Correlation between Appendix Length/ Diameter Ratio and Incidence of Appendicular Perforation: A Retrospective Study

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DOI: 10.21522/TIJPH.2013.13.03.Art022

Authors : Samir Ahmad, Mughilan Selvaraj, Santhaseelan R G, Barathi Raja Kuppusami, N Guru Prasad

Abstract:

Acute appendicitis is a common surgical emergency, with perforation leading to increased morbidity and mortality. The length-to-diameter ratio of the appendix may be considered a predictor of perforation risk. This study aims to evaluate the correlation between this ratio and the incidence of appendicular perforation. This research aims to study the correlation between the appendix length/diameter ratio to its incidence of perforation. A retrospective study was conducted on patients undergoing appendectomy from March 2022 to August 2024. A total of 120 patients were recruited in this study. Patient data, including demographics, histopathological findings, and radiological measurements, were analyzed. Patients were grouped into perforated and non-perforated appendicitis groups. Statistical analyses, including Chi-square tests and logistic regression, were performed to assess the association between appendix length/diameter ratio and perforation risk. Ethical approval was obtained from the institutional ethics committee. Among 120 patients, 65 (54.2%) were male, and 55 (45.8%) were female, with a mean age of 28.1 ± 7.4 years. Perforation was identified in 18 (15%) cases. Patients with a length/diameter ratio ≤10 had a significantly higher perforation rate (14/56, 25%) compared to those with a ratio >10 (4/64, 6.3%) (p<0.01). Logistic regression showed that a ratio ≤10 was an independent predictor of perforation (OR: 4.1, 95% CI: 1.9-8.5, p<0.001). A lower appendix length/diameter ratio significantly increases the risk of perforation in acute appendicitis. Including this parameter in preoperative radiological assessments may improve early diagnosis and improve surgical decision-making, ultimately reducing complications associated with perforated appendicitis.

References:

[1]. Jaffe, B. M., Berger, D. H., 2005, The Appendix. In: Schwartz SI, Brunicardi CF, eds. Schwartz Principles of Surgery. McGraw-Hill.

[2]. Tantarattanapong, S., & Arwae, N., 2018, Risk factors associated with perforated acute appendicitis in geriatric emergency patients. Open Access Emergency Medicine, 129-134. Doi: 10.2147/OAEM.S173930

[3]. Balogun, O. S., Osinowo, A., Afolayan, M., Olajide, T., Lawal, A., & Adesanya, A., 2019, Acute perforated appendicitis in adults: Management and complications in Lagos, Nigeria. Annals of African medicine, 18(1), 36-41. Doi: 10.4103/aam.aam_11_18.

[4]. Primatesta, P., & Goldacre, M. J., 1994, Appendicectomy for acute appendicitis and for other conditions: an epidemiological study. International journal of epidemiology, 23(1), 155-160.

[5]. Andersson, R. E., 2007, The natural history and traditional management of appendicitis revisited: spontaneous resolution and predominance of prehospital perforations imply that a correct diagnosis is more important than an early diagnosis. World journal of surgery, 31, 86-92.

[6]. Bhangu, A., Søreide, K., Di Saverio, S., Assarsson, J. H., & Drake, F. T., 2015, Acute appendicitis: modern understanding of pathogenesis, diagnosis, and management. The Lancet, 386(10000), 1278-1287.

[7]. Willekens, I., Peeters, E., De Maeseneer, M., & De Mey, J., 2014, The normal appendix on CT: does size matter?. PloS one, 9(5), e96476.

[8]. Naderan, M., Babaki, A. E. S., Shoar, S., Mahmoodzadeh, H., Nasiri, S., & Khorgami, Z., 2016. Risk factors for the development of complicated appendicitis in adults. Turkish Journal of Surgery/Ulusal cerrahi dergisi, 32(1), 37.

[9]. Vaughan-Shaw, P. G., Rees, J. R., Bell, E., Hamdan, M., & Platt, T., 2011, Normal inflammatory markers in appendicitis: evidence from two independent cohort studies. JRSM short reports, 2(5), 1-8.

[10]. Katipoglu, B., Aygun, A., & Çınar, H., 2019, The effect of appendix diameter on perforation in acute appendicitis cases. Cumhuriyet Medical Journal, 41(2), 392-397.

[11]. Yeung, K. W., Chang, M. S., & Hsiao, C. P., 2004, Evaluation of perforated and nonperforated appendicitis with CT. Clinical imaging, 28(6), 422-427.

[12]. Boumitri, C., Brown, E., & Kahaleh, M., 2017, Necrotizing pancreatitis: current management and therapies. Clinical endoscopy, 50(4), 357-365.

[13]. Andersson, R. E. B., 2004, Meta-analysis of the clinical and laboratory diagnosis of appendicitis. Journal of British Surgery, 91(1), 28-37.

[14]. Paulson, E. K., Kalady, M. F., & Pappas, T. N., 2003, Suspected appendicitis. New England Journal of Medicine, 348(3), 236-242.

[15]. Yang, J., Liu, C., He, Y., & Cai, Z., 2019, Laboratory markers in the prediction of acute perforated appendicitis in children. Emergency medicine international, 2019(1), 4608053.

[16]. Kim, H. C., Yang, D. M., Lee, C. M., Jin, W., Nam, D. H., Song, J. Y., & Kim, J. Y., 2011, Acute appendicitis: relationships between CT-determined severities and serum white blood cell counts and C-reactive protein levels. The British Journal of Radiology, 84(1008), 1115-1120.

[17]. Akturk, Y., Gunes, S. O., & Hekimoglu, B., 2018, The correlation between laboratory markers and computed tomography severity index in acute appendicitis. Annali Italiani di Chirurgia, 89(1), 56-61.

[18]. Al-Abed, Y. A., Alobaid, N., & Myint, F., 2015, Diagnostic markers in acute appendicitis. The American journal of surgery, 209(6), 1043-1047.

[19]. Barreto, S., Travers, E., Thomas, T., Mackillop, C., Tiong, L., Lorimer, M., & Williams, R., 2010, Acute perforated appendicitis: an analysis of risk factors to guide surgical decision making. Indian journal of medical sciences, 64(2), 58.

[20]. Andersson, R. E., Hugander, A., Ravn, H., Offenbartl, K., Ghazi, S. H., Nyström, P. O., & Olaison, G., 2000, Repeated clinical and laboratory examinations in patients with an equivocal diagnosis of appendicitis. World journal of surgery, 24(4), 479-485.

[21]. Kongsgaard, U. E., Thorsen, K., Soreide, J. A., 2015, CT findings of complicated appendicitis: a prospective evaluation. Journal of Surgical Research. 2015;197(1):162-8.

[22]. Ohle, R., O'Reilly, F., O'Brien, K. K., Fahey, T., & Dimitrov, B. D., 2011, The Alvarado score for predicting acute appendicitis: a systematic review. BMC Medicine, 9, 1-13.

[23]. Andersson, R. E., 2014, Short-term complications and long-term morbidity of laparoscopic and open appendicectomy in a national cohort. Journal of British Surgery, 101(9), 1135-1142.

[24]. Addiss, D. G., Shaffer, N., Fowler, B. S., & Tauxe, R. V., 1990, The epidemiology of appendicitis and appendectomy in the United States. American journal of epidemiology, 132(5), 910-925.

[25]. Coyne, S. M., Zhang, B., Trout, A. T., 2014, Does appendiceal diameter change with age? A sonographic study. American Journal of Roentgenology, 203(5):1120-6.