Biofilm: Contributing Factor to Drug Resistance in Staphylococci in Blood Stream Infections

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DOI: 10.21522/TIJMD.2013.04.01.Art012

Authors : Sandeep Thirunavukkarasu, Rathish K C, Saroj Golia


Staphylococci represent the most commonly encountered blood culture isolates from ICU patients. Slime production is considered to be a significant virulence factor for some strains of Staphylococci. The importance of the role played by slime is further increased by its frequent association to reduced antibiotic susceptibility. This study was done to find out relationship of Bio-Film formation on the susceptibility pattern of the isolates. 27.6% of the isolates produced biofilm as detected by Congo Red Agar method; commonest being Staphylococcus epidermidis (53.9%). The percentage of resistance in the group which produces biofilm is always greater than the group which does not produce biofilm. Odds ratio for overall drug resistance was 2.10 (with 95% confidence interval as [1.6 – 2.6]) and with a p-value of 0.006.


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