Teratogenic Agents and Related Conditions

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DOI: 10.21522/TIJMD.2013.05.02.Art001

Authors : Diana Karagiozova


The term “Teratogens” was first described in Paris, France in early 1932. “Teratogens” comes from the Greek word τέρας teras, which means “monster” or “marvel”. For centuries, the meaning of the term “teratogens’ changed and nowadays it refers to many factors, agents or substances that can compromise the normal development of the fetus.

Many factors/agents such as physical, chemical and environmental were found to be harmful when exposure to them occurs during the pregnancy. Exposure to high doses of ionizing radiation, usage of medications, viral and bacterial diseases during the pregnancy can only result in fetus death, congenital malformations and miscarriages.


[1].     Antepartal Care: Teratology; figure, retrieved from https://sara1hays.wordpress.com/2008/02/12/antepartal-care-teratology/

[2].     Brent RL. Reproductive and teratologic effects of low-frequency electromagnetic fields: a review of in vivo and in vitro studies using animal models. Teratology. 1999; 59(4):261–286.

[3].     Brown ZA, Selke S, Zeh J, et al. The acquisition of herpes simplex virus during pregnancy. N Engl J Med. Aug 21 1997; 337 (8):509-15. [Medline].

[4].     Brosh K1, Matok I, Sheiner E, Koren G, Wiznitzer A, Gorodischer R, Levy A. Teratogenic determinants of first-trimester exposure to antiepileptic medications. J Popul Ther Clin Pharmacol. 2011; 18:e89-98. Epub 2011 Mar 21

[5].     Bogdan J.Wlodarczyk, Ana M Palacios, Claudia J. Chapa, Huiping Zhu et al; Genetic basis of susceptibility to teratoge induced birth defects ; American Journal of Medical Genetic part C (Seminars and Genetics) 157:215-226 (2011).

[6].     Dennery PA “Effects of oxidative stress on embryonic development”. Birth defects Res. C. Embryo today 2007; 81:155-162.

[7].     E. Albert Reece, MD, PhD, MBA, John C. Hobbins “Clinical Obstetrics: The Fetus and Mother Miller JF, Williamson E, Glue J, Gordan YB et al. Lancet 1980; 2:554-556

[8].     “FDA drug categories”, table retrieved from https://login.medscape.com/login/sso/getlogin?urlCache=aHR0cDovL3d3dy5tZWRzY2FwZS5jb20vdmlld2FydGljbGUvNTYxMzU0&ac=401, 2014.

[9].     Feychting M. Non-cancer EMF effects related to children. Bioelectromagnetics. 2005; (suppl 7):S69–74.

[10].  Janine E. Polifka and J.M. Friedman “Teratogenic Effects of `Recreational' Drugs”; Can FAM Physician. 1991 Sep; 37: 1953–1962. PMCID: PMC2145913.

[11].  Morrow JI, Russell A, Gutherie E, Parsons L, Robertson I, Waddell R, et al. Malformation risks of anti-epileptic drugs in pregnancy: a prospective study from the UK Epilepsy and Pregnancy Register. J Neurol Neurosurg Psychiatry 2006; 77: 193-8.

[12].  Nora JJ, Vargo TA, Nora AH, Love KE, McNamara DG. Dexamphetamine, a possible environmental trigger in cardiovascular malformations. Lanced 1970; 1”1290-1

[13].  Omtzigt JGL at al: Valporic Acid: Neurol 42 (Suppl 5): 119, 92.

[14].  John Freeman, BSc (Hons), LLB (Hons), Corp. Vice “Global drug Safety and Risk management; fda gov.

[15].  Pass RF. Cytomegalovirus infection. Pediatr Rev. May 2002; 23(5):163-70. [Medline].

[16].  Smith, David W. (1970). "Recognizable Patterns of Human Malformation: Genetic, Embryologic, and Clinical Aspects". Major Problems in Clinical Pediatrics 7: 368

[17].  Vera M. Kolb “Teratogens: Chemicals which cause birth defects”, 1997.

[18].  Van Gelder MMHJ, van Rooij IALM, Miller RK, Zielhuis GA, de Jong-van denBerg LTW, Roeleveld N. Teratogenic mechanisms of medical drugs. Hum Reprod Update 2010; 16:378–394.