Highlighting the Epidemiology of HIV Viral Tropism in High Burden Populations

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Authors : Abdu Abdullahi Adamu


The introduction of Maraviroc which is a CCR5 antagonists as an antiretroviral drug necessitates the need to study HIV tropism for other HIV 1 subtypes especially those present in other countries in South East Asia and Sub Saharan Africa which accounts for a majority of the burden of the infection. The study under review was undertaken to evaluate HIV-1 co-receptor tropism in the developing world where non-B subtypes predominate, in order to assess the therapeutic and prophylactic potential of CCR5 antagonists in these regions.

In this vain, this review aims to highlight the prevalence of R5 and X4-tropic HIV-1 among samples obtained from patients with HIV-1 subtype C infection from India and South Africa, and with subtype A/A1 and D infection from Uganda, and to explore the demographic and clinical characteristics associated with R5 infection. In addition, the review will also highlight the ability of the Trofile® assay to determine tropism of non-B subtypes of HIV-1, which previously had not been explored in a large study.


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