Polycystic Ovarian Syndrome also called
Stein-Leventhal Syndrome or chronic oligoanoSvulation is a condition related to
hormonal imbalance that can cause menstrual disorders like oligomenorrhea or amenorrhea,
infertility, hirsutism, obesity, suffering from prompt increase in weight or having
trouble in losing weight and other symptoms in type two diabetes, oily skin, and
acne. Most of the cases of PCOS are reported in 20s and 30s with complain of difficulty
in becoming pregnant. According to the study, frequency of PCOS in the infertility
clinics in Pakistan was 17.6%. In this study Fenugreek
(Trigonellafoenum-graecum) was investigated
to treat PCOD. The plant was also subjected to different physico-chemical
and nutraceutical estimations. The present study is single blind randomized controlled trial in 90 premenopausal women diagnosed with PCOS using
fenugreek seed powder, over a period of 90 consecutive days. During the course of study, the subjects
were counseled about diet and exercise and were regularly monitored for any associated
side effects related to the administration of fenugreek seed powder. Vital clinical estimations in the human subjects were carried out at the
start of study and by the end of trail i.e. at day 90. Clinical estimations involved
evaluation of BMI, FSH, LH, ovarian size, menstrual regularity and FBG. Overall
results revealed that the prolong administration of raw fenugreek seeds in women
having PCOS was particularly found effective. Intake of fenugreek seeds for three
months had positive effect on regularity of menstrual cycle, maturation of eggs,
reducing ovarian volume and infertility.
Keywords: Polycystic Ovaries, Fenugreek, Infertility, Ovarian Size,
. Legge. J.,
E.F Ambassador (2017). Polycystic ovarian syndrome (pcos) – a guide 2017. https://ecofemme.org/polycystic-ovarian-syndrome-pcos-a-guide-2017/.
. Hussein, B., & Alalaf, S. (2013). Prevalence and characteristics
of polycystic ovarian syndrome in a sample of infertile Kurdish women attending
IVF infertility center in maternity teaching hospital of Erbil City. Open Journal
of Obstetrics and Gynecology, 3(07), 577.
. Mullaicharam, A. R., Deori, G., & Maheswari, R. U. (2013).
Medicinal values of fenugreek—A review. Res. J. Pharm. Biol. Chem. Sci, 4,
. Moradi, N., &Moradi, K. (2013). Physiological and pharmaceutical
effects of fenugreek (Trigonellafoenum-graecum L.) as a multipurpose and valuable
medicinal plant. Global Journal of Medicinal Plant Research, 1(2),
. Beretta, G., Granata, P., Ferrero, M.,
Orioli, M., & Facino, R. M. (2005). Standardization of antioxidant properties
of honey by a combination of spectrophotometric/fluorimetric assays and chemometrics.
Analytica Chimica Acta, 533(2), 185-191.
Official Method of Analysis.15th Ed., Association of Official Analytical
Chemist. Arlington, VA.USA.
. AOAC. 2000.
Official method of Analysis.17th Ed., Association of Official Analytical
Chemist. Gaithersburg, MD.USA.
. AOAC. 2005.
Official method of Analysis.18th Ed., Association of Official Analytical
Chemist. Gaithersburg, MD.USA.
. Steel, R. G. D., Torrie, J. H., & Dickey, D. A. (1997). Principles
and procedures of statistics: a biometrical approach., 3rd edn (McGraw-Hill: New
. Cresswell, J., Fraser, R. B., Bruce, C., Egger, P., Phillips,
D., & Barker, D. J. (2003). Relationship between polycystic ovaries, body mass
index and insulin resistance. Acta obstetrician et gynecologica Scandinavica,
. Bashtian, M. H., Emami, S. A., Mousavifar, N., Esmaily, H. A.,
Mahmoudi, M., & Poor, A. H. M. (2013). Evaluation of fenugreek (Trigonellafoenum-graceum
L.), effects seeds extract on insulin resistance in women with polycystic ovarian
syndrome. Iranian Journal of Pharmaceutical Research: IJPR, 12(2),
. Swaroop, A., Jaipuriar, A. S., Gupta, S. K., Bagchi, M., Kumar,
P., Preuss, H. G., &Bagchi, D. (2015). Efficacy of a novel fenugreek seed extract
(Trigonellafoenum-graecum, FurocystTM) in polycystic ovary syndrome (PCOS). International
Journal of Medical Sciences, 12(10), 825.
. Pavlik, E. J., DePriest, P. D., Gallion, H. H., Ueland, F. R.,
Reedy, M. B., Kryscio, R. J., & van Nagell Jr, J. R. (2000). Ovarian volume
related to age. Gynecologic Oncology, 77(3), 410-412.
. Van Hooff, M. H., Voorhorst, F. J., Kaptein, M. B., Hirasing,
R. A., Koppenaal, C., & Schoemaker, J. (2000). Polycystic ovaries in adolescents
and the relationship with menstrual cycle patterns, luteinizing hormone, androgens,
and insulin. Fertility and Sterility, 74(1), 49-58.
. Diamanti-Kandarakis, E., & Dunaif, A. (2012). Insulin resistance
and the polycystic ovary syndrome revisited: an update on mechanisms and implications.
Endocrine Reviews, 33(6), 981-1030.
. Dunaif, A., & Book, C. B. (1997). Insulin resistance in the
polycystic ovary syndrome. In Clinical Research in Diabetes and Obesity (pp.
249-274).Humana Press, Totowa, NJ.
. Dunaif, A. (2008). Drug insight: insulin-sensitizing drugs in
the treatment of polycystic ovary syndrome reappraisal. Nature Reviews Endocrinology,
. Ovalle, F., & Azziz, R. (2002). Insulin resistance, polycystic
ovary syndrome, and type 2 diabetes mellitus. Fertility and Sterility, 77(6),