Abstract:

A retrospective study aimed at ascertaining the prevalence of Pulmonary TB amongst patients visiting Eastern Nigeria Medical Centre, Enugu State was conducted between September, 2015 and November, 2015. Sputum samples were obtained from one hundred and twenty patients. Samples were smeared on glass slides, stained using Ziehl Neelsen Stain and observed under light (oil immersion) microscopy. Data obtained were analysed using SPSS Statistic Base 17.0, where descriptive analyses such as sum, percent distribution, and mean, were computed. While Chi- Squared Goodness of Fit, degree of differences, p- value in order to statistically determine if any significance between variables such as age groups, sex of subjects, AFB positivity and prevalence existed. The results showed positive results for tuberculosis with prevalence of 42 (35%) out of 120 subjects. The age group 21-30 years had the highest prevalence of 18 (43%) out of 42 of PTB positive subjects. There was no significant difference between sex of subjects with PTB positivity (X²: 1.33 at P= 0.12). There was significant difference between age groups of subjects with PTB positivity (X²: 33.18 at P= 0.01). It is observed that PTB is still a serious health burden in this part of the world, thus, there is need for improved TB awareness, treatment and control programme.

Keywords: Tuberculosis (TB), Pulmonary, Ziehl Neelsen.

References:

[1.]   Alan, R.L., Dzung, T., Ann, O.F., Wendy, A.M., and Kaying, H. (2002). Prevalence of Tuberculosis, Hepatitis B virus and Intestinal Parasitic infections among refugees to Minnesota, Public Health reports, 117:69-77.

[2.]   Centers for Disease Control and Prevention (2015). TB Basic facts. CDC/TB/Basic TB Facts. Available on line at http://www.cdc.gov/tb/topic/basics/default.htm

[3.]   Centers for Disease Control and Prevention (2014). TB Basic facts. CDC/TB/Basic TB Facts/Risk Factors. Available on line at http://www.cdc.gov/tb/topic/basics/risk.htm

[4.]   Corbett, E.L, Marston, B., Churchyard, G.J and De Cock, K.M. (2006), Tuberculosis in sub-Saharan Africa: opportunities, challenges, and change in the era of antiretroviral treatment. Lancet 2006; 367:926.

[5.]   deJong, B.C, Antonio, M. and Gagneux, S. (2010). Mycobacterium africa num: review of an important cause of human tuberculosis in West Africa. PLoSNegl Trop Dis 2010; 4:e744.

[6.]   D’souza, D.T., Mistry, N.F., Vira, T.S., Dholakia, Y., Hoffner, S., Pasvol, G., Nicol. M. and Wilkinson, R.J (2009): High levels of multidrug resistant tuberculosis in new and treatment-failure patients from the Revised National Tuberculosis Control Programme in an urban metropolis (Mumbai) in Western India. BMC Publ Health., 9: 211-10.1186/1471-2458-9-211.

[7.]   Gupta, S., Shenoy, V.P., Mukhopadhyay, C., Bairy, I. and Muralidharan, S. (2011): Role of risk factors and socio-economic status in pulmonary tuberculosis: a search for the root cause in patients in a tertiary care hospital, South India. Trop MedInt Health., 16 (1): 74-78. 10.1111/j.1365-3156.2010.02676.

[8.]   Jain, N.K., Chopra, K.K., Prasad, G., (1992): Initial and acquired isoniazid and rifampicin resistance to Mycobacterium tuberculosis and its implication for treatment. Indian J Tuberc. 39: 12-14.

[9.]   Khan, Q.H. (2006): Epidemiology of pulmonary tuberculosis in rural Aligarh. Indian J Community Med. (1): 39-40. 10.4103/0970-0218.54938.

[10.]      Rüsch-Gerdes, S., Pfyffer, G.E., Casal, M., Chadwick, M. and Siddiqi, S. (2006): Multicenter Laboratory validation of the BACTEC MGIT 960 technique for testing susceptibilities of mycobacterium tuberculosis to classical second-line drugs and newer antimicrobials. J Clin Microbiol. 44 (3): 688-692. 10.1128/JCM.44.3.688-692.2006.

[11.]      Sharma, S.K., Kaushik, G., Jha, B., George, N., Arora, S.K., Gupta, D., Singh, U., Hanif, M. and Vashisht, R.P. (2011): Prevalence of multidrug-resistant tuberculosis among newly diagnosed cases of sputum-positive pulmonary tuberculosis. Indian J Med Res, 133: 308-311.

[12.]      Sharma, S.K., Kaushik, G., Jha, B., George, N., Arora, S.K., Gupta, D., Singh, U., Hanif, M. and Vashisht, R.P. (2011):Prevalence of multidrug-resistant tuberculosis among Category II pulmonary tuberculosis patients. Indian J Med Res, 133: 312-315.

[13.]      Shetty, N., Shemko, M., Vaz, M. and D’souza G (2006): An epidemiological evaluation of risk factors for tuberculosis in south India: a matched case control study. Int J Tuberc Lung Dis., 10 (1): 80-86.

[14.]      Taura, D.W., Sale, I.T and Mohammed, Y. (2008). The prevalence of Tuberculosis In patients attending the Infectious Disease Hospital, Kano, Nigeria. Int. Jor. P. App. Scs., 2(3): 63-69.

[15.]      USAID Health: Infectious Diseases, Tuberculosis, Countries, Sudan. Available on line at: http://www.usaid.gov/our_work/global_health/id/tuberculosis/countries/africa/ssudan_profile.html

[16.]      Vestal, A.L. (1997): Procedures for isolation and identification of Mycobacteria, CDC Atlanta, Georgia: U.S. Department of Health, Education and Welfare, Publication No CDC-77-8230, 15-19.

[17.]      Vijay, S., Bala Sangameshwara, V.J., Jagannatha, P.S. and Kumar, P. (2004): Initial drug resistance among tuberculosis patients under DOTS Programme in Bangalore City. Indian J Tuberc., 51: 17-21.

[18.]      World Health Organization (2006): Emergence of XDR-TB. WHO concern over extensive drug resistant TB strains that are virtually untreatable.

http://www.who.int/mediacentre/news/notes/2006/np23/en/index.html. Accessed 17 January 2012

[19.]      World Health Organization (2000): Tropical Diseases Research; World Health Organization, Geneva, Switzerland.

[20.]      World Health Organization (2008): TB and Children in: Communicable disease: tuberculosis fact sheet. Geneva, Switzerland.

[21.]      World Health Organization (2010): Multidrug and extensively drug-resistant TB (M/XDR-TB):, Available:http://whqlibdoc.who.int/publications/2010/9789241599191_eng.pdf. Accessed 26 March, 2013, global report on surveillance and response.

[22.]      World Health Organization (2011): Global Tuberculosis Control: WHO report, Available: http://www.who.int/tb/publications/global_report/gtbr11_full.pdf. Accessed 26 March, 2013

[23.]      World Health Organization (2012): Tropical Diseases Research; World Health Organization report, Africa.

[24.]      World Tuberculosis Day (2008). Country 3rd in Global TB Prevalence. Daily Trust (Abuja), 21 March 2008.