Effect of Planned Exercise on Serum Biomarkers in Chronic Obstructive Pulmonary Disease

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DOI: 10.21522/TIJMD.2013.06.01.Art002

Authors : Suhail Neliyathodi, Nikhil Rajagopal


Objectives: To study the influence of planned exercise training in COPD patients on serum biomarkers - plasma fibrinogen, CRP, albumin.

Methods: This is a hospital based randomized control trial conducted in a tertiary care teaching hospital in northern Kerala from January 2016 to September 2017. 40 patients of COPD (GOLD category C& D) who are more than 40 years of age and without any serious other systemic diseases are divided equally into intervention and control group by random allocation. Both groups are given standard pharmacological treatment and the intervention group was taught about planned exercises which include purse lip breathing and diaphragmatic breathing and lower limb exercises to increase strength and stamina 25 times a day in morning and evening 5 days a week. All patients will be followed up for one year. Plasma fibrinogen, CRP, albumin were measured every 3 months during this one year follow up during stable disease.

Results and discussion: Present study had shown a significant improvement in biomarkers that include CRP, plasma fibrinogen and albumin.

Conclusion: The study concludes that there is an improvement in level of biomarkers following planned exercises.

Keywords: biomarkers, COPD, pulmonary rehabilitation, plasma fibrinogen, CRP, albumin.


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