Abstract:

ESKAPE pathogens Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumanii, Pseudomonas aeruginosa, and Enterobacter species are currently the cause of majority of hospital infections globally and they also effectively “escape” the effects of antibacterial drugs. The UNSTOPPABLE SUCCESS of these SUPERBUGS will lead to UNWINNABLE WAR. It has been suggested that resistance by these organisms are due to mutations, modification of LPS. As the crisis of antibiotic resistance continues to grow, the latest IDSA(Infectious disease society of America) "Bad Bugs, No Drugs" report examines the trickle of new antibiotics in the research and development (R&D) pipeline and proposes steps to tackle the shortage. The aim of the study was to characterize the antimicrobial resistance in ESKAPE pathogens isolated from 430 culture positive clinical sample like urine, pus, blood, wound swab and sputum,. Antibiotic resistance was determined by VITEK 2 and manual Kirby Bauer method. MIC was determined by VITEK 2 and E Test according to Clinical and Laboratory Standards Institute (CLSI). ESKAPE pathogens account for 63%. Except for S. aureus multiple drug resistance (MDR) index of ESKAPE pathogens revealed an increasing trend. The statistical analysis was done for hospital acquired and community acquired MDR infections. Extended spectrum betalactamase (ESBL), Klebsiellaspp., carbapenem resistant, A. baumannii and P. aeruginosa were identified mainly in hospital acquired than in community acquired infections. In conclusion, ESKAPE pathogens are commonly identified in alarming frequency and knowledge of antimicrobial resistance will be aided for empirical treatment.

Keywords: Multi drug Resistant, ESKAPE pathogens, Infections, antibiotics.

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