 .05 in each case). The mean (±SD) AMC (x109/l) showed no significant difference when compared among the groups (P<0.05).

The result of the present study shows that haemoglobin and packed cell volume in pulmonary tuberculosis patients were reduced while Erythrocyte is increased. Thus indicating anemia of chronic disease. It also showed that platelet count, total white blood count and absolute neutrophil count are increased while absolute lymphocyte count is decreased in pulmonary tuberculosis infection.


[1]. Al- Omar, I. A., Ashban, R. M., Shah, A. H. (2009). Hematological abnormalities in Saudis suffering from pulmonary tuberculosis and their response to the treatment. Research journal of pharmacology. 3(4): pp 78-85

[2]. Bradley, G.W., Nicholas, A.C., Banfield, L. (2003). Serological diagnosis of tuberculosis. Journal of respiratory Disease. 6: 176-713.

[3]. Cheesbrough, M. (2000). District laboratory Practice in Tropical Countries. Part 2. Pp 36-41.

[4]. Dacie, J.V., Lewis, S.M. (2001). Practical Hematology. 9th edition. Churchill Livingstone. Edinburgh, pp. 19-51.

[5]. Daniel, J.M. Baum, G.L. (2008). Immunological response to TB: Molecular characterization of haemagglutinating antibody to tuberculo-Polysaccharide in Sera from patients with tuberculosis. Amer. Journal of Res. Dis. 98: 677-680.

[6]. Kartalogu, Z.K., Cerrahoglu, O., Okutan, A., Ozturk, B., Aydilek, R. (2001). Parameters of blood Coagulation in patients with pulmonary tuberculosis. The Journal of Internal Medicine.

[7]. Konstantinous, A. (2010). Testing for Tuberculosis. Australian Prescribe 33(1): 12-18.

[8]. Kumar, V., Abbas, A.K., Fausto, N. Mitchell, R. N. (2007). Robbins Basic Pathology. 8th edition. Saunders Elservier, pp. 516-522.

[9]. Olaniyi, J.A., Aven Ovi, V.A. (2003). Hematological profile of patients with pulmonary tuberculosis in Ibadan, Nigeria. African Journal of Medical Sciences. 32 (3): 239-242.

[10]. Stop T.B. Partnership (2002). London Tuberculosis rates now at third world proportions. PR Newswire Europe Ltd. 4th December 2002. Retrieved on 3 October, 2006.

[11]. Snider, D., Roper, W. (2002). The New Tuberculosis. New England Journal of Medicine. 104.

[12]. World Health Organization (2009). Epidemiology. Global tuberculosis Control. Epidemiology, Strategy Financing. pp 6-33.