The Effect of Aspalathin on SMAD2, SMAD3, TGF-β - A Major Contributor of Inflammation – An In-silico Approach

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DOI: 10.21522/TIJPH.2013.SE.24.01.Art009

Authors : Kaviyarasi Renu, Vishnu Priya Veeraraghavan, R. Gayathri, Kavitha. S, Hirshasri A.G


Chronic inflammation plays a crucial role in the development of several illnesses, and the transforming growth factor-beta (TGF-β) pathway, including SMAD2 and SMAD3, regulates inflammatory responses. Aspalathin, a naturally-occurring compound extracted from several plant sources, has shown potential anti-inflammatory properties. This study uses computational methods to investigate how aspalathin affects SMAD2, SMAD3, and TGF-β in order to understand how it regulates inflammation. We use molecular docking to analyze how aspalathin binds with important components of the TGF-β pathway. Our research reveals promising information about the potential of aspalathin, which shows a strong ability to bind with the inflammatory regulator (SMAD2, SMAD3, and TGF-β). Aspalathin may offer therapeutic benefits for treating inflammatory diseases. Further testing in both controlled laboratory environments (in vitro) and inside live creatures (in vivo) are required to validate the computational findings and prove aspalathin's potential as a viable option for inflammation management.


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