Studies on Anti-Diabetic Activity of Cleome Viscosa in Alloxan-Induced Diabetic Rats

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Authors : Boyina Chaya Devi, Chakrapani Ramesh


Cleome viscose (L.) belonging to family (Capperdiceae), commonly called “Sticky spider flower”, is a terrestrial, annual, erect, aromatic herb. The plant has high medicinal value as it is traditionally used for its antiemetic, wound healing, antimicrobial, hepatoprotective and anti-oxidant properties. The aim of the proposed work is to evaluate the therapeutical potential of Cleome viscosa in alleviating diabetes by assessment of liver and kidney function and lipid profile parameters in alloxan-induced diabetic rats. A significant elevation (P<0.001) of blood glucose, SGPT, SGOT, ALP, urea, uric acid, creatinine and lipid profile in control groups was observed as compared to normal groups. However, there was significant reduction (P<0.001 and P<0.001) in the tested biochemical parameters in both the groups treated with extract as compared to the control group and the effect was compared with the standard drug, Metformin. From these results, it can be concluded that the methanol extract of Cleome viscosa possesses significant ability to reduce the diabetes complications


Cleome viscosa, diabetes, complications, neuropathic pain, lipid profile, liver and kidney function.


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