Abstract:

Community Based Health Insurance (CBHI) is a form of micro health insurance, which is a health insurance targeting low-income people. The specific feature of CBHI is the community involvement in driving its setup and in its management. Traditional CBHI models are small, voluntary, and often include the pooling of health risks and funds within a community. In Nigeria, many CBHI schemes have had limited success, suffering from low membership levels, and having issues such as regressive financing, poor or lack of involvement amongst scheme members amongst others. The study assessed the level of CBHI knowledge and rate of service uptake of CBHI among the traders. 300 Questionnaires were administered to the traders by face-to-face interview which gave the respondents the opportunity to respond to both the structured and open-ended questions. Inferential statistical tests were used to test the various research hypothesis that arose from the research questions in the study. Various statistical tests such as Chi-square, comparison of column proportions, correlational tests, and multiple regression were used. The result shows a mean knowledge score of 33.79 ± 3.22 with their scores ranging from 25 – 42. 2%. There was no significant relationship between knowledge level and service uptake (p = 0.351). Findings from this study noted that although awareness is poor, a good quota of the participants (79%) still have overall good knowledge of CBHI schemes. Hence, it will be beneficial to leverage on this concretize more efforts towards encouraging people to enrol with the CBHI schemes.

References:

[1] Zoidze A, Rukhazde N, Chkhatarashvili K, Gotsadze G. Promoting universal financial protection: health insurance for the poor in Georgia – a case study. Health Res Policy Syst. 2013 Nov 14;11(1):45.

[2] Rodin J, de Ferranti D. Universal health coverage: the third global health transition? The Lancet. 2012 Sep;380(9845):861–2.

[3] Collins, D., February 2015. Assessment of Akwa Ibom Community-Based Health Insurance (CBHI) Pilot Scheme. PLAN-Health Project. Management Sciences for Health.

[4] Cameron TA (1988). A new paradigm for valuing non-market goods using referendum data: maximum likelihood estimation by censored logistic regression. J Environ Econ Management, 15(3):355–379. 10.1016/0095-0696(88)90008-3.

[5] Farrugia, P., Petrisor, B.A., Farrokhyar, F., & Bhandari, M. (2010). Research questions, hypotheses and objectives. Canadian Journal of Surgery, 53 (4), 278-281.

[6] Stuart MacDonald & Nicola Headlam (2008). Research Methods Handbook: Introductory guide to research methods for social research. Centre for Local Economic Strategies Express Networks • 1 George Leigh Street, Manchester M4 5DL. ISBN: 1870053656. https://www.cles.org.uk/wp-content/uploads/2011/01/Research-Methods-Handbook.pdf.

[7] Degu, G., & Yigzaw, T. (2006). Research Methodology. Retrieved from http://www.cartercenter.org/resources/pdfs/health/ephti/library/lecture_notes/health_science_students/ln_research_method_final.pdf.

[8] Donfouet HPP, Essombè EJR, Mahieu P-A, Malin E. (2011) Social capital and willingness-to-pay for community-based health insurance in rural Cameroon. Global Journal of Health Science,3(1):142–149.

[9] Collins, D., February 2015. Assessment of Akwa Ibom Community-Based Health Insurance (CBHI) Pilot Scheme. PLAN-Health Project. Management Sciences for Health.

[10] Smith, Joanna and Firth, Jill (2011) Qualitative data analysis: the framework approach. Nurse Researcher, 18 (2). pp. 52-62. ISSN 1351-5578.

[11] Mack, N., Woodsong, C., Macqueen, K. M., Guest, G. & Namey, E. (2005). Qualitative Research Methods: A Data Collector’s Field Guide. Family Health International, North Carolina, USA.

[12] Yusuf, Hammed et al (2019). Health Insurance Knowledge, Attitude and the Uptake of Community-Based Health Insurance Scheme among Residents of a Suburb in Lagos, Nigeria. West African journal of medicine, VL – 36.

[13] Ibukun O. A. (2014) Knowledge and uptake of community-based Health Insurance Scheme among residents of Olowora, Lagos.

[14] Jütting J. (2001). The Impact of Health Insurance on the Access to Health Care and Financial Protection in Rural Developing Countries. The Example of Senegal. HNP Discussion Paper (Washington: World Bank).

[15] De Weerdt J (2002) Social networks, transfers and insurance in developing countries, no. 159. PhD Thesis, Katholieke Universiteit Leuven, Leuven.

[16] Desmet M, Chowdury AQ & Islam MdK (1999) The potential for social mobilisation in Bangladesh: the organisation and functioning of two health insurance schemes. Social Science and Medicine 48, 925–938.

[17] Dror DM, Hossain SAS, Majumdar A, Pérez Koehlmoos TL, John D, Panda PK (2016) What Factors Affect Voluntary Uptake of Community-Based Health Insurance Schemes in Low- and Middle-Income Countries? A Systematic Review and Meta-Analysis. Plos One 11(8): e0160479. https://doi.org/10.1371/journal.pone.0160479.

[18] Criel B., Noumou Barry A. & von Roenne F. (2002). Le Projet PRIMA enGuinéeConkary-uneexpérienced’organisation de mutuelles de santé enAfriquerurale. (Brussels:Medicus Mundi Belgium).

[19] Idongesit L. Silas M. & Edidiong E. (2020). Patient satisfaction with health services in public and private Hospitals in South-South Nigeria: International Journal of Research in Pharmacy and Science. Jackson et al. Int J Res Pharm Sci 2017, 7(2); 8 -15. https://www.researchgate.net/publication/338655447_Patient_satisfaction_with_health_services_in_public_and_private_Hospitals_in_South-South_Nigeria.

[20] Nageso D, Tefera K, Gutema K (2020) Enrollment in community-based health insurance program and the associated factors among households in Boricha district, Sidama Zone, Southern Ethiopia; a cross-sectional study. Plos One 15(6): e0234028. https://doi.org/10.1371/journal.pone.0234028.

Abstract:

Pre-analytical errors contribute a significant proportion of errors of all major sources of mistakes made in laboratory testing processes and are responsible for several patient safety risks. It contributes to wrong therapeutic interventions, irrelevant follow up laboratory investigations and diagnostic delays, which impact negatively on the economy and laboratory effectiveness of health services. Pre-analytical phase is directly related to the procedure of specimen collection and is mostly out of the direct control of the laboratory; further, most pre-analytical errors are related to human factors. The aim of the study is to determine the nature and the occurrence of pre-analytical errors and recommendations on possible measures to reduce these errors. A total of 300 specimens were randomly sampled from a study population of 600 patients and analyzed for pre-analytical errors. One hundred and eighty-four (184) samples were found unsuitable for further processing accounting for 1.9% of all samples analyzed for pre-analytical errors and sample rejection. Rejections were due to following reasons: hemolysis 21.7 % (40) wrong tubes 19 % (35); clotted blood 17% (32); inappropriate timing of collection 15.7% (29); mislabeled specimens 15.2% (28); insufficient specimen quantity 6.5 % (12) and lipemic specimens 4.3% (8). The overall percentage of rejection was 1.9% and the substantial numbers of the rejected specimens were re-tested. Efforts aimed to reduce the rates of rejected samples can improve the quality of laboratory-based health care response.

References:

[1] Bowen RA, Hortin GL, Csako G, Otañez OH, Remaley AT. (2010) Impact of blood collection devices on clinical chemistry assays. Clin Biochem.; 43(1-2):4-25.

[2] McCall R, Tankersley C. Phlebotomy Essentials. 5th ed. Philadelphia, PA: Lippincott, Williams, and Wilkins, 2008:245.

[3] Favaloro EJ, Adcock DM, Lippi G. (2012) Preanalytical variables in coagulation testing associated with diagnostic errors in hemostasis. Lab Med.; 43(2):1-10.

[4] Validation and verification of tubes for venous and capillary blood specimen collection; approved guideline. CLSI document GP34-A. Wayne, PA: Clinical and Laboratory Standards Institute, 2012.

[5] Lippi G, Fostini R, Guidi GC. (2008). Quality improvement in laboratory medicine: extra-analytical issues. Clin Chem Lab Med.; 28(2):285-294.

[6] Arneson W, Brickell J. (2008). Clinical Chemistry: A Laboratory Perspective. Philadelphia, PA: FA Davis Company, :418.

[7] Wallin O, Söderberg J, Van Guelpen B, Stenlund H, Grankvist K & Brulin C. (2008) pre-analytical venous blood sampling practices demand improvement — A survey of test-request management, test-tube labelling, and information search procedures. Clin Chim Acta 391; 91-7

[8] Hawkins R. (2012). Managing the pre- and post-analytical phases of the total testing process. Ann Lab Med.; 32(1):5-16.

[9] Green SF. (2013). The cost of poor blood specimen quality and errors in pre-analytical processes. Clin Biochem.; 46(13):1175-1179.

[10] Plebani M. (2007). Laboratory errors: How to improve pre- and post-analytical phases Biochemia Medica. 2; 17(1):5-9

[11] Jiu T, The importance of pre-analytical phase in laboratory testing and diagnosis.

[12] Datta P. (2005). Resolving discordant specimens. ADVANCE for Administrators of the Laboratory.: 60.

[13] Plebani M. (2006). Errors in clinical laboratories or errors in laboratory medicine? Clin Chem Lab Med.; 44(6):750-759.

[14] Lippi G, Becan-McBride K, Behúlová D, Bowen RA, Church S, Delanghe J, et al. Preanalytical quality improvement: in quality we trust. Clin Chem Lab Med. 2013;51(1):229-241.

[15] Bonini P, Plebani M, Ceriotti F, Rubboli F, Errors in Laboratory Medicine. Clinical Chemistry, 48: 5691–698 (2002).

[16] Plebani M, Carraro P. (1997) Mistakes in a stat laboratory: Types and frequency. Clin Chem.; 43(8):1348-1351.

[17] Söderberg J, Brulin C, Grankvist K, Wallin O. (2009) Pre-analytical errors in primary healthcare: a questionnaire study of information search procedures, test request management and test tube labelling. Clin Chem Lab Med.; 47(2):195–201.

[18] Söderberg J, Wallin O, Grankvist K, Brulin C. (2010) Is the test result correct? A questionnaire study of blood collection practices in primary health care. J Eval Clin Pract.; 16(4):707–711.

[19] Plebani M. (2005) Exploring the iceberg of errors in laboratory medicine. Clin Chim Acta.; 404(1):16-23.

[20] Barak M, Jaschek R. (2013). A new and effective way for preventing preanalytical laboratory errors. Clin Chem Lab Med.; 50(4):1-4.

[21] Favaloro EJ, Adcock DM, Lippi G. (2012) Preanalytical variables in coagulation testing associated with diagnostic errors in hemostasis. Lab Med.; 43(2):1-10.

[22] Hollensead SC, Lockwood WB, Elin RJ, Errors in Pathology and Laboratory Medicine: Consequences and Prevention. Journal of Surgical Oncology 2004; 88:161–181.

[23] Jiu T, The importance of pre-analytical phase in laboratory testing and diagnosis.

[24] Hammerling J. (2012) A review of medical errors in laboratory diagnostics and where we are today. Lab Med.; 43(2):41-44.

Abstract:

This study examined the effectiveness of Orthodox vaccine and Local remedy (JOHVIR) administration against Covid-19 Disease- A comparative study approach within FCT Abuja metropolis, Nigeria. 121 volunteers participated in this study, Chi-square calculated was higher than chi-square tabulated, when the lipids mixture was administered- indicating high level of significance (P< 0.05) as very effective anti-corona 2 remedy. Chi-square (χ² Cal = 38.38; χ² tab = 5.99) and (χ² Cal = 30.86; χ² tab = 5.99), the values were significant at 0.05% level, unisex. Those study subjects on orthodox vaccine therapy had a lot of life-threatening side effects and in some cases fatal consequences while in others there were reinfection with corona virus 2. after taking over booster doses of the vaccine: none of those on local herbal lipid remedy ever had any life-threatening side effects apart from mild headaches in some cases, we strongly suggest that cold viruses such as corona virus 2 that mutate a lot may not be effectively combated and handled by orthodox vaccine. Efforts must be geared towards the mass production and development of simple antivirals such as the lipids mixture used in this study termed “Joseleen herbal lipids mixture (JOHVIR)”. As it was significantly sensitive as Covid-19 antiviral agent. Alternate simple measures such as the herbal lipids mixture could be the solution to the Covid-19 Pandemic as it prevents and neutralizes the coronavirus 2 before it penetrates the cell.

References:

[1] Tella, A.,1979, Preliminary studies on nasal decongestant activity from the seed of the shea butter tree. Butyrospernum parkii. British Journal of Clinical Pharmacology. May 7(5):495-497. doi:10.1111/j.1365-2125.1979.tb00992.x. PMID: 89854; PMCID: PMC1429586.

[2] Akihisa, T., Kojima, N., Kikuchi, T., Yasukawa, K., Tokuda, H., Masters, E. T., & Manosroi, J., 2010. Anti-inflammatory and chemo preventive effects of triterpene cinnamates and acetates from shea fat. Journal of oleo science, 59(6), 273-80. doi: 10.5650/jos.59.273. PMID: 20484832.

[3] Mclintosh, K., 1974, Converses; a Comparative review. Current Top Microbial Immunol, 63 (2), 85-129. https://doi.org/10.1007/978-3-642-65775-7_3.

[4] Mizzen, L., Hilton, A., Cheley, S., & Anderson, R., 1985, Attenuation of murine coronavirus infection by ammonium chloride. Virology, 142(2), 378-88. doi: 10.1016/0042-6822(85)90345-9 PMCID: PMC7131027PMID: 2997991.

[5] Tyrell, D. A., Alexander, D. J., Almeida, J. D., Cunningham, C. H., Easterday, B. C., Garwes, D. J., Hierholzer, J. C., Kapikian, A., Macnaughton, M. R., & Mclntosh, K., 1978, Coronaviridae: second report. Intervirology, 10(6), 321-27.doi:10.1159/000148996.

[6] Cavanagh, D., Brian, D. A., Enjuanes, L., Holmes, K. V., Lai, M. M., Laude, H., Siddell, S. G., Spaan, W., Taguchi, F., & Talbot, P. J., 1990, Recommendation of the coronavirus study group for the nomenclature of the structural proteins, mRNAs, and genes of coronaviruses, 176(1), 306-7. doi: 10.1016/0042-6822(90)90259-t. PMID: 2184577; PMCID: PMC7130901.

[7] Koopmans, M., & Horzinek, M. C., 1994, Toroviruses of animals and humans: a review. In Advances in virus research, Vol. 43, pp. 233-273. doi: 10.1016/s0065-3527(08)60050-0. PMID: 8191955; PMCID: PMC7130569.

[8] Siddell, S., Wege, H., & Ter Meulen, V., 1983, The biology of coronaviruses. Journal of General Virology, 64(4): 761-76. DOI:10.1099/0022-1317-64-4-761.

[9] Snijder, E. J., & Horzinek, M. C., 1993, Toroviruses replication, evolution and comparison with some members of the coronavirus-like superrammy. Journal of General Virology, 74(11), 2305-16. doi: 10.1099/0022-1317-74-11-2305. PMID: 8245847.

[10] Boursnell, M. E., Brown, T. D., Foulds, I. J., Green, P. F., Tomley, F. M., & Binns, M. M., 1987, Completion of the sequence of the genome of the coronavirus avian infectious bronchitis virus. Journal of General Virology, 68(1), 57-77. doi: 10.1099/0022-1317-68-1-57. PMID: 3027249.

[11] Bredenbeek, P. J., Pachuk, C. J., Noten, A. F., Charite, J., Luytjes, W., Weiss, S. R., & Spaan, W. J., 1990, The primary structure and expression of the second open reading frame of the polymerase gene of the coronavirus MHV-A59: a highly conserved polymerase is expressed by an efficient ribosomal frame shitting mechanism. Nucleic acid research, 18(7), 1825-32. doi: 10.1093/nar/18.7.1825. PMID: 2159623; PMCID: PMC330602.

[12] Ching, L., Chang, S. P., Nerurkar, V. R. (2020). Principles Behind the Technology for Detecting SARS-CoV-2, the Cause of COVID-19. Hawaii J Health Soc Welf. 1;79(5):136-142. PMID: 32432217; PMCID: PMC7226308.

[13] Serwaa, D., 2020, Knowledge, risk perception and preparedness towards coronavirus disease- 2019 (COVID-19) outbreak among Ghanaians: a quick online cross-sectional survey. Pan African Medical Journal, 35(2), 44 -55. PMID: 33623569 PMCID: PMC7875746 DOI: 10.11604/pamj.supp.2020.35.2.22630.

[14] Spaan, W., Cavanagh, D., & Horzinek, M. C. 1995, Coronaviruses: structure and genome expression. Journal of General Virology, 69(12), 2939-52. DOI: 10.1099/0022-1317-69-12- 2939.

[15] Federal Capital Territory | Location & Geography | Britannica”, January 2015.

[16] Raju, V. N., & Harinarayana, N. S., 2016, Online survey tools: A case study of Google Forms. Paper presented at the National Conference on “Scientific, Computational & Information Research Trends in Engineering, GSSS-IETW, Mysore. 67 – 72.

[17] Nigeria Centre for Disease Control (NCDC) (2020). Coronovirus (COVID-19) Highlights: Case Summary in Nigeria 7th April, 2020. https://covid19.ncdc.gov.ng.

[18] Kevadiya, B. D., Machhi, J., Herskovitz, J., Oleynikov, M. D., Blomberg, W. R., Bajwa, N Soni, D, Gendelman, H. E. (2021). Diagnostics for SARS-CoV-2 infections. Nat Mater 20(5):593-605. doi: 10.1038/s41563-020-00906-z. PMID: 33589798; PMCID: PMC8264308.

[19] Corman, V. M., Landt, O., Kaiser, M., (2020), Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR. Euro Surveill. ((3)) doi: 10.2807/1560-7917.ES.2020.25.3.2000045. [PMC free article] [PubMed] [CrossRef] [Google Scholar]

[20] Kadam, P. and Bhalerao, S., (2010). Sample Size Calculation. International Journal of Ayurveda Research, 1, 55-57. http://dx.doi.org/10.4103/0974-7788.59946.

[21] Jeurissen, P., Maarse, H., 2021, The market reform in Dutch health care: Results, lessons, and prospects [Internet]. Copenhagen (Denmark): European Observatory on Health Systems and Policies. PMID: 35143144.

Abstract:

Preeclampsia is a condition that affects pregnant women and is characterized by high blood pressure, protein in the urine, and swelling in the hands, feet, and legs. There is a chance for mild to significant variances. Although it can happen earlier or immediately after delivery, it usually happens in the later stages of pregnancy. Indeed, search engines like Google, Microsoft Bing, and Baidu were used to search publications investigating the association between pre-eclampsia and risk factor. It was observed that if preeclampsia occurred during a prior pregnancy, a woman is seven times more likely to suffer it again. Primarily, initial pregnancies are affected. Preeclampsia is more likely to affect women with history of migraines, gestational diabetes, diabetes, rheumatoid arthritis, lupus, scleroderma, urinary tract infections, gum disease, polycystic ovarian syndrome, multiple sclerosis, and sickle cell disease. Additionally, it happens more commonly in pregnancies brought on by egg donation, in vitro fertilization, or donor insemination. It is recommended that high-risk pregnant women begin taking low-dose aspirin after 12 weeks to prevent preeclampsia. Preeclampsia is therefore x-rayed along with its signs and causes. There are several risk indicators that, alone or in combination, may help identify early pregnant women who are “high risk” for pre-eclampsia.

References:

[1] Leshargie CT (2020) Incidence and Predictors of Pre-Eclampsia Among Pregnant Women Attending Antenatal Care at Debre Markos Referral Hospital, Northwest Ethiopia: Prospective Cohort Study. Int J Women’s Health. 10;12:1013-1021.

[2] Frank IO, Michael JM, Jenny R, Joseph O. (2020) Prevalence and risk factors for pre-eclampsia/eclampsia in Northern Tanzania. J Public Hal Epidemiol.12(2):78–85.

[3] Mrema D., Lie R.T., Ostbye T., Mahande M.J., Daltveit A.K. (2018). The association between pre pregnancy body mass index and risk of preeclampsia: a registry-based study from Tanzania. BioMed Central Pregnancy Childbirth, 18(1):56.

[4] Keating BJ, Saxena R. (2021) Risk of pre-eclampsia in patients with a maternal genetic predisposition to common medical conditions: a case-control study. BJOG. ;128(1):55-65.

[5] Amaral LM, Wallace K, Owens M, LaMarca B (2017). Pathophysiology and Current Clinical Management of Preeclampsia. Curr Hypertens Rep. 19(8):616.

[6] Nnodim, J., Emmanuel, N., Hope, O., Nwadike, C., Ukamaka, E., Christian, O. (2017). Membrane potential, serum calcium and serum selenium decrease in preeclampsia subjects in Owerri. Universa Medicina, 36(2), 88–93.

[7] Stevens W, Shih T, Incerti D, Ton TGN, Lee HC, Peneva D, (2017) Short-term costs of preeclampsia to the United States health care system. Am J Obstet Gynecol. ;217(3):237–248.e16.

[8] Tessema G.A., Tekeste A., Ayele T.A. (2015). Preeclampsia and associated factors among pregnant women attending antenatal care in Dessie referral hospital, Northeast Ethiopia: a hospital-based study. BioMed Central Pregnancy Childbirth, 15(1):73–75.

[9] Bartsch E, Medcalf KE, Park AL, Ray JG (2016); High Risk of Pre-eclampsia Identification Group. Clinical risk factors for pre-eclampsia determined in early pregnancy: systematic review and meta-analysis of large cohort studies. BMJ. 19;353:1753.

[10] Dusse LM, Alpoim PN, Silva JT, Rios DR, Brandão AH, Cabral AC (2015). Revisiting HELLP syndrome. Clin Chim Acta. Dec 7;451(Pt B):117-20.

[11] Nguefack C.T., Ako M.A., Dzudie A.T., Nana T.N., Tolefack P.N., Mboudou E. (2018). Comparison of materno-fetal predictors and short-term outcomes between early and late onset pre-eclampsia in the low-income setting of Douala, Cameroon. International Journal of Gynecology and Obstetrics, 142(2):228–34.

[12] Say L, Chou D, Gemmill A, Tunçalp Ö, Moller AB, Daniels J, (2014) Global causes of maternal death: a WHO systematic analysis. The Lancet Global Health. 2014;2(6): e323.

[13] Shah A, Fawole B, M’Imunya JM (2009) Cesarean delivery outcomes from the WHO global survey on maternal and perinatal health in Africa, International Journal of Gynecology and Obstetrics, 107, (3):191–197

[14] Fong FM, Sahemey MK, Hamedi G, Eyitayo R, Yates D, Kuan V, Thangaratinam S, Walton RT (2014). Maternal genotype and severe preeclampsia: a HuGE review. Am J Epidemiol. 15;180(4):335-45.

[15] Sanchez, S. E., Qiu, C., Williams, M. A., Lam, N., and Sorensen, T. K. (2008). Headaches and migraines are associated with an increased risk of preeclampsia in Peruvian women. American Journal of Hypertension, 21(3), 360–364.

[16] Brew O, Sullivan MH, Woodman A (2016). Comparison of Normal and Pre-Eclamptic Placental Gene Expression: A Systematic Review with Meta-Analysis. PLoS One. 25;11(8): e0161504. August P. (2013) Preeclampsia: a “nephrocentric” view. Adv Chronic Kidney Dis.;20(3):280-6.

[17] Duley, L. (2009). The global impact of pre-eclampsia and eclampsia. Seminars in Perinatology, 33(3), 130–137.

[18] Siddiqui A, Deneux-Tharaux C, Luton D, Schmitz T, Mandelbrot L, Estellat C (2020) Maternal obesity and severe pre-eclampsia among immigrant women: a mediation analysis. Sci Rep.;10(1):1–9.

[19] Lin SY, Yang YC, Su JW, Wang JS, Jiang CC, Hsu CY, Kao CH. (2021) Association Between Preeclampsia Risk and Fine Air Pollutants and Acidic Gases: A Cohort Analysis in Taiwan.Front Public Health. 31;9:617521

[20] Skarstein Kolberg E. (2020) ACE2, COVID19 and serum ACE as a possible biomarker to predict severity of disease. J Clin Virol.;126:104350–104350

[21] Staun-Ram E, Goldman S, Gabarin D, Shalev E (2004). Expression and importance of matrix metalloproteinase 2 and 9 (MMP-2 and -9) in human trophoblast invasion. Reprod Biol Endocrinol. 2: 59.

[22] August P. (2013) Preeclampsia: a “nephrocentric” view. Adv Chronic Kidney Dis.;20(3):280-6.

[23] World Health Organisation’ (2011). WHO recommendations for prevention and treatment of preeclampsia and eclampsia. Available at: https://www.who.int/reproductivehealth/publications/maternal_perinatal_health/9789241548335/en/ (Accessed: 8 January 2021).

[24] Musa J., Mohammed C., Ocheke A., Kahansim M., Pam V., Daru P. (2018). Incidence and risk factors for pre-eclampsia in Jos Nigeria. African Health Sciences, 18(3):584–95.

[25] Verma S, Carter EB, Mysorekar IU. (2020). SARS-CoV2 and pregnancy: an invisible enemy? Am J Reprod Immunol. 2020;84(5): e13308–e13308.

[26] Schroeder B.M. (2002). ACOG practice bulletin on diagnosing and managing preeclampsia and eclampsia. American Family Physician, 66(2):330–331.

Abstract:

Malaria is a global public health problem known to be a common cause of under five children mortality in the tropical area of Africa. The aim of this study was to compare rapid diagnostic test (RDT) and microscopy technique of malaria infection among patients attending General Hospital Minna, Niger State. A convenience sampling qualitative study was carried out on 300 consenting outpatients of general hospital, Minna in Niger state. Results of the study showed that most of the respondents were females 212(71%) and Most of the participants were within the age bracket of 11-20 years (41%). This demonstrated that transmission was higher among the young age than the elderly. Microscopy was positive in 179(59%) patients and RDT was positive in 185(61%) of the total study population while 6(3%) of those negative by microscopy were also positive with RDT. There was no significant difference when the efficacy of both tests was compared. The RDT used had a sensitivity of 87%, a specificity of 98% while microscopy had sensitivity of 95% and specificity of 72%. The RDT performance was extremely high compared to microscopy in this study. RDT can still serve as the first screening test for malaria diagnosis. However, the gold standard for confirmation of clinical diagnosis for malaria is microscopy examination. Rapid diagnostic test (RDT) offers rapid, timely, accurate and accessible detection of malaria parasites which is important for prevention and treatment.

References:

[1] World Health Organization (WHO) (2014). The role of laboratory diagnosis to support malaria disease management: Focus on the use of rapid diagnostic tests in areas of high transmission. Geneva.

[2] World Health Organization (WHO) (2021). World Malaria Report 2021. Switzerland: World Health Organization. ISBN 978-92-4-004049-6.

[3] Nandwani, S., Mathur, M.& Rawat, H. (2015). Evaluation of the polymerase chain reaction for diagnosis of falciparum malariaIndia. Indian Journal of Medical Microbiology. 176-178.

[4] Ughasoro, M. D., Okafor, H. U. &Okoli, O. (2015). Malaria diagnosis and treatment among workers in University of Nigeria Teaching Enugu, Nigeria. Nigerian Journal of Clinica1 Biology. 6(3): 329-333.

[5] Federal Ministry of Health. (2018). Training Module on Monitoring and Evaluation of National Malaria Control Programme in Nigeria. For State and LGA Health Workers: Participant Manual Abuja, Nigeria. (Accessed 7^th July 2022).

[6] World Health Organization (WHO) (2015). Diagnosis of Malaria. WHO Guidelines for Malaria.

[7] Roll Back Malaria. (2012). Available from, http://www.rollbackmalaria.org/countryaction/ nigeria. html. accessed 2022 Sep 6].

[8] Moody, A. (2002). Rapid diagnostic test for malaria parasites. Clinical Microbiology Revision, 15(1): 66-78.

[9] Shillcutt, S., Morel, C., Goodman, C., Coleman, P., Bell, D. & Whitty, C. J. (2008). Cost-effectiveness of malaria diagnostic methods in sub-Saharan Africa in an era of combination therapy. Bull World Health Organ., 86: 101-110.

[10] Bell, D., Go, R., Miguel, C., Walker, J., Cacal, L. &Saul, A. (2011). Diagnosis of malaria in a remote area of the Philippines: Comparison of techniques and their acceptance by health workers and the community. Bull World Health Organ., 79: 933-941.

[11] Azikiwe, C. A., Ifezulike, C. C., Siminialayi, I. M., Amazu, L. U., Enye, J. C. & Wakwunite, O. E. (2012). A comparative laboratory diagnosis of malaria: Microscopy versus rapid diagnostic test kits. AsianPractice Journal of Tropical Biomedicine, 2(4):307-310.

[12] World Health Organization (WHO) (2006). The role of laboratory diagnosis to support malaria disease management: Focus on the use of rapid diagnostic tests in areas of high transmission. Geneva.

[13] Caraballo, H. & King, K. (2014). “Emergency department management of mosquito-borne illness: malaria, dengue, and West Nile virus”. Emergency Medicine Practice. 16 (5): 1–23.

[14] World Health Organization (WHO) (2021). World Malaria Report 2021. Switzerland: World Health Organization. ISBN 978-92-4-004049-6.

[15] Greenwood, B.M., Bojang, K., Whitty, C.J., Targett, G.A. (2015). “Malaria”. Lancet. 365 (9469): 1487–98.

[16] Worrall, E., Basu, S. & Hanson, K. (2005). “Is malaria a disease of poverty? A review of the literature”. Tropical Health and Medicine. 10 (10): 1047–59.

[17] Taylor, W.R., Hanson, J., Turner, G.D., White, N.J. & Dondorp, A.M. (2012). “Respiratory manifestations of malaria”. Chest. 142 (2): 492–505.

[18] Kajfasz, P. (2019). “Malaria prevention”. International Maritime Health. 60 (1–2).

[19] Hartman, T.K., Rogerson, S.J. & Fischer, P.R. (2010). “The impact of maternal malaria on newborns”. Annals of Tropical Paediatrics. 30 (4): 271–82.

[20] Centers for Disease Control and Prevention (CDC). (2019). “CDC - Malaria - About Malaria - History - Elimination of Malaria in the United States (1947-1951)”.

