Abstract:

Respiratory diseases are one of the most public causes of passing rates and health complications worldwide. Human Metapneumovirus (HMPV) is a respiratory pathogen and can affect both the upper and or lower airways and may spot a life-threatening risk with specific and nonspecific symptoms. Nevertheless, the prevalence and rigorousness of HMPV exposure in children remain unexplored in developing nations. A detailed analysis related to effect of HMPV based on age, gender, patient type (inpatient/outpatient), clinical characteristics, patients with chronic disorders, before corona pandemic and after corona pandemic-19, medical history of prematurity and climate conditions in varies countries. Intense cough and significant feverish symptoms were the most common HMPV clinical characteristics features observed in affected children lesser than 5 years and whereas in adult cases additionally followed by sore throat etc. Increased cognizance of HMPV's influence on public healthiness is indispensable to advance investigation, comprehensive vaccine development, and diminish pathological morbidity and mortality internationally. Our outcomes infer that developed and industrialized countries should support developing nations in augmenting their research infrastructures. Further investigations on the diagnostic features of HMPV should be accomplished recurrently for anticipation and containment about this pathogen.

References:

[1].   Lamichhane, J., Upreti, M., and Nepal, K., 2023, "Burden of human metapneumovirus infections among children with acute respiratory tract infections attending a tertiary care hospital, Kathmandu." BMC Pediatr., vol. 23, no.1,p. 388.

[2].   Fendrick, A. M., Monto, A. S., Nightengale, B., and Sarnes, M., 2003, "The economic burden of non-influenza-related viral respiratory tract infection in the United States." Arch. Intern. Med., Vol.163 no. 4, p. 487-494.

[3].   Arshad, Y., Rana, M. S., Ikram, A., Salman, M., Aamir, U. B., Zaidi, S. S. Z., Alam, M. M., Sharif, S., Shaukat, S., Khurshid, A., Hakim, R., Mujtaba, G., Umair, M., Sattar, S., and Bostan, N., 2022, "Molecular detection and genetic characterization of human metapneumovirus strains circulating in Islamabad, Pakistan." Sci. Rep., Vol.12, no. 1,p. 2790.

[4].   Feuillet, F., Lina, B., Rosa-Calatrava, M., and Boivin, G., 2012, "Ten years of human metapneumovirus research." J. Clin. Virol., Vol. 53, no. 2, p. 97–105.

[5].   Hamelin, M. E., Abed, Y., and Boivin, G., 2004, "Human metapneumovirus: a new player among respiratory viruses." Clin. Infect. Dis., Vol.38, no. 7, p. 983–990.

[6].   Van den Hoogen, B. G., de Jong, J. C., Groen, J., Kuiken, T., de Groot, R., Fouchier, R. A., and Osterhaus, A. D., 2001, "A newly discovered human pneumovirus isolated from young children with respiratory tract disease." Nat. Med., Vol.7, no.6, p. 719–724.

[7].   Russell, C. J., Penkert, R. R., Kim, S., and Hurwitz, J. L., 2020, "Human metapneumovirus: A largely unrecognized threat to human health." Pathogens, Vol.9, no. 2, p. 109.

[8].   Parida, P., N, S., E.R, S., Jagadesh, A., Marate, S., and Govindakaranavar, A., 2023, "The emergence of human metapneumovirus G gene duplication in hospitalized patients with respiratory tract infection, India, 2016–2018." Mol. Biol. Rep., Vol.50, no. 2, p. 1109–1116.

[9].   Cho, S.-J., Kim, S.-H., Lee, H., Lee, Y.-U., Mun, J., Park, S., Park, J., Park, J.-S., Lee, K., Lee, C.-M., Seo, J., Kim, Y., and Chung, Y.-S., 2023, "Re-Emergence of HMPV in Gwangju, South Korea, after the COVID-19 Pandemic." Pathogens, Vol.12, no.10, p. 1218.

[10].  Gregianini, T., Seadi, C., Menegolla, I., Martins, L., Ikuta, N., Wolf, J., and Lunge, V., 2018, "Human metapneumovirus in Southern Brazil." Rev. Soc. Bras. Med. Trop., Vol. 51, no. 1, p. 30–38.

