Prevalence of Urinary Tract Infection (Uti) and Antimicrobial Susceptibility Pattern among Patients Attending National Hospital Abuja, Fct - Nigeria
Urinary Tract Infection (UTI) is a significant
health problem worldwide, affecting all ages and both sexes. Hence, the
need for determination
of microorganisms causing urinary tract infection (UTI) and their in-vitro
susceptibility test is of paramount important to improve service delivery to
patients. With this background, a retrospective study was carried out from July
2013 to December 2013 at National Hospital Abuja (NHA).
This study is planned to determine the prevalence of
urinary tract infection (UTI) among
different sexes and age groups as well as the predominant bacterial pathogens
and their sensitivity to antibiotics so as to guide empirical antibiotic therapy.
This is aimed at
providing improved patient care and management.
MATERIALS AND METHODS
total of 2640 urine samples from patients attending both inpatient and Outpatient
departments of NHA were included in this study. Data of all patients who had positive
urine culture between July 2013 and December 2013 were systematically and
retrospectively collected from the Laboratory register of the Medical
Microbiology and Parasitology Department. Demographic data of these selected
individuals’ patient, sex, marital status, pathogens isolated and their
antimicrobial sensitivity pattern were collated and analyse. These urine
samples were earlier subjected to culture and sensitivity test with the use of
standard bacteriological techniques as described by American Society for
five percent of the total urine samples (2640) showed significant bacterial
growth. Ten different bacterial species were isolated. Among these, Escherichia coli (49.5%) was
significantly the most predominant one (P<0.05) followed by Staphylococcus aureus (14.9%), Klebsiella spp (11.8%), Enterococcus faecalis (8.9%), Pseudomonas aeruginosa (4.4%), Proteus spp (3.3%) and others.
Majority of Gram-negative bacteria showed susceptibility towards Ciprofloxacin,
Gentamicin, and Amikacin. The age group with highest frequency of UTIs was
21–30 years with females predominating in all the age groups except in less
than 1 and above 60 years (Fig. 7). The results showed that married women are
more likely to be affected than their single or widowed counterparts while the
reverse was the case in males (Fig. 8).
outcome of this study shows that there is need for more work in this area be to
consistently determine the changing pattern of microbial uropathogens and their
and Laboratory Standards Institute. Performance standards for antimicrobial
susceptibility testing, 17th informational supplement. Wayne, PA:
AK and Mandal AK. Microbes associated with urinary tract infection in Burdwan,
West Bengal. Ind J physiology and Allied Science 1993; 47:67-72.
M. District Laboratory Practice in Tropical Countries. Part 2. Cambridge
University Press: Cambridge, UK. 2002; 105-112.
Francesco, M.A., R. Guiseppe, P. Laura, N. Ricardo and M. Nino. Urinary tract
infection in Brescia, Italy: Etiology of Uropathogens and antimicrobial
resistance of common uropathogens Med. Sci Monit., 2007; 13:136-144.
N, Jamal W, Rotimi VO. Spectrum and antibiotic resistance of uropathogens
isolated from hospital and community patients with urinary tract infections in
two large hospitals in Kuwait. Med. Principl. pract. 2008; 14: 401-407.
E and Renkonen OV. Comparative in vitro activity of Norfloxacin and 7 other
antimicrobial agents against clinical isolates from urinary tract infection. Scand
J Infect Dis 1985; 17:95-8.
BA, Sahm DF and Weissfeld AS. Bailey and Scott’s Diagnostic Microbiology (11th
ed). USA: Mosby 2002.
R.T., Sr. “Uncomplicated Urinary Tract Infection in Women”. Obstet Gynecol
Clin., North Am. 2008; 35(2):235-48.
JE. Urinary tract infections in women. Urol. Clin. North Am. 1986; 13: 673-676
J.E. “Urinary Tract Infection in Women”. J. of Urol. Clin. of North Am.
B, Barlow R, D’Arcy H, et al. Urinary tract infection: Self-reported incidence
and associated costs. Ann Epidemiol 2000; 10:509–15.
Gluisier MPC. Urinary tract infection and pyelonephritis. In:
Medical Microbiology and Infectious Diseases, Braude AIP, Sander WB (ed.), WB
Comp. Philadelphia 1991; pp. 1172-1183.
K. Increasing antimicrobial resistance and the management of uncomplicated
community-acquired urinary tract infections. Int. J. Antimicrob. Agents. 2001;
D. Isenberg. Clinical Microbiology Procedures Handbook (2nd ed). Washington,
D.C.: ASM press 2004.
A, Tiwari BR and Pradhan SB. Study on Bacteria isolated from Urinary tract
infection and their sensitivity pattern. J Nep Med Assoc 2004; 43:200-3.
CM. Urinary tract infections in females. Clin. Infect. Dis. 1994; 18:
AS, Kolawale OM, Kandaki-Olukemi YT, Babatunde SK, Durowade KA, Kplawale CF.
Prevalence of urinary tract infections among patients attending Dalhatu Araf
Specialist Hospital, Lafia, Nasarawa State, Nigeria. Int. J. Med. Med. Sci. 2009;
T.M., D.A. Caugant, L.O. Froholm and E.A. Hoiby, Apparent difference in
antimicrobial susceptibility as a consequence of national guidelines. Clin
Microbiol Infect., 2000; 6:290
PN. Analysis of pathogens isolated from urinary tract infection in Barbados. West
Indi Med J 1993; 42:72-6.
Lin, K. and K. Fajardo. “US Preventive Services Task Force.
Screening for Asymptomatic Bacteriuria in Adults”. Ann. Intern. Med.
2008; 149 (1): 20-4.
TI. Prevalence and antibiogram of UTIs among prison inmates in Nigeria. Int. J.
Microbiol. 2007; 3(2): 6-12.
K and A. Bayeh. Prevalence and antibiogram of bacterial isolates from urinary
tract infections at Dessie Health research Laboratory, Ethiopia. Asian Pac. J
Trop Biomed., 2014; 4(2):164-168
Nicolle, L.E. “Uncomplicated Urinary Tract Infection in
Adults Including Uncomplicated Pyelonephritis”. J. of Urol. Clin. of North
Am. 2008; 35(1): 1-12.
S.R. “Approach to the Patient with Urinary Tract Infection”. In: Goldman L,
Ausiello, D, eds. Ceil Medicine 23rd ed. Philadephia, PA. 2007; p.306.
CL, Tarupiwa A and Simango C. Scope of urinary pathogens isolated in the public
health bacteriology laboratory. Harare: Antibiotic susceptibility patterns of
isolates and incidence of haemolytic bacteria. Central African J Med
1996; 42: 244-9.
K, Usui Y and Wananabe R. Statistic studies on bacteria isolated from urinary
tract infection (Report 6: Isolation rate and drug sensitivity from 1988
through 1989). Acta Urol Japonica 1994; 40:175-85
S.O., O.U.J. Umeora, G.O. Igberase, M.E. Azikem and E.E. Okpere.
Microbiological Isolates and sensitivity pattern of Urinary tract infection in
pregnancy in Benin city, Ebonyi Medical Journal., 2006; 5(2): 48-52.
BM. A handbook of clinical microbiology (1st ed). Kathmandu: Gorakhnath desktop
and printers 2004.
MAS. Sensitivity pattern of positive urine culture in a Teaching Hospital. Ban
Ren J 1987; 6:49-52.
H. et. al. Urinary Tract Infections. http://www.reutershealth.com/wellconnected
Accessed on 2001; 23/8/2008