[21] Howitt, P., Darzi, A., Yang, G.Z., Ashrafian, H., Atun, R., Barlow, J., Blakemore, A., Bull, A.M., Car, J., Conteh, L., Cooke, G.S., Ford, N., Gregson, S.A., Kerr, K., King, D., Kulendran, M., Malkin, R.A., Majeed, A., Matlin, S., Merrifield, R., Penfold, H.A, Reid, S.D., Smith, P.C., Stevens, M.M., Templeton, M.R., Vincent, C. & Wilson, E. (2012). “Technologies for global health”. The Lancet. 380 (9840): 507–35.

[22] Bhatt, S., Weiss, D.J., Cameron, E., Bisanzio, D., Mappin. B. & Dalrymple, U. (2015). “The effect of malaria control on Plasmodium falciparum in Africa between 2000 and 2015”. Nature. 526 (7572): 207–211.

[23] Adesina, O. (2013). Subclinical Malaria Infection among University of Maiduguri Students: Prevalence and Parasite Density. BOMJ.10.6-10.

[24] Kalu, M.K., Nwogo, A.O., Onyemachi, F. &Otuchristi, G.A. (2012). Comparative Study of the Prevalence of Malaria in Aba and UmuahiaUrban Areas of Abia State, Nigeria. Research Journal of Parasitology, 7, 17-24.

[25] Ibekwe, A.C., Okonko, I.O., Onunkwo, A.I., Ogun, A.A. &Udeze, A.O. (2019) Comparative Prevalence Level of Plasmodium in Freshmen (First Year Students) of Nnamdi Azikwe University in Akwa, Southern-Eastern, Nigeria. Malaysian Journal of Microbiology, 5, 51-54.

[26] Olatunji, M.K., Olugbenga, A.M., Yetunde, A.O. &Tolulope, O.O. (2017). Comparative Prevalence of Plasmodium falciparum Malaria inPatients Attending Okelele Health Center, Okelele, Ilorin, Nigeria. India Journal of Health Sciences and Biomedical Research, 10, 57-62.

[27] Adeyemo, F.O., Okpala, P.U., Oyana, E.N. &Imoukhuede, M.O. (2014). Malaria Infection amongst Students of the University of Benin, EdoState, Nigeria. International Journal of Recent Scientific Research, 5, 1529-1532.

[28] Ruquayyah, M.H., Nock, I.H., Ndams, S.I. & George, B.D.J. (2017). Investigating the Prevalence and Intensity of Plasmodium falciparumInfection and Two Methods of Malaria Diagnosis in North-Western Nigeria. International Journal of Tropical Disease and Health, 23, 1-8.

[29] Gilles, A.O & Warell, C.J. (2013). Estimating the global clinical burden of plasmodium falciparum in malaria in 2007. PLoS Medicine 7:6.

[30] Micheal, W. & Florence, N. (2016). Validity of presumptive diagnosis of malaria among. outpatients in a tertiary healthcare facility in River’s state, Nigeria. British Journal of Medicine and Health.3: 52-57.

[31] Obimakinde, E.T., Simon-Oke, I.A. &Osunyemi, O.S. (2018). The effectiveness of microscopy. Rapid diagnostic test and molecular
assay in diagnosis of malaria. Journal Parasit Dis DiagnTher. 3:10-14.

[32] Ilesanmi, R.I., Oluwasogo, A.O., Oluwasegun, T.A., Ayodele, O.I., Hyacinth, E. & Abimbola, O.A. (2017). Comparative Assessment ofMalaria Rapid Diagnostic Tests (RDT) in Ibadan, Nigeria. Malaria Journal, 8, 17.

Abstract:

Caesarean section is an essential clinical obstetric intervention used to reduce maternal and foetal death. Several indications contribute to the decision-making to use CS as a delivery in the clinical environment. This study sought to determine the prevalence of CS at LEKMA Hospital in Ghana and the demographic and clinical history of mothers as predictors for the prevalence. Using a retrospective study design, data for all mothers who had previously given birth at the hospital’s obstetric and gynaecological department was used. Multiple logistic regression was applied and a p-value<0.05 with a 95% confidence interval (CI) for results using IBM-SPSS version 25. From the study, the prevalence of CS was 40.6% and the average age for SVD and CS were 28.3±5.94years and CS 29.6±5.50years respectively. The likelihood of those aged 36 years and above undergoing CS was notably higher (AOR; 2.84, 95%CI 1.41-5.3, p-value <0.0001) compared to those aged 26-30 (AOR; 2.45, 95%CI 1.49-4.00, p-value: 0.004) years and 31-35 (AOR; 1.65, 95% CI 0.94-2.90, p-value: 0.080) years. The results further indicated that the risk of undergoing CS was greater among mothers with parity of 1-2 (AOR: 1.56, 95%CI 1.02-2.41, p-value: 0.040). The prevalence of CS in the study is greater than the recommended prevalence per 100 births by the World Health Organization. The sociodemographic and clinical history of a pregnant woman influenced the mode of delivery such that the increase in gestational age and parity decreased the risk of CS. Whiles the educational status and age of the mothers at the time of birth increased the risk of CS delivery.

References:

[1] Zewude B, Siraw G, Adem Y. The Preferences of Modes of Child Delivery and Associated Factors Among Pregnant Women in Southern Ethiopia. Pragmatic Obs Res. 2022; Volume 13(July):59–73.

[2] Apanga PA, Awoonor-Williams JK. Predictors of caesarean section in northern Ghana: A case-control study. Pan Afr Med J. 2018; 29:1–11.

[3] Tsegaye H, Desalegne B, Wassihun B, Bante A, Fikadu K, Debalkie M, et al. Prevalence and associated factors of caesarean section in Addis Ababa hospitals, Ethiopia. Pan Afr Med J. 2019; 34:1–9.

[4] Shit S, Shifera A. Prevalence of cesarean section and associated factor among women who give birth in the last one year at Butajira General Hospital, Gurage Zone, SNNPR, Ethiopia, 2019. Int J Pregnancy Childbirth. 2020;6(1):16–21.

[5] Prah J, Kudom A, Afrifa A, Abdulai M, Sirikyi I, Abu E. Caesarean section in a primary health facility in Ghana: Clinical indications and. J Public Health Africa. 2017;8(639):98–102.

[6] Bi S, Zhang L, Chen J, Huang M, Huang L, Zeng S, et al. Maternal age at first cesarean delivery related to adverse pregnancy outcomes in a second cesarean delivery: a multicenter, historical, cross-sectional cohort study. BMC Pregnancy Childbirth. 2021;21(1):1–10.

[7] Seidu AA, Hagan JE, Agbemavi W, Ahinkorah BO, Nartey EB, Budu E, et al. Not just numbers: Beyond counting caesarean deliveries to understanding their determinants in Ghana using a population based cross-sectional study. BMC Pregnancy Childbirth. 2020;20(1):1–10.

[8] Ghana Maternal Health Survey 2017. Vol. 13, Ekp. 2017. 1576–1580 p.

[9] Adu-Bonsaffoh K, Tamma E, Seffah J. Preferred mode of childbirth among women attending antenatal clinic at a tertiary hospital in Ghana: a cross-sectional study. Afr Health Sci. 2022;22(2):480–8.

[10] FAO. 3 : Promote gender equality and empower women 4 : Reduce child mortality GOAL 5 : Improve maternal health Maternal mortality remains unacceptably high across much of the developing world . Fully achieving the MDG 5 target of reducing by three quarters the. Fact Sheet. 2015;5–6.

[11] WHO Statement on Caesarean Section Rates. World Heal Organ. 2015;8.

[12] WHO. WHO non-clinical recommendations unnecessary to reduce interventions caesarean sections. 2018.

[13] Hailegebreal S, Gilano G, Seboka BT, Ahmed MH, Simegn AE, Tesfa GA, et al. Prevalence and associated factors of caesarian section in Ethiopia: a multilevel analysis of the 2019 Ethiopia Mini Demographic Health Survey. BMC Pregnancy Childbirth [Internet]. 2021;21(1):1–9. Available from: https://doi.org/10.1186/s12884-021-04266-7.

[14] Adewuyi EO, Auta A, Khanal V, Tapshak SJ, Zhao Y. Cesarean delivery in Nigeria: Prevalence and associated factors •a population-based cross-sectional study. BMJ Open. 2019;9(6):1–12.

[15] Tarimo CS, Mahande MJ, Obure J. Prevalence and risk factors for caesarean delivery following labor induction at a tertiary hospital in North Tanzania: A retrospective cohort study (2000-2015). BMC Pregnancy Childbirth. 2020;20(1):1–8.

[16] Das P, Samad N, Sapkota A, Al-Banna H, A Rahman NA, Ahmad R, et al. Prevalence and Factors Associated with Caesarean Delivery in Nepal: Evidence from a Nationally Representative Sample. Cureus. 2021;13(12):11–2.

[17] Alhassan AR. Prevalence and socioeconomic predictive factors of cesarean section delivery in Ghana. 2022;190–5.

[18] Gunn JKL, Ehiri JE, Jacobs ET, Ernst KC, Pettygrove S, Center KE, et al. Prevalence of Caesarean sections in Enugu, southeast Nigeria: Analysis of data from the Healthy Beginning Initiative. PLoS One. 2017;12(3):1–14.

[19] Genc S, Emeklioglu CN, Cingillioglu B, Akturk E, Ozkan HT, Mihmanlı V. The effect of parity on obstetric and perinatal outcomes in pregnancies at the age of 40 and above: a retrospective study. Croat Med J. 2021 Apr;62(2):130–6.

[20] Jahromi BN, Husseini Z. Pregnancy Outcome at Maternal Age 40 and Older. Taiwan J Obstet Gynecol
[Internet]. 2008;47(3):318–21. Available from: https://www.sciencedirect.com/science/article/pii/S102845590860131X.

[21] Manyeh AK, Amu A, Akpakli DE, Williams J, Gyapong M. Socioeconomic and demographic factors associated with caesarean section delivery in Southern Ghana: evidence from INDEPTH Network member site. 2018;(November):1–9.

[22] Ahmed MS, Islam M, Jahan I, Shaon IF. Multilevel analysis to identify the factors associated with caesarean section in Bangladesh: evidence from a nationally representative survey. Int Health. 2022;1–7.

[23] Taye MG, Nega F, Belay MH, Kibret S, Fentie Y, Addis WD, et al. Prevalence and factors associated with caesarean section in a comprehensive specialized hospital of Ethiopia: A cross-sectional study; 2020. Ann Med Surg [Internet]. 2021;67(May):102520. Available from: https://doi.org/10.1016/j.amsu.2021.102520.

[24] Sengoma JPS, Krantz G, Nzayirambaho M, Munyanshongore C, Edvardsson K, Mogren I. Prevalence of pregnancy-related complications and course of labour of surviving women who gave birth in selected health facilities in Rwanda: A health facility-based, cross-sectional study. BMJ Open. 2017;7(7).

[25] Martinelli KG. The role of parity in the mode of delivery in advanced maternal age women. 21(1):65–75.

[26] Patel RR, Peters TJ, Murphy DJ, Team S. Prenatal risk factors for Caesarean section. Analyses of the ALSPAC cohort of 12 944 women in England. 2005;(January):353–67.

[27] Lin L, Lu C, Chen W, Li C, Guo VY. Parity and the risks of adverse birth outcomes: a retrospective study among Chinese. 2021;1–11.

Abstract:

Prior to the release of the current HIV testing recommendation on retesting for verification (RFV), the Cameroon Baptist Convention Health Services (CBCHS) established 0.5% misdiagnosis and inappropriate ART treatment among ART clients in Northwest and Southwest regions. This study aimed at assessing adherence to HIV testing guideline and issues involved. This cross-sectional study was conducted at 27 purposefully selected sites where participants consented and anonymously completed a questionnaire containing questions on their knowledge and practice on RFV, challenges and facilitators. Records of clients who tested HIV positive in 2021 were reviewed to confirm RFV. Data was analysed for frequencies and proportions. A total of 25(93.6%) facilities had the minimum two laboratory staff, most (93.8%) had a minimum training at diploma level and had two or more years of work experience (91.7%). The staff knowledge was averagely 81% accurate on HIV testing algorithm, 79% on RFV and 63% on practice. The main facilitators of RFV were availability of rapid test kits (46%) and trained staff (10%) while bottlenecks were limited test kits (34%) and refusals (28%). Second event testing was performed for 92.5% (1525) of cases, of whom 93.4% was by another tester. Most independent testers knew the results of the first event test before conducting the second event test. Cases of documentation of second event testing without conducted it were reported. Staff were trained and knowledgeable on RFV, but the practice was low. More training and supervision are required for improvement on adherence to protocols for RFV.

References:

[1] V. A. Fonner et al., ‘Country adherence to WHO recommendations to improve the quality of HIV diagnosis: a global policy review’, BMJ Glob Health, vol. 5, no. 5, p.e001939, May 2020, doi: 10.1136/bmjgh-2019-001939.

[2] N. B. Njozing, K. E. Edin, and A.-K. Hurtig, ‘“When I get better, I will do the test”: Facilitators and barriers to HIV testing in Northwest Region of Cameroon with implications for TB and HIV/AIDS control programmes’, SAHARA-J: Journal of Social Aspects of HIV/AIDS, vol. 7, no. 4, pp. 24–32, Dec. 2010, doi: 10.1080/17290376.2010.9724974.

[3] P. Ngangue, M.-P. Gagnon, and E. Bedard, ‘Challenges in the delivery of public HIV testing and counselling (HTC) in Douala, Cameroon: providers perspectives and implications on quality of HTC services’, BMC Int Health Hum Rights, vol. 17, no. 1, p. 9, Dec. 2017, doi: 10.1186/s12914-017-0118-2.

[4] A report on the misdiagnosis of HIV status.pdf’.

[5] ‘Implementing HIV Retesting Before ART.pdf’.

[6] HIV Screening and Testing | Guidelines and Recommendations | HIV/AIDS | CDC’, Jan. 21, 2020. https://www.cdc.gov/hiv/guidelines/testing.html (accessed May 24, 2022).

[7] WHO Recommendations to Assure HIV Testing Quality’. Accessed: May 24, 2022. [Online]. Available: http://apps.who.int/iris/bitstream/handle/10665/179521/WHO_HIV_2015.15_eng.pdf?sequence=5.

[8] Operational Guidelines for the Implementation of the “Test and Treat” Strategy in Cameroon’. Accessed: May 24, 2022. [Online]. Available: https://differentiatedservicedelivery.org/Portals/0/adam/Content/4PguUuL3dU2mjDICEGsJFQ/File/Cameroon.pdf.

[9] A report on the misdiagnosis of HIV status.pdf’.

[10] N. Hsiao, A. Zerbe, T. K. Phillips, L. Myer, and E. J. Abrams, ‘Misdiagnosed HIV infection in pregnant women initiating universal ART in South Africa’, J Int AIDS Soc, vol. 20, no. Suppl 6, p. 21758, Aug. 2017, doi: 10.7448/IAS.20.7.21758.

[11] S. Khan et al., ‘Identification of misdiagnosed HIV clients in an Early Access to ART for All implementation study in Swaziland’, Journal of the International AIDS Society, vol. 20, p. 21756, Aug. 2017, doi: 10.7448/IAS.20.7.21756.

[12] B. Dupwa et al., ‘Retesting for verification of HIV diagnosis before antiretroviral therapy initiation in Harare, Zimbabwe: Is there a gap between policy and practice?’, Transactions of The Royal Society of Tropical Medicine and Hygiene, vol. 113, no. 10, pp. 610–616, Oct. 2019, doi: 10.1093/trstmh/trz047.

[13] S. C. Billong et al., ‘Decreased Inaccuracies in HIV Screening following Strengthening of Quality System: Evidence-based Interventions through the PMTCT Program in Cameroon’, vol. 20, p. 10, 2019.

[14] F.-L. Tianyi, J. N. Tochie, V. N. Agbor, and B. M. Kadia, ‘Audit of HIV counselling and testing services among primary healthcare facilities in Cameroon: a protocol for a multicentre national
cross-sectional study’, BMJ Open, vol. 8, no. 3, p. e020611, Mar. 2018, doi: 10.1136/bmjopen-2017-020611.

[15] Northwest Region (Cameroon)’, Wikipedia. Aug. 27, 2021. Accessed: Sep. 21, 2021. [Online]. Available: https://en.wikipedia.org/w/index.php?title=Northwest_Region_(Cameroon)&oldid=1040846875.

[16] DHIS 2 Pivot Tables’. https://dhis-minsante-cm.org/dhis-web-pivot/ (accessed Jan. 23, 2023).

[17] Cameroon-National-Laboratory-Policy.pdf’.

[18] E. T. Amin et al., ‘HIV Retesting for Verification: Uptake and Implementation in Some Health Facilities in the Littoral Region of Cameroon’, International Journal of Health Sciences, no. 6, 2019.

[19] A. J. Rogers et al., ‘Implementation of repeat HIV testing during pregnancy in Kenya: a qualitative study’, BMC Pregnancy Childbirth, vol. 16, no. 1, p. 151, Dec. 2016, doi: 10.1186/s12884-016-0936-6.

[20] Consolidated guidelines on HIV testing services (2015)’. https://www.who.int/publications-detail-redirect/9789241508926 (accessed Jan. 23, 2023).

[21] A. Lasry, M. B. Kalou, P. R. Young, J. Rurangirwa, B. Parekh, and S. Behel, ‘Cost implications of HIV retesting for verification in Africa’, PLoS ONE, vol. 14, no. 7, p. e0218936, Jul. 2019, doi: 10.1371/journal.pone.0218936.

Abstract:

Antepartum hemorrhage certainly has an easy clinical diagnosis, but it is complex because of its complications and multidisciplinary treatment. Despite initial care, some patients are still subject to perinatal and maternal morbidity and mortality. To limit these consequences, our study aims to identify the etiology, clinical manifestations, diagnosis and management of antepartum hemorrhage at the Laquintinie Hospital and the General Hospital of Douala in Cameroon. To achieve this objective, a quantitative descriptive study was conducted from May 1, 2020 to May 1, 2022 and included 166 pregnant women diagnosed with antepartum hemorrhage in the maternity wards of these hospitals. Data was collected by reviewing medical records and interviewing mothers using a questionnaire. We used the convenience sampling technique and the data collected were processed with SPSS 2.3. At the end of this analysis, the study showed that the most recurrent cause of antepartum hemorrhage was placenta abruption (51.81%). The clinical consequence was marked mainly by anemia (50.60%). Caesarean section was the most common method of management (94.20%). The results suggest that antepartum hemorrhage is a public health problem.

References:

[1] Amitava R.S., Saikat S.R., Biswa jit N., Gaurab M., Jayanta M., 2010, Management of obstetric haemorrhage. M.E. J. Anaesth. 20(4), 499-508.

[2] Lamina M.A., and Oladapo O,T., 2011, Maternal and Fetal Outcome of Obstetric Emergencies in a Tertiary Health Institution in South Western Nigeria, International Scholarly Research Network ISRN Obstetrics and Gynecology. Vol.2011, 1-4. Article ID 160932, doi:10.5402/2011/160932

[3]  Awat I. H., 2018, The maternal and perinatal outcome in antepartum hemorrhage: A cross-sectional study. Zanco J. Med. Sci., 22(2), 155-163, https://doi.org/10.15218/zjms.2018.021.

[4] Singhal S., Nymphaea, Nanda S., 2007, Maternal and perinatal outcome in antepartum hemorrhage: A study at a tertiary care referral institute. The Internet Journal of Gynecology and Obstetrics, 9(2). https://print.ispub.com/api/0/ispub-article/3465.

[5] Lakshmipriya K., Vijayalakshmi V., Padmanaban S., 2019, A study of maternal and fetal outcome in Antepartum haemorrhage. Int J Gynecol Obstet, 3(1), 96–99. doi: 10.33545/gynae.2019.v3.i1b.19.

[6] Green J. R., 1989, Placental abnormalities: Placenta previa and abruption placenta, Maternal & fetal medicine. In: Creasy RK, Resnik R editors Principles and Practice 3^rd edition. Philadelphia, WB Saunders,; 588-602.

[7] Sheikh F., Khokhar S., Sirichand P., Shaikh R., 2010, A study of antepartum haemorrhage: Maternal and perinatal outcomes. Medical Channel 16. 268-271.

[8] Royal College of Obstetricians and Gynaecologists, Antepartum Haemorrhage, Green‑top Guideline No. 63. London: RCOG; 2011.

[9] World Health Organization, 2019, Trends in maternal mortality: 2000 to 2017: estimates by WHO, UNICEF, UNFPA, World Bank Group and the United Nations Population Division. Geneva: Trends in maternal mortality: 2000 to 2017: estimates by WHO, UNICEF, UNFPA, World Bank Group and the United Nations Population Division, Geneva:

[10] Institut National de la Statistique (INS et ICF., 2019, Enquête Démographique et de Santé du Cameroun 2018. Indicateurs Clés. Yaoundé, Cameroun, et Rockville, Maryland, USA : INS et ICF.

[11] Amelia B. and Andrew N., 2005, Continuing Education in Anaesthesia. Critical Care & Pain 5(6) 183–186, https://doi.org/10.1093/bjaceaccp/mki049.

[12] Radhika M. G., Annie R., and Ayshath S., 2020, Maternal outcome in antepartum Haemorrhage: A study at a tertiary care Centre, International Journal of Clinical Obstetrics and Gynaecology, 4(5): 05-08

[13] Lankoande M., Papougnezambo B., Sosthène O., 2017, Incidence and outcome of severe antepartum hemorrhage at the Teaching Hospital Yalgado Ouédraogo in Burkina Faso, BMC Emergency Medicine 17:17, 7 pages, doi: 10.1186/s12873-017-0128-3.

[14] Subrata D., Ajit R., Bhattacharyya, 2020, A study of risk factors and obstetric outcome of antepartum haemorrhage in a tertiary care hospital of eastern India; Panacea Journal of Medical Sciences, 10(3). //doi.org/10.18231/j.pjms.2020.055, , http//www.ipinnovative.com

[15] Majumder S., Shah P., Deliwala K.J., Patel R., Madiya A., 2016, Study of foetomaternal outcome of antepartum haemorrhage in pregnancy. Int J Reprod Contracept Obstet Gynecol, 4(6):1936–1939. doi: 10.1016/j.jece.2016.08.032.

[16] Taylor V. M., Peacock S., Kramer M. D., Vaughan T. L., 1995, Increased risk of placenta previa among women of Asian origin. Obstetrics and Gynecology, 86(5):805-808.

[17] Takai I, U., Sayyadi B. M,, Galadanci H. S., 2017, Antepartum hemorrhage: A retrospective analysis from a northern Nigerian teaching hospital. International Journal of Applied and Basic Medical Research 7(2):112–116. doi: 10.4103/2229-516x.205819.

[18] Sharmila G., and Prasanna., 2016, Maternal and perinatal outcome in antepartum hemorrhage. IAIM; 3(9), 148-160

[19] Ikechebelu J. I., and Onwusulu D.N., 2007, Placenta praevia: Review of clinical presentation and management in a Nigerian teaching hospital, Niger J. Med., 16, 61‑64.

[20] Yadav M. C., Mehta K., Choudhary V. A., 2019, A study of antepartum hemorrhage and its maternal and perinatal outcome at tertiary care hospital in Western Rajasthan. JMSCR, 7(9), 80–85.

[21] Park, K. (2007). Preventive medicine in obstetrics, paediatrics and geriatrics In: Park, textbook of preventive and social medicine.
19thedition. Banaras Das Bhanot’jabalpur ,445-447.

[22] Youssouf, C. (2021).Les Hémorragies du 3^ème trimestre de la Grossesse au Centre de Santé de Référence de Kalaban Coro.

Abstract:

Plasmid is isolated from Salmonella typhimurium, an enteric bacterium responsible for gastro enteritis. Gastro enteritis remains a major clinical and public health problem all over the world, especially among children in the developing countries of the sub – Sahara Africa. The profiling of plasmid isolate of Salmonella typhimurium involved cultivation, isolation, identification, and characterization. The study aimed at investigating the multidrug resistance of salmonella typhimurium of patients attending General Hospital Asokoro with typhoid fever and the susceptibility of isolates to antibiotics. A total of thirty (30) samples, from blood, stool, and water were collected from patients attending General hospital, Asokoro and the environs. The specimens were analyzed using standard microbiological, biochemical, and serological techniques. Bacteriological analysis revealed that twenty-five (25) of the specimens were positive for Salmonella typhimurium. The other five (5) specimens were negative for salmonella typhymurium typhimurium. The biochemical test revealed that they were able to utilize sugar and are lactose fermenter. Anti-microbial susceptibility determination revealed that the most active drugs against salmonella include Ciprofloxacin, Ofloxacin, Amikacin, and Gentamicin. All the isolates were resistant to tetracycline and Ampicillin. There was marked resistance of all isolates to amoxicillin, doxycycline, and chloramphenicol. The result of findings revealed that the genes that encode resistance properties in Salmonella typhimurium are plasmid- borne in some of the bacteria. These plasmids can be cloned and used for genetic engineering and recombinant DNA technology. The antibiotic susceptibility determined the appropriate drugs efficient for therapy of Salmonella infections.

References:

[1] Ibrahim YK, Adedare TA, Ehinmidu JO (2005). Antibiotic sensitivity profiles of Salmonella organisms isolated from presumptive typhoid patients in Zaria, northern Nigeria. African Journal of Medicine Medical Science. 34(2):109-114.

[2] B. Malorny, C. Bunge, R. Helmuth (2001). Evaluation of Salmonella spp. Specific primer-sets for the validation within the Food PCR project Fed. Inst. Heal. Prot. Consum. Vet. Med. Natl. Ref. Lab. Salmonella, Diedersdofer Weg, Berlin, Ger, 1 (2001), p. 12277.

[3] Esaki H, Morioka A, Ishihara K, Kojima A, ShirokiS, Tamura Y et al. (2004). Antimicrobial susceptibility of Salmonella isolated from cattle, swine, and poultry (2001-2002): report from the Japanese Veterinary Antimicrobial Resistance Monitoring Programme. J Antimicrob Chemother 53:266-70.

[4] P J Valentine, NB Shoemaker, A.A Salyers (1988). Mobilization of Bacteroides plasmids by Bacteroides conjugal elements. J Bacteriol 170(3): 1319–1324.

[5] Ashraf AK, Cathy D, Elsie B (2007). Identification and molecular characterization of Salmonella spp. From unpasteurized orange juices and identification of new serotype Salmonella strain S. enterica serovar Tempe. J Food Microbiol 24: 539–543

[6] Koneman, E.W., Allen, S.D., Janda, W.M., Schreelen berger, P.C., and Winin, J., (1997). Introduction to Microbiology : part 1: The role of microbiology laboratory in diagnosis of infectious diseases: Guidelines to practice and management. In Color Atlas and Textbook of Diagnostic Microbiology 5th ed. Lippin Cott. Chapter 2: 69 –120.

[7] Ajoke Olutola Adagbada, Akitoye Olusegun Coker, Stella Ifeanyi Smith, Solayide Abosede Adesida (2014). The prevalence and plasmid profile of non-typhoidal Salmonellosis in children less than five years in Lagos metropolis, Nigeria. The Pan African Medical Journal. 19:359.

[8] Dunne EF, Fey PD, Kludt P, et al (2000). Emergence of domestically acquired ceftriaxone Resistant Salmonella infections associated with AmpC β-lactamase. 3151-3156.

[9] Anjum, MF, Choudhary S, Morrison V, L.C Mafura, M., Slickers, P, Ehrict, R, Woodward, M.J. (2011). Identifying antimicrobial. Resistant genes of human clinical relevance within Salmonella isolated from food animals in Great Britain. 66:550-559.

[10] Barza M, Travers K (2002). Excess infections due to antimicrobial resistance: the “Attributable Fraction”. Clinical Infectious Disease 34 (Supplement 3):126-30.

[11] Breuil J, Brisabois A, Casin I, Armand-Lefevre L, Fremy S, Collatz E (2000). Antibiotic resistance in salmonellae isolated from humans and animals in France: comparative data from 1994 and 1997. Journal of Antimicrobial Chemotherapy 46: 965-71.

[12] I. N. Okeke and R. Edelman (2001). “Dissemination of Antibiotic-Resistant Bacteria across Geographic Borders,” Clinical Infectious Diseases, 364-369.

[13] Kawagoe K, Mine H, Asai T, Kojima A, Ishihara K, Harada K et al. (2007). Changes in multidrug resistance pattern in Salmonella enterica subspecies enterica serovar typhimurium isolates from food-producing animals in Japan. J Vet Med Sci 2007; 69:1211-3

[14] Brichta-Harhay, D.M, Arthur, T.M, Bosilevac J.M, Kalchayanand, N; et al. (2011). Diversity of multidrug resistant Salmonella entrica strains associated with cattle at Harvest in the United States 77:1783-1796.

[15] Ogunleye AO and Carlson SA (2011). Survey of 3rd generation cephalosporin genes in multi-resistant Salmonella serotypes from septic poultry and an asymptomatic healthy pig from Nigeria. Afr J Microbiol Research. 5(15): 2139-2144.

[16] Erin C, Bishop J.L, Guntram A and Grassl B.F (2007). Salmonella: from Pathogenesis to Therapeutics. J Bacteriol. 189 (5): 1489-1495.

[17] Quinn, P.J., Carter, M.E., Markey, B.K. and Carter,G.B. (1994). Enterobacteriaceae. In: Bacteriology. Clinical Veterinary Microbiology. S.A. Grafos(ed.) Spain: Mosby- Year Book Europe. 209-236.

[18] Daini O.A., Odufuwa K.T. and Sule A.M.(2001). Isolation and characterization of cyclohexane – degradative plasmids of pseudomonas from petroleum- contaminated soil samples Nigeria Journal of Biochemistry and Molecular Biology diarrheal dir. Res. 15: 61-65.

[19] Daini O.A., Odufuwa K.T. and Olokunbola O.O. (2006). Isolation and characterization of benzene and xylene degradative plasmids of some gram-negative enteric bacilli from petroleum- contaminated soil samples. Journal of research in Bio-science, Vol.1, pg 51-53.

[20] Anderson E.J, Ward L.R, Saxe M.J, Desa JD, (1977). Bacteriophage typing designation of Salmonella typhimurium Journal of Hygiene. (London); 78: 297-300.

[21] A. M. Vollaard, S. Ali, H. A. van Asten, S. Widjaja, L. G. Visser, C. Surjadi, et al. (2004). “Risk Factors for Typhoid and Paratyphoid Fever in Jakarta, Indonesia,” The Journal of the American Medical Association, 2607-2715.