[11].  Costa, L. F., Yokosawa, J., Mantese, O. C., Oliveira, T. F., Silveira, H. L., Nepomuceno, L. L., Moreira, L. S., Dyonisio, G., Rossi, L. M. G., Oliveira, R. C., Ribeiro, L. Z. G., and Queiróz, D. A. O., 2006, "Respiratory viruses in children younger than five years old with acute respiratory disease from 2001 to 2004 in Uberlândia, MG, Brazil." Mem. Inst. Oswaldo Cruz, vol. 101, no. 3, p. 301–306

[12].  Gardinassi, L. G., Simas, P. V. M., Salomão, J. B., Durigon, E. L., Trevisan, D. M. Z., Cordeiro, J. A., Lacerda, M. N., Rahal, P., and de Souza, F. P., 2012, "Seasonality of viral respiratory infections in southeast of Brazil: the influence of temperature and air humidity." Braz. J. Microbiol., vol. 43, no. 1, p. 98–108.

[13].  Cuevas, L. E., Ben Nasser, A. M., Dove, W., Gurgel, R. Q., Greensill, J., and Hart, C. A., 2003, "Human metapneumovirus and respiratory syncytial virus, Brazil." Emerg. Infect. Dis., Vol. 9, no.12, p. 1626–1628.

[14].  Pilger, D. A., Cantarelli, V. V., Amantea, S. L., and Leistner-Segal, S., 2011, "Detection of human bocavirus and human metapneumovirus by real-time PCR from patients with respiratory symptoms in Southern Brazil." Mem. Inst. Oswaldo Cruz, Vol. 106, no. 1, p. 56–60.

[15].  Chow, W., Chan, Y., Oong, X., Ng, L. J., Nor'E, S. S., Ng, K. T., Chan, K. G., Hanafi, N. S., Pang, Y. K., Kamarulzaman, A., and Tee, K. K., 2016, "Genetic diversity, seasonality and transmission network of human metapneumovirus: identification of a unique sub-lineage of the fusion and attachment genes." Sci. Rep., Vol. 6, p. 27730.

[16].  Van den Hoogen, B. G., Bestebroer, T. M., Osterhaus, A. D., and Fouchier, R. A., 2002, "Analysis of the genomic sequence of a human metapneumovirus." Virology, Vol. 295, no. 1, p. 119–132.

[17].  Xie, Z., Zhu, Z., Xu, J., Mao, N., Cui, A., Wang, W., Wang, Y., Zhang, Z., Xia, B., Wang, H., Sun, Z., and Zhang, Y., 2024, "Seasonal and genetic characteristics of human metapneumovirus circulating — Henan Province, China, 2017–2023." China CDC Weekly, Vol.6, no.20, p. 450–456.

[18].  Otomaru, H., Nguyen, H. A. T., Vo, H. M., et al., 2023, "A decade of human metapneumovirus in hospitalized children with acute respiratory infection: molecular epidemiology in central Vietnam, 2007–2017." Sci. Rep., Vol.13, p.15757.

[19].  Kahn, J. S., 2006, "Epidemiology of human metapneumovirus." Clin. Microbiol. Rev., Vol.19, no.3, p.546–557.

[20].  Williams, J. V., Tollefson, S. J., Heymann, P. W., Carper, H. T., Patrie, J., and Crowe, J. E., 2005, "Human metapneumovirus infection in children hospitalized for wheezing." J. Allergy Clin. Immunol., Vol. 115, no. 6, p. 1311–1312.

[21].  Pancham, K., Sami, I., Perez, G. F., Huseni, S., Kurdi, B., Rose, M. C., Rodriguez-Martinez, C. E., and Nino, G., 2016, "Human metapneumovirus infection is associated with severe respiratory disease in preschool children with history of prematurity." Pediatr. Neonatol., Vol.57, no. 1, p. 27–34.

[22].  Williams, J. V., Edwards, K. M., Weinberg, G. A., Griffin, M. R., Hall, C. B., Zhu, Y., Szilagyi, P. G., Wang, C. K., Yang, C. F., Silva, D., Ye, D., Spaete, R. R., and Crowe, J. E., 2010, "Population-based incidence of human metapneumovirus infection among hospitalized children." J. Infect. Dis., Vol. 201, no. 12, p. 1890–1898.

