Exploration of Various Extracts of Adhatoda vasica for Use in Orthodontics
Abstract:
Fixed appliances used in orthodontics can alter
the oral microbiota, leading to an increase in aggressive gram-positive and gram-negative
bacterial species. These bacteria are strongly associated with enamel and dentin
caries and periodontal disease. Nonsteroidal anti-inflammatory drugs (NSAIDs) are
commonly used for pain control during orthodontic treatment which can affect tooth
movement and lengthen treatment time. The study evaluated the use of Adhatoda vasica
in various aspects of orthodontics. The study involved the extraction of plant material,
qualitative phytochemical analysis, GC-MS analysis, antibacterial activity testing,
and in vitro toxicity testing on bone cell lines. The results showed that Adhatoda
vasica extracts had antimicrobial activity against various pathogens and demonstrated
cytocompatibility with bone cell lines. The hydroalcoholic and pet ether extracts
showed the most promising results. The study highlights the impact of fixed appliances
on oral microbiota, the potential role of Adhatoda vasica in orthodontics, and the
need for further research in this area.
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