Institutional Factors Affecting Retention of HIV Patient on Treatment at Wuse General Hospital, Abuja, Nigeria

Download Article

DOI: 10.21522/TIJPH.2013.09.02.Art003

Authors : Uba Sabo Ado, Babashani Musa, Thaddeus Olatunbosun, Adeyemi Adedayo, Uba Belinda Vernyuy

Abstract:

Retention on treatment is a critical factor in reducing HIV-related morbidity and mortality, the incidence of new infections, and development of drug resistance among children and adults. This study examined institutional factors affecting retention of HIV patients on treatment, care, and support services at Wuse General Hospital, Abuja. A retrospective cohort study was used to access institutional factors that influence HIV patient retention on treatment. About 4,564 HIV patients were ever enrolled on a treatment programme, and 2,791 patients are currently accessing treatment. A total of 240 clients were recruited for the study, and a pre-tested interviewer-administered semi-structured questionnaire was used for data collection. Data were entered into Stata/MP 15.0 and then exported into SPSS version 23.0 for statistical analysis of the 240 respondents interviewed, the main institutional factor affecting retentions were long waiting time (61.7%), high patient load (46.9%), inadequate space for clinics (48.3%), Poor quality of services (40.8%), difficulty in accessing health facility (32.9%) and inadequate health workers/staff (31.3%). A review of socio-demographic characteristics of respondents and institutional related factors affecting retention in treatment showed an association between marital status (p=0.000), religion (p=0.006), employment status (p=0.009), and institutional related factors affecting retention in care. Retention of HIV patients in treatment and care support services is a major determinant in achieving sustained viral suppression and reduced community HIV transmission. Therefore, strategies to mitigate institutional barriers to treatment retention should be promoted to optimize retention of HIV patients in care.

References:

[1] Mondal, M., and Shitan, M., 2013, Factors affecting the HIV/AIDS epidemic: an ecological analysis of global data. Afr Health Sci, 13(2):301–310.

[2] Health FM, 2010, National guidelines for HIV and AIDS treatment and care in adolescents and adults. Federal Ministry of Health Abuja.

[3] Mberi, M.N., Kuonza, L.R., Dube, N.M., Nattey, C., Manda, S., and Summers, R., 2015, Determinants of loss to follow-up in patients on antiretroviral treatment, South Africa, 2004–2012: a cohort study. BMC Health Serv Res, 15(1):1–11.

[4] WHO. 13-15 September 2011. 2012, Retention in HIV programmes: defining the challenges and identifying solutions: meeting report.

[5] Fuente-Soro, L., López-Varela E., Augusto, O., Bernardo, E.L., Sacoor, C., and Nhacolo, A., 2020, Loss to follow-up and opportunities for re-engagement in HIV care in rural Mozambique: A prospective cohort study. Medicine (Baltimore), 99(20): e20236.

[6] Cohen, M.S., Chen, Y.Q., McCauley, M., Gamble, T., Hosseinipour, M.C., and Kumarasamy, N., 2011, Prevention of HIV-1 Infection with Early Antiretroviral Therapy. N Engl J Med, 365(6):493–505.

[7] Fox MP and Rosen, S., 2010, Patient retention in antiretroviral therapy programs up to three years on treatment in Sub-Saharan Africa, 2007–2009: systematic review. Trop Med Int Health, 15:1–15.

[8] Babatunde, O., Ojo, O.J., Atoyebi, O.A., Ekpo, D.S., Ogundana, A.O., and Olaniyan, T.O., 2015, Seven-year review of retention in HIV care and treatment in federal medical centre Ido-Ekiti. Pan Afr Med J, 22(1).

[9] Amuron, B., Namara, G., Birungi, J., Nabiryo, C., Levin, J., and Grosskurth, H., 2009, Mortality and loss-to-follow-up during the pre-treatment period in an antiretroviral therapy programme under normal health service conditions in Uganda. BMC Public Health, 9(1):290.

