Prevalence of Hand Eczema among Healthcare Workers in A Tertiary Care Hospital in the Post-COVID Era of Hand Hygiene: A Cross-Sectional Study

Abstract:
Hand eczema (HE)
is an inflammatory condition characterized by dryness and irritation of hands,
which commonly affects healthcare workers due to contact with allergens because
of frequent handwashing and the use of gloves. Long-standing eczema can
significantly affect the quality of life; hence better understanding is needed
for prevention, especially in healthcare workers. To determine the prevalence
of hand eczema in healthcare workers in the post-COVID-19 era and assess the
relationship with other variables, like socio-economic status. The prospective
cross-sectional observational study was conducted. One hundred and eight
healthcare workers with hand eczema were asked to fill out a questionnaire
regarding hand eczema and were examined for clinical signs of hand eczema. The
data was interpreted, and an association was made with the HECSI score,
Modified Kuppuswamy score and Y-BOCS score for OCD (obsessive compulsive
disorder). There were statistically significant differences in the methods of
hand sanitizing used across the socio-economic categories defined by the
Modified Kuppuswamy Scale. Additionally, there was a significant difference
in HECSI scores across different Y-BOCS categories. This study
demonstrates significant differences in hand sanitizing practices and HECSI
scores among hospital workers post-COVID-19, influenced by socioeconomic
factors and OCD.
References:
[1].
Burns, T., Breathnach,
S. M., Cox, N., Griffiths, C., (Eds.). 2008, Rook's textbook of
dermatology. John Wiley & Sons.
[2].
Agarwal, U. S.,
Besarwal, R. K., Gupta, R., Agarwal, P., Napalia, S., 2014, Hand eczema. Indian
journal of dermatology, 59(3), 213-224.
[3].
Yüksel, Y. T., Symanzik,
C., Christensen, M. O., Olesen, C. M., Thyssen, J. P., Skudlik, C., Brans, R.,
2024, Prevalence and incidence of hand eczema in healthcare workers: A
systematic review and meta‐analysis. Contact Dermatitis, 90(4),
331-342.
[4].
Armstrong, A.,
Hahn-Pedersen, J., Bartlett, C., Glanville, J., Thyssen, J. P., 2022, Economic
burden of chronic hand eczema: a review. American Journal of Clinical
Dermatology, 23(3), 287-300.
[5].
Zalewski, A., Krajewski,
P. K., & Szepietowski, J. C., 2023, Psychosocial Consequences of Hand
Eczema—A Prospective Cross-Sectional Study. Journal of Clinical
Medicine, 12(17), 5741.
[6].
Halbert, A. R., Weston,
W. L., Morelli, J. G., 1995, Atopic dermatitis: is it an allergic disease? Journal
of the American Academy of Dermatology, 33(6), 1008-1018.
[7].
Janstrup, A. K.,
Nørreslet, L. B., Toft‐Hansen, J. M., Ofenloch, R., Agner, T., & Yüksel, Y.
T., 2023, Assessment of hand eczema severity by patients using the hand eczema
severity index (HECSI). Journal of the European Academy of Dermatology
and Venereology, 37(11), 2349-2354.
[8].
Storch, E. A., De Nadai,
A. S., Do Rosário, M. C., Shavitt, R. G., Torres, A. R., Ferrão, Y. A.,
Fontenelle, L. F., 2015, Defining clinical severity in adults with
obsessive–compulsive disorder. Comprehensive psychiatry, 63,
30-35.
[9].
Quaade, A. S., Simonsen,
A. B., Halling, A. S., Thyssen, J. P., Johansen, J. D., 2021, Prevalence,
incidence, and severity of hand eczema in the general population–a systematic
review and meta‐analysis. Contact Dermatitis, 84(6),
361-374.
[10].
Thyssen, J. P.,
Johansen, J. D., Linneberg, A., Menné, T., 2010, The epidemiology of hand
eczema in the general population–prevalence and main findings. Contact
dermatitis, 62(2), 75-87.
[11].
Teo, H. G., Lim, T. H.,
Bujang, M. A., Kiing, J. W., Muniandy, P., 2023, Prevalence of occupational
hand eczema among healthcare workers and its associated risk factors in a
tertiary hospital in sarawak during covid-19 pandemic. Indian Journal
of Dermatology, 68(1), 121.
[12].
Sharma, N. R., Singh,
R., Patil, A., 2022, Hand eczema associated with frequent hand washing and use
of hand sanitizer during COVID-19 pandemic: A case series. Indian
Journal of Skin Allergy, 1(2), 50-53.
[13].
Veronese, F., Esposto,
E., Airoldi, C., Gramaglia, C., Zeppegno, P., Zavattaro, E., Savoia, P., 2023,
Prevalence of Self-Reported Hand Eczema Signs among Healthcare Workers after
the Third Wave of COVID-19 Pandemic: A Survey in a Northern Italy
Hospital. Medicina, 59(6), 1054.
[14].
Czeisler, M. É., 2020,
Demographic characteristics, experiences, and beliefs associated with hand
hygiene among adults during the COVID-19 pandemic—United States, June 24–30,
2020. MMWR. Morbidity and mortality weekly report, 69.
[15].
Patri, P., Pattayat, S.
S., Mohammed, S. N., Barik, R., Factors Influencing Facemask and Hand Sanitizer
use During the COVID-19 Pandemic in Odisha. Indian Journal of Health
Studies, 6, 49-76.
[16].
