Abstract:

Fungal infections of the nose and paranasal sinuses can be categorized into invasive and non-invasive forms. The clinical presentation and course of the disease is primarily determined by the immune status of the host and can range from harmless or subtle presentations to life threatening complications. Immunocompromised patients with poorly controlled diabetes mellitus, HIV and patients receiving chemotherapy or chronic oral corticosteroids are mostly affected In our first case A 54 years male came with complaint of nasal blockage for 3 months , UTI , headache and heaviness of head for 4 months. microscopically necrotic tissue with fungal colonies along with mixed inflammatory cell composed of neutrophilis and lymphocytes seen and silver stain both mucormycosis and aspergillosis fungal organism. A 58 years female came with complaint of nasal pain for 3 months, nasal block , headache, sneezing and heaviness of head for 4 months,right ear pain for 10years associated with tinnitus. microscopically section shows necrotic tissue with fungal colonies along with mixed inflammatory cell infiltrate composed of eosinophilis and lymphocytes and silver stain conforms the presence of both mucormycosis and aspergillosis fungal organism. Case 3 A 48 years male came with complaint of nasal blockage for 3 months. history of upper respiratory tract infection, headache and heaviness of head for 2 months. microscopically section shows necrotic tissue with fungal colonies along with mixed inflammatory cell infiltrate composed of eosinophilis and lymphocytes and silver stain conforms the presence of both mucormycosis and aspergillosis fungal organism in the slide.

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