[22] Angulo FJ, Johnson KR, Tauxe RV, Cohen ML (2000), origins and consequences of antimicrobial resistant non-typhoidal Salmonella implications for the use of fluoroquinolones in food animals. Microbial Drug Resistant; 6:77-83.

[23] Arleta G, Barrett T.J, Butaye P, Colecaert, A Mulvey MR, White DG, (2006). Salmonella resistance to extended spectrum cephalosporin’s, prevalence and epidemiology. Microbes Infect 8: 1945-1954.

[24] Mohammed A, Mohammed S, Asad K (2007). Etiology and antibiotic resistance patterns of community-acquired urinary tract infections in J N M C Hospital Aligarh, India. Ann Clinical Microbiology Antimicrobial 17

[25] Allen KJ, Poppe C (2002). Occurrence and characterization of resistance to extended-spectrum cephalosporins mediated by β-lactamase CMY-2 in Salmonella isolated from food-producing animals in Canada. Canada Journal of Veterinary Research 66: 137-144.

[26] Al-Bahry, S. N. (2000). Plasmid profiling of antibiotic resistant Salmonella species isolated in Muscat, Oman. Pakistan Journal of Biological Sciences. 215-218

[27] Adejuyigbe E A, Ako-Nai A.K and Adisa B (2004). Bacterial isolates in the sick young infant in Ile-Ife, Nigeria. Journal of Tropical Pediatrics. 50 (6): 323-327.

[28] Araque M (2009). Non-typhoidal Salmonella gastroenteritis in pediatric patients from urban areas in the city of Mérida, Venezuela. Journal of Infect Developing Countries.3 (1): 28-34.

[29] Ofaka C. E., Adebawo Olugbenga O., Njoku, M. O. (2022). Plasmid profile of environmental and clinical isolates of multidrug resistant Salmonella typhimurium from patients attending General Hospital Asokoro, Abuja and Environ, Texila International Journal.

Abstract:

Availability and accessibility of essential medicines for HIV recipients of care varies across regions in Nigeria. This study seeks to compare access and availability of medicines for HIV in the South south and Northeast regions of Nigeria. Data were collected from 120 health facilities and 385 respondents using structured questionnaires and analysed using descriptive statistics and thematic analysis. The study methodology included an exploratory sequential mixed of quantitative and qualitative methods, including facility assessments, in-depth interviews, client satisfactory questionnaire conducted amongst HIV program stakeholders and HIV recipients of care. The study found that the HIV program in the regions have made progress in improving the accessibility of essential medicines for HIV patients. The North-East had an average access rate of 87.1%, while the South-South had a slightly higher average access rate of 85.6%. The North-East had a prescription rate of 100% for antiretroviral therapy (ART) for adolescents and for the preventive treatment for tuberculosis (INH + Pyridoxine). On the other hand, access to micronutrient supplementation was higher in the South-South region at 94.7%, compared to the North-East region with a rate of 74.2%. In conclusion, this study highlights that the availability of essential medicines such as ART drugs, micronutrients and prophylaxis for opportunistic infections, medicine supply, storage and documentation has improved overtime with support from donor agencies, though still challenged with electronic management systems and need for adequate procurement, quantification, additional technical assistance, funding and supply chain infrastructure is recommended to be addressed towards achievement of HIV epidemic control in Nigeria.

References:

[1] Adewole, O. F., et al. (2021). Nigeria HIV/AIDS Indicator and Impact Survey 2018: Summary Sheet. Federal Ministry of Health, National Agency for the Control of AIDS. http://naca.gov.ng/wp-content/uploads/2021/07/Nigeria-HIV-AIDS-Indicator-and-Impact-Survey-NAIIS-2018-Summary-Sheet.pdf.

[2] Rabkin, M., Melaku, Z., Bruce, K., Reja, A., Koler, A., Tadesse, Y., Kamiru, H. N., Sibanyoni, L. T., & El-Sadr, W. (2012). Strengthening Health Systems for Chronic Care: Leveraging HIV Programs to Support Diabetes Services in Ethiopia and Swaziland. Journal of Tropical Medicine, 2012. https://doi.org/10.1155/2012/137460.

[3] Otu A., Charles CH, Ani F., et al. HIV prevalence and associated risk factors among individuals aged 15–49 in North-Eastern Nigeria. BMC Public Health. 2020;20(1):405. doi:10.1186/s12889-020-08530-5.

[4] Inyang US, Okonkwo PI, Essien EJ, Udoma EJ, Ekanem E. Assessment of the impact of insurgency on the delivery of HIV/AIDS services in North-east Nigeria. Journal of Public Health in Africa. 2018;9(1):746. doi:10.4081/jphia.2018.746.

[5] Aregbeshola, B. S. (2021). Towards Health System Strengthening: A Review of the Nigerian Health System From 1960 to 2019. SSRN Electronic Journal. https://doi.org/10.2139/SSRN.3766017.

[6] Ahmad, A., Samer, E., Jessica, B., Bruce, A., Nicaise, N., Gambo, A., Jibreel, J., Babatunde, A., Patrick, D., Alash’le, A., & Manhattan, C. (2019). Performance and trend for quality of service in a large HIV/AIDS treatment program in Nigeria. AIDS Research and Therapy, 16–29.

[7] World Health Organization. (2019). Global Health Expenditure Database. Retrieved from https://apps.who.int/nha/database/Home/Index/en.

[8] Adoyo, Maureen. (2020). Landscape analysis of healthcare policy: the instrumental role of governance in HIV/AIDS services integration framework. Pan African Medical Journal. 36. 10.11604/pamj.2020.36.27.22795.

[9] Olutuase, V.O., Iwu-Jaja, C.J., Akuoko, C.P. et al. Medicines and vaccines supply chains challenges in Nigeria: a scoping review. BMC Public Health 22, 11 (2022). https://doi.org/10.1186/s12889-021-12361-9.

[10] Murray, S. B., & Crawford-Faucher, A. C. (2022). Antiretroviral therapy for HIV infection: Overview. American Family Physician, 105(3), 311-320.

[11] World Health Organization. (2021). Antiretroviral therapy. https://www.who.int/news-room/questions-and-answers/item/antiretroviral-therapy.

[12] Centers for Disease Control and Prevention. (2021). HIV/AIDS treatment & prevention. https://www.cdc.gov/hiv/basics/index.html.

[13] United Nations Programme on HIV/AIDS. (2021). Essential medicines for HIV/AIDS. https://www.unaids.org/en/topic/essential-medicines.

[14] National Institutes of Health. (2021). HIV treatment and prevention. https://www.niaid.nih.gov/diseases-conditions/hiv-treatment-prevention.

[15] El-Sadr, W. M., & Justman, J. (2018). Access to antiretroviral therapy in Africa: Sustaining and strengthening. Current HIV/AIDS Reports, 15(2), 127-136.

[16] Adewuyi, E. O., & Ajumobi, O. (2019). Strengthening health systems to support HIV and AIDS prevention and control: A critical review of the research literature. BMC Health Services Research, 19(1), 172.

[17] Okeke, C. O., Uzochukwu, B. S., Okafor, H. U., Ani, O. E., & Isaac, A. B. (2017). Availability, stock-outs and dispensing practices of essential medicines in Nigeria: A qualitative study in rural and urban pharmacy outlets. Health Policy and Planning, 32(5), 705-713.

[18] Farge, E., Barasa, E., Waitolo, J., Winters, T., & Chuma, J. (2020). Evaluating global health partnerships: A case study of a Gavi HPV vaccine application process in Uganda. Global Public Health, 15(4), 563-575.

[19] Mbengashe, N. S., Brown, H. L., Njoroge, B., Omondi, A., & van der Straten, A. (2020). Antiretroviral therapy and the use of contraception among HIV-positive women in western Kenya. Journal of Women’s Health, 29(2), 189-195.

[20] Sheikh, K., Gilson, L., & Agyepong, I. A. (2011). Building the field of health policy and systems research: An agenda for action. Plos Medicine, 8(8), e1001081.

[21] Okeke, C. O., Uzochukwu, B. S., & Okafor, H. U. (2018). An evaluation of the supply chain management of essential medicines in Nigeria. Public Health, 161, 1-8.

[22] Tavrow, P., Kim, Y. M., & Malianga, L. (2009). Measuring the quality of supervisor-provider interactions in health care facilities in Zimbabwe. International Journal for Quality in Health Care, 21(5), 315-322.

[23] Decroo, T., Rasschaert, F., Telfer, B., Remartinez, D., Laga, M., Ford, N., & MacPherson, P. (2014). Community-based antiretroviral therapy programs can overcome barriers to retention of patients and decongest health services in sub-Saharan Africa: a systematic review. International Health, 6(4), 210-226.

[24] Ogbuabor DC, Onwujekwe OE, Okoronkwo I, Uzochukwu BS. Community ART groups as an intervention to improve retention in care among patients on ART in Nigeria: a pilot study. BMC Public Health. 2018;18(1):946. doi:10.1186/s12889-018-5852-6.

[25] Grimsrud, A., Bygrave, H., Doherty, M., Ehrenkranz, P., Ellman, T., Ferris, R., Ford, N., Killingo, B., Kruger, J., Lee, J., Mamvura, C., Mansoor, L., Maruva, M., Mohapi, L., Mohammed, S., Moyo, S., Ncube, K., & Phillips, A. (2016). Reimagining HIV service delivery: the role of differentiated care from prevention to suppression. Journal of the International AIDS Society, 19(1), 21484.

Abstract:

The study examined all the area councils within Federal Capital Territory Abuja, during the Covid 19 pandemic in order to critically appraise the extent of safety of orthodox vaccines and local herbal remedies. A total of 933 volunteers were involved. The adverse reactions post herbal and orthodox vaccinations were compared in order to ascertain which of the two regimes best suited the volunteers. Two sample sizes were estimated. One was based on the expected frequency of at least one local side effect between 48.9 and 85.8%. The second was based on the expected frequency of at least one systemic side effect between 52.6 and 70.5%. T-test calculated was far higher than the values tabulated at 99% confidence limits when the two independent population means of both volunteers that were administered with orthodox vaccine and those who received the local Joseleen lipids mixtures (JOHVIR) were compared. In other words, t-cal. 34.6> t –tab. 3.17 at P <0.01, Case fertility rates for the post orthodox vaccine administration was 14% in all the area councils unisex and across all age groups while no fatality cases were recorded post herbal lipids mixture administration to volunteers. This study provides novel evidence that there was high significant difference (P<0.01) in serious adverse reactions post orthodox vaccine administration and far milder and lesser adverse reactions post Local Joseleen Herbal Lipids mixture (Johvir) across all the ages tested.

References:

[1] Deng, S. Q. and Peng, H. J., (2020), Characteristics of and Public Health Responses to the Coronavirus Disease 2019 Outbreak in China. J Clin Med. 9(2):575. doi: 10.3390/jcm9020575. PMID: 32093211; PMCID: PMC7074453.

[2] Tiwari, R., Sircar, S., Bhat, S., Malik, Y.S., Singh, K.P., Chaicumpa, W., Bonilla-Aldana, D.K. and Rodriguez-Morales, A. J., (2020), Coronavirus disease 2019-Covid-19. Clin. Microbiol. Rev. 33, e00028-20.

[3] Liu, L., Lei, X., Xiao, X., Yang, J., Li, J., Ji, M., Du, W., Tan, H., Zhu, J., Li, B. and Jin, Z, (2020) Epidemiological and Clinical Characteristics of Patients with Coronavirus Disease-2019 in Shiyan City, China. Front. Cell. Infect. Microbiol. 10:284. doi: 10.3389/fcimb.2020.00284.

[4] Akihisa, T.N., Kojima, N., Katoh, Y., Ichimura, H., Suzuki, M., Fukatsu, S. and Maranz, E.T., (2010), Triterpene alcohol and fatty acid composition of shea nuts from seven African countries. J. Oleo Sci 59 (7) pp. 351-360, doi:10.5650/jos.59.351.

[5] Baden, L. R., El Sahly, H. M. and Essink, B., (2020), COVE Study Group. Efficacy and safety of the mRNA-1273 SARS-CoV-2 vaccine. N Engl J Med 384(5):403-416. doi:10.1056/NEJMoa2035389.

[6] Mehrbod, P., Abdalla, M. A., Njoya, E. M., Ahmed, A. S., Fotouhi, F. and Farahmand, B., (2018), South African medicinal plant extracts active against influenza A virus. BMC Complement. Altern. Med. 18 (1), 1–10. 10.1186/s12906-018-2184-y.

[7] Hensel, A., Bauer, R., Heinrich, M., Spiegler, V., Kayser, O. and Hempel, G., (2020), Challenges at the time of Covid-19: opportunities and innovations in Antivirals from nature. Planta Med. 86 (10), 659. 10.1055/a-1177- 4396.

[8] Fortner A, Schumacher D. First Covid-19 Vaccines Receiving the US FDA and EMA Emergency Use Authorization. Discoveries (Craiova). 2021 Mar 5;9(1): e122. doi: 10.15190/d.2021.1. PMID: 33969180; PMCID: PMC8101362.

[9] Gee, J., Marquez, P. and Su, J., (2021), First month of Covid-19 vaccine safety monitoring—United States, December 14, 2020-January 13, 2021. MMWR Morb Mortal Wkly Rep 70(8):283-288. doi: 10.15585/mmwr.mm7008e3.

[10] Voysey, M., and Clemens, S. A. C., (2021), Oxford Covid Vaccine Trial Group. Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK. Lancet.397 (10269):99-111. doi:10.1016/S0140-6736(20)32661.

[11] Menni, C., Klaser, K., May, A. and Spector, T. D., (2021), Vaccine side-effects and SARS-CoV-2 infection after vaccination in users of the Covid Symptom Study app in the UK: a prospective observational study. Lancet Infect Dis.21(7):939-949. doi: 10.1016/S1473-3099(21)00224-3 PMID: 33930320; PMCID: PMC8078878.

[12] Ajobiewe, J.O., Ajobiewe, H.F., Ogundeji, A.A., Umeji, L.C., Umeji, C., and Ajobiewe, D.C., (2020), Medical Potential of a Locally Sourced Lipids Mixture on Confirmed Corona Virus Infected Patients and Those At Risk of Infection, Attending National Hospital Abuja, Nigeria. -An Evidence Based Approach. Scholars Journal of Medical Case Reports. 8. 846-853. 10.36347/sjmcr. 2020.v08i09.011.

[13] Fortner, A., Schumacher, D., (2021), First Covid-19 Vaccines Receiving the US FDA and EMA Emergency Use Authorization. Discoveries (Craiova);9(1): e122. doi: 10.15190/d.2021.1. PMID: 33969180; PMCID: PMC8101362.

[14] Ojo, O. and Ndinteh, T., (2021), Traditional uses, phytochemistry, pharmacology and other potential applications of Vitellaria paradoxa (Sapotaceae): https://doi.org/10.1016/j.arabjc.2021.103213.

[15] Olusesan, O., Micheal, H. K., and Kengne, M. C., (2021), Traditional uses, phytochemistry, pharmacology and other potential applications of Vitelleria paradoxa Gaertin. (Sapotacaea): Arabian Journal of Chemistry, Vol 14, Issue 7, 2021, 103213, ISSN 1878 – 5352, https://doi. org/10.1016/j.Arabic. 2021. 103213. https://www.Sciencedirect.com/science/article/pii/S1878535221002288.

[16] World Health Organization (2021): Coronavirus Disease vaccine: is there a vaccine for Covid-19 FAQ [Online]. Available from: https://www.who.int/news-room/q-a-detail/coronavirus-disease-(Covid-19)-vaccines).

[17] Soyemi, K. V., Olagoke, E., Olomofe, C., (2021), Covid-19 Vaccine: Newspaper Coverage of the side effects of the vaccine in Nigeria medRxiv10.02.21264454; doi: https://doi.org/10.1101/2021.10.02.21264454.

[18] National Primary Healthcare Development Agency (2021) [Online]. Available from: https://www.facebook.com/NPHCDA/posts/4463147467043205.

[19] Attah, A. F., Fagbemi, A. A., Olubiyi, O., Dada-Adegbola, H., Oluwadotun, A., Elujoba, A., Babalola, C. P., (2021), Therapeutic Potentials of Antiviral Plants Used in Traditional African Medicine with Covid-19 in Focus: A Nigerian Perspective. Front Pharmacol. 26; 12:596855. doi: 10.3389/fphar.2021.596855. Erratum in: Front Pharmacol; 12:721060. PMID: 33981214; PMCID: PMC8108136.

[20] Ioannidis, J.P.A., Axfors, C., and Contopoulos-Ioannidis, D.G., (2020), Population-level Covid-19 mortality risk for non-elderly individuals overall and for non-elderly without underlying diseases in pandemic epicenters. Environ.Res188:109890. doi: 101016/j.envres.2020.109890.

Abstract:

The Nigerian economy depression, Covid 19 pandemic, nationwide insecurity, and global warming are quartile factors, that affected the already compromised nutritional status of under-five children in the country, with a resultant increase in morbidity and mortality. A community-based cross-sectional study was undertaken using two-stage cluster sampling method in Suleja, Tafa, and Gurara LGAs of Niger state. Data from 2350 under-fives were collected using questionnaires, and anthropometric measurements. WHO growth standard was used to determine the prevalence; multivariate logistic regression in IBM explored statistically significant independent variables associated with stunting, underweight and wasting using p-value of < 0.05. Prevalence of stunting was 47.4%, underweight 32.7%, and wasting 22.6% respectively. Severe stunting and underweight were higher in Suleja, severe wasting in Gurara, and male children were more affected by all indicators. Age of child, LGA, mother and father education, marital status, exclusive breastfeeding, and duration of breastfeeding; source and buying of drinking water, family type, maternal knowledge about malnutrition, and health seeking behavior of mothers were found as determinants. Under-five mortality is a good indicator of the health, and economic status of any community; thus, the health of under-fives needs the utmost attention. The high prevalence from the study is critical; a critical approach is urgently needed at the family, community, local government, state, and national levels with other stakeholders; to ensure under-fives receive adequate, quality, and affordable nutrients for health, and growth. Accessible, prompt, and sustainable interventions for identified cases are of utmost importance.

References:

[1] World Health Organization, (April 2021). Fact sheets - malnutrition. World Health Organization Retrieved November 7, 2021, from https://www.who.int/news-room/fact-sheets/detail/malnutrition.

[2] UNICEF, (2023, January 16). Nutrition. Related UNICEF Websites. Retrieved January 26, 2023, from https://www.unicef.org/nigeria/nutrition.

[3] Park, K (2019). Nutritional problems in public health, In Park’s textbook of preventive and social medicine (25^th ed., pp. 695-697), M/s Banarsidas Bhandt

[4] Mendoza‐Quispe, D., Hernández‐Vásquez, A., Miranda, J. J., Anza‐Ramirez, C., Carrillo‐Larco, R. M., Pomati, M., Nandy, S., & Bernabe‐Ortiz, A. (2021) Urbanization in Peru is inversely associated with double burden of malnutrition: Pooled analysis of 92,841 mother–child pairs. Obesity, 29(8), 1363–1374 https://doi.org/10.1002/oby.23188.

[5] Mathur, P., & Pillai, R. (2019) Over nutrition: Current scenario & combat strategies. The Indian journal of medical research, 149(6), 695–705 https://doi.org/10.4103/ijmr.IJMR_1703_18.

[6] Project, B. (2019, August 20). Fighting world hunger through the hunger project. The BorgenProject. Retrieved January 12, 2023, from https://borgenproject.org/fighting-world-hunger-through-the-hunger-project/.

[7] Global Nutrition Report, (2022) | Country Nutrition Profiles - Global Nutrition Report. (2022). Retrieved December 1, 2022, from https://globalnutritionreport.org/resources/nutrition-profiles/africa/western-africa/nigeria/.

[8] World Bank, (2020) Prevalence of underweight, weight for age (% of children under 5). Retrieved November 13, 2021, from https://data.worldbank.org/indicator/SH.STA.MALN.ZS.

[9] Regan, C. (2019) Factsheet (2019, October 16): Child under-nutrition in Africa. DevelopmentEducation.ie. Retrieved January 12, 2023, from https://developmenteducation.ie/feature/factsheet-child-undernutrition-in-africa/m.

[10] Worldometer, (2021) Nigeria population (live) Retrieved October 17, 2021, from https://www.worldometers.info/world-population/nigeria-population/.

[11] Hall, J., Walton, M., Van Ogtrop, F., Guest, D., Black, K., & Beardsley, J. (2020) Factors influencing undernutrition among children under 5 years from cocoa-growing communities in Bougainville BMJ Global Health, 5(8) https://doi.org/10.1136/bmjgh-2020-002478.

[12] Kwami, C. S., Godfrey, S., Gavilan, H., Lakhanpaul, M., & Parikh, P. (2019) Water, sanitation, and hygiene: Linkages with stunting in rural Ethiopian International Journal of Environmental Research and Public Health, 16(20), 3793 https://doi.org/10.3390/ijerph16203793.

[13] Relifweb, (2020 December) Nigeria Food Security Outlook Update, – NigeriaReliefWeb. Retrieved November 7, 2021, from https://reliefweb.int/report/nigeria/nigeria-food-security-outlook-update-december-2020.

[14] Ozoka, C. N. (2018). Burden of malnutrition in children under 5 years in Nigeria: Problem definition, ethical justification, and recommendations. Journal of Tropical Diseases, 06(03) Prevalence of underweight, weight for age (% of children under 5) Data (2021) Retrieved November 13, 2021, from https://data.worldbank.org/indicator/SH.STA.MALN.ZS.

[15] Amare, M., Arndt, C., Mahrt, K., & Mavrotas, G. (2020) Polygynous family structure and child undernutrition in Nigeria https://doi.org/10.2499/p15738coll2.133706.

[16] Agu, N., Emechebe, N., Yusuf, K., Falope, O., & Kirby, R. S. (2019) Predictors of early childhood undernutrition in Nigeria: The role of maternal autonomy. Public Health Nutrition, 22(12), 2279–2289. https://doi.org/10.1017/s1368980019000818.

[17] Kalu R., & Etim, D., (2018) Factors associated with malnutrition among under-five children in developing countries: a review global journal of pure and applied sciences vol. 24, 2018: 69-74 copyright© Bachudo science co. ltd printed in Nigeria ISSN 1118-0579 DOI: https://dx.doi.org/10.4314/gjpas.v24i1.8.

[18] Ikechukwu, H. U., Ofonime, N. U., Kofoworola, O., & Asukwo, D. E. (2020) Influence of cultural and traditional beliefs on maternal and child health practices in rural and urban communities in Cross River State, Nigeria. Annals of Medical Research and Practice, 1, 4 https://doi.org/10.25259/anmrp_4_2019.

[19] Akombi, B., Agho, K., Hall, J., Wali, N., Renzaho, A., & Merom, D. (2017) Stunting, wasting and underweight in Sub-Saharan Africa: A systematic review. International Journal of Environmental Research and Public Health, 14(8), 863 https://doi.org/10.3390/ijerph14080863.

[20] James, E., & Opiah, M., (2019), Socio-cultural factors influencing child nutrition among mothers in Calabar municipality, Cross River state Nigeria. International Journal of Interdisciplinary Research Methods Vol.6, No.4, pp. 28-51, October 2019 Published by ECRTD-UK Print ISSN: ISSN 2398-712X, Online ISSN: ISSN 2398-7138 (Accessed 7^th November 2021).

[21] Ocheke, I. E., & Thandi, P. (2015). Malnutrition in acutely ill children at the Pediatric Emergency Unit in a tertiary hospital in Nigeria, Nigerian Medical Journal, 56(2), 113https://doi.org/10.4103/0300-1652.150695.

[22] Senbanjo, I. O., Olayiwola, I. O., Afolabi, W. A., & Senbanjo, O. C. (2013) Maternal and child under-nutrition in rural and urban communities of Lagos State, Nigeria: The relationship and risk factors. BMC Research Notes, 6(1) https://doi.org/10.1186/1756-0500-6-286.

[23] Spring, (2018) Assessing drivers of malnutrition in Nigeria (2018) Retrieved November 29, 2021, from https://www.spring-nutrition.org/sites/default/files/publications/reports/nigeria_drivers_report_2-18_0.pdf.

[24] Banda, K., Chilengi-Sakala, S., Chunga, C. C., Solomon, H., Chalwe, V., Nkaama, J. M., Leonard, C., Bobo, M., Aongola, A., & Biemba, G. (2020) Towards universal coverage for nutrition services in children under five years—a descriptive analysis of the capacity of Level One hospitals to provide nutrition services in five provinces of Zambia. PLOS ONE, 15(5) https://doi.org/10.1371/journal.pone.0232663.

[25] AfricaNews. (2022, October 19). Gunmen abduct several hospital workers in Northwest Nigeria. AfricaNews. Retrieved January 22, 2023, from https://www.africanews.com/2022/10/19/gunmen-abduct-several-hospital-workers-in-northwest-nigeria//.

[26] Mkhize, M., & Sibanda, M. (2020) A review of selected studies on the factors associated with the nutrition status of children under the age of five years in South Africa. International Journal of Environmental Research and Public Health, 17(21), 7973 https://doi.org/10.3390/ijerph17217973.

[27] Kebede, D., & Aynalem, A. (2021) Prevalence of undernutrition and potential risk factors among children below five years of age in Somali Region, Ethiopia: Evidence from 2016 Ethiopian Demographic and health survey. BMC Nutrition, 7(1) https://doi.org/10.1186/s40795-021-00460-0.

[28] Adebisi, Y. A., Ibrahim, K., Lucero-Prisno, D. E., Ekpenyong, A., Micheal, A. I., Chinemelum, I. G., & Sina-Odunsi, A. B. (2019) Prevalence and socio-economic impacts of malnutrition among children in Uganda Nutrition and Metabolic Insights, 12, 117863881988739https://doi.org/10.1177/1178638819887398.

[29] Iacoella, F., & Tirivayi, N. (2020) Child nutrition during conflict and displacement: Evidence from areas affected by the Boko Haram insurgency in Nigeria Public Health, 183, 132–137 https://doi.org/10.1016/j.puhe.2020.03.012.

[30] Leidman, E., Tromble, E., Yermina, A., Johnston, R., Isokpunwu, C., Adeniran, A., & Bulti, A. (2017) Acute malnutrition among children, mortality, and humanitarian interventions in conflict-affected regions — Nigeria, October 2016–March 2017, MMWR Morbidity and Mortality Weekly Report, 66(48), 1332–1335. https://doi.org/10.15585/mmwr.mm6648a4.

[31] Amare, M., Balana, B., & Ogunniyi, A. (2020) The role of agriculture in reducing child undernutrition in Nigeria https://doi.org/10.2499/p15738coll2.133740.

[32] NBS & UNICEF, (2018) National Bureau of Statistics (NBS) and United Nations Children’s Fund (UNICEF). (2018), February 1. Multiple indicator cluster survey 2016-17 (MICS). Related UNICEF Websites. Retrieved December 11, 2022, from https://www.unicef.org/nigeria/reports/multiple-indicator-cluster-survey-2016-17-mics.

[33] Alexander K Lorraine., Lopes Brettania., Ricchetti-Masterson., & Yeatts B Karin (2015) Cross Sectional Studies - UNC gillings school of global public health. (n.d.). Retrieved January 23, 2023, from https://sph.unc.edu/wp-content/uploads/sites/112/2015/07/nciph_ERIC8.pdf.

[34] Tafa. Tafa Local Government Area. (n.d.). Retrieved January 23, 2023, from https://www.manpower.com.ng/places/lga/599/tafa.

[35] Gurara, (n.d.) Gurara Local Government Area. (n.d.). Retrieved January 23, 2023, from https://www.manpower.com.ng/places/lga/584/gurara.

[36] Raosoft, (2021). Sample size calculator Inc. Retrieved October 7, 2021, from http://www.raosoft.com/samplesize.html.

[37] DHCS, (2016 May) Guideline # 4 anthropometric measurements – Department of Healthcare Services. Child Health and Disability Preventive Program, health Assessment. Retrieved January 23, 2023, from https://www.dhcs.ca.gov/services/chdp/Documents/HAG/4AnthropometricMeasure.pdf.

[38] de Onis, M., Borghi, E., Arimond, M., Webb, P., Croft, T., Saha, K., De-Regil, L. M., Thuita, F., Heidkamp, R., Krasevec, J., Hayashi, C., & Flores-Ayala, R. (2018) Prevalence thresholds for wasting, overweight and stunting in children under 5 years Public Health Nutrition, 22(1), 175–179. https://doi.org/10.1017/s1368980018002434.

[39] Tesfaw, L. M., & Fenta, H. M. (2021) Multivariate logistic regression analysis on the association between anthropometric indicators of Under-five children in Nigeria: NDHS 2018. BMC Pediatrics, 21(1)https://doi.org/10.1186/s12887-021-02657-5.

[40] Seer-Uke, E. N., Samuel, E. S., Agajah, M. E., Ikpato, V. T., Tyoakaa, A. A., Abugu, L. I., Obi, R. I., Ityodugh, J. I., & Kparev, T. (2021). Nutritional status of children under age five in Benue State, Nigeria. African Journal of Food, Agriculture, Nutrition and Development, 21(07), 18391–18403. https://doi.org/10.18697/ajfand.102.20380.

[41] Usman, N. O., Kene-Ibeagha, N. C., Nmadu, A. G., Omole, V. N., & Adiri, F. (2018). Sociodemographic determinants of malnutrition among under-fives in MIL-goma: A rural community in Kaduna State, Northwestern Nigeria. Tropical Journal of Health Sciences. Retrieved January 12, 2023, from https://www.ajol.info/index.php/tjhc/article/view/181875.

[42] Idowu, O. S., Akindolire, A. E., Adebayo, B. E., Adebayo, A. M., & Ariyo, O. (2020) Determinants of anthropometric characteristics of under-five children in internally displaced persons’ camps in Abuja Municipal Area Council, Abuja, Nigeria. Pan African Medical Journal, 36 https://doi.org/10.11604/pamj.2020.36.313.21221.

[43] UNICEF, (November 2022) 25 million Nigerians at high risk of food insecurity in 2023. UNICEF. (2022). Retrieved January 22, 2023, from https://www.unicef.org/press-releases/25-million-nigerians-high-risk-food-insecurity-2023.

[44] Murarkar, S. K., Gothankar, J. S., Doke, P., Pore, P., Lalwani, S., Dhumale, G., Quraishi, S., Patil, R. S., Waghachavare, V., Dhobale, R., Rasote, K., Palkar, S., & Malshe, N. (2020). Prevalence and determinants of undernutrition among under-five children residing in urban slums and rural area, Maharashtra, India: A community-based cross-sectional study. https://doi.org/10.21203/rs.3.rs-15651/v6.

