belonging to family (Capperdiceae), commonly called “Sticky spider flower”, is
a terrestrial, annual, erect, aromatic herb. The plant has high medicinal value
as it is traditionally used for its antiemetic, wound healing, antimicrobial,
hepatoprotective and anti-oxidant properties. The aim of the proposed work is
to evaluate the therapeutical potential of Cleome viscosa in alleviating diabetes by assessment of liver
and kidney function and lipid profile parameters in alloxan-induced diabetic
rats. A significant elevation (P<0.001) of blood glucose, SGPT, SGOT, ALP,
urea, uric acid, creatinine and lipid profile in control groups was observed as
compared to normal groups. However, there was significant reduction (P<0.001
and P<0.001) in the tested biochemical parameters in both the groups treated
with extract as compared to the control group and the effect was compared with
the standard drug, Metformin. From these results, it can be concluded that the
methanol extract of Cleome viscosa
possesses significant ability to reduce the diabetes complications
diabetes, complications, neuropathic pain, lipid profile, liver and kidney
LD. et al. Clinical Chemistry. 1980; 26: 655.
Committee on the Diagnosis and Classification of Diabetes Mellitus. Report of
the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Diabetes
Care.1997; 20: 1183–119.
P, Principe L, Berti G. Use of 3,5-dichloro-2-hydroxybenzene sulphonic
acid-4-aminophenazone chromogenic system in direct assay of uric acid in serum
and urine. ClinicalChemistry. 1980; 26: 227-231.
AE, Kozloff EN. Essentials o f Practical Microtechnique. 2ed, Lea and Febiger,
Philadelphia, 1971; 77.
R, Vijayakumar M, Singh M, Rao CV, Shirwaikar A, Rawat AKS, Pushpangadan P.
Antiulcer and antimicrobial activity of Anogeissuslatifolia. Journal of
Ethanopharmacology. 2006: 106: 57-61.
T, Maity TK, Das M, Bose A, Dash GK. Hepatoprotective activity of
Bacopamonnieri L. against ethanol-induced hepatotoxicity in rats. Pharmacognosy
Magazine. 2007: 3(10): 95-100.
et al. In vitro regeneration of Cleome viscosa – an important medicinal herb.
D, Palumbo P, Chu C. Diabetic ketoacidosis in a community-based population Mayo
Clinic Proc. 1980; 55: 85-88.
SP, Bindu RN. Proximate composition, mineral elements and anti-nutritional
factors in Cleome viscosa L. and Cleome burmanni W. & A International
Journal of Pharmacy and Pharmaceutical Sciences. 2013; 5(1): 398-402.
A, Marklund G. Involvement of superoxide anion radical in the autoxidation of
pyrogallol and a convenient assay for superoxide dismutase. European Journal of
Biochemistry. 1974; 47: 469-474.
KL, Karunanithi M, Brindha P. Phytochemical and in vitro screening of
aerial parts of Cleome viscosa extracts. International Journal of
Pharmacy and Pharmaceutical Sciences. 2012; 4(2):
Udaykumar. Medicinal Pharmacology.CBS publishers & Distributors, New
T, Paravthi B, Rammohan M. Wound healing propertied of Cleome viscosa. Hygeia
Journal for Drugs and Medicines. 2011; 3(1): 41-45.
Panduraju T, Paravthi
B, Rammoha M. Wound healing propertied of Cleome viscosa. Hygeia Journal
for Drugs and Medicines. 2011; 3(1): 41-45.
CM. Color development time of the Lowry protein assay. Analytical Biochemistry.
JT, Pope AL, Ganther HL, Swanson AB. Selenium: biochemical role as a component
of glutathione peroxidase. Science 1973; 179: 588-590.
AK. Colorimetric assay of catalase. Analytical Biochemistry. 1972; 47: 389-394.
P. Determination of glucose in blood using glucose oxidase with an alternative
oxygen acceptor. Annals of Clinical Biochemistry. 1969; 6: 24-25.
et al. Antimicrobial effects of Cleome viscose and Trigeonellafoenum
see dextracts. Journal of Cell and Tissue Research. 2008; 8(2):
Health Organization 2000. Guidelines on Standard Operating Procedures for
Clinical Chemistry. 69-7 Bowers LD. Clinical Chemistry. 1980; 26: