Abstract:

Intravenous immunoglobulin (IVIG) is used in various autoimmune disorders and is the agent of choice in the management of Guillain Barre Syndrome. Review of literature shows association of viral and bacterial infections with the use of IVIG and in this paper we describe a case of fungal septicemia that occurred after treatment with IVIG.  

References:

[1.] Gold, R., Stangel, M., Dalakas, M. C. Drugs insight: the use of intravenous immunoglobulin in neurology-therapeutic considerations and practical issues. Nat Clin Pract Neurol. 2007; 3: 36-44.

[2.] Intravenous immunoglobulin: prevention and treatment of disease. NIH consensus development conference statement, May 21-23, 1990. Vol.8, No.5 Bethesda Md: Office of Medical Applications of Research, National Institutes of Health, 1990.

[3.] Kazatchkine, M. D., Kaveri, S.V. Immunomodulation of autoimmune and inflammatory diseases with intravenous immune globulin. N Engl J Med. 2001; 345: 747-55

[4.] Kondo, N., Ozawa, T., Mushiake, K., Motoyoshi, F., Kameyama, T., Kasahara, K. et al. Suppression of immunoglobulin production of lymphocytes by intravenous immunoglobulin. J Clin Immunol. 1991; 11: 152-8.

[5.] Mackay, I. R., and Rosen, F. S. Immunomodulation of autoimmune and inflammatory diseases with intravenous immune globulin. N Engl J Med. 2001; 345(10): 747-55.

[6.] Maddur, M. S, Othy, S., Hegde, P., Vani, J., Lacroix-Desmazes, S., Bayry, J et al. Immunomodulation by intravenous immunoglobulin: Role of Regulatory T Cells. J Clin Immunol 2010; 30: S4-S8.

[7.] Naranjo, C. A., Busto, U., Sellers, E.M, Sandor, P., Ruiz, I., Roberts E. A. et al. A method for estimating the probability of adverse drug reactions. Clin Pharmacol Ther. 1981; 30: 239-45.

[8.] Nimmerjahn, F., Ravetch, J. V. Anti-inflammatory actions of intravenous immunoglobulin. Annu Rev Immuno, 2008; 26: 513-33

[9.] Traynor, T. R., Huffnagle, G. B. Role of chemokines in fungal infections. Med. Mycol. 2001; 39: 41-50

[10.]   Wijesundere, A. Guillain-Barre syndrome in plasmodium falciparum malaria. Postgrad Med J. 1992; 68: 376-77