Abstract:

Obstructive sleep apnea is common under‐diagnosed disease associated with high incidence of cardiovascular disease and death there is a strong association between OSA and obesity, almost 70% of patients with OSA are obese. As Obesity and fat deposits may affect compliance of upper airway walls and lead to narrowing of luminal area, which increase the airway collapse

OSA is also there is strong relation between OSA and increased risk of type 2 diabetes by different mechanisms, like intermittent hypoxia, sleep disturbance and immune activation may affect this association. Which play important role in the pathogenesis

Central obesity, increase level of insulin and resistance are associated with high risk of OSA, some researches shown a high prevalence of T2DM and pre‐diabetes in obese patient with OSA, which indicate cause glucose intolerance may cause by OSA.

Study aimed to assess whether extremely obese people who have T2DM and preDM have higher odds of OSA than their counterparts with normal glucose tolerance.

References:

[1.] Type 2 diabetes and pre‐diabetes are associated with obstructive sleep apnea in extremely obese subjects Jan Magnus Fredheim 12*, Jan Rollheim1, Torbjørn Omland3, Dag Hofsø1, Jo Røislien

[2.] Type 2 diabetes and pre‐diabetes are associated with obstructive sleep apnea in extremely obese subjects: a cross‐sectional study. Fredheim JM1, Rollheim J, Omland T, Hofsø D, Røislien J, Vegsgaard K, Hjelmesæth J

[3.] Young T, Palta M, Dempsey J, Skatrud J, Weber S, Badr S: The occurrence of sleep‐disordered breathing among middle‐aged adults