[45] Tadesse, S. E., & Mekonnen, T. C. (2020) Prevalence and associated factors of stunting among children aged 6–59 months in Delanta District, Northeast Ethiopia. Nutrition and Dietary Supplements, Volume 12, 41–48. https://doi.org/10.2147/nds.s237407.

[46] Mawa, R. (2018). Malnutrition among children under five years in Uganda American Journal of Health Research, 6(2), 56. https://doi.org/10.11648/j.ajhr.20180602.14.

[47] Nigatu, G., AssefaWoreta, S., Akalu, T. Y., & Yenit, M. K. (2018) Prevalence and associated factors of underweight among children 6–59 months of age in Takusa District, Northwest Ethiopia International Journal for Equity in Health, 17(1) https://doi.org/10.1186/s12939-018-0816-y.

[48] Li, S., Odedina, S., Agwai, I., Ojengbede, O., Huo, D., & Olopade, O. I. (2020). Traditional medicine usage among adult women in Ibadan, Nigeria: A cross-sectional study. BMC Complementary Medicine and Therapies, 20(1). https://doi.org/10.1186/s12906-020-02881-z.

[49] Kiarie, J., Karanja, S., Busiri, J., Mukami, D., & Kiilu, C. (2021) The prevalence and associated factors of undernutrition among under-five children in South Sudan using the standardized monitoring and assessment of relief and Transitions (SMART) methodology BMC Nutrition, 7(1) https://doi.org/10.1186/s40795-021-00425-3.

[50] Mann, D. M., Swahn, M. H., & McCool, S. (2021) Undernutrition and malaria among under-five children: Findings from the 2018 Nigeria demographic and health survey. Pathogens and Global Health, 115(6),423–433. https://doi.org/10.1080/20477724.2021.1916729.

[51] NDHS (2018) Nigeria demographic and health survey. (2018) Retrieved November 28, 2021, from http://cs-sunn.org/wp-content/uploads/2018/10/NDHS-2018.pdf.

[52] Adedokun, S. T., & Yaya, S. (2021). Factors associated with adverse nutritional status of children in Sub‐Saharan Africa: Evidence from the demographic and health surveys from 31 countries. Maternal & Child Nutrition, 17(3). https://doi.org/10.1111/mcn.13198.

[53] Obasohan, P. E., Walters, S. J., Jacques, R., & Khatab, K. (2020) Risk factors associated with malnutrition among children under-five years in Sub-Saharan African countries: A scoping review. International Journal of Environmental Research and Public Health, 17(23), 8782 https://doi.org/10.3390/ijerph17238782.

[54] Li, Z., Kim, R., Vollmer, S., & Subramanian, S. V. (2020) Factors associated with child stunting, wasting, and underweight in 35 low- and middle-income countries. JAMA Network Open, 3(4) https://doi.org/10.1001/jamanetworkopen.2020.3386.

[55] Elechi-Amadi, K. N., Briggs, O. N., Konne, F. E., Giami, L. K., & C. Ajufo, B. (2021). Perception and acceptance of herbal medicines among residents of Port Harcourt, Nigeria. Journal of Complementary and Alternative Medical Research, 24–34. https://doi.org/10.9734/jocamr/2020/v12i330209.

[56] Oyira, E (2021) Retrieved November 7, 2021, from https://www.researchgate.net/profile/Emilia-Oyira/publication/338213241_Article_on_socio-cultural_factors_influencing_child_nutrition_among_mothers_in_Calabar_Municipality/links/5e075e01299bf10bc37e87fa/Article-on-socio-cultural-factors-influencing-child-nutrition-among-mothers-in-Calabar-Municipality.

[57] Hamel, C., Enne, J., Omer, K., Ayara, N., Yarima, Y., Cockcroft, A., & Andersson, N. (2015) Childhood malnutrition is associated with maternal care during pregnancy and childbirth: A cross-sectional study in Bauchi and Cross River States, Nigeria. Journal of Public Health Research, 4(1) https://doi.org/10.4081/jphr.2015.408].

[58] Afework, E., Mengesha, S., & Wachamo, D. (2021) Stunting and associated factors among under-five age children in West Guji Zone, Oromia, Ethiopia Journal of Nutrition and Metabolism, 2021, 1–8. https://doi.org/10.1155/2021/8890725.

[59] UNICEF, (2022 December 22) Fathers leading the way to adequate nutrition. Related UNICEF Websites. Retrieved January 26, 2023, from https://www.unicef.org/nigeria/stories/fathers-leading-way-adequate-nutrition.

[60] UNICEF, (2021 February 24) SDG goal 2: Zero hunger. UNICEF DATA. Retrieved January 23, 2023, from https://data.unicef.org/sdgs/goal-2-zero-hunger/.

Abstract:

In Cameroon, HIV prevalence among youths (15-24 years) is 2% and 26.5% of them have unwanted pregnancies. Sexual and reproductive health (SRH) services are widely available, whose optimal utilization will reduce these high rates of HIV/STI transmission and pregnancies, but their knowledge and uptake of these services are unknown. This study aimed to assess determinants of SRH knowledge and uptake among HIV-infected youths in the Northwest region of Cameroon. This cross-sectional study received administrative authorization from the Delegation of Northwest and CBCHB IRB approval (IRB2021-77). We sequentially sampled youths living with HIV and receiving care at 16 treatment sites. Data was anonymously collected from consented participants between February and April 2022 using a structured questionnaire. The data was analysed using Stata version 14.0. In total 340 participants were enrolled, 70% female, 62% within 15-19 age group. Overall, knowledge of participants on SHR services was 78% and its uptake was 58%. Knowledge was 71% for SRH counselling, 78% for pregnancy prevention, 78% for STIs services and uptake of these services was 78%, 70% and 76% respectively. Increased age positively predicted SRH knowledge while urban residence had a negative influence. Being a male, living in urban residence and not schooling was negatively associated with SRH service uptake while good SRH knowledge positively predicted uptake. The suboptimal level of knowledge, consistent with low service uptake suggests the need for more sensitization and education on SHR services which is key to influencing uptake of these services and consequently reducing unintended pregnancies and HIV/STIs transmission.

References:

[1] Adolescents_Living_with_HIV.pdf’. Accessed: Sep. 17, 2021. [Online]. Available: https://www.unicef.org/eca/sites/unicef.org.eca/files/2017-10/Adolescents_Living_with_HIV.pdf.

[2] H. Gebreyesus, M. Teweldemedhin, and A. Mamo, ‘Determinants of reproductive health services utilization among rural female adolescents in Asgede-Tsimbla district Northern Ethiopia: a community based cross-sectional study’, Reprod Health, vol. 16, no. 1, p. 4, Dec. 2019, doi: 10.1186/s12978-019-0664-2.

[3] COP-2020-Cameroon-SDS-FINAL (1).pdf’.

[4] 3471CAMPHIA_Cameroon-SS_A4_v13_requests_7.25.18.pdf’. Accessed: Dec. 12, 2022. [Online]. Available: https://phia.icap.columbia.edu/wp-content/uploads/2018/07/3471CAMPHIA_Cameroon-SS_A4_v13_requests_7.25.18.pdf.

[5] R. M. Fubam, N. Tendongfor, O. Olayemi, and A.-T. A. Odukogbe, ‘Sexual and reproductive health knowledge of secondary school adolescents in Fako, Cameroon’, The Pan African Medical Journal, vol. 41, no. 340, Art. no. 340, Apr. 2022, doi: 10.11604/pamj.2022.41.340.31686.

[6] B. E. Birhanu, D. L. Kebede, A. B. Kahsay, and A. B. Belachew, ‘Predictors of teenage pregnancy in Ethiopia: a multilevel analysis’, BMC Public Health, vol. 19, 2019, doi: 10.1186/s12889-019-6845-7.

[7] B. O. Ahinkorah et al., ‘Access to Adolescent Pregnancy Prevention Information and Services in Ghana: A Community-Based Case-Control Study’, Frontiers in Public Health, vol. 7, 2019, doi: 10.3389/fpubh.2019.00382.

[8] S. Lawrence et al., ‘“They Just Tell Me to Abstain:” Variable Access to and Uptake of Sexual and Reproductive Health Services Among Adolescents Living with HIV in Kenya’, Frontiers in Reproductive Health, vol. 3, 2021, Accessed: Sep. 13, 2022. [Online]. Available: https://www.frontiersin.org/articles/10.3389/frph.2021.644832.

[9] L. S. Mkumba, M. Nassali, J. Benner, and T. D. Ritchwood, ‘Sexual and reproductive health needs of young people living with HIV in low- and middle-income countries: a scoping review’, Reproductive Health, vol. 18, no. 1, p. 219, Nov. 2021, doi: 10.1186/s12978-021-01269-7.

[10] D. R. McCarraher et al., ‘Adolescents living with HIV in the Copperbelt Province of Zambia: Their reproductive health needs and experiences’, PLoS One, vol. 13, no. 6, Jun. 2018, doi: 10.1371/journal.pone.0197853.

[11] L. R. Ninsiima, I. K. Chiumia, and R. Ndejjo, ‘Factors influencing access to and utilisation of youth-friendly sexual and reproductive health services in sub-Saharan Africa: a systematic review’, Reproductive Health, vol. 18, 2021, doi: 10.1186/s12978-021-01183-y.

[12] T. N. Ndongmo, C. B. Ndongmo, and C. Michelo, ‘Sexual and reproductive health knowledge and behavior among adolescents living with HIV in Zambia: a case study’, Pan Afr Med J, vol. 26, Feb. 2017, doi: 10.11604/pamj.2017.26.71.11312.

[13] L. Vu et al., ‘Increasing Uptake of HIV, Sexually Transmitted Infection, and Family Planning Services, and Reducing HIV-Related Risk Behaviors Among Youth Living with HIV in Uganda’, Journal of Adolescent Health, vol. 60, no. 2, Supplement 2, pp. S22–S28, Feb. 2017, doi: 10.1016/j.jadohealth.2016.09.007.

[14] S. Okawa et al., ‘Sexual and reproductive health behavior and unmet needs among a sample of adolescents living with HIV in Zambia: a cross-sectional study’, Reproductive Health, vol. 15, no. 1, p. 55, Mar. 2018, doi: 10.1186/s12978-018-0493-8.

[15] V. Chandra-Mouli, A. Armstrong, A. Amin, and J. Ferguson, ‘A pressing need to respond to the needs and sexual and reproductive health problems of adolescent girls living with HIV in low- and middle-income countries’, Journal of the International AIDS Society, vol. 18, p. 20297, Dec. 2015, doi: 10.7448/IAS.18.6.20297.

[16] F. Sevidzem Wirsiy, D. S. Nsagha, O. Njajou, and J. Besong Besong, ‘Determinants of Sexo-Reproductive Health Needs of Adolescent Girls in the Kumbo West Health District of Cameroon’, J Environ Sci Public Health, vol. 03, no. 02, 2019, doi: 10.26502/jesph.96120057.

[17] Encouraging young people to access SRHR information’, Reproductive Health Supplies Coalition. https://www.rhsupplies.org/activities-resources/initiatives/whos-holding-up-our-pillars/cameroon-agenda-for-sustainable-development/ (accessed Sep. 13, 2022).

[18] Pregnancy and Associated Factors Among Adolescents and Young Adults Living with HIV in the Northwest Region of Cameroon’. https://www.fortunejournals.com/articles/pregnancy-and-associated-factors-among-adolescents-and-young-adults-living-with-hiv-in-the-northwest-region-of-cameroon.html (accessed Nov. 21, 2022).

[19] M. Loutfy, R. Khosla, and M. Narasimhan, ‘Advancing the sexual and reproductive health and human rights of women living with HIV’, J Int AIDS Soc, vol. 18, no. 6Suppl 5, Dec. 2015, doi: 10.7448/IAS.18.6.20760.

[20] T. N. Ndongmo, C. B. Ndongmo, and C. Michelo, ‘Sexual and reproductive health knowledge and behavior among adolescents living with HIV in
Zambia: a case study’, Pan Afr Med J, vol. 26, 2017, doi: 10.11604/pamj.2017.26.71.11312.

[21] M. Lowe, P. I. G. Sagnia, O. Awolaran, and Y. A. M. Mongbo, ‘Sexual and reproductive health of adolescents and young people in the Gambia: a systematic review’, Pan Afr Med J, vol. 40, p. 221, 2021, doi: 10.11604/pamj.2021.40.221.25774.

Abstract:

The word “biocompatibility” has been gaining popularity, primarily in the field of dentistry but also in other fields of medicine. In essence, it means that biocompatible materials shouldn’t harm the recipient. The materials used in typical dental operations currently consist of literally hundreds of different components, and more are being developed every year. The relevance of using the patient’s most biocompatible material is increasingly being reported in scientific literature. According to research, choosing the least reactive material is crucial, but so is considering how that material might interact with any other implants that may already be in the mouth cavity. The application of these techniques may also result in a deeper comprehension of the biological reactions’ underlying mechanisms (mechanistic approach) when describing the biocompatibility of dental restorative materials. This review article aims to summarize the biocompatibility of restorative materials in general and the effects on immunological reaction caused by them.

References:

[1] Delves, P.J.; Martin, S.J.; Burton, D.R.; Roitt, I.M. Roitt’s Essential Immunology; John Wiley & Sons: Hoboken, NJ, USA, 2011.

[2] Mariani E, Lisignoli G, Borzì RM, Pulsatelli L. Biomaterials: Foreign Bodies or Tuners for the Immune Response? Int J Mol Sci. 2019 Feb 1;20(3):636. Doi: 10.3390/ijms20030636. PMID: 30717232; PMCID: PMC6386828.

[3] Zabrovsky, A. & Beyth, N., Pietrokovski, Yoav & Ben-Gal, Gilad & Houri-Haddad, Y. (2016). Biocompatibility and Functionality of Dental Restorative Materials: 10.1016/B978-0-08-100884-3.00005-9.

[4] G. Schmalz. Concepts in biocompatibility testing of dental restorative materials. Clin Oral Invest (1997) 1: 154–162.

[5] A Hensten-Pettersen, N Jacobsen. Biocompatibility of restorative materials. Operative dentistry supplement 2001, 6: 229-235.

[6] Andersen KE, Benezra C, Burrows D, Camarasa J, Doom-Gooseme A, Ducombs G, Frosch P, Lachapelle JM, Lahti A, Menné T, Rycroft R, Scheper P, White I & Wilkinson J (1987) Contact dermatitis: A review Contact Dermatitie 16(2) 55-78.

[7] McGivern B, Pemberton M, Theaker ED, Buchanan JAG & Thornhill MH (2000) Delayed and immediate hypersensitivity reactions associated with the use of amalgam British Dental Journal 188(2) 73-76.

[8] Hensten-Pettersen A (1992) Casting alloys; side effects Advances in Dental Research 6 38-43.

[9] Hensten-Pettersen A (1998) Skin and mucosal reactions associated with dental materials European Journal of Oral Science 106(2 pt 2) 707-712.

[10] Hensten-Pettersen A & Jacobsen N (1990) The role of biomaterials as occupational hazards in dentistry. International Dental Journal 40(3) 159-166.

[11] Hensten-Pettersen A & Jacobsen N (1991) Perceived side effects of biomaterials in prosthetic dentistry Journal of Prosthetic Dentistry 65(1) 138-144.

[12] Stenman E & Bergman M (1989) Hypersensitivity reactions to dental materials in a referred group of patients. Scandinavian Journal of Dental Research 97(1) 76-83.

[13] Kanerva L, Alanko K, Estlander R, Jolanki R, Lahtinen A & Savela A (2000) Statistics on occupational contact dermatitis from (meth) methacrylates in dental personnel Contact Dermatitis 42(3) 175-176.

[14] Bratel J, Hakeberg M & Jontell M (1996) Effecte of replacement of dental amalgam on oral lichenoid reactions. Journal of Dentistry 24(1-2) 41-45.

[15] Vanes JS, Morken T, Helland S & Gjerdet NR (2000) Dental gold alloys and contact hypersensitivity Contact Dermatitis 42(3) 128-133.

[16] Tsuruta K, Matsunaga K, Suzuki K, Suzuki R, Akita H, Washimi Y, Tomitaka A & Ueda H (2001) Female pre- dominance of gold allergy Contact Dermatitis 44(1) 55-56.

[17] Jacobsen N, Aasenden R & Hensten-Pettersen A (1991) Occupational health complaints and adverse patient reactions as perceived by personnel in public dentistry Community Dentistry and Oral Epidemiology 19(3) 155-159.

[18] Fisher A (1982) Contact dermatitis in medical and surgical personnel in Occupational and Industrial Dermatology (des Maibach HI & Gellin GA) Yearbook Medical Publishers, Inc pp 219-228.

[19] Seppälainen AM & Rajaniemi R (1984) Local neurotoxicity of methylmethacrylate among dental technicians American Journal of Industrial Medicine 5(6) 471-477.

[20] Mandel, I.D., 1987. The functions of saliva. J. Dent. Res. 66 Spec No: 623-7.

[21] Hatton, M.N., Loomis, R.E., Levine, M.J., Tabak, L.A., 1985. Masticatory lubrication. The role of carbohydrate in the lubricating property of a salivary glycoprotein-albumin complex. Biochem. J. 230, 817–820.

[22] Aguirre, A., Mendoza, B., Levine, M.J., Hatton, M.N., Douglas, W.H., 1989. In vitro characterization of human salivary lubrication. Arch. Oral Biol. 34, 675–677.

[23] Wahl, M.J., Swift Jr., E.J., 2013. Critical appraisal: dental amalgam update—part II: biological effects. J. Esthet. Restorative Dent. 25, 433–437.

[24] Van Landuyt, K.L., Nawrot, T., Geebelen, B., De Munck, J., Snauwaert, J., Yoshihara, K., et al., 2011. How much do resin-based dental materials release? A meta-analytical approach. Dent. Mater. 27, 723–747.

[25] Sideridou, I., Tserki, V., Papanastasiou, G., 2002. Effect of chemical structure on degree of conversion in light-cured dimethacrylate-based dental resins. Biomaterials 23, 1819–1829.

[26] Kildal, K.K., Ruyter, I.E., 1994. How different curing methods affect the degree of conversion of resin-based inlay/onlay materials. Acta Odontol. Scand. 52, 315–322.

[27] Feng, L., Carvalho, R., Suh, B.I., 2009. Insufficient cure under the condition of high irradiance and short irradiation time. Dent. Mater. 25, 283–289.

[28] Anderson, J.M.; Rodriguez, A.; Chang, D.T. Foreign body reaction to biomaterials. Semin. Immunol. 2008, 20, 86–100.

Abstract:

Oral health plays an important role in patients suffering with mental disorders. It is important to focus on a multidisciplinary approach including psychiatrists, general practitioners, dental practitioners, psychologists and nutritionists. The most common dental diseases encountered in patients with mental disorders are dental caries and periodontal diseases. Thus, it is required to bridge the professional gap for maintaining adequate oral health and for diagnosing the mental health issues In the present review article, we emphasize an overview on providing the basic information about the dental concerns of patients with mental disability. The electronic database included Pub Med, Medline, Science Direct, Goggle Scholar using terms mental disability and Down syndrome etc. Relevant articles published in English on reference lists were identified and retrieved from electronic and print journals.

References:

[1] Mental disorders. World Health Organisation. https://www.who.int/news-room/fact-sheets/detail/mental-disorders. Visited on 16.02.2023.

[2] Charlson, F., van Ommeren, M., Flaxman, A., Cornett, J., Whiteford, H., & Saxena, S 2019. New WHO prevalence estimates of mental disorders in conflict settings: a systematic review and meta-analysis. Lancet. 2019; 394,240–248.

[3] Mental Health and Covid-19: Early evidence of the pandemic’s impact. Geneva: World Health Organization; 2022.

[4] Mental Health. World Health Organisation. https://www.who.int/india/health-topics/mental-health. Visited on 16.02.2023.

[5] Kenny, A., Dickson-Swift, V., Gussy, M. et al. 2020 Oral health interventions for people living with mental disorders: protocol for a realist systematic review. Int J Ment Health Syst 2020; 14:24.

[6] Cockburn N, Pradhan A, Taing M, Kisely S, Ford P 2017. Oral health impacts of medications used to treat mental illness. J Affect Disord. 2017;223:184–193.

[7] Aljabri MK, Gadibalban IZ, Kalboush AM, Sadek HS, Abed HH. 2018 Barriers to special care patients with mental illness receiving oral healthcare. A cross sectional study in the Holy City of Makkah, Saudi Arabia. Saudi Med J. 2018 Apr;39(4):419-423.

[8] Ohtawa Y, Tsujino K, Kubo S, Ikeda M. 2012 Dental treatment for patients with physical or mental disability under general anesthesia at Tokyo Dental College Suidobashi Hospital. Bull Tokyo Dent Coll. 2012;53(4):181-7. doi: 10.2209/tdcpublication.53.181. PMID: 23318923.

[9] Poornachitra, Narayan V.2023 Management of Dental Patients with Mental Health Problems in Special Care Dentistry: A Practical Algorithm. Cureus 2023;15(2): e34809.

[10] Tiwari T, Kelly A, Randall CL, Tranby E and Franstve-Hawley J (2022) Association Between Mental Health and Oral Health Status and Care Utilization. Front. Oral. Health 2:732882. doi: 10.3389/froh.2021.732882.

[11] Kukreja S, Kalra G, Shah N, Shrivastava A:2013 Polypharmacy in psychiatry: a review. Mens Sana Monogr. 2013, 11:82-99.

[12] McCance-Katz EF, Sullivan LE, Nallani S. 2010 Drug interactions of clinical importance among the opioids, methadone and buprenorphine, and other frequently prescribed medications: a review. Am J Addict. 2010, 19:4-16.

[13] Nalliah RP, Da Silva JD, Allareddy V 2013. The characteristics of hospital emergency department visits made by people with mental health conditions who had dental problems. J Am Dent Assoc. 2013 Jun;144(6):617-24.

[14] Hugoson A, Hellqvist L, Rolandsson M, Birkhed D. 2012 Dental caries in relation to smoking and the use of Swedish snus: epidemiological studies covering 20 years (1983-2003). Acta Odontol Scand. 2012 Jul;70(4):289-96.

[15] Nur’aeny N.2016 The dental management of patients with severe depression disorder (Literature review). J Dentomaxillofac Sci 2016; 1(Suppl 1):89.

[16] Chu KY, Yang NP, Chou P, Chiu HJ, Chi LY.2012 Comparison of oral health between inpatients with schizophrenia and disabled people or the general population. J Formos Med Assoc. 2012 Apr;111(4):214-9.

[17] McNamara G, Millwood J, Rooney YM, Bennett K 2014. Forget me not - the role of the general dental practitioner in dementia awareness. Br Dent J. 2014 Sep;217(5):245-8.

[18] Santos Miotto Amorim C, Firsoff EF, Vieira GF, Costa JR, Marques AP 2014. Effectiveness of two physical therapy interventions, relative to dental treatment in individuals with bruxism: study protocol of a randomized clinical trial. Trials. 2014 Jan 7; 15:8.

[19] Shilpa Shetty, Varun Pitti, C. L. Satish Babu, G. P. Surendra Kumar, and B. C. Deepthi 2010 Bruxism: A Literature Review J Indian Prosthodont Soc. Sep; 10(3): 141–148.

[20] Bader G, Lavigne G. 1999 Sleep bruxism; an overview of an oromandibular sleep movement disorder. Sleep Med Rev. 2000; 4:27–43. doi: 10.1053/smrv.0070. [PubMed] [CrossRef] [Google Scholar].

Abstract:

Mother-to-child transmission (MTCT) is by far the largest source of HIV infection in children below the age of 15 years. The virus may be transmitted during pregnancy, child birth or breast feeding. Globally 2.7 million children under  the age of 15 years have died of AIDS Over 9 in 10 were I infected by their mothers. Recently however, many interventions are available to reduce mother to child transmission, such as anti-retroviral drug and avoidance of breast feeding. To assess the knowledge pregnant women have on HIV/AIDS, mother to child transmission of HIV/AIDS and how PMTCT services are utilized in a tertiary health facility in The Gambia. A structured questionnaire was used to obtain data from 150 women that consecutively attended the antenatal clinic of Hands On Care. Approval was obtained from the Director of Hand On Care. Sexually active population (15 – 24yrs) constituted 34% whilst 72.0% were housewives. Myths and misconceptions of HIV/AIDS, 42.7% said mosquito bites can cause HIV; 25.3% said sharing of meals with infected person can transmit HIV. Utilization of PMTCT services was high with 92.7% tested for HIV. Out of those respondents 50.0% had ever discussed PMTCT services with their husband. Utilization of PMTCT services among pregnant women was high. However, knowledge on the causes and transmission of HIV was inadequate. Need to formulate policies aim at sensitizing women about the causes and transmission of HIV/AIDS. Promoting the uptake of PMTCT services will also go a long way reducing the transmission of unborn babies by infected mothers.

Keywords: Antenatal Care; HIV/AIDS; Knowledge; Prevention of Mother to Child Transmission; Pregnant Wome; Utilization.

References:

[1] UNAIDS W. AIDS epidemic update: December 2000. Geneva: Joint United Nations Programme on HIV. AIDS. 2000;

[2] Van Rensburg D, Friedman I, Ngwena C, Pelser A, Steyn F, Booysen F, et al. Strengthening local government and civic responses to the HIV/AIDS epidemic in South Africa. Centre for Health Systems Research & Development; 2002.

[3] Stringer EM, Sinkala M, Stringer JS, Mzyece E, Makuka I, Goldenberg RL, et al. Prevention of mother-to-child transmission of HIV in Africa: successes and challenges in scaling-up a nevirapine-based program in Lusaka, Zambia. AIDS (London, England). 2003;17(9):1377.

[4] Abdool K, Abdool KQ, Adhikari M. Vertical HIV transmission in South Africa: translating research into policy and practice. The Lancet. 2002;359(9311):992–3.

[5] Peitzmeier S, Mason K, Ceesay N, Diouf D, Drame F, Loum J, et al. A cross-sectional evaluation of the prevalence and associations of HIV among female sex workers in the Gambia. International journal of STD & AIDS. 2014;25(4):244–52.

[6] Amornwichet P, Teeraratkul A, Simonds RJ, Naiwatanakul T, Chantharojwong N, Culnane M, et al. Preventing mother-to-child HIV transmission: the first year of Thailand’s national program. Jama. 2002;288(2):245–8.

[7] Secretariat NA. The Gambia Global AIDS Response Progress Report. 2015.

[8] Afridi NK, Khan S, Fatima S. Factors affecting accessibility and acceptability of voluntary counselling and testing among high risk group (HRG) for human immunodeficiency virus (HIV) in NWFP Pakistan. JPMA The Journal of the Pakistan Medical Association. 2010;60(4):265.

[9] Gobezie F. Assessment of Opportunities and Challenges towards the Implementation of PMTCT Guideline in Public Hospitals of Addis Ababa City Government [PhD Thesis]. Addis Ababa University Addis Ababa, Ethiopia; 2014.

[10] Theuring S, Mbezi P, Luvanda H, Jordan-Harder B, Kunz A, Harms G. Male involvement in PMTCT services in Mbeya Region, Tanzania. AIDS and Behavior. 2009;13(1):92–102.

[11] Adeneye AK, Mafe MA, Adeneye AA, Salami KK, Brieger WR, Titiloye MA, et al. Knowledge and perception of HIV/AIDS among pregnant women attending antenatal clinics in Ogun State, Nigeria. African journal of AIDS research. 2006;5(3):273–9.

[12] Jallow C. The Gambia 2010 behavioral surveillance survey on HIV & AIDS. Banjul: Actionaid the Gambia, National AIDS Secretariat. 2011.

[13] Okonkwo KC, Reich K, Alabi AI, Umeike N, Nachman SA. An evaluation of awareness: attitudes and beliefs of pregnant Nigerian women toward voluntary counseling and testing for HIV. AIDS Patient Care and STDs. 2007;21(4):252–60.

[14] Alene GD. Knowledge and practice of condom in preventing HIV/AIDS infection among commercial sex workers in three small towns of northwestern Ethiopia. The Ethiopian Journal of Health Development. 2002;16(3).

[15] Ekanem EE, Gbadegesin A. Voluntary Counselling and Testing (VCT) for Human Immunodeficiency Virus: A study on acceptability by Nigerian women attending antenatal clinics. African Journal of Reproductive Health. 2004;91–100.

[16] Kibombo R, Neema S, Ahmed FH. Perceptions of risk to HIV infection among adolescents in Uganda: are they related to sexual behaviour? African journal of reproductive health. 2007;11(3):168–81.

[17] Bassett MT, Mhloyi M. Women and AIDS in Zimbabwe: the making of an epidemic. In: Women’s Health, Politics, and Power: Essays on Sex/Gender, Medicine, and Public Health. Routledge; 2020. p. 269–83.

[18] Control C for D, Prevention (CDC. HIV surveillance–United States, 1981-2008. MMWR Morbidity and mortality weekly report. 2011;60(21):689–93.

[19] Unaids. 2008 UNAIDS Annual Report. World Health Organization; 2010.

[20] Chama C, Gashau W, Oguche S. The value of highly active antiretroviral therapy in the prevention of mother-to-child transmission of HIV. Journal of obstetrics and gynaecology. 2007;27(2):134–7.

[21] Kasenga F, Hurtig AK, Emmelin M. Home deliveries: implications for adherence to nevirapine in a PMTCT programme in rural Malawi. AIDS care. 2007;19(5):646–52.

[22] Newell ML. Current issues in the prevention of mother-to-child transmission of HIV-1 infection. Transactions of the Royal Society of Tropical Medicine and Hygiene. 2006;100(1):1–5.

[23] Wolinsky SM, Wike CM, Korber BT, Hutto C, Parks WP, Rosenblum LL, et al. Selective transmission of human immunodeficiency virus type-1 variants from mothers to infants. Science. 1992;255(5048):1134–7.

[24] Ariyoshi K, Weber J, Walters S. Contribution of maternal viral load to HIV-1 transmission. Lancet (British edition). 1992;340(8816).

[25] Bulterys M, Chao A, Dushimimana A, Habimana P, Nawrocki P, Kurawige JB, et al. Multiple sexual partners and mother-to-child transmission of HIV-1. AIDS (London, England). 1993;7(12):1639–45.

[26] Moses AE, Chama C, Udo SM, Omotora BA. Knowledge, attitude, and practice of ante-natal attendees toward prevention of mother to child transmission (PMTCT) of HIV infection in a tertiary health facility, Northeast-Nigeria. East African journal of public health. 2009;6(2):128–35.