[10] Giordano, T.P., Gifford, A.L., White Jr, A.C., Almazor, MES., Rabeneck, L., and Hartman C, 2007, Retention in care: a challenge to survival with HIV infection. Clin Infect Dis, 44(11):1493–1499.

[11] Paracha, S.I., Hafeez, F., Habib, H., Yaqoob, A., Fatima, R., and Saeed, Q., 2019, The extent of loss to follow among patients initiated on antiretroviral treatment, Pakistan 2017-2018: a retrospective cross-sectional study.

[12] Zürcher, K., Mooser, A., Anderegg, N., Tymejczyk, O., Couvillon, M.J., and Nash, D., 2017, Outcomes of HIV‐positive patients lost to follow‐up in African treatment programmes. Trop Med Int Health., 22(4):375–387.

[13] Egger, M., Spycher, B.D., Sidle, J., Weigel, R., Geng, E.H., and Fox, M.P., 2011. Correcting mortality for loss to follow-up: a nomogram applied to antiretroviral treatment programmes in sub-Saharan Africa. PLoS Med.; 8(1): e1000390.

[14] Cornell, M., Lessells, R., Fox, M.P., GARONE, D.B, Giddy, J., and Fenner, L., 1999. Mortality among adults transferred and lost to follow-up from antiretroviral therapy programmes in South Africa: a multicentre cohort study. J Acquir Immune Defic Syndr. 2014;67(2): e67.

[15] Geng, E.H., Odeny, T.A., Lyamuya, R., Nakiwogga-Muwanga. A., Diero, L., and Bwana, M., 2016, Retention in care and patient-reported reasons for undocumented transfer or stopping care among HIV-infected patients on antiretroviral therapy in Eastern Africa: application of a sampling-based approach. Clin Infect Dis. 62(7):935–944.

[16] Brinkhof, M.W., Pujades-Rodriguez, M., and Egger M., 2009, Mortality of patients lost to follow-up in antiretroviral treatment programmes in resource-limited settings: systematic review and meta-analysis. PloS One, 4(6): e5790.

[17] Opio, D., Semitala, F.C., Kakeeto, A., Sendaula E., Okimat, P., and Nakafeero, B., 2019, Loss to follow-up and associated factors among adult people living with HIV at public health facilities in Wakiso district, Uganda: a retrospective cohort study. BMC Health Serv Res; 19(1):628.

[18] Rachlis, B., Bakoyannis, G., Easterbrook, P., Genberg, B., Braithwaite, R.S., and Cohen C.R., 2016, Facility-level factors influencing retention of patients in HIV care in East Africa. PloS One, 11(8): e0159994.

[19] Geng, E.H., Bangsberg, D.R., Musinguzi, N., Emenyonu, N., Bwana, M.B., and Yiannoutsos, C.T.., 2010, Understanding reasons for and outcomes of patients lost to follow-up in antiretroviral therapy programs in Africa through a sampling-based approach. J Acquir Immune Defic Syndr, 53(3):405.

[20] Tuller, D.M., Bangsberg D.R., Senkungu, J., Ware N.C., Emenyonu, N., and Weiser SD., 2010, Transportation costs impede sustained adherence and access to HAART in a clinic population in southwestern Uganda: a qualitative study. AIDS Behav, 14(4):778–784.

[21] Ochieng-Ooko, V., Ochieng, D., Sidle, J.E., Holdsworth, M., Wools-Kaloustian, K., and Siika, A.M., 2010, Influence of gender on loss to follow-up in a large HIV treatment programme in western Kenya. Bull World Health Organ, 88:681–688.

[22] Chan A.K, Mateyu, G., Jahn, A., Schouten, E., Arora, P., Mlotha, W., 2010, Outcome assessment of decentralization of antiretroviral therapy provision in a rural district of Malawi using an integrated primary care model. Trop Med Int Health, 15:90–97.

