Piperine Regulates Inflammatory Signalling Molecules in Adipose Tissue: A High Fat Diet Sucrose Induced Type II Diabetic Experimental Model

Download Article

DOI: 10.21522/TIJPH.2013.SE.24.01.Art011

Authors : Gayathri R, Vishnu Priya Veeraraghavan, Ashwin Jaikumar Ram, J. Selvaraj, B. Sadhvi


Metabolic inflammation is an essential event in obesity-induced diabetes and insulin resistance. An extract of the active phenolic component of black pepper (Piper nigrum), piperine, is well known to provide beneficial physiological effects. This study aims to assess the regulation of inflammatory signalling molecules in adipose tissue by Piperine using a high diet and sucrose-induced type II diabetic experimental model. Our results suggest that piperine has the potential as a therapeutic drug or dietary supplement.


[1] Gupta SC, Prasad S, Aggarwal BB (2016) Anti-inflammatory Nutraceuticals and Chronic Diseases. Springer.

[2] Smilkov K, Ackova DG, Cvetkovski A, Ruskovska T, Vidovic B, Atalay M (2019) Piperine: Old Spice and New Nutraceutical? Current Pharmaceutical Design 25:1729–1739.

[3] Smilkov K, Ackova DG, Cvetkovski A, Geskovski N, Pejova B, Boev B, Makreski P (2021) First characterization of functionalized nanoparticles—tandem of biosynthesized silver nanoparticles conjugated with piperine. Chemical Papers. https://doi.org/10.1007/s11696-021-01911-5.

[4] Kuete V (2017) Medicinal Spices and Vegetables from Africa: Therapeutic Potential against Metabolic, Inflammatory, Infectious and Systemic Diseases. Academic Press.

[5] Che C-T, Zhang H (2019) Plant Natural Products for Human Health. MDPI.

[6] Shah S, Shah G, Singh S, Gohil P, Chauhan K, Shah K, Chorawala M (2011) Effect of piperine in the regulation of obesity-induced dyslipidemia in high-fat diet rats. Indian Journal of Pharmacology 43:296.

[7] Bang JS, Oh DH, Choi HM, Sur B-J, Lim S-J, Kim JY, Yang H-I, Yoo MC, Hahm D-H, Kim KS (2009) Anti-inflammatory and antiarthritic effects of piperine in human interleukin 1beta-stimulated fibroblast-like synoviocytes and in rat arthritis models. Arthritis Res Ther 11:R49.

[8] Umar S, Golam Sarwar AHM, Umar K, Ahmad N, Sajad M, Ahmad S, Katiyar CK, Khan HA (2013) Piperine ameliorates oxidative stress, inflammation and histological outcome in collagen-induced arthritis. Cell Immunol 284:51–59.

[9] Huvers FC, Popa C, Netea MG, van den Hoogen FHJ, Tack CJ (2006) Improved insulin sensitivity by anti-TNF antibody treatment in patients with rheumatic diseases. Annals of the Rheumatic Diseases 66:558–559.

[10] Okumura Y, Narukawa M, Watanabe T (2010) Adiposity Suppression Effect in Mice Due to Black Pepper and Its Main Pungent Component, Piperine. Bioscience, Biotechnology, and Biochemistry 74:1545–1549.

[11] Okumura Y, Narukawa M, Iwasaki Y, Ishikawa A, Matsuda H, Yoshikawa M, Watanabe T (2010) Activation of TRPV1 and TRPA1 by Black Pepper Components. Bioscience, Biotechnology, and Biochemistry 74:1068–1072.

[12] Ealla KKR, Veeraraghavan VP, Ravula NR, Durga CS, Ramani P, Sahu V, Poola PK, Patil S, Panta P (2022) Silk Hydrogel for Tissue Engineering: A Review. J Contemp Dent Pract 23:467–477

[13] Noland D, Drisko JA, Wagner L (2020) Integrative and Functional Medical Nutrition Therapy: Principles and Practices. Springer Nature.

[14] Grant RW, Dixit VD (2013) Mechanisms of disease: inflammasome activation and the development of type 2 diabetes. Front Immunol 4:50.

[15] Subaraman M, Gayathri R, Priya VV (2020) In vitro antidiabetic activity of crude acetone leaf extract of Annona muricata. Drug Invention Today.

[16] Dinarello CA (2010) Anti-inflammatory Agents: Present and Future. Cell 140:935–950.

[17] Gayathri R, Priya VV (2020) Evaluation of Antidiabetic Potential of Crude Methanolic Leaf Extract of Gymnema Sylvestre-An In Vitro Study. International Journal of Pharmaceutical Research.

[18] Shankar P, Gayathri R, Selvaraj J, Priya VV (2021) Antidiabetic and Antiinflammatory Potentials of Sida Acuta Leaf Ethanolic Extract. Journal of Pharmaceutical Research International 33:8

[19] Karthik EVG, Priya V (2021) Gayathri. R, Dhanraj Ganapathy. Health Benefits Of Annona Muricata-A Review. Int J Dentistry Oral Sci 8:2965–2967

[20] Priya DV, (2020) Knowledge and awareness on HIV/AIDS among college students in A university hospital setting. Int J Dent Oral Sci 1182–1186