This paper evaluates HIV sero-positivity among Multi- Drug Resistance
Tuberculosis adult patients at Ndola Central Hospital, Ndola, Zambia.
question: How many patients who were admitted at Ndola Central Hospital had HIV
/ MDR- TB co-infections, and how many died?
A Retrospective Cohort study using the existing data and laboratory results in
patient files and MDR TB register (sampling frame) were reviewed for all MDR TB
patients whose culture and drug susceptibility test done at Ndola Central Hospital
were assessed for HIV sero-status from January 2010 to June 2014. Review of records
was done from 15/08//2014 to 22//o8/14 and sample comprised of 114 records
which were available during the stated period using convenient sampling. A semi-structured
questionnaire was used for data collection on the existing data base on
patient’s file and MDR- TB patient register. Data analyzed using Epi data
version 3 and bivariate analysis.
The study revealed that 68.1% of the MDR TB patients were males, compared to
31.9% females; however there was no association between MDR TB and sex. The study
showed that 42% of the respondents with MDR TB were co-infected with HIV. It
also revealed that mortality among HIV / MDR TB co-infected patients was 36%
and those negative accounted 12.7% showing an association between HIV sero
status and MDR TB co-infection mortality.
HIV / MDR TB co-infection is a major public health problem needing urgent
interventions, and proper treatment options for policy direction.
Evaluation, HIV / MDR-TB co-infection, Ndola, Zambia.
. Nathason E
va 2010 et al MDR Tuberculosis- critical steps for prevention and control.
. "UNAIDS Report on the Global AIDS Epidemic
2012", UNAIDS, 2012 www.unaids.org/en/resources/campaigns/20121120_globalreport2012/
S. "Is HIV infection a Risk Factor for Multi-Drug Resistant Tuberculosis?
A Systematic Review" PLoS one, May 2009, 4(5): e5561http://www.plosone.org/article/
Tuberculosis Control 2012", WHO, Geneva, 2012
and the Stop TB Partnership join forces to stop HIV/TB deaths", UNAIDS,
. Remarks by
Nelson Mandela: "Confronting the Joint HIV/TB Epidemics", XV
International AIDS Conference, Bangkok, 2004 http://quod.lib.umich.edu/c/cohenaids/
asked questions about TB and HIV", WHO, Geneva www.who.int/tb/challenges/hiv/faq/en/
. Luetkemeyer, A. "Tuberculosis and HIV", HIVInSite, http://hivinsite.ucsf.edu/
. Mayer, K. "Synergistic Pandemics: Confronting the
Global HIV and Tuberculosis Epidemics" Clinical Infectious Diseases, 2010,
Volume 50, Supplement 3, S67 http://cid.oxfordjournals.org/content/50/Supplement_3/"
. "Tribute to Winston", Action www.action.org/blog/post/tribute_to_winstone
Global Plan to Stop TB", WHO, Geneva, 2011,
. Mayer, K. "Synergistic Pandemics: Confronting the Global
HIV and Tuberculosis Epidemics" Clinical Infectious Diseases, 2010, Volume
50, Supplement 3, S67 http://cid.oxfordjournals.org/content/50/Supplement_3/"
. Mwiinga V.
2014: prevalence of Multi Drug Resistance Tuberculosis at Ndola Central Hospital
(NCH) among Adults, Ndola, Zambia.(un published)
. "Frequently asked questions about TB and HIV",
. Bond V.,
Chileshe M. Magazi B. Zambart Project: Zambia and South Africa ; Final working
report February 2009, Renewal program. WHO (2005).
. WHO (2007) (WHO, United nation joint programme on HIV /
AIDS. Guidance on provider initiated HIV testing and counseling in health
. Manda SOM, Masenyetse LJ,
Lancaster JL , van der Walt ML (2013) Risk of Death among HIV Co-Infected
Multidrug Resistant Tuberculosis Patients, Compared To Mortality in the General
Population of South Africa. J AIDS Clinic Res S3:007.
. Deivanayagam CN1, Rajasekeran S,
Venkantesan R, Mahilmaran A, Ahmed PR, Annadurai S, Kumar S, Chandrasekar C,
Ravichandran N, Penicillaiah R, (2002) Prevalence of acquired MDR TB & HIV
. WHO Global
Tuberculosis Report 2014 Supplement DRUG-RESISTANT TUBERCULOSIS SURVEILLANCE
. 21. WHO
(2012) Global TB control, Geneva. www.who.int/tb/publications/global report
27-29 May (2014) Public-Private mix. Model for the sustainability of successful
TB control initiatives
(2014) Twin epidemic HIV & TB co-infection
. Kapata N.
et al 2013 Multi Drug Resistant TB in Zambia: a review of national data from
2001 to 2011.
Central Hospital: MDR TB WARD; HMIS 2009 TO 2014: CASES of MDR TB patients who were
admitted at NCH.
. MOH: The
National tuberculosis and leprosy program. TB manual 3rd edition.
. DOI: http://dx.doi.org/10.1016/j.tube.2013.08.009
Home » Citations » Journal
of AIDS & clinical research » Risk of Death among HIV
Co-Infected Multidrug Resistant Tuberculosis Patients, Compared To Mortality in
the General Population of South Africa.