Abstract:

Facial rejuvenation treatments have become increasingly popular, with microneedling radiofrequency (MNRF) and platelet rich plasma (PRP) injections emerging as prominent options. This study aimed to compare the efficacy of MNRF and PRP injections in facial rejuvenation. A total of 40 participants, aged >18 years, seeking treatment for open pores and facial rejuvenation, were enrolled and randomly assigned to two groups: the MNRF group (n=20) and the PRP injection group (n=20). The MNRF group received five sessions of microneedling radiofrequency at third weekly intervals, while the PRP group underwent five sessions of autologous PRP injections over the same period. Efficacy was assessed using the VAS score at baseline, third, sixth, ninth and twelfth weeks by the patient and investigator. Participants in the MNRF group demonstrated a statistically significant improvement compared with the PRP group (P < 0.05%). Patient satisfaction was higher in the MNRF group, with fewer reports of side effects, which were mostly mild and transient in both groups. Microneedling radiofrequency shows superior efficacy in reducing open pores and improving skin texture and firmness compared with PRP injections. The higher patient satisfaction and more significant clinical improvements suggest that MNRF is a preferable option for individuals seeking facial rejuvenation.

References:

[1]    Bandral, M. R., Padgavankar, P. H., Japatti, S. R., Gir, P. J., Siddegowda, C. Y., & Gir, R. J., 2019. Clinical evaluation of microneedling therapy in the management of facial scars: a prospective randomized study. Journal of Maxillofacial and Oral Surgery, 18, 572-578. https://doi.org/10.1007/s12663-018-1155-7

[2]    McCall-Perez, F., Stephens, T. J., & Herndon Jr, J. H., 2011. Efficacy and tolerability of a facial serum for fine lines, wrinkles, and photodamaged skin. The Journal of clinical and aesthetic dermatology, 4(7), 51. https://pmc.ncbi.nlm.nih.gov/articles/PMC3140905/

[3]    Ibrahim, Z. A., El‐Ashmawy, A. A., & Shora, O. A., 2017. Therapeutic effect of microneedling and autologous platelet‐rich plasma in the treatment of atrophic scars: a randomized study. Journal of cosmetic dermatology, 16(3), 388-399. https://doi.org/10.1111/jocd.12356

[4]    Badran, K. W., & Nabili, V., 2018. Lasers, microneedling, and platelet-rich plasma for skin rejuvenation and repair. Facial Plastic Surgery Clinics, 26(4), 455-468. https://doi.org/10.1016/j.fsc.2018.06.007

[5]    Atiyeh, B., Oneisi, A., & Ghieh, F., 2021. Platelet-rich plasma facial rejuvenation: myth or reality? Aesthetic Plastic Surgery, 45(6), 2928-2938. https://doi.org/10.1007/s00266-021-02300-9

[6]    Spataro, E. A., Dierks, K., & Carniol, P. J., 2022. Microneedling-associated procedures to enhance facial rejuvenation. Facial Plastic Surgery Clinics, 30(3), 389-397. https://doi.org/10.1016/j.fsc.2022.03.012

[7]    Juhasz, M. L., & Cohen, J. L., 2020. Microneedling for the treatment of scars: an update for clinicians. Clinical, cosmetic and investigational dermatology, 997-1003. https://doi.org/10.2147/CCID.S267192

[8]    Sidharthan, S., Dharmarajan, G., Iyer, S., Poulose, M., Guruprasad, M., & Chordia, D., 2024. Evaluation of microneedling with and without injectable-platelet rich fibrin for gingival augmentation in thin gingival phenotype-A randomized clinical trial. Journal of oral biology and craniofacial research, 14(1), 49-54. https://doi.org/10.1016/j.jobcr.2023.10.008

[9]    Manishaa, V., 2024. Evaluation of the efficacy of platelet-rich plasma injections with and without microneedling for managing atrophic facial acne scars: a prospective comparative study. Cureus, 16(5), e60957. https://doi.org/10.7759/cureus.60957

[10] Thahir, M., Misbah, I., Bhaskaran, J., Syed, N. H., Ashraf, M., & Balasubramanian, N., 2024. Efficacy of Intraoperative Platelet-Rich Plasma After Meniscal Repair: Systematic Review and Meta-analysis. Indian Journal of Orthopaedics, 58, 845–857. https://doi.org/10.1007/s43465-024-01155-x

[11]    Peng, G. L., 2019. Platelet-Rich Plasma for Skin Rejuvenation: Facts, Fiction, and Pearls for Practice. Facial plastic surgery clinics of North America, 27(3), 405-411. https://doi.org/10.1016/j.fsc.2019.04.006

[12]    Vladulescu, D., Scurtu, L. G., Simionescu, A. A., Scurtu, F., Popescu, M. I., & Simionescu, O. 2023. Platelet-rich plasma (PRP) in dermatology: cellular and molecular mechanisms of action. Biomedicines, 12(1), 7. https://doi.org/10.3390/biomedicines12010007

[13]    Ibrahim, M. K., Ibrahim, S. M., & Salem, A. M., 2018. Skin microneedling plus platelet-rich plasma versus skin microneedling alone in the treatment of atrophic post acne scars: a split-face comparative study. Journal of dermatological treatment, 29(3), 281-286. https://doi.org/10.1080/09546634.2017.1365111