Abstract:

The biggest burden in peritoneal dialysis is still peritonitis which increases the rate of mortality and hospitalization. The aim of our research was to address one of the ISPD (international society of peritoneal dialysis) guidelines 2016 which advocate the use of prophylactic antibiotic in peritoneal dialysis patients before going to colonoscopy, but this recommendation is class C which means a weak one. Our aim was to look at the effect of giving intraperitoneal ceftazidime before the procedure of colonoscopy in reducing the possible risk of peritonitis.

Patients and methods: Over a period of 2 years and 6 months, from January 2016 we managed to enroll 120 patients out of 163 whom we performed 120 colonscopies. Patients were randomized for Ceftazidime use by 1:1 method, ending up with 60 patients in group A who received the drug and 60 patients in group B who did not receive the drug.

Results: peritonitis occurred within 48 hours following the procedure. It was documented in 4 (6.7%) and 5 (8.3%) patients in groups 1 and 2 respectively (p =0.3243); the causative organisms were mainly gram-negative bacteria.

Conclusion: It appeared that giving intraperitoneal Ceftazidime prior to colonoscopy did not offer greater benefits in reducing the risk of peritonitis when compared with the group who did not receive it.

Keywords: Peritoneal dialysis, peritonitis, colonoscopy, ESRD, colon cancer, ceftazidime.

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