pathogens Enterococcus faecium, Staphylococcus aureus, Klebsiella
pneumoniae, Acinetobacter baumanii, Pseudomonas aeruginosa,
species are currently the cause of majority of hospital infections globally and
they also effectively “escape” the effects of antibacterial drugs. The UNSTOPPABLE
SUCCESS of these SUPERBUGS will lead to UNWINNABLE WAR. It has been suggested that
resistance by these organisms are due to mutations, modification of LPS. As the
crisis of antibiotic resistance continues to grow, the latest IDSA(Infectious disease
society of America) "Bad Bugs, No Drugs" report examines the trickle of
new antibiotics in the research and development (R&D) pipeline and proposes
steps to tackle the shortage. The
aim of the study was to characterize the antimicrobial resistance in ESKAPE pathogens
isolated from 430 culture positive clinical sample like urine, pus, blood, wound
swab and sputum,. Antibiotic resistance was determined by VITEK 2 and manual Kirby
Bauer method. MIC was determined by VITEK 2 and E Test according to Clinical and
Laboratory Standards Institute (CLSI). ESKAPE pathogens account for 63%. Except
for S. aureus multiple drug resistance (MDR) index of ESKAPE pathogens revealed
an increasing trend. The statistical analysis was done for hospital acquired and
community acquired MDR infections. Extended spectrum betalactamase (ESBL), Klebsiellaspp.,
carbapenem resistant, A. baumannii and P. aeruginosa were identified mainly in hospital
acquired than in community acquired infections. In conclusion, ESKAPE pathogens
are commonly identified in alarming frequency and knowledge of antimicrobial resistance
will be aided for empirical treatment.
Multi drug Resistant, ESKAPE pathogens, Infections, antibiotics.
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86-91 JMID doi: 10.5799/ahinjs
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Klebsiella pneumonia new Journal of Antimicrobial Chemotherapy (2008) 62, 1311–1318
doi:10.1093/jac/dkn425 Advance Access publication 15 October (2008)
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pneumoniae: A Report of 2 Cases and a Brief Review of the Literature Clin Infect
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c, e Susan M. Ray,c, e, i Patrick McGann, g Jan Pohl, h Emil P. Lesho, g David S.
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Advance Access publication 7 April 2014
López-Rojas,a,c Michael J. McConnell,a,c Manuel Enrique Jiménez-Mejías, Colistin
Resistance in a Clinical Acinetobacter baumannii Strain Appearing after Colistin
Treatment: Effect on Virulence and Bacterial Fitness. Antimicrobial agents chemother
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Global Challenge of Multidrug-Resistant Acinetobacter baumannii ANTIMICROBIAL AGENTS
AND CHEMOTHERAPY, Oct. (2007), p. 3471–3484
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American Society for Microbiology.
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