[27] NAS. (2006) Unpublished. The Gambia PMTCT Impact Study: National AIDS Secretariat.

Abstract:

The Covid-19 pandemic is the largest and longest outbreak in modern times, with socio-economic, political, and educational disruptions. This study was to appraise the level of efforts and the impact of these interventions in the health sector. A mixed methodology approach involving quantitative research techniques. The study revealed that there was generally a high level of awareness and good compliance to government policies and guidelines on Covid-19 regulations being highest in Lagos state compared to FCT and Kaduna state. The public perception of the use of facemask and its enforcement and handwashing practices by health facilities was rated high across the three states. Client education and public perception of Covid-19 counselling was different across the three states, being highest in Lagos in comparison to FCT and Kaduna. Hence the study recommended refreshers training of health workers on awareness creation and counselling of clients at all levels of care.

References:

[1] Adepoju P. (2020) Nigeria responds to Covid-19; first case detected in sub-Saharan Africa. Nat Med. 2020 Apr;26(4):444-448. doi: 10.1038/d41591-020-00004-2. PMID: 32161414.

[2] UNDP Covid-19 Pandemic Humanity Needs Leadership and Solidarity o DefeattheVirus.UNDP;2020.[Accessedatttps://www.undp.org/coronavirus on 25th September 2021]https://www.who.int/emergencies/diseases/novel-coronavirus-2019.

[3] World Health Organization. Archived: WHO Timeline - Covid-19.( 2020) Available from: https://www.who.int/news-room/detail/27-042020-who-timeline—covid-19.

[4] World Health Organisation. Covid-19 Dashboard. Geneva: WHO (2021). Available online at: https://covid19.who.int (accessed May 20, 2021).

[5] Nigeria Centre for Disease Control (2021) Dashboard for Covid cases available on https://covid19.ncdc.gov.ng/ [Accessed on 11^th September 2021]

[6] Atzrodt, C. L., Maknojia, I., McCarthy, R., Oldfield, T. M., Po, J., Ta, K., Stepp, H. E., & Clements, T. P. (2020). A Guide to Covid-19: a global pandemic caused by the novel coronavirus SARS-CoV-2. The FEBS journal, 287(17), 3633–3650. https://doi.org/10.1111/febs.15375.

[7] Palinkas LA, Springgate BF, Sugarman OK, Hancock J, Wennerstrom A, Haywood C, Meyers D, Johnson A, Polk M, Pesson CL, Seay JE, Stallard CN, Wells KB. A Rapid Assessment of Disaster Preparedness Needs and Resources during the Covid-19 Pandemic. Int J Environ Res Public Health. 2021 Jan 7;18(2):425. doi: 10.3390/ijerph18020425. PMID: 33430355; PMCID: PMC7825778.

[8] Umar, S. S., Muhammad, B. O., & Zaharadeen, S. B. (2020). Preparedness of Nigerian health institutions toward managing lassa fever epidemic and Covid-19 pandemic. Niger J Med [serial online] 2020 [cited 2021 Sep 11]; 29:303-7. Available from: http://www.njmonline.org/text.asp?2020/29/2/303/287943.

[9] OECD (2020), Containment and mitigation policy actions are key to fight the Covid-19 pandemic, OECD, Paris.

[10] Presidential Task Force on Covid19 report (2021) available https://statehouse.gov.ng/covid19/objectives/.

[11] Adesanya, O. A. (2020). Government preparedness and response towards Covid-19 outbreak in Nigeria: A retrospective analysis of the last 6 months. Journal of Global Health; 10(2). Accessed at http://www.jogh.org/documents/issue202002/jogh-10-020382.htm.

[12] Israel, G.D., (1992). Determining Sample Size. Fact Sheet PEOD-6. University of Florida.

[13] Golden Owhonda, Omosivie Maduka, Ifeoma Nwadiuto, Charles Tobin-West, Esther Azi, Chibianotu Ojimah, Datonye Alasia, Ayo-Maria Olofinuka, Vetty Agala, John Nwolim Paul, Doris Nria, Chinenye Okafor, Ifeoma Ndekwu, Chikezie Opara, Chris Newsom, Awareness, perception and the practice of Covid-19 prevention among residents of a state in the South-South region of Nigeria: implications for public health control efforts, International Health, Volume 14, Issue 3, May 2022, Pages 309–318, https://doi.org/10.1093/inthealth/ihab046.

[14] Naumann E, Möhring K, Reifenscheid M, Wenz A, Rettig T, Lehrer R, Krieger U, Juhl S, Friedel S, Fikel M, Cornesse C, Blom AG. COVID-19 policies in Germany and their social, political, and psychological consequences. Eur Policy Anal. 2020 Dec;6(2):191-202. doi: 10.1002/epa2.1091. Epub 2020 Sep 28. PMID: 34616900; PMCID: PMC7537296.

[15] Faiva E, Hashim HT, Ramadhan MA, Musa SK, Bchara J, Tuama YD, Adebisi YA, Kadhim MH, Essar MY, Ahmad S, Lucero-Prisno DE 3rd. Drug supply shortage in Nigeria during COVID-19: efforts and challenges. J Pharm Policy Pract. 2021 Jan 22;14(1):17. doi: 10.1186/s40545-021-00302-1. PMID: 33482871; PMCID: PMC7820524.

[16] Aregbesola S and Folayan M (2021) Nigeria’s financing of health care during the Covid-19 pandemic: Challenges and recommendations https://doi.org/10.1002/wmh3.484.

[17] Dixit, S, ogundeji KY and Onwujekwe 0 (2020) How well has Nigeria responded to Covid 19 (Accessed from 2^nd July 2020.).

[18] OECD (2020) Regulatory Quality and Covid-19: Managing the Risks and Supporting the Recovery, contributing to global efforts. OECD.org.com.

[19] Davie Madziatera, Kondwani Stanslas Msofi, Thokozani V Phiri, Samuel Devaughn Mkandawire, Amy Comber (2020) Availability, Accessibility and Proper Use of Personal Protective Equipment in Wards at Queen Elizabeth Central Hospital (QECH) Blantyre, Malawi: An Observational Study.

[20] Oladele DA, Idigbe IE, Musa AZ, Gbaja-Biamila T, Bamidele T, Ohihoin AG, Salako A, Odubela T, Aina O, Ohihoin E, David A, Ezechi O, Odunukwe N, Salako BL. Self-reported use of and access to personal protective equipment among healthcare workers during the Covid-19 outbreak in Nigeria. Heliyon. 2021 May;7(5): e07100. doi: 10.1016/j.heliyon. 2021.e07100. Epub 2021 May 19. PMID: 34031646; PMCID: PMC8133390. M. A. Alao, A. O. Durodola, O. R. Ibrahim, O. A. Asinobi, “Assessment of Health Workers’ Knowledge,
Beliefs, Attitudes, and Use of Personal Protective Equipment for Prevention of Covid-19 Infection in Low-Resource Settings”, Advances in Public Health, vol. 2020, Article ID 4619214, 10 pages, 2020. https://doi.org/10.1155/2020/4619214.

[21] World Health Organisation (2020) Combatting health worker infections in Nigeria: Combatting health worker infections in Nigeria | WHO | Regional Office for Africa.

Abstract:

A few years after the implementation of policies to combat maternal mortality, antepartum hemorrhage, which is one of the main causes, is not systematically documented to the point where we are left to wonder what it is prevalence in the major cities of Cameroon. This study was conducted in the Gynecological and Obstetric units of the Laquintinie hospital and the General hospital of the city of Douala, from May 01, 2020, to April 30, 2022, has been to determine the prevalence of antepartum hemorrhage in Douala. It included 166 women who had had antepartum hemorrhage. The data collected with an indirect self-administered questionnaire was processed by SPSS 23. Following this treatment, participants had an average age of 31.28 ± 6.33 years. The prevalence of antepartum hemorrhage in the two hospitals was 3.47% and of 166 cases, 51.80% had placenta abruption.

References:

[1] Amitava R.S., Saikat S.R., Biswa J. N., Gaurab M., Jayanta M., 2010, Management of obstetric haemorrhage. M. E. J. Anaesth., 20 (4), 499-508.

[2] Lamina M., A., Oladapo O.T., 2011, Maternal and Fetal Outcome of Obstetric Emergencies in a Tertiary Health Institution in SouthWestern Nigeria. Gynecology Obstetrics and Gynecology, Article ID 160932, 4 doi:10.5402/2011/160932.

[3] Hamadameen,A.I., 2018, The maternal and perinatal outcome in antepartum hemorrhage: A cross-sectional study, Zanco J. Med. Sci., 22(2), 155-163, https://doi.org/10.15218/zjms.2018.021.

[4] Arora R., Devi U., Majumdar K., 2001, Perinatal morbidity and mortality in antepartum haemorrhage, J Obstet Gynae India., 51(3):102-104.

[5] Singhal S, N., Nanda S., 2007, Maternal and perinatal outcome in antepartum hemorrhage : à study at a tertiary care referral institute. Int J Gynecol Obstet, 9(2). Available from : https://print.ispub.com/api/0/ispub-article/3465.

[6] Kainer F., Hasbargen U., 2008, Emergencies associated with pregnancy and delivery : Peripartum hemorrhage. Dtsch Arztebl Int, 105 :629‑638.

[7] Lakshmipriya K., Vijayalakshmi V., Padmanaban S., 2019, A study of maternal and fetal outcome in Antepartum haemorrhage, Int J Gynecol Obstet, 3(1) :96–99. doi: 10.33545/gynae.2019.v3.i1b.19.

[8] Bhide A, Thilaganathan B., 2004, Recent advances in the management of placenta previa. Curr Opin Obstet Gynecol., 16(6):447-451.

[9] Mishra R., 2014, Ian Donald’s Practical Obstetric Problems. Seventh edition. LWW, 315-328.

[10] Wekere F., Chikaike C., Kua P., L., Akani A., B., and Adetomi B., 2021, Prevalence, maternal and perinatal sequelae of antepartum haemorrhage in a tertiary hospital in southsouth, Nigeria, International Journal of Clinical Obstetrics and Gynaecology, 5(5), 206-210.

[11] Bener A., Saleh N.M., Yousafzai M.T., 2012, Prevalence and associated risk factors of ante-partum hemorrhage among Arab women in an economically fast growing society Nigerian Journal of Clinical Practice 15(2), doi: 10.4103/1119-3077.97315, www.njcponline.com.

[12] Wasnik S. K., Naiknaware S. V., 2015, Antepartum haemorrhage: causes and its effects on mother and child: an evaluation. Obstetrics & Gynecology International Journal, 3(1):00072.

[13] Sharmila G, Prasanna, 2016, Maternal and perinatal outcome in antepartum hemorrhage. Int Arch Integr Med, 3(9):148–160.

[14] Onebunne C. A. C., Christopher O. A., 2019, Prevalence and pregnancy outcomes in patients with antepartum haemorrhage in a tertiary hospital in Ibadan, Nigeria. International Journal of Reproduction, Contraception, Obstetrics and Gynecologywww.ijrcog.org pISSN 2320-1770 | eISSN 2320-1789; doi:, http://dx.doi.org/10.18203/2320-1770.ijrcog20193017.

[15] Tyagi P., Nidhi Y., Parul S., Uma G., 2016, Study of antepartum haemorrhage and its maternal and perinatal outcome ; International Journal of Reproduction, Contraception, Obstetrics and Gynecology, Int J Reprod Contracept Obstet Gynecol, 5(11), 3972-3977 www.ijrcog.org pISSN 2320-1770 | eISSN 2320-1789, doi: http://dx.doi.org/10.18203/2320-1770.ijrcog20163873.

[16] Adekanle A., Adeyemi A., Fadero F., 2011, Antepartum haemorrhage in LAUTECH Teaching Hospital, South‑Western Nigeria. J Med Sci, 2, 1243‑1247.

[17] Samal S. K., Setu R., Reddi R., Seetesh G., 2017, Maternal and perinatal outcomes in cases of antepartum haemorrhage: a 3-year observational study in a tertiary care hospital; International Journal of Reproduction, Contraception, Obstetrics and Gynecology, 6(3):1025-1029; www.ijrcog.org, pISSN 2320-1770 | eISSN 2320-178.

[18] Radhika M. G., Rajaratnam A., Ayshath S., 2020, Maternal outcome in antepartum Haemorrhage: A study at a tertiary care Centre International Journal of Clinical Obstetrics and Gynaecology, 4(5), 05-08.

[19] Kulkarni A.R., Shirsath S., 2021, Study of antepartum hemorrhage and its maternal and perinatal outcome at a tertiary care hospital international Journal of Reproduction, Contraception, Obstetrics and Gynecology, Int J Reprod Contracept Obstet Gynecol, 10(6), 2210-2214 www.ijrcog.org pISSN2320-1770 | eISSN2320-1789.

[20] Lankoande M., Bonkoungou P., Ouandaogo S., 2017, Incidence and outcome of severe antepartum hemorrhage at the Teaching Hospital Yalgado Ouédraogo in Burkina Faso, BMC Emergency Medicine 17(17). doi 10.1186/s12873-017-0128-3.

[21] Rocha F. E.A., Costa M.L., Cecatti J. G., Parpinelli M. A, Haddad S. M., Sousa M. H., Melo E. F. J. R., Surita F. G., Souza J. P., and the Brazilian network for surveillance of severe maternal morbidity study group, 2015, Contribution of antepartum and intrapartum hemorrhage to the burden of maternal near miss and death in a national surveillance study. Acta Obstet Gynecologica Scandinavica; 94, 50–58.

[22] Langer J., Berger C., Magnin G., 1985, Diagnostic et conduite à tenir devant une grossesse au 3ème trimestre. Obstétrique pour le praticien. Edit SIMEP, 595.

[23] Yadav M. C., Mehta K., Choudhary V. A., 2019, A study of antepartum hemorrhage and its maternal and perinatal outcome at tertiary care hospital in Western Rajasthan. JMSCR, 7(9):80–85.

[24] Park, K. (2007). Preventive medicine in obstetrics, paediatrics and geriatrics In : Park, textbook of preventive and social medicine. 19th edition. Banaras Das Bhanot’jabalpur ,445-447.

Abstract:

Inadequate quality management during laboratory analysis can increase errors, specimen rejection, and economic resources wastages. A laboratory quality management system (QMS) helps to streamline and coordinate all the processes and operations within the lab, ensuring that each step is well planned, controlled, and correctly performed. Quality management ensures that results are accurate, reliable, and obtained under a traceable process that can easily detect errors. The study aimed to investigate quality practice among laboratory workers during pre-analytical phase activities. Unexpected deviation from quality procedures consequently compromise laboratory test results, leading to patient mismanagement and patient safety risks. Analysis of results showed that 97.1% (340 respondents) were knowledgeable on quality management of pre-analytical phase, and 2.9% (10 respondents) were not. 99.1% (347respondents) agreed to availability of quality management materials and 0.9% (3 respondents) had no resources. 4.6% (16 respondents) do not practice quality management system at pre-analytical phase and 94.5% (334 respondents) practiced quality improvements. 3.4% (12 respondents) agreed that quality improvement is the responsibility of phlebotomist and field staff. 96.6% (338 respondents) agreed that quality management is the responsibility of everyone at the facility. There was maximum knowledge of quality management at the facility. Availability of quality management resources at the facility was standard. The practice of quality management was below standard. Facility requires training in quality management. It is recommended that quality management system be integrated into the curriculum of school of health technology to guide graduates at work.

References:

[1] Barak M, Jaschek R. (2014). A new and effective way for preventing pre-analytical laboratory errors. Clin Chem Lab Med. 52(2): e5-8.

[2] Cornes MP, Atherton J, Pourmahram G, et al. (2016). Monitoring and reporting of pre-analytical errors in laboratory medicine: the UK situation. Ann Clin Biochem. 53(Pt 2):279-284.

[3] Sciacovelli L, Panteghini M, Lippi G, et al. (2017). Defining a roadmap for harmonizing quality indicators in Laboratory Medicine: a consensus statement on behalf of the IFCC Working Group “Laboratory Error and Patient Safety” and EFLM Task and Finish Group “Performance specifications for the extra-analytical phases”. Clin Chem Lab Med. 55(10):1478–1488.

[4] Lippi G, Chance JJ, Church S, et al. (2011). Pre-analytical quality improvement: from dream to reality. Clin Chem Lab Med. 49(7):1113–1126.

[5] O’Kane M. (2009). The reporting, classification, and grading of quality failures in the medical laboratory. Clin Chim Acta. 404: 28 – 31.

[6] Atay A, Demir L, Cuhadar S, Saglam G, Unal H, Aksun S, et al. (2014). Clinical biochemistry laboratory rejection rates due to various types of preanalytical errors. Biochem Med 24(3): 376-382.

[7] Holman JW, Mifflin TE, Felder RA; Demers LM. (2002). Evaluation of an automated preanalytical robotic workstation at two academic health centers. Clin Chem. 48:540–548.

[8] Renshaw AA, Gould Ew. (2006). Measuring the value of review of pathology material by a second pathologist. Am J. Clin Pathol. 125: 737–739.

[9] Wallin O, Söderberg J, Van Guelpen B, Stenlund H, Grankvist K, Brulin C. (2008). Preanalytical venous blood sampling practices demand improvement: a survey of test-request management, test-tube labelling, and information search procedures. Clin Chim Acta. 391:91–97.

[10] Lippi G, Fostini R, Guidi GC. (2008). Quality improvement in laboratory medicine: extra-analytical issues. Clin Lab Med. 28: 285–294.

[11] Sciacovelli L, Secchiero S, Zardo L, D’Osualdo A, Plebani M. (2007). Risk management in laboratory medicine: quality assurance programs and professional competence. Clin Chem Lab Med. 45: 756 –765.

[12] Begum F. A study of pre-analytical errors in a hospital-based clinical biochemistry laboratory. IntJ Bioassays, 2014; 3(9): 3270-3275.

[13] Vacata V, Jahns-Streubel G, Baldus M, Wood WG. (2007). Practical solution for control of the pre-analytical phase in decentralized clinical laboratories for meeting the requirements of the medical laboratory accreditation standard DIN EN ISO 15189. Clin Lab. 53: 211 – 215.

[14] Clinical and Laboratory Standards Institute (CLSI). Procedures for the Collection of Diagnostic Blood Specimens by Venipuncture. Approved Standard, GP41-A6. Wayne, PA: CLSI; 2013.

[15] Howanitz PJ. (2005). Errors in laboratory medicine: practical lessons to improve patient safety. Arch Pathol Lab Med.129:1252–1261.

[16] ISO 15189:2007: Medical laboratories: requirements for quality and competence International Organization for Standardization Geneva, Switzerland.

[17] Rin G Da. (2009). Pre-analytical workstations: A tool for reducing laboratory errors. Clin Chim Acta, 404(1): 68-74.

[18] Simundic A, Lippi G. (2012). Preanalytical phase - a continuous challenge for laboratory professionals. Biochem Med, 22(2): 145-149.

[19] Sciacovelli L, Lippi G, Sumarac Z, et al. (2017). Working Group “Laboratory Errors and Patient Safety” of International Federation of Clinical Chemistry and Laboratory Medicine (IFCC). Quality Indicators in Laboratory Medicine: the status of the progress of IFCC Working Group “Laboratory Errors and Patient Safety” project. Clin Chem Lab Med. 55(3):348-357.

[20] The Joint Commission. 2014 national patient safety goals. Available at http://www.jointcommission.org/standards_information/npsgs.aspx. Accessed April 2, 2014.

[21] Kellerman PS, Thornbery JM. (2005). Pseudohyperkalemia due to pneumatic tube transport in a leukemic patient. Am J Kidney Dis. 46(4):746-748.

[22] Lippi G, Becan-McBride K, Behúlová D, et al. (2013). Pre-analytical quality improvement: in quality we trust. Clin Chem Lab Med. 51(1):229-2.

[23] American Clinical Laboratory association (ACLA). The value of lab testing. Available at http://www.acla.com/value-of-lab-testing/. Accessed April 2, 2014.

[24] Cao L, Chen M, Phipps RA, Del Guidice RE, Handy BC, Wagar EA, Meng QH. (2016). Causes and impact of specimen rejection in a clinical chemistry laboratory. Clin Chim Acta. 458: 154-158.

[25] Saleem S, Mani V, Chadwick MA, et al. (2009). A prospective study of causes of haemolysis: tourniquet time should be kept to a minimum. Ann Clin Biochem. 46(Pt 3):244- 246.

[26] Kaushik N, Green S. (2014). Pre-analytical errors: Their impact and how to minimize them. MLO Med Lab Obs 46(5): 22, 24, 26.

[27] Lippi G, Guidi GC. (2007). Risk management in the preanalytical phase of laboratory testing. Clin Chem Lab Med. 45: 720 –727.

[28] Howantiz PJ, Steindel SJ, Heard NV. (2002). Laboratory critical values policies and procedures: a College of American Pathologists Q-Probes Study in 623 institutions Arch Pathol Lab Med 126: 663–669

[29] Al-Ghaithi H, Pathare A, Al-Mamari S, Villacruris R, Fawaz N, Alkindi S. (2017). Impact of educational activities in reducing pre-analytical laboratory errors. Sultan Qaboos Univ Med J, 17(3): 309-313.

[30] Nichols JH, Bartholomew C, Brunton M et al. (2004). Reducing medical errors through barcoding at the point of care. Clin Leadersh Manag Rev. 18: 328 – 334.

[31] Dighe AS, Rao A, Coakley AB, Lewandrowski KB. (2006). Analysis of laboratory critical value reporting at a large academic medical center. Am J Pathol. 125:758–764.

[32] Ofaka CE, Nafarnda WD, Sonika RG. (2022). Quality improvements measures on pre-analytical errors in the laboratory. Texila International Journal.

[33] NCCLS. Application of a quality management system model for laboratory services; Approved Guideline: Third Edition. NCCLS document GP26-A3. NCCLS. Wayne, Pennsylvania. 2004.

[34] ISO 15189:2007. Medical laboratories: requirements for quality and competence. Geneva, Switzerland: International Organization for Standardization; 2007.

[35] Verónica Valdivieso-Gómez and Rocío Aguilar-Quesada (2018). Quality Management Systems for Laboratories and External Quality Assurance Programs, Quality Control in Laboratory, Gaffar Sarwar Zaman, IntechOpen, DOI: 10.5772/intechopen.73052.

[36] Guide to Quality in Analytical Chemistry and Aid to Accreditation. 2002 CITAC and Eurachem publishing.

[37] Roberta B. Carey, Sanjib Bhattacharyya, Sue C. Kehl, Larissa M. Matukas, Michael A. Pentella, Max Salfinger, and Audrey N. Schuetzg (2018). Implementing a Quality Management System in the Medical Microbiology Laboratory. Clinical microbiology reviews. doi 10.1128/CMR.00062-17.

Abstract:

Interpersonal Communication (IPC)between healthcare practitioners and patients enhances client satisfaction, adherence, and health outcomes. In developed countries, effective IPC improves health, but little is known about Nigeria. Using a quasi-experimental approach, this study investigated the influence of interpersonal communication training for ART practitioners on patient satisfaction in Gombe state public ART hospitals. The study looked at clients’ satisfaction before and after IPC training for ART providers. Six public ART hospitals were chosen at random; three were assigned to intervention and control groups, respectively, and 250 HIV patients receiving treatment at these facilities were chosen at random; 125 from each of the three intervention and control facilities. At both the intervention and control locations, levels of satisfaction were evaluated both before and six weeks after IPC training. The data were obtained using a Patient Satisfaction Questionnaire (PSQ), and the reliability of the questionnaire was determined using the Cronbach Alpha test (0.76). For data analysis, SPSS 22 was used. Findings revealed that, 42.4% of the clients had been living with HIV for 1-5 years and the mean client satisfaction score with their providers' IPC training was 87.5 in the intervention group and 76.45 in the control group (P = 0.05) while, the mean difference before and after training in the intervention and control groups were 0.46 and 11.05, respectively and a p-value 0.000 was obtained. Therefore, there was a positive association between higher client satisfaction with ART services and training of ART providers on IPC. It is recommended that ART facilities should receive IPC training on a regular basis.

References:

[1] Aharony, .L, Stressor, S., 1993, Patient satisfaction: what we know about and what we still need to explore. Medical Care Review, 50(1),49-79, https://doi.org/10.1177/00257087930500010.

[2] Pascoe, G.C., 1983, Patient satisfaction in primary health care: a literature review and analysis. Eval programme plan, 6(1)185-210. https://doi.org/10.1016/0149-7189(83)90002-2.

[3] Lonc., N., Polański, J., Tański, W., 2020, Impact of satisfaction with physician–patient communication on self-care and adherence in patients with hypertension: cross-sectional study. BMC Health Serv Res 20(1) 1046, https://doi.org/10.1186/s12913-020-05912-0.

[4] Ezeah, G., Ogechi, E.O., Ohia, N.C., Celestine, G.V., 2020, Measuring the effect of interpersonal communication on awareness and knowledge of COVID-19 among rural communities in Eastern Nigeria. Health Educ Res., 35(5):481-489. https://doi.org/10.1093/her/cyaa033.

[5] Reda, A.A., Biadgilign, S., 2012, Determinants of Adherence to Antiretroviral Therapy among HIV-Infected Patients in Africa. AIDS Res Treat. 574656, https://doi.org/doi:10.1155/2012/574656.

[6] Berger, R., Bulmash, B., Drori, N., Ben-Assuli, O., Herstein, R.,2020, The patient-physician relationship: an account of the physician's perspective. Isr J Health Policy Res. https://doi.orgdoi/10.1186/s13584-020-00375-4.

[7] Oche, M.O, Raji, M.O, Kaoje, A.U, Gana, G., Ango, T., Okafoagu, N., Umar, A.S., 2013, Clients satisfaction with anti retroviral therapy services in a tertiary hospital in Sokoto, Nigeria. J AIDS HIV Res, 5(9), 328-33, https://academicjournals.org/journal/JAHR/article-full-text-pdf/67BB0138037.

[8] Chichirez, C., Purcărea, V.J., Jom, L,.2018, Interpersonal communication in healthcare, Journal of Medicine and Life, 11(2), 119-122, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6101690/pdf/JMedLife-11-119.pdf.

[9] Brown L. D., De Negri B., Hernandez, O., Dominguez L, Sanchack JH, Roter D., 2000, An evaluation of the impact of training Honduran health care providers in interpersonal communication. International Journal for Quality in Health Care, 12(6), 495-501, https://pubmed.ncbi.nlm.nih.gov/11202603/.

[10] Buluba, S., Mawi, N.E., Tarimo, E. A.M., 2021, Clients' satisfaction with HIV care and treatment centres in Dar es Salaam, Tanzania: A cross-sectional study. PLoS One, 16(2), 22-23 https://doi.org/10.1371/journal.pone.0247421.

[11] Ashenafi, H., Yibeltal, K., Client, E.Y.,2017, Satisfaction and its determinants with Anti- Retroviral Therapy (ART) services in public hospitals of West Wollega Zone, Ethiopia. Galore Int J Appl Sci Human, 1(1), 23-43, www.gkpublication.in.

[12] AGENCY GSAC, 2021, Gombe State HIV/AIDS Strategic Plan 2017-2021, https://naca.gov.ng/wp-content/uploads/2018/05/National-HIV-and-AIDS-Strategic-Plan-FINAL1.pdf.

[13] Gombe State Agency for the Control of AIDS (GomSACA), 2016. Fact sheet. http://www.aessweb.com/html/3737.

[14] National AIDS & STIS Control Programme (NASCP), 2014, Annual Report on HIV/AIDS Health Sector Response in Nigeria. Federal Ministry of Health. Abuja, Nigeria. https://naca.gov.ng/wp-content/uploads/2016/11/2014-ANNUAL-REPORT-ON-HEALTH-SECTOR-HIV-and-AIDS-IN-NIGERIA.pdf.

[15] National Demographic and Household Survey (NDHS), 2008. National population Commission, Abuja, Nigeria. https://dhsprogram.com/pubs/pdf/fr222/fr222.pdf.

[16] Whitley, E., Ball, J., 2002, Statistics review 4: sample size calculations. Critical care, 6(1), 1-7, https://ccforum.biomedcentral.com/articles/10.1186/cc1521.

[17] Tanveer, F., Shahid, S., Hafeez, M. M., 2018, Impact of doctor’s interpersonal communication skill on patient’s satisfaction level. Isra Med J, 10(5), 306-309, https://www.researchgate.net/publication/325603811.

[18] Thayaparan, A.J., Mahdi, E., 2013, The Patient Satisfaction Questionnaire Short Form (PSQ-18) as an adaptable, reliable, and validated tool for use in various settings. Med Educ Online, 18(1), 21747. http://doi:10.3402/meo.v18i0.21747.

[19] Wung, B.A., Peter, N.F., Atashili, J., 2015, Clients' satisfaction with HIV treatment services in Bamenda, Cameroon: A cross-sectional study. BMC Health Serv Res, 16:280, https://bmchealthservres.biomedcentral.com/counter/pdf/10.1186/s12913-016-1512-5.pdf.

[20] Mosha, F.,Victor, M., Matetee, M., Raphael,Z.S., Jurgen, V., Nsubuga, P., 2013, Gender difference in HIV disease progression and treatment outcomes among HIV patients one year after starting antiretroviral treatment (ART) in Dar es Salaam, Tanzania). BMC Public Health, 13(38), 1-7, http://www.biomedcentral.com/1471-2458/13/38.

[21] Cornell, M., Schomaker, M., Garone, D.B., Giddy, J., Hoffmann, C.J., Lessells, R., 2012, Gender differences in survival among adult patients starting antiretroviral therapy in South Africa: a multicentre cohort study. PLoS Med, 9(1), https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1001304.

[22] Sachdeva, R.K., Wanchu, A., 2008, Women’s issues in HIV infection. JK Science, 8(3), 129–132, https://www.jkscience.org/archive/Volume83/womens.pdf.

[23] Cornell, M., 2013, Gender inequality: bad for men’s health. S Afr J HIV Med, 14(1):12–14, https://dx.doi.org/10.7196/sajhivmed.894.

[24] Labor Force Statistics - Volume I: Unemployment and Underemployment Report (Q4 2017-Q3 2018), https://nigerianstat.gov.ng/elibrary?queries[search]=unemployment.

[25] Braitstein, P., Boulle, A., Nash, D., Brinkhof, M.W., Dabis, F., Laurent, C., 2008, Gender and the use of antiretroviral treatment in resource‐constrained settings: findings from a multicenter collaboration. J Women's Health, 17(1), 47–55, https://www.liebertpub.com/doi/10.1089/jwh.2007.0353.

