Abstract:

Twenty albino mice of both sexes were used in this study. The animals were kept in steel cages of the animal house of the College of Veterinary Medicine of Tikrit University. The animals were distributed into two groups. Group A (10) animals were administered ivermectin subcutaneously (s/c) at a dose of 0.02mg/kg every 48 hours for two weeks. Group B (10), considered as control, received normal saline for two weeks’ s/c too. The whole animals were sacrificed by a deep, intensive dose of chloroform in closed glass box. Histological Technique was done to obtain tissues from the kidney, liver and stomach. The results were indicated that the kidney tissue had sloughing of the bowman’s capsule, lymphocytic aggregation on glomerular surfaces, widening of capsular space and presence of glomerular filtrate in the lumen of proximal and distal convoluted tubules with hypertrophy of epithelial cells of those tubules and the liver tissue demonstrated the presence of hyperplasia of liver cells, presence of many Kupffer cells in the narrowed blood sinusoids and pyknosis of many nuclei of liver cells. The gastric mucosa was demonstrated the degeneration of epithelial cells of gastric pits and damage to the chief cells and parietal cells of lamina propria with WBCs infiltration in the interstitial c.t of gastric mucosa. In conclusion: the chemical drug ivermectin had many histopathological effects on the visceral organs although consider as anti-parasitic drug used commonly in the world.

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