Compare the Effect of Thiopental and Propofol on Neonatal and Maternal Outcomes after Caesarean Section: Anon-Systematic Review

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DOI: 10.21522/TIJMD.2013.04.02.Art011

Authors : Jean Claude Nkola Ndomba

Abstract:

Background: obstetric anaesthesia recommends that caesarean sections are done under regional anaesthesia, but there are conditions for which regional anaesthesia is contraindicated, so in those conditions general anaesthesia is the only choice.

For general anaesthesia thiopental 4-5mg/kg l and propofol 2,5mg/kg are both used for caesarean section.

Methods: we have reviewed articles from 1989 up to 2016 comparing the use of thiopental to propofol in caesarean sections.

Result: a total of 20 published articles and abstracts from 1989 up to 2016 were reviewed. These articles show that propofol was the best alternative drug for general anaesthesia induction in caesarean section and has few disadvantages according to the neonate Apgar score at one minute.

Conclusions: these articles reviewed show that propofol is currently the most commonly used induction agent and alternative for obstetric general anaesthesia and has better neonatal and maternal outcomes post operation than thiopental.

Keywords: propofol, obstetric anaesthesia, thiopental, caesarean section

References:

[1]. Arzu Mercan et al. A prospective, randomized comparison of the effects of thiopental and propofol on bispectral index during caesarean section till delivery of new-born. 2012.

[2]. Celleno D1 et al.1993 J Clin Anesth. 1993 Jul-Aug; 5(4):284-8.

[3]. Dr Tom Lupton &Dr Oliver Pratt. Tutorial on: Intravenous drugs used for the induction of anesthesia. Salford Royal Hospitals NHS Foundation Trust, Salford, UK (2003).

[4]. Dadras MM, Mahjoobifard M, Panahipoor A, &Dadras MA. Comparing propofol with sodium thiopental on neonatal Apgar score after elective cesarean section. Zahedan J Res Med Sci (ZJRMS) 2013; 15(4): 21-24.

[5]. Heather McKenzie et al. The pregnant patient: assessment and perioperative management...2015.

[6]. Mahjoobifard M et al. The comparison of propofol with thiopental as induction drug on neonatal Apgar during elective cesarean section. Zahedan J Res Med Sci (Zahedan Journal of Research in medical sciences) 2011; 13(4):35-39.

[7]. M. Valtonen et al. Comparison of propofol and thiopentone for induction of anesthesia for elective Caesarean section. 1989.

[8]. M. Mamidi, Shiva Prasad D. Propofol and Thiopentone as induction agents in obstetric anesthesia – A comparative study. IAIM, 2016; 3(4): 111-117.

[9]. Michael A et al. Propofol infusion for cesarean section. 1990; 37:5 pp514-20.

[10]. Perisa Golfam et al. The effect of propofol and thiopental on apgar score during caesarean section. 2009.

[11]. Rob Dyer. Update on general anesthesia for C/S. South African Journal of Anesthesia Analgesia 2011; 17(1).

[12]. South African guidelines for safe use of procedural sedation and analgesia for diagnostic and therapeutic procedures in adults: 2010.

[13]. Tiffany Sun Moon &Joshua Sappenfield Anaesthesia management and challenges in the pregnant patient. 2016; 6:89-94.

[14]. Tumukunde et al. The effect of propofol versus thiopental on Apgar scores in newborns and peri-operative outcomes of women undergoing emergency caesarean section: a randomized clinical trial. 2015.

[15]. Update on use of propofol and thiopental 2016.

[16]. Which induction drug for cesarean section? A comparison of thiopental sodium, propofol, and midazolam.

[17]. Vedat et al. Comparison of the effect of thiopental sodium and propofol on haemodynamics, awareness and newborns during caesarean section under general anaesthesia 2015. Turk Journal of anaesthesia reanimation.

[18]. xJR Sneyd. Recent advances in intravenous anesthesia. British Journal of Anesthesiology 2004; 93: 725–36