[26] National Population Commission, 2015, Nigeria Education Data Survey (NEDS), Gombe report,https://www.nigerianstat.gov.ng/pdfuploads/Gombe_PDF_rev.compressed.pdf.

[27] Carter, A., Eun, M. J., Chau,W., Lima, V.D., Kestler, M., 2014, Gender Inequities in Quality of Care among HIV-Positive Individuals Initiating Antiretroviral Treatment in British Columbia, Canada (2000–2010). PLOS ONE 9(3), 1-7, https://doi.org/10.1371/journal.pone.0092334.

[28] Kiflay, G., Daniel, A., 2018, High antiretroviral therapy service delivery satisfaction and its associated factors at Midre-genet hospital; Northwest Tigray, Ethiopia. BMC Health Serv Res, 8(1), 223. https://dx.doi.org/10.1186/s12913-018-3055-4.

[29] Natsayi, C.H., Til,l B., Marie, L., 2014, Patient satisfaction with HIV and TB treatment in a public program in rural KwaZulu-Natal: evidence from patient-exit interviews. BMC Health Serv Res, 14(32), http://www.biomedcentral.com/1472-6963/14/32.

[30] Tessema, S.B., Adane, M.M., 2015, Assessment of antiretroviral treatment (ART) care service provision in Tigray Region health centers, North Ethiopia. BMC Health Serv Res, 15(368), https://doi.org/10.1186/s12913-015-1032-8.

[31] Farghaly, M., Kamal, A., El-Setouhy, M., Hirshon, J. M., El-Shinawi, M., 2021, Patient satisfaction with a tertiary hospital in Egypt using a HCAHPS-derived survey. Journal of Multidisciplinary Healthcare, 1(1), 3053-3060, https://doi.org/10.2147/JMDH.S317322.

[32] Doyore, F., Moges, B., 2016, Client satisfaction to antiretroviral treatment services and associated factors among clients attending ART clinics in Hossana Town, Southern Ethiopia. Clin Res Trials, 2(6), 1-8, https://doi.org/10.1186/s12913-020-4934-z.

[33] Kiflay, G., Daniel, A., 2018, High antiretroviral therapy service delivery satisfaction and its associated factors at Midre-genet hospital; Northwest Tigray, Ethiopia. BMC Health Serv Res, 8(1), 223. https://dx.doi.org/10.1186/s12913-018-3055-4.

[34] Greenwood, J., 2013, The importance of the Interpersonal communication process within the health care workplace, https://work.chron.com/importance-interpersonal-communication-process-within-health-care-workplace-7377.html.

[35] Alsayali, M. M., Al-Sahafi, A., Mandoura, N., Shah, H. B. U., Rashid, O. A. A., AlSharif, K., Mohammad, A. I., 2019, Patients’ Satisfaction after Primary Health Care Centers’ Integration with Ministry of Health Hospitals, Jeddah. Journal of Epidemiology and Global Health, 9(2), 135, https://pubmed.ncbi.nlm.nih.gov/31241872/.

[36] Young, G.J., Meterko, M., Desai, K.R., 2000 Patient satisfaction with hospital care: effects of demographic and institutional characteristics. , 1(1), 325-34, https://pubmed.ncbi.nlm.nih.gov/10718357/.

[37] Jatulis DE, Bundek NI, Legorreta APJAJoMQ. Identifying predictors of satisfaction with access to medical care and quality of care. 1997;12(1):11-7, https://pubmed.ncbi.nlm.nih.gov/9116525/.

Abstract:

The incidence of breast cancer is increasing in many underdeveloped nations and constituted a major public health burden. Despite this, most breast cancer patients in many underdeveloped nations present with late diseases when few options of treatment are available. Early detection through screening remains the main means of improving breast cancer outcomes. Nurses are a group of healthcare professionals and are thus expected to advocate for breast cancer screening programs. This study was conducted to determine the extent of utilisation and predictors of the practice of breast self-examination among nurses in a tertiary health care centre. The study prospectively surveyed 189 nurses on knowledge and practice of breast self-examination (BSE) using a stratified random sampling technique. Data were obtained through a pretested self-administered structured questionnaire. The mean age of the respondents was 41.44 (±5.66) years. Sixty-seven (35.4%) of the respondents practiced BSE of which only 31.3% practiced it monthly as recommended. Family history of breast cancer (p<0.001), age greater than 50 (p<0.001), post-menopausal women (p<0.001), and posting in surgical-related wards (p<0.001) were significantly associated with the practice of BSE. The practice of BSE among the respondents was poor and the few who practiced it lacked the correct technique. The teaching of BSE should be encouraged at nursing schools with an emphasis on practice and techniques. We also suggest a need for continued nursing education.

References:

[1] Ezeome ER. Delay in presentation and treatment of breast cancer in Enugu, Nigeria. Nigerian Journal of Clinical Practice. 2010; 13(3):311-316.

[2] Anyawu SNC. Temporal Trends in Breast Cancer Presentation in the third World UICC World Cancer Congress. Washington DC 2006.

[3] Akanbi O O, Adeoti ML, Aderounmu AOA, Idris O and Abayomi O. Delay presentation of breast cancer: A study among southwestern Nigerian women. International Journal of Current Research. 2015:7.

[4] Nakhichevan NO and Secginli. Health belief related to breast self-examination in a sample of Turkish women. Oncol Nurs Forum 2007;8:5-10.

[5] Baxter N. Canadian task force on preventive health care. Preventive Health Care. 2001 update: should women be routinely taught self-breast examination to screen for breast cancer? CMAJ. 2001;164:1837-46.

[6] Akhtari-Zavare M., Latiff L.A., Juni M.H., S. Said S.M., Ismail I.Z. Knowledge of female undergraduate students on breast cancer and breast self-examination in Klang Valley, Malaysia. Asian Pacific Journal of Cancer Prevention. 2015;16(15):6231–6235.

[7] Banaian SH, Kazemian A, Soleiman KH. Knowledge, attitude, and practice among women referred to health centers in Broojen about screening methods of breast cancer. J Shahrekord Univ Med Sci. 2005; 7:28-34.

[8] Family Planning association of Hong Kong. Report on Women’s Health Survey. Hong Kong: Family Planning Association of Hong Kong. !996.

[9] Nwagbo DF, Akpala OO. Awareness of breast cancer and breast –self-examination among women in Enugu urban, Eastern Nigeria. J Coll. Med. 1996; 1:34-6.

[10] Irurhe NK et al. Knowledge, attitude, and practices of BSE among female medical Students in the University of Lagos. The Internet Journal of Health.,2011,12 (1).

[11] Alkhasawneh LM, Akhu-Zaheya LM, Suleiman SM. Knowledge and practice of self-breast examination. J Adv Nurs. 2009;65:412-6.

[12] Ibraim NA, Odusanya OO. Knowledge of risk factors, beliefs and practices of female health care professionals towards breast cancer in a tertiary institution in Lagos, Nigeria. BMC Cancer 2009;9:76.

[13] Akhigbe AO, Omuemu VO. Knowledge, attitude and practice of breast cancer screening among female health care workers in a Nigerian Urban city. BMC Cancer. 2009;9:203.

[14] Agboola AO, Deji-Agboola AM, Oritogun KS, Musa AA, Oyebadejo TY, Ayoade BA. Knowledge, attitude, and practice of female health care workers in Olabisi Onabanjo University Teaching Hospital, Sagamu, Nigeria. Int Med J 2007;8:5-10.

[15] Al-Naggar RA, DH, Bobryshev YV, Chan R, Assabri A. Practice and barrier towards self-breast examination among young Malaysian women. Asian Pac J Cncer Prev. 2011;12:1173-8.

[16] Karima FE, Ashraf MS, knowledge, and practice of breast cancer screening among Egyptian nurses. J Heamatol Oncol. 2010;1:122-8.

[17] Fondjo LA, Owusu-Afriye O, Osei-Bonsu E et al. prevalence of comorbidities and quality of life assessment among breast cancer patients at the Komfo Anokye Teaching Hospital: a descriptive cross-sectional study. Edorium J Cancer 2017;3:1-9.

[18] Godazande GH, Khani H, Khalilian AR, Atarod Z, Firouzjai MA, Partoei A et al. knowledge and practice of women over 15 years about breast cancer in Sari. J Mazandaran Univ Med Sci. 2006;16:64-74.

[19] Karayurt O, Dramali A. Adaptation of Champion’s Health Belief Model Scale for Turkish women and evaluation of the selected variables associated with breast self-examination. Cancer Nurs. 2007;30:69-77.

[20] Montgomery GH, Erblich J, DiLorenzo T, Bovberg DH. Family and friend with disease: their
impact on perceived risk. Prev Med 2003;37:242-9.

[21] Habib F, Salman M, Shalaby S. Awareness, and knowledge of breast cancer Among University Students in Al Madina Al Munawara Region. Middle East J Cancer. 2010;1:159-66.

[22] Chong PN, Krishnan M, Hong CY, Swash TS. Knowledge and practice of breast cancer screening amongst public health nurses in Singapore. Singapore Med J. 2002;43:509-16.

[23] Abdel-Fattah M, Zaki A, Basili A, El-Shzly M, Tognoni G. Breast self-examination practice and its impact on breast cancer diagnosis in Alexandria, Egypt. East Mediterr Health J. 2000;6:34-40.

Abstract:

Vaccination is very important to improve population health throughout life – but despite strong evidence, it is misunderstood and undervalued. Catch-up vaccination aims to provide optimal protection against disease as quickly as possible by completing a person’s recommended vaccination schedule in the shortest but most effective time frame. This descriptive cross-sectional implementation Research was designed to solve problems for Covid–19 recoveries for routine immunization program in private Nursery and primary school in Kosofe Local Government Area Lagos (School-based intervention). The sample size of 135 was adopted with purposive sampling method from the target population. All data were coded, entered, cleaned, and then analyzed using the IBM PSPP. Children that missed vaccination were tracked out more (90) and vaccinated, demand generation with the help of vaccine demand pooling in school for secondary vaccines, the awareness of vaccine-preventable diseases were created more at different schools Parents Teachers Association's meetings. Implementation Research is one of the measures and a component in the Immunization Agenda 2030 (IA 2030) designed to achieve the Life course immunization. Creating awareness and sensitization is very important in schools, especially using the power of storytelling for positive change in vaccination uptake. There are parents who can afford to pay for secondary vaccines but don't have the information and there are parents who have the information but can't afford to pay for secondary vaccines due to economic hardship in Nigeria. We recommend that vaccine demand pooling in schools is championed to enable parents to afford secondary vaccines for their children.

References:

[1] Odis Adaora Isabella, Ogbenna Ann, Okpoko Pius, Ganu Daniel, (2022), Epidemics and Vaccination Dilemma in Complex Networks: A Case Study of Kosefe and Shomolu Local Government Area Lagos Nigeria, Texila International Journal of Academic Research, Special Edition Apr 2022, DOI: 10.21522/TIJAR.2014.SE.22.01.Art002. https://www.texilajournal.com/adminlogin/download.php?category=article&file=Academic%20Research_Special_Edition_021.pdf.

[2] Ophori EA, Tula YM, Azih A, Okojie R, Ikpo PE. (2014) “Current Trends of Immunization in Nigeria: Prospect and Challenges”. Tropical Medicine and Health. Vol. 42, no. 2, pp., 67–75. Article PubMed PubMed Central Google Scholar.

[3] Aniekan J. Etokidem, EnNsan and Wo Ndifon, (2013), “Myths and misconceptions as barriers to uptake of immunization services in Nigeria”, 3rd International Conference on Vaccines & Vaccination, July 29-31, 2013, Embassy Suites Las Vegas, NV, USA. https://www.longdom.org/proceedings/myths-and-misconceptions-as-barriers-to-uptake-of-immunization-services-in-nigeria-1153.html.

[4] Adedokun, S.T., Uthman, O.A., Adekanmbi, V.T. et al., (2017), “Incomplete childhood immunization in Nigeria: a multilevel analysis of individual and contextual factors”. BMC Public child health services” Department of Community Health and Primary Care, College of Medicine, University of Lagos, Lagos, Nigeria.

[5] WHO, 2022, Essential Programme on Immunization https://www.who.int/teams/immunization-vaccines-and-biologicals/essential-programme-on-immunization/implementation/catch-up-vaccination.

[6] Shahara reporters “Nigeria Loses 466 Persons To Cholera In 2022 – Monitoring Agency, NCDC” https://saharareporters.com/2022/11/26/nigeria-loses-466-persons-cholera-2022-monitoring-agency-ncdc.

[7] Anyichie Odis Adaora, 2022, Ethical approval https://www.linkedin.com/posts/dr-adaora-anyichie-odis-ph-d-5163a913_ethical-approval-activity-6970458432952766464-_j5-?utm_source=share&utm_medium=member_desktop.

[8] Anyichie Odis Adaora, 2022, Approval from Lagos state Ministry of health to conduct research https://www.linkedin.com/posts/dr-adaora-anyichie-odis-ph-d-5163a913_lagos-state-ministry-of-health-activity-6978139769914408960-6wVb?utm_source=share&utm_medium=member_desktop.

[9] WHO, 2021, Leave no one behind: guidance for planning and implementing catch-up vaccination https://apps.who.int/iris/rest/bitstreams/1342095/retrieve.

[10] Australian Technical Advisory Group on Immunisation (ATAGI), 2022, Australian Immunisation Handbook, Australian Government Department of Health, Canberra: Catch-up vaccination https://immunisationhandbook.health.gov.au/contents/catch-up-vaccination.

[11] Anyichie Odis Adaora, 2022, Respondent informed consent form https://www.linkedin.com/posts/dr-adaora-anyichie-odis-ph-d-5163a913_respondent informed-consent-form-activity-6988132525973884929 Hmfl?utm_source=share&utm_medium=member_desktop.

[12] Anyichie Odis Adaora, 2022, Sensitization, https://www.linkedin.com/posts/dr-adaora-anyichie-odis-ph-d-5163a913_vaccinessavelives-vaccineswork-vacciness-activity-6996109506078232576-D9sA?utm_source=share&utm_medium=member_desktop.

[13] Anyichie Odis Adaora, 2022, Demand pooling, https://www.linkedin.com/posts/dr-adaora-anyichie-odis-ph-d-5163a913_vaccinessavelives-research-merck-activity-6998034050619719680-HGgz?utm_source=share&utm_medium=member_desktop.

[14] Anyichie Odis Adaora, 2023, Implementation research approach pg. 5 of ppt https://www.linkedin.com/posts/dr-adaora-anyichie-odis-ph-d-5163a913_implementation-research-ppt-activity-7034149378349015040-ndKb?utm_source=share&utm_medium=member_desktop.

[15] Anyichie Odis Adaora, 2022, Sensitization, https://www.linkedin.com/posts/dr-adaora-anyichie-odis-ph-d-5163a913_lagos-who-unicef-activity-6989470780539441152-y0A3?utm_source=share&utm_medium=member_desktop.

[16] Sun News, 2022, FG introduces HPV, malaria vaccines in routine immunization https://www.operanewsapp.com/ng/en/share/detail?news_id=746500b57949481c75c013a12122c1b6&news_entry_id=d5d5a52230209en_ng&open_type=transcoded&from=news&request_id=share_request.

[17] Anyichie Odis Adaora, 2022, Challenges in scaling up intervention, https://www.linkedin.com/posts/dr-adaora-anyichie-odis-ph-d-5163a913_research-implementationresearch-tdr-activity-6970813497827831808-9Pzz?utm_source=share&utm_medium=member_desktop.

[18] Anyichie Odis Adaora, 2023, Communication https://www.linkedin.com/posts/dr-adaora-anyichie-odis-ph-d-5163a913_communication-administration-planning-activity-7022145547830501376-TkxE?utm_source=share&utm_medium=member_desktop.

[19] Burches E, Burches M (2020) Efficacy, Effectiveness and Efficiency in the Health Care: The Need for an Agreement to Clarify its Meaning. Int Arch Public Health Community Med 4:035. https://www.clinmedjournals.org/articles/iaphcm/international-archives-of-public-health-and-community-medicine-iaphcm-4-035.php?jid=iaphcm.

[20] News desk, 2023, Nigeria diphtheria outbreak update: More than 300 confirmed cases Diphtheria http://outbreaknewstoday.com/nigeria-diphtheria-outbreak-update-more-than-300-confirmed-cases-53006/.

Abstract:

It is well documented in the literature that there is poor treatment outcome in patients with Tuberculosis and Diabetes (TBDM) comorbidity due to the observed interference of drugs for Tuberculosis (TB) treatment on anti-diabetic drugs and elevated glucose level reduces the efficacy of anti- tuberculosis drugs leading to poor TB treatment outcome, and that insulin therapy is not affected by this drug interaction. Importantly, access to Insulin is a challenge due to its prohibitive out-of-pocket cost. The only alternative sustainable treatment for TBDM patients in resource-limited communities is lifestyle-based intervention. This study evaluated the impact of lifestyle intervention on TB treatment outcomes in patients with TBDM comorbidity. This study is a quasi-experimental intervention involving two cohorts of 25 TBDM patients each, as control and experimental cohorts. Their enrolment was from Tuberculosis patients from health facilities in Lagos and Oyo states. The questionnaires were administered before the commencement of the Intervention and at 8 weeks. The sputum Acid Fast Bacillus (AFB) was checked, and chest x-ray (CXR) done before Intervention and Sputum AFB at 8 weeks. The Control group showed no difference in the means of the sputum AFB 95%CI: 0.12(- 0.12 – 0.36; p>0.05), which was an indication of poor treatment outcome. The difference in the means of the sputum AFB in the intervention group was statistically significant 95%CI: -0.8(-0.9 - -0.6; p<0.05). The intervention with educational and behavioral lifestyle modifications significantly improved the outcome of treatment of TB in TBDM comorbidity.

References:

[1] World Health Organization. (2020). Tuberculosis. https://www.who.int/news-room/fact- sheets/detail/tuberculosis. Assessed 15/04/21.

[2] Afroz, A., Alramadan, M. J., Hossain, M. N., Romero, L., Alam, K., Magliano, D. J., & Billah, B. (2018). Cost-of-illness of type 2 diabetes mellitus in low and lower-middle-income countries: a systematic review. BMC health services research, 18(1), 972. https://doi.org/10.1186/s12913-018-3772-8.

[3] Lin, X., Xu, Y., Pan, X. et al. (2020). Global, regional, and national burden and trend of Diabetes in 195 countries and territories: an analysis from 1990 to 2025. SciRep 10, 14790. https://doi.org/10.1038/s41598-020-71908-9.

[4] Dunachie, S., & Chamnan, P. (2019). The double burden of Diabetes and global infection in low and middle-income countries. Transactions of the Royal Society of Tropical Medicine and Hygiene, 113(2), 56–64. https://doi.org/10.1093/trstmh/try124.

[5] Saklayen M. G. (2018). The Global Epidemic of the Metabolic Syndrome. Current hypertension reports, 20(2), 12. https://doi.org/10.1007/s11906-018-0812-z.

[6] York E, Atiase Y, et al. (2017). The Bidirectional Relationship between Tuberculosis and Diabetes. Tuberculosis Research and Treatment.1702578. https://doi.org/10.1155/2017/1702578. Assessed 16/04/21.

[7] Silva, D. R., Muñoz-Torrico, M., Duarte, R., Galvão, T., Bonini, E. H., Arbex, F. F., Arbex, M. A., Augusto, V. M., Rabahi, M. F., & Mello, F. (2018). Risk factors for tuberculosis: diabetes, smoking, alcohol use, and the use of other drugs. Jornal brasileiro de pneumologia: publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia, 44(2), 145–152. https://doi.org/10.1590/s1806-37562017000000443.

[8] Sahakyan, S., Petrosyan, V., & Abrahamyan, L. (2020). Diabetes mellitus and treatment outcomes of pulmonary Tuberculosis: a cohort study. International journal of public health, 65(1), 37–43. https://doi.org/10.1007/s00038-019-01277-2.

[9] Ayelign, B., Negash, M., Genetu, M., Wondmagegn, T., & Shibabaw, T. (2019). Immunological Impacts of Diabetes on the Susceptibility of Mycobacterium tuberculosis. Journal of immunology research, 2019, 6196532. https://doi.org/10.1155/2019/6196532.

[10] Mahishale, V., Avuthu, S., Patil, B., Lolly, M., Eti, A., & Khan, S. (2017). Effect of Poor Glycemic Control in Newly Diagnosed Patients with Smear-Positive Pulmonary Tuberculosis and Type-2 Diabetes Mellitus. Iranian journal of medical sciences, 42(2), 144–151. Available at http://www.ncbi.nlm.nih.gov>articles>PMC5366362. Accessed 22/05/21.

[11] Alawode, G.O., Adewole, D.A. (2021). Assessment of the design and implementation challenges of the National Health Insurance Scheme in Nigeria: a qualitative study among sub- national level actors, healthcare, and insurance providers. BMC Public Health 21,124. https://doi.org/10.1186/s12889-020-10133-5. Accessed 23/04/2021.

[12] Wenzel, I. C.., Silva, K. A.., Furino, V. de O.., Duarte, F. O.., Castro, C. A. de, & Duarte, A. C. G. O. (2022). Impact of Postural Corrective Training (TCP®) on overall glycemic control in diabetic middle-aged women. Research, Society and Development, 11(14), e194111435600. https://doi.org/10.33448/rsd-v11i14.35600).

[13] Kirwan, J. P., Sacks, J., & Nieuwoudt, S. (2017). The essential role of exercise in the management of type 2 diabetes. Cleveland Clinic journal of medicine, 84(7 Suppl 1), S15–S21. https://doi.org/10.3949/ccjm.84.s1.03.

[14] Yang D, Yang Y, Li Y, Han R. (2019). Physical Exercise as Therapy for Type 2 Diabetes Mellitus: From Mechanism to Orientation. Ann Nutr Metab. 74:313–321. DOI: 10.1159/000500110.

[15] Katula, J. A., Kirk, J. K., Pedley, C. F., Savoca, M. R., Effoe, V. S., Bell, R. A., Bertoni, A. G., & LIFT Diabetes Team (2017). The Lifestyle Intervention for the Treatment of Diabetes study (LIFT Diabetes): Design and baseline characteristics for a randomized translational trial to improve control of cardiovascular disease risk factors. Contemporary clinical trials, 53, 89–99. https://doi.org/10.1016/j.cct.2016.12.005.

[16] Alessandra Celli, Yoann Barnouin, Bryan Jiang, Dean Blevins, Georgia Colleluori, Sanjay Mediwala, Reina Armamento-Villareal, Clifford Qualls, Dennis T. Villareal. (2022). Lifestyle Intervention Strategy to Treat Diabetes in Older Adults: A Randomized Controlled Trial. Diabetes Care. 45 (9), 1943–1952. https://doi.org/10.2337/dc22-0338.

[17] Middelbeek, R.J.W., Hafida, S., Schrager, C. (2022). Medical Nutrition Therapy for the Treatment of Diabetes: Prioritizing Recommendations Based on Evidence. In: Wilson, T., Temple, N.J., Bray, G.A. (eds) Nutrition Guide for Physicians and Related Healthcare Professions. Nutrition and Health. Humana, Cham. https://doi.org/10.1007/978-3-030-82515-7_10.

[18] Sami, W., Ansari, T., Butt, N. S., & Hamid, M. R. A. (2017). Effect of diet on type 2 diabetes mellitus: A review. International journal of health sciences, 11(2), 65–71.

[19] Yoshino, M., Kayser, B. D., Yoshino, J., Stein, R. I., Reeds, D., Eagon, J. C., ... & Klein, S. (2020). Effects of diet versus gastric bypass on metabolic function in diabetes. New England Journal of Medicine, 383(8), 721-732.

[20] World Health Organization. (2018). Latent TB Infection: Updated and consolidated guidelines for programmatic management. https://www.who.int/tb/publications/2018/latent-tuberculosis- infection/en/. Assessed 19/04/21.

[21] Asemahagn, M.A. (2021). Sputum smear conversion and associated factors among smear-positive pulmonary tuberculosis patients in East Gojjam Zone, Northwest Ethiopia: a longitudinal study. BMC Pulm Med 21, 118. https://doi.org/10.1186/s12890-021-01483-w.

[22] Centers for Disease Control and Prevention (.gov). › eat-well › meal-plan-method. https://www.cdc.gov.

[23] Wolff, K., Cavanaugh, K., Malone, R., et al. (2009). The Diabetes Literacy and Numeracy Education Toolkit (DLNET): materials to facilitate diabetes education and management in patients with low literacy and numeracy skills. The Diabetes Educator. 35(2):233-6, 238-41, 244-5. DOI: 10.1177/0145721709331945.

[24] Africa, S. S. (2006). Diabetes Education Training Manual. www.worlddiabetesfoundation.org.

[25] Rekha, V. B., Balasubramanian, R., Swaminathan, S., Ramachandran, R., Rahman, F., Sundaram, V., ... & Narayanan, P. R. (2007). Sputum conversion at the end of intensive phase of Category-1 regimen in the treatment of pulmonary tuberculosis patients with diabetes mellitus or HIV infection: An analysis of risk factors. Indian Journal of Medical Research, 126(5), 452-458.

[26] Odume, B., Falokun, V., Chukwuogo, O., Ogbudebe, C., Useni, S., Nwokoye, N., Aniwada, E., Olusola Faleye, B., Okekearu, I., Nongo, D., Odusote, T., & Lawanson, A. (2020). Impact of COVID-19 on TB active case finding in Nigeria. Public health action, 10(4), 157–162. https://doi.org/10.5588/pha.20.0037.

[27] Essar, M. Y., Nemat, A., Ahmad, S., Zil-E-Ali, A., Marzo, R. R., & Head, M. (2022). Highlighting the forgotten: Tuberculosis amidst the humanitarian crisis and COVID-19 in Afghanistan. Annals of medicine and surgery (2012), 77, 103671. https://doi.org/10.1016/j.amsu.2022.103671.

[28] Nwene E. K. (2016). Tuberculosis and gender in nigeria, sex differences in diagnosis and treatment outcome of tb and tb hiv infected patients. Texila international journal of public health ISSN: 2520-3134. DOI: 10.21522/TIJPH.2013.04.04.Art035.

[29] Enikuomehin, A., Kolawole, B. A., Soyoye, O. D., Adebayo, J. O., & Ikem, R. T. (2020). Influence of gender on the distribution of type 2 diabetic complications at the obafemi awolowo teaching hospital, Ile-Ife, Nigeria. African health sciences, 20(1), 294–307. https://doi.org/10.4314/ahs.v20i1.35.

Abstract:

This study conducted a comparative case study analysis of the HIV program in Nigeria’s South-South and North-East regions of Nigeria to determine the access and quality of HIV care and treatment services. Service delivery is an essential component of the WHO Health systems framework. Data were collected from 385 respondents using structured questionnaires and analysed using descriptive and inferential statistics. The study found that the North-East region of Nigeria had significantly lower numbers of primary healthcare facilities and inpatient beds per 10,000 population compared to the South-South region. The North-East region had an average of 0.02 inpatient beds per 1,000 population, significantly below the WHO standard, while the South-South region had an average of 0.18 inpatient beds per 1,000 population, relatively closer to the WHO standard. The general service readiness score for delivering HIV program services was at least 94% in all health facilities in both the North-East and South-South regions. The HIV service readiness index for the North-East region was higher than that of the South-South region, with some disparities in the availability of national ART guidelines, national HIV counselling and testing guidelines, staff training, and availability of HIV prevention services. HIV testing and counselling services were described as readily available and accessible in both regions, with some communities taking ownership of promoting the availability of these services. However, both regions had a relatively high service readiness score for delivering HIV program services, with some disparities in the availability of national guidelines and training of staff. These findings demonstrate extensive investment of government and donor agencies in delivering quality HIV services with areas to improve to ensure alignment with WHO system strengthening framework.

References:

[1] WHO. (2019). World Health Organisation. Health Systems Strengthening Glossary; 2019. Retrieved Online.

[2] Stephanie Kandasami, Shamsuzzoha Babar Syed, Anbrasi Edward, Sodzi Sodzi-Tettey, Ezequiel Garcia-Elorrio, Nana Mensah Abrampah, Peter M Hansen, Institutionalizing Quality Within National Health Systems: Key Ingredients For Success, International Journal For Quality In Health Care, Volume 31, Issue 9, November 2019, Pages G136–G138, https://Doi.Org/10.1093/Intqhc/Mzz116.

[3] Haldane V, Chuah Flh, Srivastava A, Singh Sr, Koh Gch, Seng Ck, Legido-Quigley H. Community Participation In Health Services Development, Implementation, And Evaluation: A Systematic Review Of Empowerment, Health, Community, And Process Outcomes. Plos One. 2019 May 10;14(5):E0216112. Doi: 10.1371/Journal.Pone.0216112. Pmid: 31075120; Pmcid: Pmc6510456.

[4] Izugbara, C. O., & Wekesah, F. (2019). HIV epidemic and human rights in Nigeria: Harm reduction and equitable access to prevention and treatment services. BMC international health and human rights, 19(1), 1-9. doi: 10.1186/s12914-019-0195-6.

[5] Odafe, S., Torpey, K., Khamofu, H., Ogbanufe, O., Oladele, E., Kuti, O., ... & Idoko, J. (2012). Integrating HIV care into primary health care services: impact on patient satisfaction and stigma in rural Nigeria. Patient preference and adherence, 6, 115-122. doi: 10.2147/PPA.S29852.

[6] Adebajo, S., Obianwu, O., Eluwa, G., Vu, L., Oginni, A., Tunji-Ajayi, T., ... & Charurat, M. (2017). Evaluating the effectiveness of a community-based peer-led intervention for reducing HIV-related stigma and discrimination in Nigeria. AIDS and Behavior, 21(8), 2234-2245. doi: 10.1007/s10461-017-1699-2.

[7] Shrivastava, S. R., Shrivastava, P. S., & Ramasamy, J. (2015). Exploring the determinants of HIV epidemic in Nigeria. Annals of Tropical Medicine and Public Health, 8(3), 58-59. doi: 10.4103/1755-6783.157124.

[8] Grimsrud, A., Bygrave, H., Doherty, M., Ehrenkranz, P., Ellman, T., Ferris, R., Ford, N., Killingo, B., Kruger, J., Lee, J., Mamvura, C., Mansoor, L., Maruva, M., Mohapi, L., Mohammed, S., Moyo, S., Ncube, K., & Phillips, A. (2016). Reimagining HIV service delivery: the role of differentiated care from prevention to suppression. Journal of the International AIDS Society, 19(1), 21484.

