Abstract:

Infertility is increasing and becoming a major concern, particularly in a nation like India where there are large populations on the one hand and childless couples on the other. Male infertility affects that half of the population. A number of factors contribute to infertility, some of which are environmental in nature. One of such notable factor of environmental pollutant is the lead. Lead is almost present in all of your surroundings in different ways, especially usage of lead in the paint industries, lead pipes and in toys. Its effect is detrimental to reproductive organs especially to testis. To treat this issue withaferin A is used to scientifically validate its fertility enhancing property. A total of five sets of Wistar rats were obtained. Control, lead acetate (Pb), lead acetate + withaferin A, lead acetate + vitamin A & selenium and withaferin A alone, comprise Group I, II, III, IV and V respectively. Following the experiment, rats were euthanized and samples were collected for histopathological examination. Group I and Group V animals in the control and drug control group exhibit no alterations. After being exposed to lead acetate solution and inflicting several reproductive cell damages, Group II undergoes a substantial pathological alteration. Withaferin A considerably improves the lead induced toxic condition of testis than vitamin A and selenium treated group. Alternate approach makes substantial use of the withaferin A in animal models of reproductive cell damage caused by oxidative stress upon lead toxicity. Thus, withaferin A have encouraging outcomes on male infertility.

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