Evaluation of Antioxidant and Xanthine Oxidase Inhibitory Potential of Methanolic Extract of Myristica fragrans (Mace)

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DOI: 10.21522/TIJPH.2013.SE.24.01.Art017

Authors : Gayathri R, Kavitha S, Vishnu Priya Veeraraghavan, Bingha. M, J. Selvaraj


Myristica fragrans is commonly named as nutmeg or mace. It is native to Moluccas of Indonesia. It is used in folk medicine. Phytochemicals present in the plant are responsible for the medicinal properties of the plant. Antioxidants neutralise the free radicals that are produced in our body due to various biochemical reactions .Gout is a clinical condition caused due to accumulation of Uric acid crystals in one or more joints leading to inflammation. Xanthine oxidase inhibitory potential of the extract helps in preventing excess production of uric acid. The extract was found to be rich in phytochemicals such as saponin, alkaloid, terpenoids and flavonoids. The IC50 for the antioxidant potential of the extract was 280µg/ml and the IC 50 for the xanthine oxidase inhibitory potential of the extract was 320 µg/ml.


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