[9] Delvaux, T., Samreth, S., Barr-DiChiara, M., & Kanal, K. (2019). Decentralization of HIV care and treatment services in Central Province, Zambia: Implementation progress and challenges. Journal of public health in Africa, 10(Suppl 2), 121-127. doi: 10.4081/jphia.2019.1391.

[10] Kipp, W., Konde-Lule, J., Rubaale, T., & Okech-Ojony, J. (2016). From decentralization to integrated care: A case study of the evolution of a comprehensive HIV/AIDS care program in western Uganda. International Journal of Integrated Care, 16(2), 1-14. doi: 10.5334/ijic.1974.

[11] Kredo, T., Adeniyi, F. B., Bateganya, M. H., & Pienaar, E. D. (2014). Task shifting from doctors to non-doctors for initiation and maintenance of antiretroviral therapy. Cochrane Database of Systematic Reviews, (7), CD007331. doi: 10.1002/14651858.CD007331.pub3.

[12] Medley, A., Bachanas, P., Grillo, M., Hasen, N., & Amanyeiwe, U. (2019). Strengthening differentiated care for clients with HIV: A toolkit for health facilities. Journal of the International AIDS Society, 22(Suppl 4), e25315. doi: 10.1002/jia2.25315.

[13] Ajisegiri Ws, Abimbola S, Tesema Ag, Odusanya Oo, Peiris D, Joshi R (2022) The Organisation Of Primary Health Care Service Delivery For Non-Communicable Diseases In Nigeria: A Case-Study Analysis. Plos Glob Public Health 2(7): E0000566. https://Doi.Org/10.1371/Journal.Pgph.0000566.

[14] Azeez Ia, Dairo Md, Akinyemi Jo. Treatment Response in Adult Patients with Hypertension Attending A Secondary Health Care Center In South-West Nigeria. Ann Ib Postgrad Med. 2019 Dec;17(2):138-144. Pmid: 32669990; Pmcid: Pmc7358807.

[15] Oleribe, O. O., Salako, B. L., & Ka, M. M. (2018). Public health implications of inadequate funding for the Nigerian health sector. Health services insights, 11, 1178632918760560. https://doi.org/10.1177/1178632918760560.

[16] Oladipo, J. A., & Ishola, S. O. (2019). Challenges facing healthcare delivery in Nigeria: The role of philanthropy. International Journal of Humanities and Social Science Research, 2(2), 50-58. https://doi.org/10.11648/j.hssr.20190302.11.

[17] Mbachu, C., & Azuike, E. C. (2020). Donor funding and health systems performance in Nigeria. International Journal of Health Policy and Management, 9(10), 422-429. https://doi.org/10.34172/ijhpm.2020.97.

[18] National Agency for The Control of Aids (Naca), Global Aids Response Country Progress Report, Abuja, Nigeria, 2015.

[19] Kruk, M. E., Gage, A. D., Arsenault, C., Jordan, K., Leslie, H. H., Roder-DeWan, S., ... & Adanu, R. M. (2018). High-quality health systems in the Sustainable Development Goals era: time for a revolution. The Lancet Global Health, 6(11), e1196-e1252. doi: 10.1016/S2214-109X(18)30386-3.

[20] Nesbitt, R. C., Lohela, T. J., Manu, A., Vesel, L., Okyere, E., Edmond, K. M., & Kirkwood, B. R. (2016). Quality along the continuum: a health facility assessment of intrapartum and postnatal care in Ghana. PloS One, 11(11), e0166623. doi: 10.1371/journal.pone.0166623.

[21] Boerma, T., AbouZahr, C., Evans, D., & Evans, T. (2018). Monitoring intervention coverage in the context of universal health coverage. PLoS Medicine, 15(1), e1002503. doi: 10.1371/journal.pmed.1002503.

[22] Gupta, I., & Trivedi, M. (2019). A critical analysis of health system readiness for health promotion in India. Journal of Public Health Policy, 40(3), 310-325. doi: 10.1057/s41271-019-00173-w.

[23] Ahmed, S., Autrey, J., Katz, I. T., Fox, M. P., Rosen, S., & Onoya, D. (2018). Why do people living with HIV not initiate treatment? A systematic review of qualitative evidence from low- and middle-income countries. Social Science & Medicine, 213, 72-84. doi: 10.1016/j.socscimed.2018.07.034.

[24] Medlock, J., & Pandey, A. (2017). The effect of HIV testing and counselling on HIV prevention and care: a systematic review of the literature. AIDS Care, 29(12), 1471-1478. doi: 10.1080/09540121.2017.1333849.

[25] Topp, S. M., Chipukuma, J. M., Giganti, M., Mwango, L. K., Chiko, M. M., Tambatamba-Chapula, B., & Reid, S. E. (2015). Strengthening health systems at facility-level: feasibility of integrating antiretroviral therapy into primary health care services in Lusaka, Zambia. PLoS ONE, 10(7), e0133336. doi: 10.1371/journal.pone.0133336.

[26] Ayisi Addo, S., Abdulai, M., Yawson, A. Et Al. Availability of HIV Services Along The Continuum Of HIV Testing, Care And Treatment In Ghana. Bmc Health Serv Res 18, 739 (2018). https://Doi.Org/10.1186/S12913-018-3485-Z.

[27] Aliyu, A. A., Dahiru, T., & Amadu, L. (2020). Geographical and sociodemographic factors associated with access to healthcare in Nigeria: a national population-based survey. PloS one, 15(9), e0238801. https://doi.org/10.1371/journal.pone.0238801.

[28] Ogbonna, B. O., & Adebayo, S. B. (2021). Health inequality and regional disparities in healthcare services in Nigeria: evidence from the National Health Insurance Scheme. Health economics review, 11(1), 1-18. https://doi.org/10.1186/s13561-021-00301-9.

[29] Ushie, B. A., Bamidele, J. O., Uthman, O. A., & Aremu, O. (2020). Geographical disparities and determinants of access to basic HIV/AIDS-related services: a systematic review and meta-analysis in Nigeria. BMJ open, 10(1), e034028. https://doi.org/10.1136/bmjopen-2019-034028.

[30] Okoro, O. A., & Adebisi, Y. A. (2021). Geospatial analysis of the distribution of healthcare facilities and population in Nigeria. African Journal of Health Sciences, 34(1), 7-20. https://doi.org/10.4314/ajhs.v34i1.2.

[31] National Bureau of Statistics, 2021 Report.

[32] Abimiku, A. G., Adebayo, S. B., & Akinyele, A. O. (2021). Healthcare infrastructure in Nigeria: Challenges and opportunities. Journal of Public Health in Africa, 12(2), 157-166. doi: 10.4081/jphia.2021.1678.

[33] Idris, J., Afolabi, A., & Ahmed, A. (2019). Health infrastructure and healthcare delivery in Nigeria: Challenges and prospects. European Journal of Medical and Health Sciences, 1(3), 1-9.

[34] Olawepo, J. O., Asaolu, I. O., & Fashola, A. O. (2020). Healthcare infrastructure development in Nigeria: Challenges and the way forward. International Journal of Healthcare Management, 13(1), 23-30. doi: 10.1080/20479700.2018.1531186.

[35] Yusuf, A. O., Abdu, A. H., & Idris, A. (2018). Health infrastructure and human resources for health in northern Nigeria: Needs, challenges, and opportunities. Journal of Public Health in Africa, 9(2), 801. doi: 10.4081/jphia.2018.801.

[36] Doherty, J. E., & Hardee, K. (2018). Overcoming challenges to health system capacity building in low- and middle-income countries: Lessons from research and experience. Global Health: Science and Practice, 6(3), 485-508. doi: 10.9745/GHSP-D-17-00291.

[37] Ohiri, K., & Gukas, I. D. (2020). Improving healthcare delivery in Africa: A perspective from Nigeria. International Journal of Surgery: Global Health, 3(2), e22. doi: 10.1097/GH9.0000000000000022.

[38] Masiye, F., & Chitah, B. M. (2017). Improving access to and use of health services in rural areas: Case study of Kapiri Mposhi district in Zambia. Journal of Health, Population, and Nutrition, 36(1), 1-10. doi: 10.1186/s41043-017-0093-x.

[39] Shrestha, S. (2018). Strengthening healthcare systems in low-income countries: An overview of systematic reviews on healthcare infrastructure and workforce. Global Health Action, 11(1), 1-14. doi: 10.1080/16549716.2018.1484107.

[40] Nwadiuto, C. A. (2019). The impact of healthcare financing on access to health services in Nigeria: An exploratory study. Journal of Public Health in Africa, 10(S2), 142-151. doi: 10.4081/jphia.2019.1056.

[41] Sarma, H., Saikia, P., & Mahanta, L. B. (2019). Factors influencing health seeking behaviour among indigenous people in Northeast India: A qualitative study. BMC Public Health, 19(1), 1-9. doi: 10.1186/s12889-019-6981-7.

[42] Okechukwu, I. E., Onwujekwe, O. E., Uzochukwu, B. S., Okoronkwo, I. L., & Ibe, O. P. (2020). The effect of healthcare financing on healthcare utilization and health outcomes in Nigeria: An evaluation of the basic healthcare provision fund. PLoS ONE, 15(12), 1-15. doi: 10.1371/journal.pone.0244685.

[43] Fortney, J. C., Pyne, J. M., Edlund, M. J., Robinson, D. E., Mittal, D., Henderson, K. L., & Enderle, M. A. (2015). A randomized trial of telemedicine-based collaborative care for depression. Journal of General Internal Medicine, 30(8), 1057-1064. doi: 10.1007/s11606-015-3235-4.

[44] Scott, K., Beckham, S. W., Gross, M., Pariyo, G., Rao, K. D., Cometto, G., & Perry, H. B. (2017). What do we know about community-based health worker programs? A systematic review of existing reviews on community health workers. Human Resources for Health, 15(1), 1-17. doi: 10.1186/s12960-017-0184-z.

[45] Chib, A., van Velthoven, M. H., Car, J., & Zhang, M. W. (2015). Use of mobile phones in an emergency reporting system for infectious disease surveillance after the Sichuan earthquake in China. Bulletin of the World Health Organization, 93(5), 345-351. doi: 10.2471/BLT.14.141737.

[46] Kasthurirathne, S. N., Mamady, K., Nishiura, H., & Kucharski, A. J. (2019). Effectiveness of community event-based surveillance in detecting Ebola virus disease outbreaks in Guinea, 2015. BMJ Global Health, 4(3), e001474. doi: 10.1136/bmjgh-2019-001474.

[47] Das, J., & Woskie, L. R. (2018). Physician participation in telemedicine: What is the expectation? The Lancet Global Health, 6(11), e1169-e1170. doi: 10.1016/S2214-109X(18)30395-9.

Abstract:

Telehealth programs have been documented to help conserve scarce resources and enable the provision of quality and convenient patient care. Given the high HIV prevalence in sub-Saharan Africa, it is crucial for telehealth programs to be implemented. The purpose of this scoping review is to map the literature on telehealth in HIV care in sub-Saharan Africa, determine gaps in the utilisation of telehealth, and identify the barriers to implementation. A keyword search for studies reporting on telehealth in HIV care from PubMed, Research gate and gray literature was conducted, and studies published from 2015 to 2022, meeting the research criteria were included in the scoping review. Thematic content analysis was used to analyze findings from the included articles. Extraction of themes was performed using NVIVO version 12. Quality appraisal of the included studies was conducted using the mixed methods appraisal tool 2018 version. Database search retrieved 395 potentially eligible articles. Of these, 13 studies reported evidence of telehealth in HIV care. Included studies were conducted in South Africa, Kenya, Zambia, Zimbabwe, Togo, Mozambique, Tanzania, and Uganda. Three main themes emerged from the thematic content analysis: telehealth systems in sub-Saharan Africa are still at pilot stages or not widely implemented; users accept telehealth but raise concerns about privacy; and that low mobile phones ownership hampers telehealth implementation. The review revealed evidence for the effectiveness of telehealth in HIV care despite the presence of barriers. In this sense, it is recommended to adopt telehealth, which is cost effective, and improves access to healthcare.

References:

[1] Waterfield, K. C., Shah, G. H., Etheredge, G. D., & Ikhile , C. (2021). Consequences of Covid-19 crisis for persons with HIV: the impact of social determinants of health. BMC Public Health, 21(299), 23-27. doi:10.1186/s12889-021-10296-9.

[2] Yelverton, V., Qiao, S., Weissman, S., Olatosi, B., & Li, X. (2021). Telehealth for HIV Care Services in South Carolina: Utilization, Barriers, and Promotion Strategies During the Covid-19 Pandemic. AIDS and behavior, 25(12), 3909–3921. doi:10.1007/s10461-021-03349-y.

[3] Chenneville, T., Gabbidon, K., Hanson, P., & Holyfield, C. (2020). The Impact of Covid-19 on HIV Treatment and Research: A Call to Action. International Journal OF Environmental Research and Public Health, 17(12), 4548. doi:10.3390/ijerph17124548.

[4] Cornelius, T., Jones, M., Merly, C., Welles, B., Kalichman, M. O., & Kalichman, S. C. (2017). Impact of food, housing, and transportation insecurity on ART adherence: a hierarchical resources approach. AIDS Care, 29(4), 449-457. doi:10.1080/09540121.2016.1258451.

[5] Dandachi, D., Freytag, J., Giordano, T. P., & Dang, B. N. (2020). It is Time to Include Telehealth in Our Measure of Patient Retention in HIV Care. AIDS and behavior, 24(9), 2463-2465. doi:10.1007/s10461-020-02880-8.

[6] Lurie, N., & Carr, B. G. (2018). The Role of Telehealth in the Medical Response to Disasters. JAMA Internal Medicine, 178(6), 745-746. doi:10.1001/jamainternmed.2018.1314.

[7] Smith, A. C., Thomas, E., Snoswell, C. L., Haydon, H., Mehrotra, A., Clemensen, J., & Caffery, L. J. (2020). Telehealth for global emergencies: Implications for coronavirus disease 2019 (COVID-19). Journal of Telemedicine and Telecare, 26(5), 309-313. doi:10.1177/1357633X20916567.

[8] Siddiquee, N., Poudyal, A., Pandey, A., Shrestha, N., Karki, S., Subedi, R., & Sah, A. K. (2019). Telemedicine in Resource-Limited Setting: Narrative Synthesis of Evidence in Nepalese Context. Smart Homecare Technology and TeleHealth, 6, 1-14. doi:https://doi.org/10.2147/SHTT.S227854.

[9] Catalyst, N. (2018). What is Telehealth? Retrieved from https://catalyst.nejm.org/doi/full/10.1056/CAT.18.0268.

[10] Mbunge, E., Muchemwa, B., & Batani, J. (2022). Are we there yet? Unbundling the potential adoption and integration of telemedicine to improve virtual healthcare services in African health systems. Sensors International, 3. doi:10.1016/j.sintl.2021.100152.

[11] Chitungo, I., Mhango, M., Mbunge, E., Dzobo, M., Musuka, G., & Dzinamarira, T. (2021). Utility of telemedicine in sub‐Saharan Africa during the COVID‐19 pandemic. A rapid review. Human behavior and emerging technologies, 3(5), 843-853. doi:10.1002/hbe2.297.

[12] Rogers, B. G., Coats, C. S., Adams, E., Murphy, M., Stewart, C., Arnold, T., & Chan, P. A. (2020). Development of Telemedicine Infrastructure at an LGBTQ+ Clinic to Support HIV Prevention and Care in Response to COVID-19, Providence, RI. AIDS and Behaviour, 24(10), 2743-2747. doi:10.1007/s10461-020-02895-1.

[13] Dourado, I., Magno, L., Soares, F., Massa, P., Nunn, A., Dalal, S., & Grangeiro, A. (2020). Adapting to the COVID-19 Pandemic: Continuing HIV Prevention Services for Adolescents Through Telemonitoring, Brazil. AIDS and Behaviour, 24(7), 1994-1999. doi:10.1007/s10461-020-02927-w.

[14] Kharsany AB., & Karim QA. (2016). HIV Infection and AIDS in Sub-Saharan Africa: Current Status, Challenges and Opportunities. Open AIDS Journal, 8(10), 34-48. doi: 10.2174/1874613601610010034.

[15] Tafuma, T. A., Mahachi, N., Dziwa, C., Moga, T., Baloyi, P., Muyambo, G., . . . Lew, K. (2021). Barriers to HIV service utilisation by people living with HIV in two provinces of Zimbabwe: Results from 2016 baseline assessment. Southern African Journal of HIV Medicine, 19(1), 721. doi:10.4102/hivmed.v19i1.721.

[16] Arksey, H., & Omalley, L. (2005). Scoping studies: towards a methodological framework. International Journal of Social Research Metholody, 8(1), 19-32. doi:10.1080/1364557032000119616.

[17] Kurth A.E., Sidle J.E., Chhun N., Lizcano J.A., Macharia S.M., Garcia M.M., Mwangi A., Keter A., & Siika A.M. (2019). Computer-Based Counseling Program (CARE+ Kenya) to Promote Prevention and HIV Health for People Living With HIV/AIDS: A Randomized Controlled Trial. AIDS Education and Prevention, 31(5), 395-406. doi: 10.1521/aeap.2019.31.5.395.

[18] Sarna A., Saraswati L.R., Okal J., Matheka J., Owuor D., Singh R.J., Reynolds N., & Kalibala S. (2019). Cell Phone Counseling Improves Retention of Mothers With HIV Infection in Care and Infant HIV Testing in Kisumu, Kenya: A Randomized Controlled Study. Global Health Science and Practice, 7(2), 171-188. doi: 10.9745/GHSP-D-18-00241.

[19] Venables E., Ndlovu Z., Munyaradzi D., Martínez-Pérez G., Mbofana E., Nyika P., Chidawanyika H., Garone D.B., & Bygrave H. (2019). Patient and health-care worker experiences of an HIV viral load intervention using SMS: A qualitative study. PLoS One, 14(4). doi: 10.1371/journal.pone.0215236. PMID.

[20] Gbeasor-Komlanvi F.A., Chokpon A.C., Zida-Compaore W.I.C., Sadio A., Bali L.G., Hounou-Adossi A.F.E., Mensah E., Patassi A., Lepere P., & Ekouevi D.K. (2020). Acceptability of the use of mobile phones for HIV management in Togo. Sante Publique, 32(2-3), 253-262. doi: 10.3917/spub.202.0253.

[21] DiAndreth L., Krishnan N., Elf J.L., Cox S., Tilchin C., Nthulana M., Jarrett B., Kronis N., Dupuis E., Motlhaoleng K., Chon S., Martinson N., & Golub J.E. (2020). Formative research for an mHealth program to improve the HIV care continuum in South Africa. AIDS Care, 32(6), 744-748. doi: 10.1080/09540121.2019.1640850.

[22] Campbell B.R., Choi K., Neils M.G., Canan C., Moll A., Dillingham R., & Shenoi S.V. (2021). Mobile Device Usage by Gender Among High-Risk HIV Individuals in a Rural, Resource-Limited Setting. Telemedicine & E-Health Journal, 27(6), 615-624. doi: 10.1089/tmj.2020.0218. Epub 2020 Aug 21.

[23] Madhvani N., Longinetti E., Santacatterina M., Forsberg B.C., & El-Khatib Z. (2015). Correlates of mobile phone use in HIV care: Results from a cross-sectional study in South Africa. Preventive Medicine Reports, 14(2), 512-516. doi: 10.1016/j.pmedr.2015.06.010.

[24] Nhavoto J.A., Grönlund Å., & Klein G.O. (2017). Mobile health treatment support intervention for HIV and tuberculosis in Mozambique: Perspectives of patients and healthcare workers. PLoS One, 12(4). doi: 10.1371/journal.pone.0176051.

[25] Mbotwa C., Kazaura M., Moen K., Leshabari M., Metta E., Leyna G., & Mmbaga E.J. (2022). Predictors of mHealth use in promoting adherence to pre-exposure prophylaxis among female sex workers: an evaluation of the Jichunge intervention in Dar es Salaam, Tanzania. BMC Health Services Research, 22(1), 859. doi: 10.1186/s12913-022-08245-2.

[26] Siedner M.J, Santorino D., Haberer J.E, & Bangsberg D.R. (2015). Know your audience: predictors of success for a patient-centered texting app to augment linkage to HIV care in rural Uganda. Journal of Medical Internet Research, 17(3):e78. doi: 10.2196/jmir.3859. PMID: 25831269.

[27] Mogoba P., Phillips T.K., Myer L., Ndlovu L., Were M.C., & Clouse K. (2019). Smartphone usage and preferences among postpartum HIV-positive women in South Africa. AIDS Care, 31(6), 723-729. doi: 10.1080/09540121.2018.1563283.

[28] Ivanova O., Wambua S., Mwaisaka J., Bossier T., Thiongo M., Michielsen K., & Gichangi P. (2019). Evaluation of the ELIMIKA Pilot Project: Improving ART Adherence among HIV Positive Youth Using an eHealth Intervention in Mombasa, Kenya. African Journal of Reproductive Health, 23(1), 100-110. doi: 10.29063/ajrh2019/v23i1.10.

[29] Sutcliffe C.G., Thuma P.E., Van Dijk J.H., Sinywimaanzi K., Mweetwa S., Hamahuwa M., & Moss W.J. (2017). Use of mobile phones and text messaging to decrease the turnaround time for early infant HIV diagnosis and notification in rural Zambia: an observational study. BMC Pediatrics, 17(1), 66. doi: 10.1186/s12887-017-0822-z.

[30] Ross, J., Stevenson, F., Lau, R., & Murray, E. (2014). Exploring the challenges of implementing e-health: a protocol for an update of a systematic review of reviews. BMJ Open, 5(4). doi:10.1136/bmjopen-2014-006773.

[31] Mohr, D. C., Burns, M. N., Schueller, S. M., Clarke, G., & Klinkman, M. (2013). Behavioral intervention technologies: evidence review and recommendations for future research in mental health. General Hospital Psychiatry, 35(4), 332-338. doi:10.1016/j.genhosppsych.2013.03.008.

[32] Scott, R., & Mars, M. (2015). Telehealth in the developing world: current status and future prospects. Smart Homecare Technology and TeleHealth, 3, 25-37. Doi: https://doi.org/10.2147/SHTT.S75184.

[33] David, K. B., Solomon, J. K., Yunusa, I., Lawal, B. K., Marshal, C. S., Okereke, M., & Ozuluoha, C. C. (2020). Telemedicine: an imperative concept during COVID-19 pandemic in Africa. The Pan African Medical Journal, 35(2), 129. doi:10.11604/pamj.supp.2020.35.25281.

[34] Biruk, K., & Abetu, E. (2018). Knowledge and Attitude of Health Professionals toward Telemedicine in Resource-Limited Settings: A Cross-Sectional Study in North West Ethiopia. Journal of Healthcare Engineering. doi:10.1155/2018/2389268.

[35] Kruse S.C., Karem P., Shifflett K., Vegi L., Ravi K., & Brooks M. (2018). Evaluating barriers to adopting telemedicine worldwide: A systematic review. Journal of Telemedicine and Telecare, 24(1), 4-12. doi: 10.1177/1357633X16674087.

[36] Mothobi, O., & Grzybowski, L. (2017). Infrastructure deficiency and adoption of mobile
money in Sub-Suharan Africa. Information Economics and Policy, 40(13), 71-79. doi.org/10.1016/j.infoecopol.2017.05.003.

[37] Mobile network coverage in Africa (n.d) The Global Economy.com. Available at: https://www.theglobaleconomy.com/rankings/Mobile_network_coverage/Africa/ (Accessed: July 28, 2022).

Abstract:

Antiretroviral pre-exposure prevention (PrEP) to stop HIV transmission was 1st approved by the USA Food and Drug Administration in 2012. Despite correlations of decreases in new HIV infections being greatest wherever PrE-exposure prophylaxis has been deployed, the uptake of PrE-exposure prophylaxis is insulant, significantly among populations with disproportionate HIV burden. This narrative review seeks to spot individual and general barriers to PrE-exposure prophylaxis usage in African country. A comprehensive search of recent literature uncovered a fancy array of structural, social, clinical, and behavioral barriers, as well as knowledge/awareness of PrE exposure prophylaxis, perception of HIV risk, stigma from care suppliers or family/partners/friends, distrust of care providers/systems, access to school assignment, prices of PrE exposure prophylaxis, and issues around school assignment facet effects/medication interactions. significantly, these barriers might have totally different effects on specific populations in danger. The complete potential of PrE-exposure prophylaxis for HIV interference won't be realized till these problems area unit self-addressed. Ways to realize this goal ought to embody academic interventions, innovative approaches to delivery of HIV care, resource, and DE stigmatization of PrE-exposure prophylaxis and PrE-exposure prophylaxis users. Until then, PrE-exposure prophylaxis `uptake can still be suboptimal, significantly among people who would like it most. Results: Stigma influences uptake of pre-exposure prophylaxis; HIV risk perception does not affect uptake of pre-exposure prophylaxis; and a significant negative relationship between stigma and pre-exposure prophylaxis uptake. Conclusion: This study was conducted to investigate barriers to oral pre-exposure prophylaxis. Significant findings of the study conclude: stigma influences uptake of oral pre-exposure prophylaxis for HIV.

References:

[1] Strug, DL et al, 2002, Challenges and Changing Roles in HIV/AIDS Social Work, Social Work in Health Care, Volume 35, 2002 - Issue 4, p. 1 -19. https://doi.org/10.1300/J010v35n04_01.

[2] U Koppe · 2021 Barriers to using Pre-Exposure prophylaxis (PrEP).

[3] Fonner VA et al. (2016) ‘Effectiveness and safety of oral HIV pre-exposure prophylaxis for all populations’, AIDS, Volume 30, Issue 12, p.1973–83.

[4] McCormack, S et al. (2014) ‘Pre-exposure prophylaxis to prevent the acquisition of HIV-1 infection (PROUD): effectiveness results from the pilot phase of a pragmatic open-label randomised trial’, The Lancet, Volume 387, Issue 10013, p.53-60.

[5] Baeten, JM et al. (2012) 'Antiretroviral Prophylaxis for HIV-1 Prevention among Heterosexual Men and Women', New England Journal of Medicine, Volume 367, Issue 5, p.399-410.

[6] Grant, RM et al. (2010) 'Preexposure Chemoprophylaxis for HIV Prevention in Men Who Have Sex with Men', New England Journal of Medicine, Volume 363, p.2587-2599.

[7] BBC (10 April 2017) ‘NHS Scotland to fund 'game-changer' Prep HIV drug’.

[8] Public Health Society of Kenya (2017) ‘Why PrEP tool is a game-changer in fight against spread of HIV.

[9] San Francisco Bay Times ‘PrEP Could Be a Game Changer in the Fight Against HIV/AIDS’ (all accessed April 2019).

[10] Goffman, E. (1963). Stigma. Notes on the Management of Spoiled Identity. London: Penguin Books.

[11] World Health Organization (WHO) (2015) 'Policy brief: WHO expands recommendation on oral pre-exposure prophylaxis of HIV infection (PrEP)' [pdf].

[12] San Francisco Department of Public Health, Population Health Division (2015) 'HIV Epidemiology Annual Report 2014' [pdf].

[13] World Health Organization (WHO) (2015) 'Policy brief: WHO expands recommendation on oral pre-exposure prophylaxis of HIV infection (PrEP)' [pdf].

[14] UNAIDS (2018) ‘Miles to go: global AIDS update 2018’, p.59. [pdf].

[15] Prince O. Ezekiel (2022), Investigating the Effectiveness of Case Management among Orphans and Vulnerable Children at Household Level in Enugu State, Nigeria. Texila International Journal of Academic Research Special Edition Apr 2022, https://www.texilajournal.com/academic-research/article/2035-investigating-the-effectiveness.

[16] Aidsmap (2016) ‘Two cases of PrEP failure on solo tenofovir pose significant research questions’ (accessed April 2019).

[17] US Department of Health and Human Sciences: AIDSinfo ‘Maraviroc (HIV prevention)’ (accessed April 2019).

[18] Aidsmap (2015) 'Evidence for PrEP efficacy grows, but implementation presents challenges' (accessed April 2019).

[19] Centers for Disease Control and Prevention (CDC) ‘PrEP’ (accessed April 2019).

[20] Simon J, Agada1 and Prince Ezekiel (2023), Barriers to HIV Testing among Clients of Female Sex Workers an Assessment of Ogoja Local Government Area, Texila International Journal of Public Health: 2520-3134, https://doi.org/10.21522/TIJPH.2013.11.01.Art016.

[21] Hiv.gov/basics of hiv, retrieved on 18th November 2021.

[22] Centers for Disease Control and Prevention. Application number: 021752Orig1s030 https://www.accessdata.fda.gov/drugsatfda_docs/nda/2012/021752Orig1s030SumR.pdf.

[23] HIV and AIDS in Kenya. https://www.avert.org/professionals/hiv-around-world/sub-saharan-africa/kenya Accessed 15 Apr 2020.

[24] Ramjee G, Daniels B. Women and HIV in sub-Saharan Africa. AIDS Res Ther. 2013;10(1):30. https://doi.org/10.1186/1742-6405-10-30.

[25] UNAIDS. Advocating for zero discrimination in health-care settings in Kenya 2018. https://www.unaids.org/en/resources/presscentre/featurestories/2018/may/zero-discrimination-health-care-settings-kenya.

[26] Thomson K, Baeten J, Mugo N, Bekker L, Celum C, Heffron R. (2016), Tenofovir-based oral preexposure prophylaxis prevents HIV infection among women. Curr Opin HIV AIDS.;11(1):18–26.

[27] Jackson-Gibson, M., Ezema, A.U., Orero, W. et al. (2021), Facilitators and barriers to HIV pre-exposure prophylaxis (PrEP) uptake through a community-based intervention strategy among adolescent girls and young women in Seme Sub-County, Kisumu, Kenya. BMC Public Health 21, 1284 https://doi.org/10.1186/s12889-021-11335-1.