[23] Dalhatu I, Onotu D, Odafe S, Abiri O, Debem H, Agolory S, Shiraishi RW, Auld AF, Swaminathan M, Dokubo K, Ngige E, Asadu C, Abatta E, Ellerbrock., 2016, Outcomes of Nigeria's HIV/AIDS Treatment Program for Patients Initiated on Antiretroviral Treatment between 2004-2012.

[24] Assefa Y, Worku A, Wouters E, Koole O, Haile Mariam D, Van Damme W. 2012, Simplified tools for measuring retention in care in antiretroviral treatment program in Ethiopia: cohort and current retention in care. PLoS One. 2012;7(6): e38555. doi: 10.1371/journal.pone.0038555.

[25] Chemutai, R.J, Mwaniki, P., Mutai, J.K., Njenga, S., and Kyalo, M.A., 2018, Factors Associated with Retention in Care among HIV Positive Adults Attending Pumwani Comprehensive Care Centre, In Nairobi County, Kenya.

[26] Bekker, L.G., Venter, F., Cohen, K., Goemare, E., Van Cutsem, G., and Boulle, A., 2014, Provision of antiretroviral therapy in South Africa: the nuts and bolts.

[27] Miller, C.M., Ketlhapile, M., Rybasack‐Smith, H., and Rosen, S., 2010, Why are antiretroviral treatment patients lost to follow‐up? A qualitative study from South Africa. Trop Med Int Health; 15:48–54.

[28] Fernandes, C.M., Daya, M.R., Barry. S., and Palmer, N., 1994, Emergency department patients who leave without seeing a physician: the Toronto Hospital experience. Ann Emerg Med, 24(6):1092–1096.

[29] Callaghan, M., Ford, N., and Schneider, H., 2010, A systematic review of task-shifting for HIV treatment and care in Africa. Hum Resour Health; 8(1):8.

[30] Govindasamy, D., Ford, N, and Kranzer, K.., 2012, Risk factors, barriers and facilitators for linkage to antiretroviral therapy care 2012: a systematic review. Aids, 26 16):2059–2067.

[31] Duncombe, C., Rosenblum, S., Hellmann, N., Holmes, C., Wilkinson, L., and Biot, M., 2015, Reframing HIV care: putting people at the centre of antiretroviral delivery. Trop Med Int Health, 20(4):430–447.

[32] Mukumbang, F.C., Mwale, J.C., and Van Wyk, B., 2017, Conceptualising the factors affecting retention in care of patients on antiretroviral treatment in Kabwe District, Zambia, using the ecological framework. AIDS Res Treat.

[33] Mwale, J.C., 2016, Factors affecting retention in care of patients on antiretroviral treatment in the Kabwe district, Zambia.

[34] Kalinjuma, A.V., Glass, T.R., Weisser, M., Myeya, S.J, Kasuga, B., and Kisung’a, Y., 2020, Prospective assessment of loss to follow‐up: incidence and associated factors in a cohort of HIV‐positive adults in rural Tanzania. J Int AIDS Soc, 23(3): e25460.

[35] Larson, B.A., Brennan, A., McNamara, L., Long, L., Rosen, S., and Sanne, I., 2010, Early loss to follow up after enrolment in pre‐ART care at a large public clinic in Johannesburg, South Africa. Trop Med Int Health, 15:43–47.

[36] Francis, J., Geldsetzer, P., Ulenga, N., Sando, D., Lema, I., and Mboggo, E., 2018, The impact of community delivery of antiretroviral therapy on viral
load suppression: findings from a pragmatic randomized non-inferiority trial in Dar es Salaam, Tanzania. In: Journal of the International AIDS Society. John Wiley & Sons Ltd the atrium, southern gate, chichester, PO19 8SQ, W 94–94.

[37] Layer, E.H., Kennedy, C.E., Beckham, S.W., Mbwambo, J.K, Likindikoki, S., Davis, W.W., 2014, Multi-level factors affecting entry into and engagement in the HIV continuum of care in Iringa, Tanzania. PloS One, 9(8): e104961.