The Human Immunodeficiency Virus sero-Prevalence and AIDS- Related Opportunistic Infection Patterns among Women with Retained Placenta in Eastern Tanzania

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DOI: 10.21522/TIJNR.2015.03.02.Art022

Authors : Admirabilis Kalolella

Abstract:

The objective of this study was to characterize women with Retained Placenta (RP) attending obstetric care in eastern Tanzania. We assessed the HIV sero-prevalence, then screened for medical conditions related to RP and described their AIDS related opportunistic infection patterns for the women that were HIV-sero-positive.

The cross sectional study design using medical questionnaires and self-report checklist was used to collect data. The study assessed if there is any relationship between retained placenta and HIV sero-status, and if sero -status and HIV opportunistic infection patterns has relationship with pregnancy outcome and other medical conditions related to pregnancy.

In our study, HIV sero-positive was detected in 105 out of 251 women (42%). HIV sero-positive women developed prolonged labor, 23(79.3%), significantly more often compared to HIV sero-negative women, 6 (20.6%), P value <0.0001. The HIV positive women are significantly more likely to develop Post- partum hemorrhage (P value= 0.0031) and to undergo Caesarian section compared to pregnant women without HIV (P value = 0.0113). The pregnant women under antenatal ARV Triple (B+) therapy are significantly more likely to end up with preterm delivery (P value= 0.0443). Women with HIV progressive symptoms of memory loss, depression, and other neurologic disorders had more underweight babies born (P- Value= 0.0316), while women with pneumonia developed vaginal tears more often during delivery (P- Value =0.0693).

In conclusion, RP is common among women with HIV. The prolonged labor is the major medical condition currently faced by HIV infected pregnant women during delivery. Women with HIV progressive symptoms are at risk to give birth to underweight baby and get vaginal tear during delivery. The current B+ ARV treatment during antenatal period has positively changed some the pregnancy outcomes among HIV infected pregnant women.

Keywords: Retained placenta, sero-positive, HIV sero-status, prolonged labor, HIV opportunistic infection patterns, pregnant women, Post-partum hemorrhage, B+ ARV triple therapy.

References:

[1].     Agrawal, A. Thakur, A. Rijal, P. Basnet, P. Ghimire, A & Uprety, D. (2013). Management of retained placenta in patient with valvular heart disease with pulmonary oedema. Health Renaissance, 201(1), 199-205.

[2].     Aniji C D,1 FCOG (SA); O A Towobola,1 PhD; M E Hoque,2 MSc; T J Mashamba,1 MB ChB; S Monokoane,1 FCOG (SA) (2013). Impact of antiretroviral therapy on pregnancy outcomes. S Afr J HIV Med 2013; 14(4):176-178. DOI:10.7196/SAJHIVMED.834.

[3].     Calvert C, Ronsmans C. (2015). Pregnancy and HIV disease progression: a systematic review and meta-analysis. Journal of Tropical Medicine and International Health, 20(2):122-45. Retrieved June 5, 2016, from PubMed.

[4].     Illah E, Mbaruku G, Masanja H, Kahn K. (2013). Causes and risk factors for maternal mortality in rural Tanzania--case of Rufiji Health and Demographic Surveillance Site (HDSS). Afr J Reprod Health. 2013 Sep; 17(3):119-30.

[5].     Jayne E, Marshall, Maureen D Raynor (2014). Myles' Textbook for Midwives, 16th Edition, UK: Elsevier Health Sciences.

[6].     Jennifer A Slyker, Janna Patterson, Gwen Ambler, Barbra A Richardson, Elizabeth Maleche-Obimbo, Rose Bosire, Dorothy Mbori-Ngacha, Carey Farquhar, and Grace John-Stewart (2014). Correlates and outcomes of preterm birth, low birth weight, and small for gestational age in HIV-exposed uninfected infants. BMC Pregnancy and Childbirth 201414:7. DOI: 10.1186/1471-2393-14-7.

[7].     Kumar, N. (2016). Postpartum Hemorrhage; a Major Killer of Woman: Review of Current Scenario. Obstetrics & Gynecology International Journal, 4(4). Published online.

[8].     Ngarina M, Tarimo EAM, Naburi H, Kilewo C, Mwanyika-Sando M, Chalamilla G, et al. (2014) Women's Preferences Regarding Infant or Maternal Antiretroviral Prophylaxis for Prevention of Mother-To-Child Transmission of HIV during Breastfeeding and Their Views on Option B+ in Dar es Salaam, Tanzania. PLoS ONE 9(1): e85310. doi:10.1371/journal.pone.0085310.

[9].     PMTCT Tanzania. National resource centre for prevention of mother to child HIV transmission (2016). Retrieved June 15 2016 from http://pmtct.or.tz/pmtct-tanzania/pmtct-in-tanzania/.

[10].  Short C-ES, M Douglas, JH Smith and GP Taylor (2014) Preterm delivery risk in women initiating antiretroviral therapy to prevent HIV mother-to-child transmission. HIV medicine 201415, 233-238. DOI: 10.111/hiv.12083.

[11].  Tikkanen M1, Paavonen J, Loukovaara M, & Stefanovic V. (2011) Antenatal diagnosis of placenta accreta leads to reduced blood loss. Journal of Acta Obstetricia et Gynecologica Scandinavica, 90(10), 1140-6.See comment in PubMed Commons below

[12].  Watts DH1, Williams PL, Kacanek D, Griner R, Rich K, Hazra R, Mofenson LM, Mendez HA; Pediatric HIV/AIDS Cohort Study (2013). Combination antiretroviral use and preterm birth. J Infect Dis. 2013 Feb 15; 207(4):612-21. doi: 10.1093/infdis/jis728.

[13].  WHO (2015) Guideline on when to start antiretroviral therapy and on pre Exposure prophylaxis for HIV (pdf). Retrieved June 15 2016 from http://www.who.int/hiv/pub/guidelines/clinicalstaging.pdf).