Abstract:

Adherence to self-care practices among diabetes mellitus patients is vital in achieving optimal glycemic control and delaying the progression of the disease complications. There is limited information regarding diabetes self-care among diabetic patients in Eastern Uganda, where the disease is most prevalent. The aim of this study was to determine the level of adherence to diabetes mellitus self-care practices and the associated factors among adult diabetic outpatients at a tertiary hospital in Eastern Uganda. A cross-sectional study was conducted at Mbale Regional Referral Hospital in Eastern Uganda between September and October 2020, on a sample of 156 diabetic patients recruited through systematic random sampling. A structured questionnaire was used to collect data through self-report. Descriptive and Logistic regression analyses were conducted using STATA version 15.0, and a 5% level of significance. Most of the study participants were female (63.8%) with an average age of 52.3 years (SD 13.8). The prevalence of adherence to self-care was 36.5%. The factors associated with adherence to self-care were good diabetes knowledge (AOR=2.5; 95% CI= 1.2-5.3, p = 0.016), and high self-efficacy (AOR=3.9; 95% CI= 1.8 – 8.7, p = 0.001). Less than half of the patients attending the diabetic clinic at Mbale Regional Referral Hospital in Eastern Uganda adhere to self-care practices. Patients ought to receive comprehensive, consistent, and contextualized diabetes education to enrich their knowledge, as well as a boost of their self-efficacy through interventions like counseling, positive feedback, role models, and peer education.

References:

[1] Abate TW, Tareke M, Tirfie M. Self-care practices and associated factors among diabetes patients attending the outpatient department in Bahir Dar, Northwest Ethiopia. BMC Res Notes [Internet]. 2018;11(1):800. Available from: https://doi.org/10.1186/s13104-018-3874-8.

[2] Adongo R, Id A, Id VB, Bavo T, Id A, Afaya A, et al. Medication adherence and self-care behaviours among patients with type 2 diabetes mellitus in Ghana. 2020; Available from: https://doi.org/10.1371/journal.pone.0237710.

[3] Chali SW, Salih MH, Abate AT. Self-care practice and associated factors among Diabetes Mellitus patients on follow up in Benishangul Gumuz Regional State Public Hospitals, Western Ethiopia: A cross-sectional study. BMC Res Notes [Internet]. 2018 Nov 26 [cited 2022 Feb 18];11(1):1–8. Available from: https://bmcresnotes.biomedcentral.com/articles/10.1186/s13104-018-3939-8.

[4] Saeedi P, Petersohn I, Salpea P, Malanda B, Karuranga S, Unwin N, et al. Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: Results from the International Diabetes Federation Diabetes Atlas, 9th edition. Diabetes Res Clin Pract. 2019 Nov 1; 157:107843.

[5] International Diabtes Federation. IDF Diabetes Atlas (9th ed.) [Internet]. 2019 [cited 2022 Feb 18]. Available from: https://idf.org/52-about-diabetes/451-diabetes-risk-factors.html.

[6] Williams R, Karuranga S, Malanda B, Saeedi P, Basit A, Besançon S, et al. Global and regional estimates and projections of diabetes-related health expenditure: Results from the International Diabetes Federation Diabetes Atlas, 9th edition. Diabetes Res Clin Pract. 2020 Apr; 162:108072.

[7] International Diabetes Federation. Uganda’s Diabetes Mellitus Prevalence [Internet]. 2020 [cited 2022 Feb 18]. Available from: https://idf.org/our-network/regions-members/africa/members/29-uganda.html.

[8] Uganda Diabetes Association. Diabetes in Uganda: The facts [Internet]. 2017 [cited 2022 Feb 18]. Available from: http://ugandadiabetesassociation.org/index.php?option=com_content&view=article&id=12&Itemid=150.

[9] Mayega RW, Makumbi F, Rutebemberwa E, Peterson S, Östenson CG, Tomson G, et al. Modifiable Socio-Behavioural Factors Associated with Overweight and Hypertension among Persons Aged 35 to 60 Years in Eastern Uganda. PLoS One. 2012 Oct 15;7(10).

[10] World Health Organization. Diabetes [Internet]. 2018 [cited 2022 Feb 18]. Available from: https://www.who.int/news-room/fact-sheets/detail/diabetes.

[11] Gurmu Y, Gela D, Aga F. Factors associated with self-care practice among adult diabetes patients in West Shoa Zone, Oromia Regional State, Ethiopia 11 Medical and Health Sciences 1117 Public Health and Health Services. BMC Health Serv Res [Internet]. 2018 Sep 24 [cited 2022 Feb 18];18(1):1–8. Available from: https://bmchealthservres.biomedcentral.com/articles/10.1186/s12913-018-3448-4.

[12] Rajasekharan D, Kulkarni V, Unnikrishnan B, Kumar N, Holla R, Thapar R. Self-Care Activities Among Patients with Diabetes Attending a Tertiary Care Hospital in Mangalore Karnataka, India. Ann Med Health Sci Res [Internet]. 2015 [cited 2022 Feb 18];5(1):59. Available from: /pmc/articles/PMC4350065/.

[13] Kwanjo Banda C, Gombachika BT, Nyirenda MJ, Sinjani Muula A, Petersen F, Brew-Sam N. Self-management and its associated factors among people living with diabetes in Blantyre, Malawi: a cross-sectional study. AAS Open Research 2021 2:161 [Internet]. 2021 Dec 23 [cited 2022 Feb 18]; 2:161. Available from: https://aasopenresearch.org/articles/2-161.

[14] Mukeshimana M, Hakizimana G, Mwali C, Umuhoza C, Uwambajimana J, Asingizwe D. The knowledge and practice of self-care management among patients attending a diabetes clinic in Kigali, Rwanda. Rwanda Journal [Internet]. 2015 Oct 8 [cited 2022 Feb 18];2(1):24–30. Available from: https://www.ajol.info/index.php/rj/article/view/123966.

[15] Denyes MJ, Orem DE, Bekel G. Self-care: a foundational science. Nurs Sci Q [Internet]. 2001 [cited 2022 Feb 18];14(1):48–54. Available from: https://pubmed.ncbi.nlm.nih.gov/11873354/.

[16] Shrivastava SRBL, Shrivastava PS, Ramasamy J. Role of self-care in management of diabetes mellitus. J Diabetes Metab Disord [Internet]. 2013 Mar 5 [cited 2022 Feb 18];12(1). Available from: https://pubmed.ncbi.nlm.nih.gov/23497559/.

[17] Lu Y, Xu J, Zhao W, Han HR. Measuring Self-Care in Persons with Type 2 Diabetes: A Systematic Review. Eval Health Prof [Internet]. 2016 Jun 1 [cited 2022 Feb 18];39(2):131–84. Available from: https://pubmed.ncbi.nlm.nih.gov/26130465/.

[18] Toobert DJ, Hampson SE, Glasgow RE. The summary of diabetes self-care activities measure: results from 7 studies and a revised scale. Diabetes Care [Internet]. 2000 [cited 2022 Feb 18];23(7):943–50. Available from: https://pubmed.ncbi.nlm.nih.gov/10895844/.

[19] Bariyyah NKMH, Bujang MA, Baharum N, Mastura I, Shah SA. Self-care activities among diabetic patients and factors affecting glycemic control in primary health care, Malaysia. Journal of Diabetes and Clinical Practice. 2018;1(1).

[20] Bigdeli MA, Saeed S, Nazari H, Khodakarim S, Brodati H, Bigdeli MA. Factors Affecting Self-Care in Patients with Type II Diabetes Using Path Analysis. Iranian Journal of Health Sciences [Internet]. 2016 Oct 10 [cited 2022 Feb 18];4(3):10–21. Available from: http://jhs.mazums.ac.ir/article-1-435-en.html.

[21] Nejaddadgar N, Solhi M, Jegarghosheh S, Abolfathi M, Ashtarian H. Self-Care, and Related Factors in Patients with Type 2 Diabetes. Asian Journal of Biomedical and Pharmaceutical Sciences [Internet]. 2017 Apr 21 [cited 2022 Feb 18];7(61):6–10. Available from: https://www.alliedacademies.org/articles/selfcare-and-related-factors-in-patients-with-type-2-diabetes.html.

[22] Elliott JA, Das D, Cavailler P, Schneider F, Shah M, Ravaud A, et al. A cross-sectional assessment of diabetes self-management, education and support needs of Syrian refugee patients living with diabetes in Bekaa Valley Lebanon Bayard Roberts, Kiran Jobunputra, Preeti Patel, and Pablo Perel. Confl Health [Internet]. 2018 Sep 12 [cited 2022 Feb 18];12(1):1–10. Available from: https://conflictandhealth.biomedcentral.com/articles/10.1186/s13031-018-0174-9.

[23] de Man J, Aweko J, Daivadanam M, Alvesson HM, Delobelle P, Mayega RW, et al. Diabetes self-management in three different income settings: Cross-learning of barriers and opportunities. PLoS One [Internet]. 2019 Mar 1 [cited 2022 Feb 18];14(3):e0213530. Available from: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0213530.

[24] Baumann LC, Opio CK, Otim M, Olson L, Ellison S. Self-care beliefs and behaviors in Ugandan adults with type 2 diabetes. Diabetes Educ [Internet]. 2010 [cited 2022 Feb 18];36(2):293–300. Available from: https://pubmed.ncbi.nlm.nih.gov/20067944/.

[25] Bagonza J, Rutebemberwa E, Bazeyo W. Adherence to anti diabetic medication among patients with diabetes in eastern Uganda; a cross sectional study. BMC Health Serv Res [Internet]. 2015 Apr 19 [cited 2022 Feb 18];15(1). Available from: https://pubmed.ncbi.nlm.nih.gov/25898973/.

[26] Kalyango JN, Owino E, Nambuya AP. Non-adherence to diabetes treatment at Mulago Hospital in Uganda: prevalence and associated factors. Afr Health Sci [Internet]. 2008 Jun [cited 2022 Feb 18];8(2):67. Available from: /pmc/articles/PMC2584325/.

[27] Mafabi D. More patients sleep on the floor than beds at Mbale hospital. The Daily Monitor [Internet]. 2013 Jun 18 [cited 2022 Feb 18]; Available from: https://www.monitor.co.ug/SpecialReports/More-patients-sleep-on-floor-than-beds-at-Mbale-hospital/-/688342/1886140/-/767b0u/-/index.html.

[28] Olaka D. Busitema University Faculty of Health Sciences Opens in Mbale [Internet]. Uganda Radio Network. 2013 [cited 2022 Feb 18]. Available from: https://ugandaradionetwork.com/a/story.php?s=57599.

[29] Yamane T. Statistics: an introduction analysis. Harper and Row; 1973.

[30] Habib A, johargy A, Mahmood K. Design and Determination of The Sample Size In Medical Research. IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) e-ISSN [Internet]. 2014 [cited 2022 Feb 18]; 13:21–31. Available from: www.iosrjournals.orgwww.iosrjournals.org.

[31] Kumar A, Dogra S, Kaur A, Modi M, Thakur A, Saluja S. Approach to sample size calculation in medical research. Curr Med Res Pract [Internet]. 2014 [cited 2022 Feb 18];4(2):87–92. Available from: https://www.academia.edu/13800960/Approach_to_sample_size_calculation_in_medical_research.

[32] Pourhoseingholi MA, Vahedi M, Rahimzadeh M. Sample size calculation in medical studies. Gastroenterol Hepatol Bed Bench [Internet]. 2013 [cited 2022 Feb 18];6(1):14. Available from: /pmc/articles/PMC4017493/.

[33] Omair A. Sample size estimation and sampling techniques for selecting a representative sample. Journal of Health Specialties [Internet]. 2014 [cited 2022 Feb 18];2(4):142. Available from: https://www.academia.edu/24683129/Sample_size_estimation_and_sampling_techniques_for_selecting_a_representative_sample.

[34] Taherdoost H. Sampling Methods in Research Methodology; How to Choose a Sampling Tech-nique for Research. International Journal of Academic Research in Management (IJARM) [Internet]. 2016 [cited 2022 Feb 18];5. Available from: https://hal.archives-ouvertes.fr/hal-0254679.

[35] Garcia AA, Villagomez ET, Brown SA, Kouzekanani K, Hanis CL. The Starr County Diabetes Education Study: development of the Spanish-language diabetes knowledge questionnaire. Diabetes Care [Internet]. 2001 [cited 2022 Feb 18];24(1):16–21. Available from: https://pubmed.ncbi.nlm.nih.gov/11194219/.

[36] AlQahtani AH, Alzahrani AS, Alzahrani SH, Alqahtani SM, AlOtaibi AF, Khan AA. Levels of Practice and Determinants of Diabetes Self-Care in Primary Health Care in Jeddah City, Saudi Arabia. Cureus [Internet]. 2020 Jun 25 [cited 2022 Feb 18];12(6). Available from: https://www.cureus.com/articles/33698-levels-of-practice-and-determinants-of-diabetes-self-care-in-primary-health-care-in-jeddah-city-saudi-arabia.

[37] Karve S, Cleves MA, Helm M, Hudson TJ, West DS, Martin BC. Good and poor adherence: optimal cut-point for adherence measures using administrative claims data. Curr Med Res Opin [Internet]. 2009 Sep [cited 2022 Feb 18];25(9):2303–10. Available from: https://pubmed.ncbi.nlm.nih.gov/19635045/

[38] Bursac Z, Gauss CH, Williams DK, Hosmer DW. Purposeful selection of variables in logistic regression. Source Code Biol Med. 2008 Dec 16;3(1):17.

[39] Kang H. The prevention and handling of missing data. Korean J Anesthesiol [Internet]. 2013 May [cited 2022 Feb 18];64(5):402. Available from: /pmc/articles/PMC3668100/.

[40] Dasappa H, Prasad S, Sirisha M, Prasanna SVNR, Naik S. Prevalence of self-care practices and assessment of their sociodemographic risk factors among diabetes in the urban slums of Bengaluru. J Family Med Prim Care [Internet]. 2017 [cited 2022 Feb 18];6(2):218. Available from: /pmc/articles/PMC5749060/.

[41] Huang M, Zhao R, Li S, Jiang X. Self-Management Behavior in Patients with Type 2 Diabetes: A Cross-Sectional Survey in Western Urban China. PLoS One [Internet]. 2014 Apr 17 [cited 2022 Feb 18];9(4):e95138. Available from: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0095138.

[42] Bukhsh A, Khan TM, Nawaz MS, Ahmed HS, Chan KG, Goh BH. Association of diabetes knowledge with glycemic control and self-care practices among Pakistani people with type 2 diabetes mellitus. Diabetes Metab Syndr Obes [Internet]. 2019 [cited 2022 Feb 18]; 12:1409. Available from: /pmc/articles/PMC6698595/.

[43] Jackson IL, Adibe MO, Okonta MJ, Ukwe C v. Knowledge of self-care among type 2 diabetes patients in two states of Nigeria. Pharm Pract (Granada) [Internet]. 2014 [cited 2022 Feb 18];12(3). Available from: https://pubmed.ncbi.nlm.nih.gov/25243026/.

[44] Mamo M, Demissie M. Self-care practice and its associated factors among diabetic patients in Addis Ababa public hospitals: A cross sectional study. J Diabetes Metab [Internet]. 2016 [cited 2022 Feb 18];07(06). Available from: https://www.iomcworld.com/proceedings/self-care-practice-and-its-associated-factors-among-diabetic-patients-in-addis-ababa-public-hospitals-a-cross-sectional--32225.html.

[45] Adejoh SO. Diabetes Knowledge, Health Belief, and Diabetes Management Among the Igala, Nigeria: https://doi.org/101177/2158244014539966 [Internet]. 2014 Jun 26 [cited 2022 Feb 18];4(2). Available from: https://journals.sagepub.com/doi/full/10.1177/2158244014539966.

[46] Vilchez-Cornejo J, Romani L, Reategui S, Gomez-Rojas E, Silva C. Factors associated with the Performance of Self-care Activities in Diabetic Patients in Three Ucayali Hospitals Faculty of Human Medicine URP. Rev Fac Med Hum [Internet]. 2020 [cited 2022 Feb 18];20(2):254–60. Available from: http://revistas.urp.edu.pe/index.php/RFMH.

[47] Ghannadi S, Amouzegar A, Amiri P, Karbalaeifar R, Tahmasebinejad Z, Kazempour-Ardebili S. Evaluating the Effect of Knowledge, Attitude, and Practice on Self-Management in Type 2 Diabetic Patients on Dialysis. J Diabetes Res [Internet]. 2016 [cited 2022 Feb 18];2016. Available from: https://pubmed.ncbi.nlm.nih.gov/27478845/.

[48] Takele GM, Weharei MA, Kidanu HT, Gebrekidan KG, Gebregiorgis BG, Takele GM, et al. Diabetes self-care practice and associated factors among type 2 diabetic patients in public hospitals of Tigray regional state, Ethiopia: A multicenter study. PLoS One [Internet]. 2021 Apr 1 [cited 2022 Feb 18];16(4):1–11. Available from: https://EconPapers.repec.org/RePEc:plo:pone00:0250462.

[49] Formosa C, Muscat R. Improving Diabetes Knowledge, and Self-Care Practices. J Am Podiatr Med Assoc [Internet]. 2016 [cited 2022 Feb 18];106(5):352–6. Available from: https://pubmed.ncbi.nlm.nih.gov/27762618/.

[50] Alhaik S, Anshasi HA, Alkhawaldeh J, Soh KL, Naji AM. An assessment of self-care knowledge among patients with diabetes mellitus. Diabetes
Metab Syndr [Internet]. 2019 Jan 1 [cited 2022 Feb 18];13(1):390–4. Available from: https://pubmed.ncbi.nlm.nih.gov/30641730/.

Abstract:

The World Health Organization recommends retesting of newly diagnosed HIV cases for verification of results prior to antiretroviral therapy (ART) initiation. This study aimed at ascertaining the HIV status of clients on lifelong ART. We tested 25% of ART clients in 6 care and treatment (C&T) sites and all HIV-positive women receiving ART in 22 prevention of mother-to-child HIV transmission (PMTCT) sites in Northwest and Southwest regions. Testing was proposed consecutively to clients in group education sessions during ART refill visit until the sample size was achieved. Individual counselling was provided to clients who opted to be retested. Testing was with Determine HIV-1/2 and First Response rapid tests and further testing was with DNA-PCR. Clients with negative test results were counseled to discontinue ART. Results were analyzed comparing misdiagnosis at ART and PMTCT sites. A total of 4526 ART clients were retested for HIV; 3914(86.5%) from ART and 612(13.5%) from PMTCT sites. Female participants dominated (79%) and the median age was 39 years. Higher proportions of clients retested at PMTCT sites were negative with both tests (0.8% vs 0.1%) and had discordant results (1.1% vs 0.4%) than at ART sites. All 32 clients with negative or discordant results were tested with DNA-PCR and 22(0.5%) were negative; 11(0.3%) in ART and 11(1.8%) in PMTCT sites. HIV positive status was confirmed for 99.5% of clients retested, with a lower rate at PMTCT (98.2%) than C&T (99.7%) sites; meaning misdiagnosis and inappropriate ART treatment was more likely at PMTCT. Adherence to recommendation for HIV retesting for verification will reduce inappropriate treatment.

References:

[1] R. A. Ajeh et al., ‘Determinants of retention in HIV antiretroviral treatment (ART) in the Cameroon International epidemiology Database to Evaluate AIDS (IeDEA) study clinics: the context of the HIV treat all strategy in Cameroon’, p. 12.

[2] A. A. Agbor et al., ‘Characteristics of patients co-infected with HIV at the time of inpatient tuberculosis treatment initiation in Yaoundé, Cameroon: a tertiary care hospital-based cross-sectional study’, Arch Public Health, vol. 73, no. 1, p. 24, Dec. 2015, doi: 10.1186/s13690-015-0075-y.

[3] CAMPHIA. Cameroon population-based HIV impact assessment CAMPHIA 2017. Summary sheet: preliminary findings. New York, USA: ICAP at Columbia University; 2018.’

[4] ‘Cameroon_SDS_Final-Public_Aug-11-2021.pdf’. Accessed: May 02, 2022. [Online]. Available: https://www.state.gov/wp-content/uploads/2021/09/Cameroon_SDS_Final-Public_Aug-11-2021.pdf.

[5] West and Central Africa | UNAIDS’. https://www.unaids.org/en/keywords/west-and-central-africa (accessed Apr. 22, 2022).

[6] T. P. Muffih, ‘CBCHS Annual Report 2020’, p. 114.

[7] Operational Guidelines for The Implementation of the “Test and Treat” Strategy In Cameroon, February 2017’.

[8] World Health Organization, caring for women subjected to violence: a WHO curriculum for training health-care providers. Geneva: World Health Organization, 2019. Accessed: May 02, 2022. [Online]. Available: https://apps.who.int/iris/handle/10665/330084.

[9] S. C. Kagulire et al., ‘Field evaluation of five rapid diagnostic tests for screening of HIV-1 infections in rural Rakai, Uganda’, Int J STD AIDS, vol. 22, no. 6, pp. 308–309, Jun. 2011, doi: 10.1258/ijsa.2009.009352.

[10] D. B. Klarkowski, J. M. Wazome, K. M. Lokuge, L. Shanks, C. F. Mills, and D. P. O’Brien, ‘The evaluation of a rapid in situ HIV confirmation test in a programme with a high failure rate of the WHO HIV two-test diagnostic algorithm’, PLoS One, vol. 4, no. 2, p. e4351, 2009, doi: 10.1371/journal.pone.0004351.

[11] C. Johnson et al., A report on the misdiagnosis of HIV status. World Health Organization, 2015. Accessed: May 16, 2022. [Online]. Available: https://www.ncbi.nlm.nih.gov/books/NBK316023/.

[12] World Health Organization, ‘Diagnostics for HIV diagnosis’, World Health Organization, Geneva,
2015. Accessed: May 02, 2022. [Online]. Available: https://apps.who.int/iris/handle/10665/180221.

[13] Dupwa et al. - 2019 - Retesting for verification of HIV diagnosis before.pdf’.

[14] False-Positive HIV Test Results’.

[15] Antiretroviral Therapy Guidelines for HIV-Infected Adults and Adolescents May 2013(1) _0.pdf’. Accessed: May 02, 2022. [Online]. Available: http://naco.gov.in/sites/default/files/Antiretroviral%20Therapy%20Guidelines%20for%20HIV-Infected%20Adults%20and%20Adolescents%20May%202013%281%29_0.pdf.

[16] WHO report in partnership with UNICEF and UNAIDS, June 2013’. Accessed: May 02, 2022. [Online]. Available: https://apps.who.int/iris/bitstream/handle/10665/85326/9789241505734_eng.pdf?sequence=1.

[17] Antiretroviral Drugs for Treating Pregnant Women for Their Own Health and to Prevent HIV Infection in Their Infants. World Health Organization, 2010. Accessed: May 03, 2022. [Online]. Available: https://www.ncbi.nlm.nih.gov/books/NBK304945/.

[18] S. Khan et al., ‘Identification of misdiagnosed HIV clients in an Early Access to ART for All implementation study in Swaziland’, Journal of the International AIDS Society, vol. 20, p. 21756, Aug. 2017, doi: 10.7448/IAS.20.7.21756.

[19] N. Hsiao, A. Zerbe, T. K. Phillips, L. Myer, and E. J. Abrams, ‘Misdiagnosed HIV infection in pregnant women initiating universal ART in South Africa’, J Int AIDS Soc, vol. 20, no. Suppl 6, p. 21758, Aug. 2017, doi: 10.7448/IAS.20.7.21758.

[20] Avoiding false positives: rapid HIV tests vary in their accuracy, so need to be used in combination’, aidsmap.com, May 02, 2017. https://www.aidsmap.com/news/may-2017/avoiding-false-positives-rapid-hiv-tests-vary-their-accuracy-so-need-be-used (accessed Feb. 06, 2023).

Abstract:

In this study, we conducted a statistical assessment of the economic and healthcare issues of leading countries affected due to the Covid-19 pandemic. We sought to consider the pandemic's progressive components, including the total tests, total cases, total deaths, total recoveries, and the total number of active cases. We also investigated the population dispersion, health index, and annual per capita income of the target countries. Real-time information regarding the topics is gathered from reputable institutional websites across the world, then organized and analyzed using statistical techniques. Both the graphical and tabular approaches are employed to present statistical manifestations. While some countries are shown to be in the leading position for most of the target issues, some inconsistencies are observed among a few. Concerning the annual per capita income and health index of the target countries, the Covid-19 components are not very relevant, but there is a slight similarity when looking at the overall population. Interestingly, regions with very low population densities show a higher prevalence of Covid-19. No discernible trend is attained from Bangladesh's perspective.

References:

[1] Shang, Y., Li, H., & Zhang, R. (2021). Effects of pandemic outbreak on economies: evidence from business history context. Frontiers in Public Health, 9, 632043.

[2] OECD (2021): Health at a Glance 2021: OECD Indicators, OECD Publishing, Paris, France.

[3] Kaye, A. D., Okeagu, C. N., Pham, A. D., Silva, R. A., Hurley, J. J., Arron, B. L., & Cornett, E. M. (2021). Economic impact of Covid-19 pandemic on healthcare facilities and systems: International perspectives. Best Practice & Research Clinical Anaesthesiology, 35(3), 293-306.

[4] Vo, T. D., & Tran, M. D. (2021). The impact of Covid-19 pandemic on global trade. International Journal of Social Science and Economics Invention, 7(1), 1-7.

[5] Donthu, N., & Gustafsson, A. (2020). Effects of Covid-19 on business and research. Journal of business research, 117, 284-289.

[6] Almeida, F., Santos, J. D., & Monteiro, J. A. (2020). The challenges and opportunities in the digitalization of companies in a post-Covid-19 World. IEEE Engineering Management Review, 48(3), 97-103.

[7] Ali, I., & Alharbi, O. M. (2020). Covid-19: Disease, management, treatment, and social impact. Science of the total Environment, 728, 138861.

[8] Ciotti, M., Ciccozzi, M., Terrinoni, A., Jiang, W. C., Wang, C. B., & Bernardini, S. (2020). The Covid-19 pandemic. Critical reviews in clinical laboratory sciences, 57(6), 365-388.

[9] Li, H., Li, H., Ding, Z., Hu, Z., Chen, F., Wang, K., ... & Shen, H. (2020). Spatial statistical analysis of coronavirus disease 2019 (Covid-19) in China. Geospatial Health, 15(1).

[10] Alkhowailed, M., Shariq, A., Alqossayir, F., Alzahrani, O. A., Rasheed, Z., & Al Abdulmonem, W. (2020). Impact of meteorological parameters on Covid-19 pandemic: a comprehensive study from Saudi Arabia. Informatics in medicine unlocked, 20, 100418.

[11] Sadiq, I. A., Sharma, S. K., & Ado, R. (2020). Statistical analysis of future prospective in Covid-19 cases in India. International Journal of Engineering Research & Technology, 9(11), 627-631.

[12] Fawad, M., Mubarik, S., Malik, S. S., & Ren, J. (2021). Statistical analysis of Covid-19 infection caused by environmental factors: Evidence from Pakistan. Life Sciences, 269, 119093.

[13] Cuadros, D. F., Branscum, A. J., Mukandavire, Z., Miller, F. D., & MacKinnon, N. (2021). Dynamics of the Covid-19 epidemic in urban and rural areas in the United States. Annals of epidemiology, 59, 16-20.

[14] Wilasang, C., Jitsuk, N. C., Sararat, C., & Modchang, C. (2022). Reconstruction of the transmission dynamics of the first Covid-19 epidemic wave in Thailand. Scientific Reports, 12(1), 2002.

[15] Uddin, M., Shawpnil, K., Mugdha, S. B. S., & Ahmed, A. (2023). A Statistical Synopsis of Covid-19 Components and Descriptive Analysis of Their Socio-Economic and Healthcare Aspects in Bangladesh Perspective. Journal of Environmental and Public Health, 2023.

[16] Mugdha, S. B. S., Uddin, M., & Islam, M. (2021). Extended epidemiological models for weak economic region: Case studies of the spreading of Covid-19 in the South Asian subcontinental countries. BioMed Research International, 2021.

[17] Uddin, M., Mugdha, S. B. S., Shermin, T., & Chowdhury, K. N. (2022). An Improved Epidemiological Model for the Underprivileged People in Contemporary Pandemics. BioMed Research International, 2022.

[18] Padhan, R., & Prabheesh, K. P. (2021). The economics of Covid-19 pandemic: A survey. Economic analysis and policy, 70, 220-237.

[19] Spinelli, A., & Pellino, G. (2020). Covid-19 pandemic: perspectives on an unfolding crisis. Journal of British Surgery, 107(7), 785-787.

[20] Yıldırım, M., & Güler, A. (2022). Factor analysis of the Covid-19 Perceived Risk Scale: A preliminary study. Death studies, 46(5), 1065-1072.

Abstract:

There is an observed poor treatment outcome of Diabetes mellitus (DM) in patients with Tuberculosis and Diabetes (TBDM) comorbidity due to interference of drugs used in the treatment of Tuberculosis (TB) with first- line drugs used in the treatment of DM. Insulin does not interact with TB drugs, but it is not accessible and affordable to low–resource communities due to high cost. Hence a lifestyle-based intervention, which this study evaluated to determine its effect on Diabetes control in these individuals. It is a quasi-experimental intervention with two groups of 25 participants each as experimental and control cohorts, enrolled from Tuberculosis Healthcare centers in Lagos and Oyo states. The questionnaires were administered after the baseline Glycated hemoglobin (HBA1c) has been measured, repeated after 12 weeks, and analyzed with SPSS software. In the control cohort, the difference in the means of HBA1c was statistically significant at 95%CI: 1.1(0.2 – 2.1; p<0.05), indicating a worsening of blood glucose control. The difference in the means of educational scores was not significant 95%CI: -0.04(-2.8 – 2.7; p<0.05), showing no uptake. In the intervention group, the difference in the means of the HBA1c was statistically significant 95%CI: -2.4(-3.1 – 1.6: p<0.05), indicating improvement in glucose control. The difference in the means of the educational and behavioral score was significant statistically 95%CI: 40.6(37.7 – 43.6; p<0.05) indicating uptake of behavioral changes. The intervention with educational and behavioral lifestyle modifications improved the blood glucose control as an adjunct to the conventional treatment with drugs compared to the control group.

Keywords: Behavioral change, Lifestyle, Treatment, Tuberculosis-Diabetes comorbidity.

References:

[1] Saklayen M. G. (2018). The Global Epidemic of the Metabolic Syndrome. Current hypertension reports, 20(2), 12. https://doi.org/10.1007/s11906-018-0812-z.

[2] Dunachie, S., & Chamnan, P. (2019). The double burden of Diabetes and global infection in low and middle-income countries. Transactions of the Royal Society of Tropical Medicine and Hygiene, 113(2), 56–64. https://doi.org/10.1093/trstmh/try124.

[3] Lin, X., Xu, Y., Pan, X. et al. (2020). Global, regional, and national burden and trend of Diabetes in 195 countries and territories: an analysis from 1990 to 2025. SciRep 10, 14790. https://doi.org/10.1038/s41598-020-71908-9.