Clinical Pattern and Outcome of Intrauterine Growth Retardation (IUGR) Babies admitted in the Sick Neonatal Nursery (SNN) of a Tertiary Care Centre in South Tamilnadu, India

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DOI: 10.21522/TIJMD.2013.04.01.Art015

Authors : Diana Thamby Ebenezer, Pethuru Devadason, Ravichandran T., Kathir Subramaniam T.


Introduction: Intra-Uterine Growth Retardation (IUGR) is failure to attain optimal intrauterine growth. Next to preterm birth, IUGR is the second leading cause of perinatal mortality. As many as 53% of preterm stillbirths and 26% of term stillbirths are growth restricted. Given the immediate and long-term implications of IUGR and its high prevalence in India, a focus on IUGR is both rational and strategic.

Objectives: 1) To study the Clinical pattern and outcome of IUGR babies and their Outcome during hospital stay. 2) To find out the Factors associated with Morbidity and Mortality of IUGR babies. 

Methodology: This Cross sectional Descriptive Study was carried out in the Department of Pediatrics, Sick Neonatal Nursery(SNN) ward, Department of Pediatrics, Tirunelveli Medical College Hospital. 120 babies were selected by systematic random sampling. The socio- demographic and antenatal characteristics were collected by interviewing the mother using a structured proforma. The outcome measures like morbidity pattern and condition at discharge were quantified.

Results:  Of 120 IUGR babies 22 (18.3%) are Preterm babies and 98 (81.7%) are Term babies. Hypoglycemia (63.3%) and Perinatal Asphyxia (45.0%), Sepsis (33.3%), Hypocalcaemia (30.0%), Hypothermia (28.3%) and Thrombocytopenia (25.0%) are the common complications.  22 (18.3%) have died at hospital and 98 (81.7%) have been discharged. Perinatal asphyxia and Meconium Aspiration are significantly associated with abnormal neurological examination at Discharge. Lower gestational age, Normal delivery and Lower weight of the baby are the statistically significant risk factors associated with mortality. 

Conclusion: Hypoglycemia  and Perinatal Asphyxia are the commonest complications of IUGR. Perinatal asphyxia, Meconium Aspiration, Gestational age, Delivery category and Weight of the baby are significant risk factors associated with morbidity and mortality.


[1]. Barker, D. J. P. (1998), Mothers, Babies and Health in Later Life, Edinburgh, Churchill Livingstone.

[2]. Chard T, Yoong A, Macintosh M. (1993). The myth of fetal growth retardation at term. Br J Obstet Gynaecol; 100: 1076.

[3]. De Onis, M., Villar, J., Gulmezoglu, M. (1998), ‘Nutritional interventions to prevent intrauterine growth retardation: Evidence from randomized controlled trials’, European Journal of Clinical Nutrition, 52(1).

[4]. Erich Cosmi, Tiziana Fanelli, Silvia Visentin, Daniele Trevisanuto, Vincenzo Zanardo. (2011). Consequences in Infants That Were Intrauterine Growth Restricted. Journal of Pregnancy; Volume 2011, Article ID 364381, 6 pages: /364381

[5]. Garite TJ. (2004). Intrauterine growth restriction increases morbidity and mortality among premature neonates. Am J Obstet Gynecol; 191:481- 487.

[6]. Hack M, Fanaroff AA (2000). Outcomes of children of extremely low birth weight and gestational age in 1990s. Semin Neonataol; 5; 89-106.

[7]. Hawdon JM, Platt MPW. (1993). Metabolic adaptation in small for gestational age infants. Arch Dis Child; 68: 262.

[8]. Henry L. Galan. (2008). Introduction to IUGR. Seminars in Perinatology. Vol: 32, No: 3 June 2008; 139-40.

[9]. Kliegman RM. (1989). Alterations of fasting glucose and fat metabolism in intrauterine growth-retarded newborn dogs. Am J Physiol 1989; 256: E380.

[10]. Neelam Kle, Naveen Gupta. (2009).  Intrauterine Growth Retardation: Journey from conception to late adulthood. Indian Journal of Practical Pediatrics; 11(1) : 68- 81.

[11]. Pallotto EK1, Kilbride HW. (2006). Perinatal outcome and later implications of intrauterine growth restriction. Clin Obstet Gynecol. 2006 Jun;49(2):257-69.

[12]. Perez-Escamilla R, Pollitt E. (1992). Causes and consequences of intrauterine growth retardation in Latin America. Bull Pan Am Health Organ; 26(2):128-47.