Assefa, D., Melaku, T.,
Bayisa, B., Alemu, S., 2021, Knowledge, attitude and self-reported performance
and challenges of hand hygiene using alcohol-based hand sanitizers among
healthcare workers during covid-19 pandemic at a tertiary hospital: A
cross-sectional study. Infection and drug resistance, 303-313.
[17].
Pinciotti, C. M.,
Bulkes, N. Z., Bailey, B. E., Storch, E. A., Abramowitz, J. S., Fontenelle, L.
F., Riemann, B. C., 2023, Common rituals in obsessive–compulsive disorder and
implications for treatment: A mixed-methods study. Psychological
Assessment, 35(9), 763.
[18].
Jelinek, L., Göritz, A.
S., Miegel, F., Schuurmans, L., Moritz, S., Yassari, A. H., Müller, J. C., 2024,
Too much of a good thing? Hand hygiene and the long-term course of
contamination-related obsessive-compulsive symptoms. Frontiers in
Psychology, 15, 1279639.
[19]. Jalal, B., Chamberlain, S. R.,
Robbins, T. W., Sahakian, B. J., 2022, Obsessive–compulsive
disorder—contamination fears, features, and treatment: novel smartphone
therapies in light of global mental health and pandemics (COVID-19). CNS
spectrums, 27(2), 136-144.
[20]. Dennis, D., McGlinchey, E., &
Wheaton, M. G., 2023, The perceived long-term impact of COVID-19 on OCD
symptomology. Journal of Obsessive-Compulsive and Related Disorders, 38,
100812.
[21]. Jaganathan, R.,
Vishnuvanditha, V., Selvankumar, T., 2024, Control of Multidrug-Resistant
Hospitalized Pathogenic Bacteria Using the Secondary Metabolites of Calotropis
procera and In-silico Analysis of Bacterial Virulent Proteins. Texila
International Journal of Public Health. DOI: 10.21522/TIJPH.2013.SE.24.05.
Art036
[22]. Jaganathan, R.,
Kumaradhas, P., 2024, Structural insights into Furin enzyme inhibition to block
SARS-CoV-2 spike protein cleavage: an in-silico approach. 3 Biotech, 14(9),
213.
[23]. Prathima, R.,
Basalingappa, K. M., Arjun, K. R., Kanavi, G., Suresh, J., Murugesan, K.,
Maghimaa, M., 2024, Fluorescence capturing behaviour of cyanobacterial
resilience: Insights into UV-exposed ecosystems and its environmental
applications. Luminescence: the journal of biological and chemical
luminescence, 39(9), e4898.
[24]. Ranjitha, S.,
Bhuvaneswari, S., Kumar, R. S., Thirumalaisamy, R., Ameer, K., Selvankumar, T.,
2025, Synthesis of nanostructured semiconducting cerium oxide associated
titanium dioxide as photoanodic material for dye sensitized solar cells. Chemical
Physics Impact, 10, 100790.
[25]. Mousa, N. M.,
Attia, A. J., & Ali, K. F., 2025, Design, Molecular Docking, Molecular
Dynamics and Preliminary Pharmacological Evaluation of New Thioimidazole-4-One
Derivatives.
[26]. Udappusamy, V.,
Thinagaran, R., Mayakrishnan, V., Balakarthikeyan, J., Kannappan, P.,
Al-Ghamdi, S., Ramesh, T., 2025, An integrated in vitro and in silico approach
to assess targeted cytotoxicity against MDA-MB-231 triple-negative breast
cancer cells with Psidium guajava peel-derived chitosan nanoparticles. Artificial
Cells, Nanomedicine, and Biotechnology, 53(1), 43-55.
[27]. Thozhukkad
Moosaripparambil, S., Vadakkadath Meethal, K., 2025, Exploring the anticancer
potential of Hewittia malabarica through phytochemical analysis and molecular
docking study. Scientific Reports, 15(1), 4088.
[28].
Shanmugam,
K. S., Lakshmanan, R., Jagadeesan, R., Maghimaa, M., Hemapriya, N., Suresh, S.,
2024, Green synthesis of bimetallic Ag-ZnO nanocomposite using polyherbal
extract for antibacterial and anti-inflammatory activity. Chemical
Physics Impact, 9, 100763.
[29].
Maghimaa,
M., Sagadevan, S., Suryadevara, P. R., Sudhan, H. H., Burle, G. S. R.,
Ruokoalinen, J., Kesari, K. K., 2024, Cytotoxicity and targeted drug delivery
of green synthesized metallic nanoparticles against oral Cancer: A
review. Inorganic Chemistry Communications, 113806.
[30].
Maghimaa,
M., Sagadevan, S., Boojhana, E., Fatimah, I., Lett, J. A., Moharana, S., Al-Anber,
M. A., 2024, Enhancing Biocompatibility and Functionality: Carbon
Nanotube-Polymer Nanocomposites for Improved Biomedical Applications. Journal
of Drug Delivery Science and Technology, 105958.
[31].
Pariyapurath,
N. K., Jagannathan, S., Mathanmohun, M., Pillai, S. B., Dhandapani, K.,
Pachamuthu, R. G., Namassivayam, H., 2024, Targeted Immunization Strategies and
Designing Vaccine against Indian Nipah Virus Strain (NiV B) and Malaysian
Variant (NiV M). International Journal of Pharmaceutical Investigation, 14(4).
[33]. Muthuvel, R., Jagannathan, S., Pariyapurath, N. K., Pachamuthu, R. G., Mathanmohun, M., & Sagadevan, S., 2024, Harnessing Nutritional Powerhouse: Millets and Probiotics in Anticancer Therapy. Current Pharmacology Reports, 1-8.