In Vitro Assessment of Cytotoxic Effects of Ipomoea Batatas Fruit Extract on Breast Cancer Cells
Abstract:
Purple sweet potatoes, or Ipomoea batatas, are well-known for their high antioxidant content and possible health advantages, including anticancer effects. This investigation looked at the bioactive components that were responsible for the cytotoxic effects of Ipomoea batatas fruit extract on breast cancer cells. Ipomoea batatas extracts were synthesized in the study using an ethanol extraction method, and their antioxidant activity was evaluated using DPPH and nitric oxide radical scavenging assays. Using the MTT assay, the extract's cytotoxicity was assessed on MDAMB-231 breast cancer cells, and docking studies were used to examine molecular interactions. With an IC50 value of roughly 125 µg/ml, the results showed a considerable cytotoxic effect. Eriodictyol had the highest binding affinity (-7.7 kcal/mol) to the STAT3 target protein. Lipinski's Rule of Five was not broken by any of the six phytochemicals examined, indicating that they all had promising drug-like qualities. These results demonstrate the potential of Ipomoea batatas extract and its constituents as therapeutic agents with promise for the treatment of breast cancer. However, more investigation is required to validate these findings and maximize the therapeutic use of these bioactive substances, including preclinical and clinical studies.References:
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