[23].  Centers for Disease Control and Prevention (CDC), 2013, "Outbreaks of human metapneumovirus in two skilled nursing facilities—West Virginia and Idaho, 2011–2012." MMWR Morb. Mortal. Wkly. Rep., Vol. 62, no. 46, p. 909–913.

[24].  Yang, S. L., Chiu, T. Y., Tsai, K. L., Li, C. H., Yang, J. Y., Liu, M. T., and Wu, F. T., 2024, "Epidemiology of human metapneumovirus in Taiwan from 2013 to 2023." Arch. Virol., Vol. 169, no. 11, p. 229.

[25].  Wei, T., Wang, C., Ma, F., Guo, J., Chen, A., Huang, Y., Xie, Z., and Zheng, L., 2023, "Whole genome sequencing and evolution analyses of Human metapneumovirus." Virus Genes, Vol. 59, no. 4, p.524–531.

[26].  Arshad, Y., Rana, M. S., Ikram, A., et al., 2022, "Molecular detection and genetic characterization of human metapneumovirus strains circulating in Islamabad, Pakistan." Sci. Rep., Vol. 12, p. 2790.

[27].  Parida, P., N., S., E.R., S., et al., 2023, "The emergence of human metapneumovirus G gene duplication in hospitalized patients with respiratory tract infection, India, 2016–2018." Mol. Biol. Rep., Vol. 50, p. 1109–1116.

[28].  Foley, D. A., Sikazwe, C. T., Minney-Smith, C. A., Ernst, T., Moore, H. C., Nicol, M. P., Smith, D. W., Levy, A., and Blyth, C. C., 2022, "An Unusual Resurgence of Human Metapneumovirus in Western Australia Following the Reduction of Non-Pharmaceutical Interventions to Prevent SARS-CoV-2 Transmission." Viruses, Vol.14, no. 10, p. 2135.

[29].  Xie, Z., Zhu, Z., Xu, J., Mao, N., Cui, A., Wang, W., Wang, Y., Zhang, Z., Xia, B., Wang, H., Sun, Z., and Zhang, Y., 2024, "Seasonal and Genetic Characteristics of Human Metapneumovirus Circulating — Henan Province, China, 2017–2023." China CDC Weekly, Vol. 6, no. 20, p. 450–456.

[30].  Falsey, A. R., et al., 2021, "Risk factors and medical resource utilization of respiratory syncytial virus, human metapneumovirus, and influenza-related hospitalizations in adults—a global study during the 2017–2019 epidemic seasons (Hospitalized Acute Respiratory Tract Infection [HARTI] Study)." Open Forum Infect. Dis., Vol.8, no. 11, p. 474.

[31].  Yang, S. L., Chiu, T. Y., Tsai, K. L., Li, C. H., Yang, J. Y., Liu, M. T., and Wu, F. T., 2024, "Epidemiology of human metapneumovirus in Taiwan from 2013 to 2023." Arch. Virol., Vol. 169, no. 11, p. 229.

[32].  Gregianini, T., Seadi, C., Menegolla, I., Martins, L., Ikuta, N., Wolf, J., and Lunge, V., 2018, "Human metapneumovirus in Southern Brazil." Rev. Soc. Bras. Med. Trop., Vol.51, no. 1, p.30–38.

[33].  Piñana, M., et al., 2023, "The emergence, impact, and evolution of human metapneumovirus variants from 2014 to 2021 in Spain." J. Infect., Vol.87, no. 2), p. 103–110.

[34].  Otomaru, H., Nguyen, H. A. T., Vo, H. M., et al., 2023, "A decade of human metapneumovirus in hospitalized children with acute respiratory infection: molecular epidemiology in central Vietnam, 2007–2017." Sci. Rep., Vol.13, p. 15757.

[35].  Xie, Z., Zhu, Z., Xu, J., Mao, N., Cui, A., Wang, W., Wang, Y., Zhang, Z., Xia, B., Wang, H., Sun, Z., and Zhang, Y., 2024, "Seasonal and genetic characteristics of human metapneumovirus circulating — Henan Province, China, 2017–2023." China CDC Wkly, Vol. 6, no. 20, p. 450–456.

[36].  Jallow, M. M., Fall, A., Kiori, D., et al., 2019, "Epidemiological, clinical and genotypic features of human Metapneumovirus in patients with influenza-like illness in Senegal, 2012 to 2016." BMC Infect. Dis., Volk. 19, p. 457.