Abstract:

This study attempted to assess the impact of fluoxetine on the submandibular salivary gland of Albino rats. Thirty rats weighing 160–230 gm was randomly divided into 3 groups, 7 rats each; group I (control group), group II (20mg/kg single dose fluoxetine-treated group included 10 rats that received 20mg/kg fluoxetine as a single intraperitoneal dose, while the group III were treated with (60mg /kg body weight) of fluoxetine. Blood samples were collected for measuring malondialdehyde (MDA) superoxide dismutase (SOD), hydrogen peroxide H₂O₂ and histopathological examination for both salivary and parotid gland tissue. According to the histological study’s findings, the second group (G2) experienced histopathological changes that included. The study upheld that reiterated by oral intake of fluoxetine induced significant toxic impacts on blood parameters, increased serum MDA and H₂O₂ levels while downregulated SOD and GSH-Px level and histopathological changes in parotid gland. The current study decided that fluoxetine has many toxic effects on blood parameters, induces oxidative stress and histopathological alteration in the parotid gland.

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